Evaluation of peptide secondary structure and intracellular uptake by introducing disubstituted amino acids into the amphipathic helical peptide C18AA by Takuma Kato, Go Ofuka, Ryota Kobayashi, Akiko Asano, Mitsunobu Doi

“…Amphipathic helical peptides are common among antimicrobial and cell membrane-permeable peptides, and amino acid substitutions within existing peptides have been an effective means of new peptide drug development. …”
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In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta by Cyboran-Mikołajczyk Sylwia, Csonka Ákos, Molnar Joseph, Szabó Diana, Oszmiański Jan, Kleszczyńska Halina

“…This activity was determined by studying kiwi leaves extract anti-hemolytic, cytotoxic and antiproliferative activity, and its ability to change the physical properties of the cell membrane and inhibit multidrug resistance of mouse lymphoma cells. …”
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Inhibitory Substances Produced by Native Lactobacillus plantarum UTNCys5-4 Control Microbial Population Growth in Meat by Gabriela N. Tenea, Juan Martin Guaña

“…The Cys5-4 peptides exerted their bacteriolytic mode of action inducing damage in the cell membrane of the target bacteria, allowing the leaching of DNA/RNA content. …”
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Immune regulation is more effective in the U937 inflammation model with mesenchymal stem cell extracellular vesicles stimulated by pro-inflammatory cytokines by Canan Öztürk, Zehra S. Halbutoğullari

“…MSCs also exert immunoregulatory effects through extracellular vesicles (EVs), cell membrane structures that carry paracrine factors. …”
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Nutrition in patients with traumatic brain injury: Nutrition in patients with TBI by Stojanović Milena, Janković Radmilo, Ranđelović Milica, Vasilijić Milena, Nikolić Aleksandar, Radeka Jovan

“…After the initial injury, a cascade of events at the cellular and molecular level, including cell swelling, changes in cell membrane permeability, influx of immune or inflammatory mediators, and release of excitatory neurotransmitters result in so-called "secondary" brain damage. …”
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Antimicrobial Efficacy and Cell Adhesion Inhibition of In Situ Synthesized ZnO Nanoparticles/Polyvinyl Alcohol Nanofibrous Membranes by Jian Li, Qun Zhang, Minjing Xu, Changzhu Wu, Ping Li

“…Our data revealed that the major antimicrobial mechanism could be attributed to cell membrane damage and cellular internalization of ZnO NPs, while the hydrophobic surface of the membrane primarily contributed to the cell adhesion inhibition. …”
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Risk of hereditary spherocytosis misdiagnosis due to limited effective diagnostic methods by Hien Thanh Dao, Triet Hy Van, Tuyet Thi Bach Tran, Dat Quoc Ngo, Anh Thi Mai Nguyen

“…The percentage of spherocytes was scored from peripheral blood smear observation; the percentage of decreased mean fluorescent intensity from Eosin-5'-maleimide binding assay was used to determine red cell membrane protein deficiency, and hereditary spherocytosis was finally confirmed by gene sequencing as a gold standard. …”
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Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa by Bridget Kamurai, Molly Mombeshora, Stanley Mukanganyama

“…Curcumin caused protein and nucleic acid leakage from the bacterial cell membrane in both bacterial species. When curcumin was combined with ciprofloxacin, it was found to enhance the antibacterial effects of ciprofloxacin. …”
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Inovirus-Encoded Peptides Induce Specific Toxicity in <i>Pseudomonas aeruginosa</i> by Juehua Weng, Yunxue Guo, Jiayu Gu, Ran Chen, Xiaoxue Wang

“…The overexpression of PftP4 demonstrated cellular toxicity in <i>P. aeruginosa</i>, with subcellular localization indicating its presence in the cell membrane and a subsequent increase in membrane permeability. …”
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Mechanisms of RCD-1 pore formation and membrane bending by Keli Ren, James Daniel Farrell, Yueyue Li, Xinrui Guo, Ruipei Xie, Xin Liu, Qiaozhen Kang, Qihui Fan, Fangfu Ye, Jingjin Ding, Fang Jiao

“…However, the underlying mechanisms by which RCD-1 acts on the cell membrane remain elusive. Here, we demonstrate that RCD-1 binds acidic lipid membranes, forms pores, and induces membrane bending. …”
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The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis by Ying He, Ying He, Yongqing Liu, Min Zhang

