Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy by Shunqiao Jin, Shunqiao Jin, Xiaojiao Liu, Xiaojiao Liu, Lingqin Cai, Lingqin Cai, Jiayu Yan, Ling Li, Hongjun Dong, Yuxue Gao, Xicong Zhu, Cong Zhang, Xuezhu Xu

“…Itraconazole inhibited melanoma cell proliferation by inducing G1 phase arrest and autophagy-mediated apoptosis in A375 and A2058 cells. …”
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Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study by Zhao HW, Liu ST, Wang XJ, Zhang XM, Ma X

“…YAP expression was knocked down using siRNA transfection to examine its effects on inflammatory cytokines.Results: DMOG significantly increased HIF-1α expression while reducing IL-1β and TNF-α levels in LPS-treated hPDLSCs. 0.1 mmol/L DMOG inhibited cell proliferation after 72 hours (P < 0.001). ELISA results showed that HIF-1α concentrations in the LPS + DMOG group were significantly higher than in the LPS group (P < 0.01), while IL-1β and TNF-α levels were significantly reduced (P < 0.01). …”
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The Association of HOTAIR with the Diagnosis and Prognosis of Gastric Cancer and Its Effect on the Proliferation of Gastric Cancer Cells by Zhiying Xu, Hui Chen, Bin Yang, Xiangfeng Liu, Xiaoli Zhou, Hongfang Kong

“…And HOTAIR promoted GC cell proliferation.…”
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Effect of Qingjie Fuzheng Granules on Proliferation, Apoptosis and Migration of Colorectal Cancer SW620 Cells by Xiaoqin ZHU, Hong YANG, Bin HUANG, Lihui WEI, Jiumao LIN

“…The inhibitory effect of QFG on cell proliferation was detected by MTT assay after 24 h and 48 h. …”
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Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells by Junjie Wang, Dongdong Fu, Soulixay Senouthai, Yan Jiang, Rentong Hu, Yanwu You

“…In addition, Cyr61 expression was increased in accordance with induction of cell cycle arrest and apoptosis and inhibition of cell proliferation induced by Ang II. Knockdown of Cyr61 in HEK293T cells promoted cell cycle procession, decreased apoptosis, and promoted cell proliferation. …”
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Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights by Lingxia Wu, Chenxiaoxiao Liu, Weicai Hu

“…Functional assays, including cell proliferation, colony formation, and wound healing, were conducted post-MMP7 knockdown using siRNA in A375 cells. …”
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Developmental changes of skin quality from breast, back, and thigh of Pekin ducks from 1 to 6 weeks of age by Hao Li, Wenxuan Zheng, Shuo Xin, Ye Hui, Yijun Zhu, Xi Lin, Huaqi Zhang, Yongwen Zhu

“…The skin quality was increased in a quadratic manner, which was associated with the changes in mRNA expression of target genes related to cell proliferation and collagen synthesis.…”
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TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis by Xinxing Wang, Mingze Ma, Shuai Shao, Xianwen Xu, Chuan Qin, Ruxin Gao, Zhenhai Zhang

“…Results TWIST1 expression was significantly elevated in PDAC tissues, and over-expression of TWIST1 in PDAC cells enhanced colony formation and cell proliferation. Notably, HK2 levels were markedly higher in pancreatic cancer tissues compared to adjacent normal tissues. …”
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Reduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms by Jua Kim, Jeremy L. Gilbert, William W. Lv, Ping Du, Haobo Pan

“…This study shows that Mg corrosion can enhance cell proliferation by reducing intracellular ROS. However, Mg cannot decrease ROS and promote cell proliferation in simulated inflammatory conditions, meaning the microenvironment is critical. …”
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The Role of Indoxyl Sulfate in Exacerbating Colorectal Cancer During Chronic Kidney Disease Progression: Insights into the Akt/β-Catenin/c-Myc and AhR/c-Myc Pathways in HCT-116 Col... by Yu Ichisaka, Chihiro Takei, Kazuma Naito, Manami Higa, Shozo Yano, Toshimitsu Niwa, Hidehisa Shimizu

“…Indoxyl sulfate significantly induced CRC cell proliferation at concentrations exceeding 62.5 µM, a process suppressed by the c-Myc inhibitor 10058-F4. …”
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ELAVL1‐dependent SOAT2 exacerbated the pancreatitis‐like cellular injury of AR42J cells induced by hyperstimulation with caerulein by Yu‐Jing Sun, Hua‐Ying Chen, Xiao‐Qin Lai

