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541
Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages
Published 2010-01-01“…Tumor-Associated Macrophages (TAMs) are abundantly present in the stroma of solid tumors and modulate several important biological processes, such as neoangiogenesis, cancer cell proliferation and invasion, and suppression of adaptive immune responses. …”
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542
Effects of early local administration of high-dose bFGF on a recurrent laryngeal nerve injury model
Published 2023-07-01“…Conclusions A single, early local administration of high-dose bFGF prevented atrophic changes in the thyroarytenoid muscles by activating satellite cell proliferation and reforming neuromuscular junctions. …”
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543
Cellular Mechanisms of Multiple Myeloma Bone Disease
Published 2013-01-01“…This review focuses on the current knowledge of MM bone disease biology, with particular regard on the role of bone and immune cells in producing cytokines critical for malignant plasma cell proliferation as well as in osteolysis development. …”
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544
Enitociclib, a selective CDK9 inhibitor: in vitro and in vivo preclinical studies in multiple myeloma
Published 2025-02-01“…In this study, a library of 216 clinically feasible small-molecule inhibitors was screened to identify agents that selectively inhibit MM cell proliferation. Enitociclib, a cyclin-dependent kinase 9–specific small-molecule inhibitor, was found to be highly effective in decreasing cell viability and inducing apoptosis in 4 MM cell lines. …”
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545
FBXL16 Promotes Endometrial Progesterone Resistance via PP2AB55α/Cyclin D1 Axis in Ishikawa
Published 2022-01-01“…Cells were screened and established with Ishikawa cells which proved the fundamental role of FBXL16 in regulating cell proliferation and cell cycle. The MPA-resistant endometrial carcinoma cell line Ishikawa/MPA was established. …”
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546
Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines
Published 2025-02-01“…Moreover, sub-fractions obtained from the ethyl acetate extract inhibited pancreatic cancer cell proliferation, especially fraction EA-III-2 tested at 50–150 μg/mL. …”
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547
The perfect molecule for hormonal contraception: Estetrol benefits. A review
Published 2024-12-01“…The data analyzed suggest that E4 may reduce the risk of breast cancer, as it induces less breast cell proliferation compared to other estrogens. During E4 therapy, the risk of venous thromboembolism is minimized, and there is less impact on hepatic enzymes, which improves the quality of sexual life and opens up the opportunities of prescribing COCs with E4 to women who are continuously receiving other drugs – statins, antiretroviral agents, or anticonvulsants. …”
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548
The Nod2 Agonist Muramyl Dipeptide Cooperates with the TLR4 Agonist Lipopolysaccharide to Enhance IgG2b Production in Mouse B Cells
Published 2019-01-01“…Collectively, this study suggests that Nod2 signaling enhances TLR4-activated B cell proliferation, IgG2b switching, and IgG2b production.…”
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549
The Effect of Pyrroloquinoline Quinone on the Expression of WISP1 in Traumatic Brain Injury
Published 2017-01-01“…WISP1, as a member of the CCN4 protein family, has cell protective effects of promoting cell proliferation and inhibiting cell apoptosis. Although some studies have confirmed that WISP1 is concerned with colon cancer and lung cancer, there is little report about the influence of WISP1 in traumatic brain injury. …”
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550
The beneficial effects of thymoquinone on viability and differentiation of human adipose tissue-derived mesenchymal stem cells
Published 2024-04-01“…As a result of our study, doses of 50 nM, 100 nM, 200 nM, and 300 nM thymoquinone have been demonstrated to enhance cell proliferation, prevent apoptosis, and contribute to adipogenic, chondrogenic, and osteogenic differentiation. …”
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551
Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway.
Published 2025-01-01“…These results showed that inotodiol has the ability to promote apoptosis, as well as inhibit the ability of cell proliferation, migration, and clonogenic ability. The cell cycle was arrested in G1 phase, when the expression of CDK2, CDK4, CDK6 and Cyclin D were inhibited. …”
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552
A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology
Published 2025-02-01“…Numerous studies have demonstrated that Schisandrin B exhibits significant antitumor activity against various malignant tumors in preclinical studies, which is achieved by inhibiting cell proliferation and metastasis and promoting apoptosis. …”
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553
Effects of Renal Denervation on Ouabain-Induced Hypertension in Rats
Published 2024-01-01“…RDN could inhibit the pressor effect and the myocardial remodeling induced by ouabain potentially via inhibiting catecholamine release and vascular smooth muscle cell proliferation. Clinical studies are needed to explore whether RDN may exhibit better antihypertensive effects on hypertensive patients with high plasma ouabain levels as compared to those with normal plasma ouabain levels.…”
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554
Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer
Published 2025-02-01“…PI3K and MAPK pathways are frequently activated, promoting cell proliferation and survival. Epigenetic alterations, including DNA methylation and histone modifications, are also prevalent in both cancer types. …”
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555
GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling
Published 2021-01-01“…Ectopic expression of GTSE1 in lung cancer cells significantly increased while knockdown of GTSE1 decreased cell proliferation, cell migration, and cell invasion in H460 and A549 cells. …”
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556
Salivary stimulatory and anti-inflammatory effects of aqueous Lilium brownii var. viridulum Baker extract for Sjögren’s syndrome: in vitro and in vivo studies
Published 2025-01-01“…LB significantly increased NS-SV-AC cell proliferation, fluid secretion, and AQP-5 expression. …”
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557
In Vitro Investigation of Potential Anti-Diabetic Activity of the Corm Extract of Hypoxis Argentea Harv. Ex Baker
Published 2018-12-01“…In this study, we investigated the effects of non-toxic concentrations (12.5-100 μg mL-1) of the aqueous extract of H. argentea (HAA) corms on glucose uptake, pancreatic beta cell proliferation, and adipocyte differentiation. HAA stimulated glucose uptake in HepG2 cells up to 19.6 % and 17.0 % in L6 myotubes. …”
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558
Potensi Eugenol Fraksi Etil Asetat Bunga Cengkeh terhadap Proliferasi Kanker Serviks (HeLa Cell Line)
Published 2024-09-01“…</p><p><strong>Keywords</strong>: anti-cervical cancer, cervical cancer, cell proliferation, MTT assay, scratch assay </p>…”
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559
Synergistic effects of platelet-rich fibrin and photobiomodulation on bone regeneration in MC3T3-E1 Preosteoblasts
Published 2025-02-01“…Background: Platelet-rich fibrin (PRF) and Photobiomodulation (PBM) are established methods for promoting bone healing. PRF enhances cell proliferation and migration due to its rich concentration of growth factors, while PBM stimulates tissue repair through mitochondrial activation. …”
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560
Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A
Published 2021-01-01“…In vitro experiments showed that fenofibrate regulated cell cycle distribution, promoted apoptosis, and suppressed cell proliferation and epithelial mesenchymal transition by activating PPARA. …”
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