ROS-ERK Pathway as Dual Mediators of Cellular Injury and Autophagy-Associated Adaptive Response in Urinary Protein-Irritated Renal Tubular Epithelial Cells by Jian-kun Deng, Xueqin Zhang, Hong-luan Wu, Yu Gan, Ling Ye, Huijuan Zheng, Zebing Zhu, Wei Jing Liu, Hua-feng Liu

“…ERK, an extracellular signal-regulated protein kinase, is involved in various biological responses, such as cell proliferation and differentiation, cell morphology maintenance, cytoskeletal construction, apoptosis, and canceration of cells. …”
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Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology by Xuan Lin, Kun Lin, Yue Lai, Qingping Peng, Miao Xu, Yiting Xu, Jialin Yang, Huan Liu, Jianlin Shen

“…Our findings revealed that low-dose ATBC (100 μM) significantly impaired cell proliferation and migration. Concurrently, we observed a downregulation in the transcriptional expression of key epigenetic regulators (KDM1A, EP300, HDAC2), suggesting that ATBC can disrupt bone metabolism at the cellular level. …”
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Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes by Mengmeng Sang, Jia Ge, Juan Ge, Juan Ge, Gu Tang, Qiwen Wang, Jiarun Wu, Liming Mao, Liming Mao, Xiaoling Ding, Xiaorong Zhou

“…For validation, a clinical cohort of patients diagnosed with pancreatic adenocarcinoma was examined using multiplex immunohistochemistry.ResultsWe were able to differentiate between hot and cold tumors in various types of cancer (bladder urothelial carcinoma, pancreatic adenocarcinoma, and cervical squamous cell carcinoma) by analyzing the presence of CD8+ T cells, activated natural killer cells, and M2-type macrophages, as well as the cytolytic activity and T cell proliferation. Hub genes that regulate the TME, including PDCD1, CD276, and NT5E, were discovered. …”
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Quaternary ammoniums activate human dendritic cells and induce a specific T-cell response in vitro by Marine Peyneau, Mathilde Zeller, Virginie Paulet, Benoît Noël, Marie-Hélène Damiens, Natacha Szely, Andreas Natsch, Marc Pallardy, Sylvie Chollet-Martin, Luc de Chaisemartin, Saadia Kerdine-Römer

“…Furthermore, activation by polyquaternium-7 could induce T-cell proliferation in heterologous and autologous coculture models, demonstrating that this molecule can induce a specific CD4+ T cell response. …”
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Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways by Qiqi Meng, Qiqi Meng, Zhiping Li, Xiaofeng He, Yuanhao Hu, Guiyun Wu, Jiawen Huang, Zhuohui Luo, Zhuohui Luo, Yingjie Hu, Xiaoling Shen

“…In MDA-MB-231 and Hs-578T cells, LAF markedly suppressed cell proliferation, migration and invasion, and promoted apoptosis. …”
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Bergapten alleviates senescence of chondrocytes in osteoarthritis by YE Yuanlan, LIU Kaiwen, PAN Yiming

“…Immunofluorescence assay, RT-qPCR and Western blotting indicated that bergapten treatment induced significant increases in the expression of cell proliferation markers such as PCNA, CCND1 and CCNE1 (P<0.05), while decreases in the expression of apoptosis markers Caspase3 and BAX (P<0.05). …”
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Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Bozitinib demonstrates a strong effect on MET-amplified gastric cancer cells by blocking the c-Met signaling pathway, leading to the inhibition of cell proliferation and survival, as well as the induction of G0/G1 phase arrest and apoptosis. …”
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Immunogenic Evaluation of Ribosomal P-Protein Antigen P0, P1, and P2 and Pentameric Protein Complex P0-(P1-P2)2 of Plasmodium falciparum in a Mouse Model by Agnieszka Szuster-Ciesielska, Leszek Wawiórka, Dawid Krokowski, Nikodem Grankowski, Łukasz Jarosz, Urszula Lisiecka, Marek Tchórzewski

“…An in vitro exposure of spleen lymphocytes from the immunized mice especially to the P1, P2, and P0-(P1-P2)2 protein caused 2-3-fold higher cell proliferation than that in the case of lymphocytes from the nonimmunized animals, suggesting development of immune memory. …”
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Adeno-associated virus mediated artificial circular RNA for triggering cancer immunotherapy to treat prostate cancer by Chujin Ye, Chujin Ye, Zhiye Liu, Zhiye Liu, Qifan Xie, Qifan Xie, Yanlin Tang, Yanlin Tang, Jiayi Zeng, Jiayi Zeng, Ziwei Feng, Ziwei Feng, Jiumin Liu, Jiumin Liu, Haibiao Xie, Haibiao Xie

“…In prostate cancer cell lines, the competitive inhibition of the ScircRNA on miR-375 and miR-21 activity was evaluated using luciferase report gene, cell proliferation, and apoptosis assays.ResultsWe found that ScircRNAs were more resistant to nuclease digestion and more effective inhibiting target miRNAs than linear RNA sponges. …”
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Cross-Talk between NOK and EGFR: Juxtamembrane and Kinase domain interactions enhancing STAT3/5 signaling in breast cancer tumorigenesis by Yinyin Wang, Bingdong Zhang, Chunhua He, Bo Tian, Sihan Liu, Jianghua Li, Jiayu Wang, Shigao Yang, Bingtao Zhu, Xiaoguang Wang, Zhijie Chang, Chenxi Cao