“…Curcumin also activates redox reactions within cells inducing ROS production that leads to the upregulation of apoptosis receptors on the tumor cell membrane. Curcumin can also upregulate the expression and activity of p53 that inhibits tumor cell proliferation and increases apoptosis. …”
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Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ETA Receptor to Describe the Pharmacological Profile of Natural Pr... by Catherina Caballero-George, Thomas Sorkalla, Daniel Jakobs, Jessica Bolaños, Huzefa Raja, Carol Shearer, Eldredge Bermingham, Hanns Häberlein

“…Two different lateral mobilities of the receptor-ligand complexes within the cell membrane were found allowing the discrimination of different states for this complex. …”
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Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice by Hua Yang, Mengjie Zhang, Jiahao Shi, Yunhe Zhou, Zhipeng Wan, Yicheng Wang, Yinghan Wan, Jun Li, Zhugang Wang, Jian Fei

“…Compared with Ctrls, SNAP-25 was dramatically reduced by about 60% both in cytoplasm and in membrane fractions of cerebral cortex of cKOs, while the other two core members of SNARE complex: Syntaxin-1 (increased ~80%) and Vamp2 (increased ~96%) were significantly increased in cell membrane part. Riluzole, a glutamate release inhibitor, significantly attenuated the locomotor hyperactivity deficits in cKO mice. …”
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<i>Epigynum auritum</i>-Derived Near-Infrared Carbon Dots for Bioimaging and Antimicrobial Applications by Wenfeng Shi, Jiahui Li, Junmei Pu, Guiguang Cheng, Yaping Liu, Shanshan Xiao, Jianxin Cao

“…The antimicrobial effect is likely attributed to the NIR-CDs disrupting the cell membrane integrity, leading to the leakage of the intracellular contents. …”
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Altered shear stress of blood flow causes plasma membrane damage in endothelial cells by Nikita Raj, Chang Pan, Ann Marleen Starke, Anna L. L. Matos, Oliver Soehnlein, Volker Gerke

“…Abstract: The endothelial lining of blood vessels faces many mechanical challenges, including the shear stress (SS) of blood flow, which render it prone to cell membrane ruptures. Such ruptures must be repaired efficiently to maintain cellular integrity and proper vascular function. …”
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An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders by Mohammed Alghamdi, Doaa Alasmari, Amjad Assiri, Ehab Mattar, Abdullah A. Aljaddawi, Sana G. Alattas, Elrashdy M. Redwan

“…It can target a wide range of proteins in the cell membrane, cytoplasm, nucleus, and mitochondria. …”
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Targeted delivery of curcumin and CM11 peptide against hepatocellular carcinoma cells based on binding affinity of PreS1-coated chitosan nanoparticles to SB3 protein by Danial Rahmani, Ramezan Ali Taheri, Mehrdad Moosazadeh Moghaddam

“…SEM and DLS analysis confirmed that the PreS1-Cur-CM11-CS NPs had a size of about 132 nm, the ideal size for penetrating the cell membrane. The loading of Cur and CM11 was equal to 87% and 65%, respectively, which had a sustained and better release in the acidic environment than in the physiological environment. …”
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The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole. by Marie Seveno, Manon N Loubens, Laurence Berry, Arnault Graindorge, Maryse Lebrun, Catherine Lavazec, Mauld H Lamarque

“…During this process, named egress, the infected red blood cell undergoes sequential morphological events: the rounding-up of the surrounding parasitophorous vacuole, the disruption of the vacuole membrane and finally the rupture of the red blood cell membrane. These events are coordinated by two intracellular second messengers, cGMP and calcium ions (Ca2+), that control the activation of their dedicated kinases, PKG and CDPKs respectively, and thus the secretion of parasitic factors that assist membranes rupture. …”
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Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway by Wang Fengling, Ye Xi, Zhai Dandan, Dai Wenting, Wu Yifan, Chen Jin, Chen Weidong

“…Evidence indicates that low expression of death receptors (DRs) on cancer cell membranes leads to attenuated apoptosis signaling. …”
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Three-Dimensional Shapes and Cell Deformability of Rat Red Blood Cells during and after Asphyxial Cardiac Arrest by Hui Jai Lee, SangYun Lee, HyunJoo Park, YongKeun Park, Jonghwan Shin

“…Dynamic membrane fluctuations in the cell membrane were also quantitatively and sensitively measured in order to investigate cell deformability. …”
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