“…Cell viability was determined using a cell counting kit‐8 (CCK‐8) assay, while cell proliferation was analyzed through a 5‐Ethynyl‐2′‐deoxyuridine assay. …”
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The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas by Juan Du, Anli Tong, Fen Wang, Yunying Cui, Chunyan Li, Yushi Zhang, Zhaoli Yan

“…LY294002 (10 μM), U0126 (10 μM), AZD8055 (1 μM), and sunitinib (1 μM) inhibited PPGL cell proliferation in ten primary cultures of tissues, including four from patients with gene mutations. …”
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Gut microbiota derived metabolite trimethylamine N-oxide influences prostate cancer progression via the p38/HMOX1 pathway by Yuhua Zhou, Jing Lv, Shengkai Jin, Chaowei Fu, Bo Liu, Yang Shen, Menglu Li, Yuwei Zhang, Ninghan Feng, Ninghan Feng, Ninghan Feng, Ninghan Feng

“…Subsequently, CCK8 time gradients, colony formation assays, and EdU assays measured TMAO’s influence on cell proliferation. Wound healing and transwell migration assays evaluated TMAO’s effect on cell migration. …”
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Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription by Lipeng Pei, Yan Zhu, Wenpeng Li, Bin Xu, Jingli Sun

“…Overexpression of KAT2B in UCEC inhibited cell proliferation and increased DNA damage and apoptosis. …”
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Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways by Jie Lin, Jinlong Tian, Chi Shu, Zhen Cheng, Yunen Liu, Weisheng Wang, Ruihai Liu, Bin Li, Yuehua Wang

“…The results showed that Mv-3-gal inhibited the cell proliferation and colony formation ability, induced cell cycle arrest and apoptosis in a dose-dependent manner. …”
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BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia by Xu Sang, Yongping Zhang, Fang Fang, Li Gao, Yanfang Tao, Xiaolu Li, Zimu Zhang, Jianwei Wang, Yuanyuan Tian, Zhiheng Li, Di Yao, Yumeng Wu, Xinran Chu, Kunlong Zhang, Li Ma, Lihui Lu, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Zhen Zhang, Jian Pan, Shaoyan Hu

“…GNE-987 inhibited AML cell proliferation by inhibiting the cell cycle and inducing apoptosis. …”
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Mesenchymal Stromal Cells from Osteoarthritic Synovium Are a Distinct Population Compared to Their Bone-Marrow Counterparts regarding Surface Marker Distribution and Immunomodulati... by Sebastien Hagmann, Claudia Rimmele, Florin Bucur, Thomas Dreher, Felix Zeifang, Babak Moradi, Tobias Gotterbarm

“…Their unique ability to suppress CD3/CD28 induced CD4+ T-cell proliferation makes them a potential target for future therapeutic approaches.…”
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Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner I... by Lianet Lopez, Hannah Shuster-Hyman, Eden Marco, Hasna Khan, Avishai Gasner, Aleksandra Uzelac, Brandon Wyse, Poonam Mander, Mugundhine Sangaralingam, Joseph Fish, Ariel Gorodensky, Samar Mouazz, Amanda Kauffman, Denis Gallagher, Andrée Gauthier-Fisher, Clifford L. Librach

“…Cell fate and tumor cell proliferation, apoptosis, vascularization as well as tumor-associated immune cells were assessed using immunostaining and flow cytometry. …”
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Ampelopsin induces MDA-MB-231 cell cycle arrest through cyclin B1-mediated PI3K/AKT/mTOR pathway in vitro and in vivo by Meng Minjun, Yang Qiaolu, Ouyang Zhong, Yang Qingmo, Wu Xinyi, Huang Yufan, Su Yonghui, Chen Shuanglong, Chen Wenlin

“…Also, it was observed that cyclin B1 overexpression attenuated cell apoptosis and weakened the inhibitory effects of AMP on cell proliferation. Together, AMP could inhibit breast cancer MDA-MB-231 cell proliferation in vitro and in vivo, due to cell cycle arrest at G2/M by inactivating PI3K/AKT/mTOR pathway regulated by cyclin B1.…”
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Antiproliferative evaluation of various aminoquinoline derivatives by Zorc Branka, Rajić Zrinka, Perković Ivana

“…Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.…”
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