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221
The p85 Regulatory Subunit of PI3K Mediates cAMP-PKA and Insulin Biological Effects on MCF-7 Cell Growth and Motility
Published 2014-01-01“…Furthermore, the p85αPI3KS83 phosphorylation plays a central role in the control of insulin-mediated cell proliferation, cell migration, and adhesion. This study highlights the p85αPI3KS83 role as a key regulator of cell proliferation and motility induced by insulin in MCF-7 cells breast cancer model.…”
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222
Filamented hydrogels as tunable conduits for guiding neurite outgrowth
Published 2025-04-01“…While significant differences in neurite outgrowth and alignment were observed between bulk and FLight gels, further increases in porosity from 40 % to 70 % enhanced cell migration and axon bundling without significantly affecting maximal outgrowth. …”
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223
Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration
Published 2020-01-01“…In PMN-Arf6 cKO mice, the recruitment of PMNs into the dorsal air pouch injected with LPS or the chemoattractant fMLP was significantly diminished. Impaired cell migration correlated with reduced cell surface expression of CD11a and CD11b in Arf6 cKO PMNs. …”
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224
Ionizing radiation and photodynamic therapy lead to multimodal tumor cell death, synergistic cytotoxicity and immune cell invasion in human bladder cancer organoids
Published 2025-02-01“…A matrix-based co-culture model was used to study T cell migration into the environment of treated organoids. …”
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225
Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis
Published 2025-02-01“…Findings of in vitro studies revealed considerable inhibitory effects of sunitinib and analogs on LoVo cell migration and invasion in hypoxic condition. Gelatin zymography and qPCR analysis indicated decreased activity of MMP-2 and MMP-9, along with downregulation of EMT transcription factors in hypoxic condition. …”
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226
GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia
Published 2025-02-01“…The effects of AST on cell migration and angiogenesis were studied using wound healing assays and angiogenesis assays. …”
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227
Colony Formation, Migratory, and Differentiation Characteristics of Multipotential Stromal Cells (MSCs) from “Clinically Accessible” Human Periosteum Compared to Donor-Matched Bone...
Published 2019-01-01“…This study is aimed at comparing human periosteum and donor-matched iliac crest BM MSC content and characterising MSCs in terms of colony formation, growth kinetics, phenotype, cell migration patterns, and trilineage differentiation capacity. …”
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228
TWIST1 regulates HK2 ubiquitination degradation to promote pancreatic cancer invasion and metastasis
Published 2025-02-01“…Knockdown of TWIST1 or HK2 enhanced the inhibitory effects of 2DG on cell migration and invasion. Treatment with Elesclomol-Cu and 2DG significantly reduced the expression of the cuproptosis-related factor FDX1 with no impact on other cell death factors. …”
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229
Exploring Methacrylated Gellan Gum 3D Bioprinted Patches Loaded with Tannic Acid or L-Ascorbic Acid as Potential Platform for Wound Dressing Application
Published 2025-01-01“…The positive effect of GGMA patches on cell migration was assessed through a wound healing assay. …”
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230
Unlocking melanoma Suppression: Insights from Plasma-Induced potent miRNAs through PI3K-AKT-ZEB1 axis
Published 2025-02-01“…Various biological processes and underlying molecular mechanisms were assessed using Alamar Blue, propidium iodide (PI) uptake, cell migration, and clonogenic assays followed by qRT-PCR and flow cytometry. …”
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231
Inhibition of id-1 reduces osteosarcoma growth and metastasis through mediation of snail
Published 2025-01-01“…Transwell invasion and scratch assays were used to assess cell migration and invasion. WB was employed to detect the expression of Id-1, Snail, and epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, vimentin, and N-cadherin) in the OS cells of each group. …”
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232
Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation
Published 2016-01-01“…Transwell migration assay showed that (i) CXCL8 increased cell migration in both TPC-1 and BCPAP cells; (ii) IFNγ significantly reduced the migration only of BCPAP cells; and (iii) CXCL8 reverted the effect of IFNγ. …”
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233
Aberrant Expression of JAM2 Inhibits Invasion and Migration in Lung Adenocarcinoma
Published 2025-01-01“…Its downregulation in LUAD, potential role as a prognostic gene, and influence on cell migration, invasion, and inflammatory infiltration make it a valuable target for further research and development of therapeutic strategies.…”
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234
Nephronectin Is Required for Vascularization in Zebrafish and Sufficient to Promote Mammalian Vessel‐Like Structures in Hydrogels for Tissue Engineering
Published 2025-02-01“…Moreover, nephronectin promotes mammalian endothelial cell migration and tube formation in 2D and 3‐dimensional in vitro tissue culture. …”
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235
Scutellarin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF/ERK/FAK/Src Pathway Signaling
Published 2019-01-01“…HRECs were cultured in high glucose- (30 mM D-glucose) and hypoxia (cobalt chloride-treated)-stimulated diabetic condition to evaluate the antiangiogenic effects of SCU by CCK-8 test, cell migration experiment (wound healing and transwell), and tube formation experiment. …”
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236
Simvastatin Posttreatment Controls Inflammation and Improves Bacterial Clearance in Experimental Sepsis
Published 2020-01-01“…We measured plasma biochemical markers of organ dysfunction, cell migration, cell activation, bacterial elimination, production of nitric oxide 24 h after CLP, survival rate for 7 days, and cognitive impairment 15 days after CLP. …”
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237
Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway
Published 2024-10-01“…Knockdown of CHRNA5 can reduce cell migration, invasion, and proliferation, whereas nicotine exposure can reverse this trend. …”
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238
Establishing a Surgical Procedure for Rhesus Epiretinal Scaffold Implantation with HiPSC-Derived Retinal Progenitors
Published 2018-01-01“…The successful delivery and long-term fixation provide a prerequisite for cell migration and integration.…”
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239
Composition analysis and mechanism of Guizhi Fuling capsule in anti-cisplatin-resistant ovarian cancer
Published 2025-02-01“…Then, LC-MS/MS analysis of GFC chemical composition. qRT-PCR, scratch tests, transwell, pseudopodium formation, immunofluorescence, and western blotting were used to explore the mechanism by which GFC inhibited A2780/DDP cell migration and invasion. Finally, the anti-tumor efficacy of GFC was verified by in vivo experiments. …”
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240
Investigation of <i>ITGB3</i> Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer
Published 2024-12-01“…The impact of <i>ITGB3</i> on TGF-β-responsive genes <i>(WWP1</i>, <i>CARM1</i>, <i>RASGRP1</i>, <i>THBS1</i>, <i>KCTD5</i>, <i>SGCA</i>, <i>EIF3S6</i>, <i>MCAM</i>, <i>FXR2</i>, <i>MTMR3</i>, <i>SOCS3</i>, <i>SLC2A4RG</i>, <i>MMP2</i>, <i>MMP9</i>, and <i>HSP47)</i> and cell migration (<i>Col4a1</i>, <i>fibronectin</i>, <i>ICAM1</i>, <i>Timp2</i>, and <i>vimentin</i>) was analysed using luciferase reporter assays and real-time PCR. …”
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