Pharmacologic Targets and Prototype Therapeutics in the Kallikrein-Kinin System: Bradykinin Receptor Agonists or Antagonists by J. N. Sharma, G.J. AL-Sherif

“…It is a proinflammatory polypeptide that is involved in many pathological conditions and can cause pain, inflammation, increased vascular permeability, vasodilation, contraction of various smooth muscles, as well as cell proliferation. On the other hand, it has been shown that BK has cardioprotective effects, as all components of KKS are located in the cardiac muscles. …”
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Comparison of In Vitro Endocrine Activity of Phthalates and Alternative Plasticizers by Hélène Moche, Aouatif Chentouf, Sergio Neves, Jean-Marc Corpart, Fabrice Nesslany

“…In the E-Screen assay, only DEHP moderately induced MCF-7 cell proliferation; none of the other tested substances were estrogenic or antiestrogenic. …”
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Chemokines in Renal Diseases by Stephan Segerer, Peter J. Nelson

“…In addition to their effects on migration, chemokines can also activate effector function in leukocytes and are involved in cell proliferation and angiogenesis. Therefore, it is not surprising that chemokines play important roles in a wide range of human diseases, including genetic immunodeficiencies, infections, autoimmune diseases, and malignant tumors. …”
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The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) by Shin Takasawa, Tomoko Uchiyama, Maiko Takeda

“…They are closely associated with cell and tissue regeneration, cell proliferation, and anti-apoptosis in various tissues and cells including pancreatic β cells. …”
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A Pleural Solitary Fibrous Tumor, Multiple Gastrointestinal Stromal Tumors, Moyamoya Disease, and Hyperparathyroidism in a Patient Associated with NF1 by Yoko Yamamoto, Ken Kodama, Shigekazu Yokoyama, Masashi Takeda, Shintaro Michishita

“…Loss of the gene function, due to a point mutation, leads to an increase in cell proliferation and the development of several tumors. …”
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Molecular Imaging of IGF-1R in Cancer by Yingying Sun PhD, Xilin Sun PhD, Baozhong Shen MD, PhD

“…Increased IGF-1R activity promotes cancer cell proliferation, migration, and invasion and is associated with tumor metastasis, treatment resistance, poor prognosis, and shortened survival in patients with cancer. …”
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Migration and proliferation drive the emergence of patterns in co-cultures of differentiating vascular progenitor cells by Jose E. Zamora Alvarado, Kara E. McCloskey, Ajay Gopinathan

“…Vascular cells self-organize into unique structures guided by cell proliferation, migration, and/or differentiation from neighboring cells, mechanical factors, and/or soluble signals. …”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…Results from numerous pre-clinical studies suggest that a well known anticonvulsant drug valproic acid (VPA) and other short-chain fatty acids (SCFAs) cause significant inhibition of cancer cell proliferation by modulating multiple signaling pathways. …”
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Histone Deacetylases Inhibitors in the Treatment of Retinal Degenerative Diseases: Overview and Perspectives by Hua Zhang, Xufeng Dai, Yan Qi, Ying He, Wei Du, Ji-jing Pang

“…The histone deacetylase inhibitors (HDACis) have the ability to cause hyperacetylation of histone and nonhistone proteins, resulting in a variety of effects on cell proliferation, differentiation, anti-inflammation, and anti-apoptosis. …”
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Inhibition of IGF-1R-Dependent PI3K Activation Sensitizes Colon Cancer Cells Specifically to DR5-Mediated Apoptosis But Not to rhTRAIL by Bodvael Pennarun, Jan H. Kleibeuker, Tjitske Oenema, Janet H. Stegehuis, Elisabeth G.E. de Vries, Steven de Jong

“…The activity of the insulin-like growth factor 1 (IGF-1) survival pathway is often increased in cancer, influencing both cell proliferation and apoptosis. We hypothesized that inhibiting the IGF-1 receptor (IGF-1R) using NVP-AEW541, a small molecular weight tyrosine kinase inhibitor of the IGF-1R, could increase death receptor (DR)-mediated apoptosis in colon cancer cells.…”
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Targeting glycolysis: exploring a new frontier in glioblastoma therapy by Lu Yang, Sijia Li, Lei Yu, Jiao Leng, Na Li

“…Lactate has been implicated in promoting tumor cell proliferation, invasion, and immune evasion. Additionally, this review systematically analyzes potential therapeutic strategies targeting key molecules within the glycolytic pathway, such as Glucose Transporters (GLUTs), Monocarboxylate Transporters(MCTs), Hexokinase 2 (HK2), 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3), Pyruvate Kinase Isozyme Type M2 (PKM2), and the Lactate Dehydrogenase A (LDHA). …”
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Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair by Gurleen Kaur, Chuanxi Cai

“…Pharmaceutical administration is another approach that allows for manipulation of signaling pathways related to cell proliferation and cell senescence. Since the stem cell niche can contribute to the age-related decline in stem cell function, rejuvenation strategies also include optimization of extracellular factors. …”
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The Role of MicroRNAs in Cardiac Stem Cells by Nima Purvis, Andrew Bahn, Rajesh Katare

“…Recent studies have demonstrated the important role of miRs in regulating stem cell proliferation and differentiation, as well as other physiological and pathological processes related to stem cell function. …”
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Impaired Muscle Regeneration in Ob/ob and Db/db Mice by Mai-Huong Nguyen, Ming Cheng, Timothy J. Koh

“…Muscle regeneration was delayed in ob/ob and db/db mice, but not in a less severe model of insulin resistance – feeding a high-fat diet to wild-type mice. Angiogenesis, cell proliferation, and myoblast accumulation were also impaired in ob/ob and db/db mice, but not the high-fat diet mice. …”
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Multiple Factors Determine the Oncolytic or Carcinogenic Effects of TLRs Activation in Cancer by Yingxiang Yang, Chengyue Jin, Anthony Yeo, Bo Jin

“…However, TLRs are also overexpressed in human cancer cells resulting in increased cell proliferation, migration, invasion, and angiogenesis. …”
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Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm by Andrew A. Davis, Virginia G. Kaklamani

“…Specifically, increased leptin and decreased adiponectin levels disrupt homeostatic signaling pathways involved in cell proliferation, survival, cell-cycle regulation, and angiogenesis. …”
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ANRIL regulates retinoblastoma progression via targeting autophagy by miR-328-3p/TSC1/ULK signaling by Yang Yang, Yuezhi Zhang, Yanmei Fu, Shuanglian Li, Xiaolong Yin

“…Finally, our results indicated that ANRIL overexpression facilitated Y79 cell proliferation and cisplatin-induced apoptosis. Our results indicated that ANRIL promoted the proliferation and cisplatin resistance of Y79 cells through activating autophagy by promoting TSC1/ULK2 ex- pression via acting as a miR-328-3p sponge.…”
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Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury by Yu Peng, Qiang Li, Lu Zhang, Ming Bai, Zheng Zhang

“…It modulates smooth muscle cell proliferation and inflammatory cytokines in vitro. …”
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Dysplasia in Inflammatory Bowel Diseases: Definition and Clinical Impact by Karel Geboes, Paul Rutgeerts

“…They can identify changes in DNA content and molecular changes resulting from defects of genes controlling cell proliferation and death or tissue structure. These changes can, however, be absent, appear early or late in the transition from normality toward dysplasia and cancer, or appear during repair. …”
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miRNAs and Melanoma: How Are They Connected? by Adriana Taveira da Cruz, Miriam Galvonas Jasiulionis

“…Therefore these molecules are considered essential in the processing of many biological responses, such as cell proliferation, apoptosis, and stress responsiveness. …”
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