Quercetin inhibits the biological activity of endometrial cancer by regulating autophagy: A network pharmacology analysis and cellular experimental validation by Lingchen Yang, Hongwei Ma

“…Cell Counting Kit-8 and flow cytometry assays were used to evaluate cell proliferation and apoptosis; cell invasive and migratory abilities were assessed by Transwell and wound healing assays, respectively; the observation of the cell ultrastructure was performed by transmission electron microscopy; the relative protein expressions were measured by the western blot assay. …”
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The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer by Marisa Rosso, Miguel Muñoz, Michael Berger

“…Recently, it has become apparent that SP can induce tumor cell proliferation, angiogenesis, and migration via the NK-1 receptor, and that the SP/NK-1 receptor complex is an integral part of the microenvironment of inflammation and cancer. …”
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GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth by Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Michael G Rosenblum, Brian Aguirre, Cheng-Hsiang Lu, Anubhav Chandla, Nidhi Kejriwal, Lucia Liu, Ann M Chan, SuYin Kok, Sergio Duarte, David Casero, Madhuri Wadehra

“…In vivo, the GrB-Fc-KS49 showed efficacy against a TNBC syngeneic (4T1/FLuc) mouse model, reducing tumor volume and cell proliferation and increasing cell death compared with controls. …”
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

“…The combination of bakuchiol and isobavachalcone synergistically inhibited cancer cell proliferation in vitro. Importantly, it also prevented tumor development in xenografted NOD/SCID mice. …”
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NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner by Tiange Lu, Juan Yang, Yiqing Cai, Mengfei Ding, Zhuoya Yu, Xiaosheng Fang, Xiangxiang Zhou, Xin Wang

“…NCAPD3 deficiency impeded cell proliferation, induced apoptosis and increased the chemosensitivity. …”
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Myotubularin-Related Phosphatase 3 Promotes Growth of Colorectal Cancer Cells by Bo’an Zheng, Xiaojun Yu, Rui Chai

“…Knockdown of MTMR3 resulted in a significant reduction in cell proliferation in both HCT116 and SW1116 cells. Moreover, knockdown of MTMR3 led to S phase cell cycle arrest. …”
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Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies by Hana Yeh, Matthew A. De Cruz, Yang You, Seiko Ikezu, Tsuneya Ikezu

“…The addition of doxycycline facilitates rapid cell proliferation, allowing for population expansion. Upon withdrawal of doxycycline, this monoclonal microglial cell line differentiates, resembling in vivo microglial physiology as demonstrated by the expression of microglial genes, innate immune responses, chemotaxis, and phagocytic abilities. …”
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lncRNA HOTTIP Recruits EZH2 to Inhibit PTEN Expression and Participates in IM Resistance in Chronic Myeloid Leukemia by Jing Liu, Lin Yang, Xiaojun Liu, Lu Liu, Menghan Liu, Xuefeng Feng, Jianmin Luo

“…In in vitro experiments, lentiviral knockdown of HOTTIP inhibited CML cell proliferation and promoted apoptosis, and knockdown of HOTTIP also increased sensitivity to IM. …”
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Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice by Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner

“…Oxysterols are naturally occurring molecules that play important role in various metabolic and inflammatory processes and their levels are elevated in patients suffering from obesity and diabetes. 25-Hydroxycholesterol (25-OHC) is produced in cells from cholesterol by the enzyme cholesterol 25-hydroxylase (Ch25h) and is involved in lipid metabolism, inflammatory processes, and cell proliferation. Here, we investigated the role of hepatic Ch25h in the transition from metabolically healthy obesity to insulin resistance and diabetes. …”
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Plant stem cells: unity and diversity by I. E. Dodueva, V. E. Tvorogova, M. Azarakhsh, M. A. Lebedeva, L. A. Lutova

“…WOX-CLAVATA systems are a regulatory component conservative for different meristems and providing consistency of the composition of the meristem, as well as the balance of stem cell proliferation and differentiation. In this review, we will consider the similarities and differences between the principles of organization of stem cell niches in plants and animals, as well as in a variety of meristems of higher plants; special attention will be paid to the role of WOX-CLAVATA systems in maintaining meristems and their interaction with other meristem regulators.…”
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The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach by Kellik Setiawan Volta, Affan Ali Murtadlo Ahmad, Nur Muhammad Ansori Arif, Dhea Kharisma Viol, Dayu Rahma Turista Dora