“…Epidermal growth factor receptor (EGFR) plays an important role in the regulation of cell proliferation and migration [1]. It forms a homodimer or heterodimer with other ErbB receptor family members to activate downstream signaling. …”
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3D nanocomposites of β-TCP-H3BO3-Cu with improved mechanical and biological performances for bone regeneration applications by Sarvesh Kumar Avinashi, Rajat Kumar Mishra, Shweta, Saurabh Kumar, Amreen Shamsad, Shama Parveen, Surajita Sahu, Savita Kumari, Zaireen Fatima, Sachin Kumar Yadav, Monisha Banerjee, Monalisa Mishra, Neeraj Mehta, Chandki Ram Gautam

“…Abstract Recently, 3-D porous architecture of the composites play a key role in cell proliferation, bone regeneration, and anticancer activities. …”
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Ly6E on tumor cells impairs anti-tumor T-cell responses: a novel mechanism of tumor-induced immune exclusion by Lan Hailin, Chen Yiting, Wu Yue, Li Lijun, Zhang Renlu, Chen Yunhan, Zhu Yanyang, Zhang Qiuyu

“…After analyzing Ly6E expression levels in human breast cancer tissues and tumor cell lines, we generated Ly6E knockout (KO) and overexpression (OE) mouse cell lines. Cell proliferation ability in vitro and the ability of growth and metastasis in mouse tumor models were compared between KO/OE and wild-type tumor cells. …”
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Exosomes from LPS-Stimulated hDPSCs Activated the Angiogenic Potential of HUVECs In Vitro by Xiangyu Huang, Wei Qiu, Yuhua Pan, Jianjia Li, Zhao Chen, Kaiying Zhang, Yifei Luo, Buling Wu, Wenan Xu

“…The proangiogenic potential of exosomes was evaluated by endothelial cell proliferation, migration, and tube formation abilities in vitro. …”
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Medicarpin suppresses lung cancer cell growth in vitro and in vivo by inducing cell apoptosis by Shen Zongyi, Yin Liqi, Chang Manxia, Wang Haifeng, Hao Mingxuan, Liang Youfeng, Guo Rui, Bi Ying, Wang Jiansong, Yu Changyuan, Li Jinmei, Zhai Qiongli, Cheng Runfen, Zhang Jinku, Sun Jirui, Yang Zhao

“…Overall, MED inhibited LC cell growth in vitro and in vivo via suppressing cell proliferation and inducing cell apoptosis, suggesting the therapeutic potential of MED in treating LC.…”
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Potential of Liposomal FTY720 for Bone Regeneration: Proliferative, Osteoinductive, Chemoattractive, and Angiogenic Properties Compared to Free Bioactive Lipid by Mouzoura P, Marazioti A, Gkartziou F, Metsiou DN, Antimisiaris SG

“…FTY720 demonstrated the ability to increase cell proliferation at 10– 300nM doses but was cytotoxic at doses> 400nM while the corresponding liposomal-FTY720 doses were non-cytotoxic, proving its reduced toxicity. …”
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Breast Cancer Conditioned Media Modulate the Expression of Immune Checkpoints and Adhesion Molecules in Endothelial Cells by İpek Türkdönmez, Emel Şahin, Mehmet Şahin

“…Results: CRL-2329-CM was found to increase cell proliferation at the end of 48 h but not 24 h, compared to the control (CRL-4010-CM) group (p=0.0052). …”
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DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer by Xiao Hong Zhao, Man Man Han, Qian Qian Yan, Yi Meng Yue, Kaihong Ye, Yuan Yuan Zhang, Liu Teng, Liang Xu, Xiao-Jing Shi, Ting La, Yu Chen Feng, Ran Xu, Vinod K. Narayana, David P. De Souza, Lake-Ee Quek, Jeff Holst, Tao Liu, Mark A. Baker, Rick F. Thorne, Xu Dong Zhang, Lei Jin

“…The addition of purine nucleobases adenine and guanine along with the pyrimidine nucleoside uridine restored replication fork progression and cell proliferation, whereas the supplementation of exogenous aspartate recovered the nucleotide pool, demonstrating a causal role of the aspartate shortage in OXPHOS inhibition-induced nucleotide deficiencies and consequently replication stress and reductions in proliferation. …”
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Super-enhancer-driven SLCO4A1-AS1 is a new biomarker and a promising therapeutic target in glioblastoma by Yibo Wu, Fang Li, Chen Yang, Xuehai Zhang, Zhiwei Xue, Yanfei Sun, Xiaoying Lin, Xuemeng Liu, Zhimin Zhao, Bin Huang, Qibing Huang, Xingang Li, Mingzhi Han

“…Knockdown of SLCO4A1-AS1 decreased glioma cell proliferation, invasive ability, self-renewal ability, and increased apoptosis. …”
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Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies by Wen-Ting K. Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J. Carter

“…Assay methods used include dendritic cell internalization, T cell proliferation, and T cell epitope identification by in silico prediction and MHC-associated peptide proteomics. …”
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Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits by Jie Wu, Jiamin Zhai, Haofan Jia, Ifeanyi Solomon Ahamba, Xianggui Dong, Zhanjun Ren

“…Numerous studies have confirmed the crucial roles of mRNAs and non-coding RNAs (ncRNAs) in regulating key cellular processes such as cell proliferation, differentiation, apoptosis and immunity. …”
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