The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis by Qin Qi, Rui Zhong, Yan Huang, Yong Tang, Xiao-wen Zhang, Chang Liu, Chun-fang Gao, Lin Zhou, Jian Yu, Lu-yi Wu

“…The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in cell proliferation and metastasis and is upregulated in a variety of cancers. …”
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Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review by Andrada Pintea, Andrei Manea, Cezara Pintea, Robert-Alexandru Vlad, Magdalena Bîrsan, Paula Antonoaea, Emöke Margit Rédai, Adriana Ciurba

“…Peptides are novel active ingredients that improve collagen synthesis, enhance skin cell proliferation, or decrease inflammation. Based on their mechanism of action, they can be classified into signal peptides, carrier peptides, neurotransmitter inhibitor peptides, and enzyme inhibitor peptides. …”
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Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro i... by Shiya Yu, Shiyao Zheng, Jinwei Qiu, Hongming Lin, Xiaojuan Yu, Huiyan Chen, Junhong Wu, Weihang Wu, Jiong Chen, Yongyuan Chen, Jianwei Chen, Hu Zhao, Yu Wang

“…Cellular experiments have shown that PAPPA promotes cell proliferation, and its deficiency can inhibit the proliferation of GC cells, inducing cell cycle arrest at the G1/S phase. …”
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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…Subsequently, in vitro experiments confirmed that POSTN knockdown significantly inhibited HeLa cell proliferation, invasion, and enhanced radiosensitivity, while promoting apoptosis. …”
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Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 by Yanqing Liu, Jie Chen, Xiang Li, Yu Fan, Cheng Peng, Xiaochun Ye, Yingshuang Wang, Xin Xie

“…RAS proteins, as pivotal signal transduction molecules, are frequently mutated and hyperactivated in various human cancers, closely associated with tumor cell proliferation, survival, and metastasis. Despite extensive research on RAS targeted therapies, developing effective RAS inhibitors remains a significant challenge. …”
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Reduced UPF1 levels in senescence impair nonsense-mediated mRNA decay by Dahyeon Koh, Yebin Lee, Kyuchan Kim, Hyeong Bin Jeon, Chaehwan Oh, Sangik Hwang, Minjung Lim, Kwang-Pyo Lee, Yeonkyoung Park, Yong Ryoul Yang, Yoon Ki Kim, Donghwan Shim, Myriam Gorospe, Ji Heon Noh, Kyoung Mi Kim

“…Moreover, knockdown of UPF1 in proliferating WI-38 cells induces senescence, as evidenced by increased senescence-associated β-galactosidase activity, alterations in senescence-associated molecular markers, increased endogenous γ-H2AX levels, and reduced cell proliferation. These findings suggest that the decline in UPF1 levels during cellular senescence accelerates the senescent phenotype by impairing NMD activity and the consequent accumulation of abnormal mRNA.…”
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Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cells Combined with Normothermic Machine Perfusion Repairs Bile Duct Injury in a Rat Model of DCD Liver Transplantation via A... by Xuan Tian, Huan Cao, Longlong Wu, Weiping Zheng, Mengshu Yuan, Xiang Li, Hongli Song, Zhongyang Shen

“…In the group treated with HO-1/BMMSCs combined with NMP (HBP group), liver functions and bile duct histology were improved; meanwhile, cell apoptosis was reduced and cell proliferation was active. A large number of regenerative cells appeared at the injured site, and the defective bile duct epithelium was restored. …”
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Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation by Md. Abul Barkat, Afreen Fatima, Bushra Riaz, Mohd. Zaheen Hassan, Tanveer Ahamad, Abdulkareem A. Alanezi, Harshita Barkat, Afaf F. Almuqati, Yahya I. Asiri, Sahabjada Siddiqui

“…PGP has shown a potential to reduce lung cancer cell proliferation while evading normal cell death. PGP induced apoptosis by arresting cells in the G0/G1 phase and generating ROS. …”
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Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Deliver miR-21 to Promote Corneal Epithelial Wound Healing through PTEN/PI3K/Akt Pathway by Xiaolong Liu, Xuran Li, Guangyuan Wu, Pengfei Qi, Yanyan Zhang, Zhiyu Liu, Xinyue Li, Yu Yu, Xiangmei Ye, Yang Li, Dongguang Yang, Yueqiu Teng, Ce Shi, Xin Jin, Sen Qi, Yuting Liu, Shudan Wang, Ying Liu, Fenglin Cao, Qingran Kong, Zhenkun Wang, Hong Zhang

“…The sEVs derived from HUMSCs can significantly promote corneal epithelial cell proliferation, migration in vitro, and corneal epithelial wound healing in vivo. …”
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Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1 by Yanbin Zhang, Peng Lv, Qing Zhang, Wei Xiang, Xiaobing Jiang, Zijun Guo, Tao Zhang

“…We found that GAMSCs promote GBM cell proliferation, migration, invasion and glycolysis by releasing exosomes. …”
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Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma by Chuyu He, Xuejuan Wang, Yi-Shiou Chiou, Basappa Basappa, Tao Zhu, Vijay Pandey, Peter E. Lobie