“…Molecular docking analysis demonstrated that Quercetin and Eleutherol exhibit high binding affinities (−9 and −8 kcal/mol, respectively) with target proteins, indicating significant potential for inhibiting cancer cell proliferation by targeting proteins like EGFR, JNK, and NUDT5. …”
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Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct by Wattanapitayakul Suvara K., Chularojmontri Linda, Schäfer-Korting Monika

“…UVB enhanced the accumulation of reactive oxygen species (ROS) and halted cell replication as detected by BrdU cell proliferation assay. The senescence phenotype was evaluated by beta-galactosidase (β-gal) staining and qPCR of genes related to senescent regulation, i.e. p16INK4a, cyclin D2, and IFI27. …”
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PPARγ and Its Agonists in Chronic Kidney Disease by Yuhua Ma, Manman Shi, Yuxin Wang, Jian Liu

“…The function of PPARγ in the kidney ranges from energy metabolism, cell proliferation to inflammatory suppression, although major renal side effects of existing agonists (including TZDs) have been reported, which limited their application in treating CKD. …”
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Preparation and Bioactivity Properties of a Novel Composite Membrane of Fructose Mediated β-Tricalcium Pyrophosphate/(Polyethylene Glycol/Chitosan) for Guided Tissue Regeneration by Jian-Wen Wang, Min-Hsiung Hon, Yi-Ming Kuo, Mei-Hui Chung

“…Most importantly, the release of calcium ions and glucosamine from the composite membranes was proved to increase the cell proliferation of NIH3T3. The results of this study have indicated that this novel F-β-TCP/CS/PEG composite can be a suitable material for GTR applications.…”
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Acetylation Modification Improves Immunoregulatory Effect of Polysaccharide from Seeds of Plantago asiatica L. by Le-Ming Jiang, Shao-Ping Nie, Dan-Fei Huang, Zhi-Hong Fu, Ming-Yong Xie

“…Besides, DCs treated with the Ac-PLCPs showed extremely strong T cell proliferation stimulating activity (P<0.01). These data showed that Ac-PLCPs had higher maturation-stimulating activity on DCs than PLCP, which indicated that acetylation modification improved the immunoregulatory effect of PLCP.…”
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The role of Box A of HMGB1 in producing γH2AX associated DNA breaks in lung cancer by Sirapat Settayanon, Pithi Chanvorachote, Apiwat Mutirangura

“…Then, we demonstrated the downstream effects of DSBs on lung cancer, lowering cell proliferation, decreasing cell migration, and promoting apoptosis. …”
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Administration of Iodine-125 Seeds Promotes Apoptosis in Cholangiocarcinoma through the PI3K/Akt Pathway by Junqing Lin, Leye Yan, Xiaolong Wang, Zhengzhong Wu, Kun Ke, Xin Lin, Ning Huang, Weizhu Yang

“…In vitro, human cholangiocarcinoma RBE cells were treated with 125I seeds (0.39 mCi or 0.85 mCi) for 72 h, 120 h, and 168 h. Cell proliferation and apoptosis were assessed. The expression of Bcl-2 and Bax was detected by RT-PCR, and Western blotting was carried out to explore changes in Akt activity. …”
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Vitreous Mediators in Retinal Hypoxic Diseases by Roberto dell'Omo, Francesco Semeraro, Giulio Bamonte, Francesco Cifariello, Mario R. Romano, Ciro Costagliola

“…Cytokines, which usually serve as signals between neighboring cells, are involved in essentially every important biological process, including cell proliferation, inflammation, immunity, migration, fibrosis, tissue repair, and angiogenesis. …”
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Carcinogenic and anticancer activities of microbiota-derived secondary bile acids by Mobina Kouhzad, Friedrich Götz, Tahereh Navidifar, Elahe Taki, Mahsa Ghamari, Roghayeh Mohammadzadeh, Maryam Seyedolmohadesin, Narjess Bostanghadiri

“…Conversely, some SBAs exhibit anticancer properties by inducing apoptosis, inhibiting cell proliferation, and modulating immune responses. The article also discusses the complex interplay between SBAs and the host’s genetic and environmental factors, highlighting potential therapeutic implications and the need for targeted strategies to mitigate risks while harnessing beneficial effects. …”
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Existence of Neural Stem Cells in Mouse Spleen by Koichi Tomita, Hiroshi Ishikawa

“…Some of the cells generated sphere-like formations, which may have been neurospheres. Cell proliferation was best in medium containing 10% FBS. …”
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