“…Elevated expression of TFF3 promoted the oncogenicity of ER+HER2+ MC cells, including enhanced cell proliferation, survival, anchorage-independent growth, 3D growth, cancer stem cell-like (CSC-like) phenotype, migration, invasion, and xenograft growth. …”
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Inhibition of miR-182-5p Targets FGF9 to Alleviate Osteoarthritis by Yang Sun, Sanmao Su, Mengjun Li, Ang Deng

“…Cell counting kit-8 (CCK8), plate cloning assay, and flow cytometry were conducted to evaluate cell proliferation and apoptosis. The expression of inflammatory factors, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and interleukin (IL)-8, was evaluated using enzyme-linked immunosorbent assay (ELISA). …”
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Low-Intensity Pulsed Ultrasound Modulates RhoA/ROCK Signaling of Rat Mandibular Bone Marrow Mesenchymal Stem Cells to Rescue Their Damaged Cytoskeletal Organization and Cell Biolog... by Rong Zhang, Zhaoling Wang, Guoxiong Zhu, Gaoyi Wu, Qingyuan Guo, Hongchen Liu, Lei Chen

“…In this study, the effects of LIPUS on cytoskeletal reorganization, cell viability, and osteogenic differentiation capacity of rat mandible-derived bone marrow mesenchymal stem cells (M-BMMSCs) induced by radiation were determined by immunofluorescence staining, CCK-8 cell proliferation assay, quantification of alkaline phosphatase (ALP) activity, alizarin red staining, and real-time RT-PCR, respectively. …”
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METTL3-dependent DLG2 inhibits the malignant progression of cervical cancer by inactivating the Hippo/YAP signaling by Mei Pu, Xia Xiao, Shasha Lv, Daqing Ran, Qian Huang, Mingming Zhou, Qirong Lei, Lingshuang Kong, Qing Zhang

“…Elevating DLG2 levels significantly suppressed cervical cancer cell proliferation, migration, and invasion, while promoting apoptosis. …”
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Effect of Activated Platelet-Rich Plasma on Chondrogenic Differentiation of Rabbit Bone Marrow-Derived Mesenchymal Stem Cells by Zhen Wang, Zheng Wang, Bin Zhang, Qinghua Zhao, Yubao Liu, Wei Qi

“…Cell counting assays were performed to evaluate the cell proliferation of BMSCs. BMSCs (5×105 cells/well in 6-well plates) were induced in four conditions for 21 days to chondrogenic differentiation evaluation, including commercial chondrogenic medium (control), 5% PRP (HG-DMEM+5% PRP), 10% PRP (HG-DMEM+10% PRP), and 15% PRP (HG-DMEM+15% PRP). …”
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CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation by Jingjing Yang, Jingjing Yang, Qiqi Fan, Yiyun Wang, Yuanyue Liu, Xiaoning Xu, Yeqi Liang, Jiakang Xie, Jiajie Li, Fengting Ai, Yong Cao, Shangzhen Yu, Jinman Liu

“…This review summarizes the role of circRNAs in CRC, particularly their mechanisms in cell proliferation, migration, apoptosis, tumor microenvironment (TME) remodeling, and immune evasion. …”
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Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HA/Collagen/PLA Scaffold by Xing Wang, Helin Xing, Guilan Zhang, Xia Wu, Xuan Zou, Lin Feng, Dongsheng Wang, Meng Li, Jing Zhao, Jianwei Du, Yan Lv, Lingling E, Hongchen Liu

“…Scanning electron microscopy, a cell proliferation assay, and supernatant detection indicated that the nHAC/PLA provided a suitable environment for aBMSCs. …”
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Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives by Nikolaos Nektarios Karamanolis, Dimitris Kounatidis, Natalia G. Vallianou, Krystalia Dimitriou, Eleni Tsaroucha, Georgios Tsioulos, Ioanna A. Anastasiou, Evangelos Mavrothalassitis, Irene Karampela, Maria Dalamaga

“…These mechanisms include the induction of apoptosis and cell cycle arrest, generation of reactive oxygen species, and inhibition of key regulators of cell proliferation and migration. Additional effects involve the disruption of angiogenesis and modulation of pivotal processes such as inflammation, immune response, mitochondrial dynamics, ferroptosis, and autophagy. …”
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Long Noncoding RNA HCG9 Promotes Osteosarcoma Progression through RAD51 by Acting as a ceRNA of miR-34b-3p by Lu Wang, ShuangQing Li, Lin Qi, Lin Ling

“…Overexpression and silence of RNA were detected by qRT-PCR. Osteosarcoma cell proliferation was measured with CCK-8 assay, and the migration and invasion were evaluated with Transwell assay. …”
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circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression by Yue Ma, Yanyi Ren, Huitao Wen, Chengcheng Cui

“…Inhibition of circCOL1A1/miR-145/RABL3 could effectively suppress gastric cancer cell proliferation, migration, and invasion. circCOL1A1 also promote the transformation of M1 into M2 macrophage. …”
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