-
81
Mesenchymal stem cell-derived exosome and liposome hybrids as transfection nanocarriers of Cas9-GFP plasmid to HEK293T cells.
Published 2025-01-01“…Meanwhile, the treatment of the cells with plasmids alone, without any vesicles, resulted in no transfection, indicating that the exosome and exosome-liposome hybrids are essential for the transfer of the plasmids across the cell membrane. The pure exosomes and the hybrids incorporating liposomes obtained by the heating method transfected the cells more efficiently than those containing liposomes obtained by the thin film hydration technique. …”
Get full text
Article -
82
Optically driven microtools with an antibody‐immobilised surface for on‐site cell assembly
Published 2023-05-01“…The cells were captured by the microtool through the bindings between the antibodies on the microtool and the antigens on the cell membrane. Transmembrane proteins, CD51/61 and CD44 that facilitate cell adhesion, commonly found on the surface of cancer cells were targeted. …”
Get full text
Article -
83
Treatment of irritable bowel syndrome: the past, present and future
Published 2015-03-01“…Considering new data on IBS pathogenesis (disorder of intestinal microbiome, functional and structural remodeling of proteins of cell membrane at the level of synapses of spinal cord posterior horns), prescription of probiotics and peripheral opioid receptors agonists is proven as well. …”
Get full text
Article -
84
A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation
Published 2021-01-01“…SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, uses the host cell membrane receptor angiotensin-converting enzyme 2 (ACE2) for anchoring its spike protein, and the subsequent membrane fusion process is facilitated by host membrane proteases. …”
Get full text
Article -
85
Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of <i>Candida albicans</i> Biofilms
Published 2025-01-01“…Confocal microscopy demonstrated that CT-GNE penetrated the dense <i>C. albicans</i> biofilm and disrupted the fungal cell membrane. Overall, the combination of essential oils with terbinafine in GNE provided a promising treatment for fungal biofilms.…”
Get full text
Article -
86
Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies
Published 2024-12-01“…In the case of monoclonal antibodies (mAbs) against cell membrane antigens, this requires quantitative insight into the target tissue concentration levels. …”
Get full text
Article -
87
Role of cytokines in myocardial ischemia and reperfusion
Published 1997-01-01“…At the cellular level it has been shown that hypoxia causes a series of well documented changes in cardiomyocytes that includes loss of contractility, changes in lipid metabolism and subsequent irreversible cell membrane damage leading to cell death. For instance, hypoxic cardiomyocytes produce interleukin-6 (IL-6) which could contribute to the myocardial dysfunction observed in ischemia reperfusion injury. …”
Get full text
Article -
88
The Effects of Urethane on Rat Outer Hair Cells
Published 2016-01-01“…We found that urethane hyperpolarizes the outer hair cell membrane potential in a dose-dependent manner and elicits larger outward current. …”
Get full text
Article -
89
A plant-derived biostimulant Aminolom Enzimatico® application stimulates chlorophyll content, electrolyte leakage, stomata density and root yield of radishes under salinity stress
Published 2025-01-01“…Therefore, the study aimed to determine how applying a foliar plant-derived biostimulant (Aminolom Enzimatico® 24%) affects the growth (leaf area, biomass weight, root diameter, root fresh weight, and water-soluble dry matter), physiology (chlorophyll content, electrolyte leakage, cell membrane stability, and relative water content), and stomata of the lower and upper parts of leaves in radish plants (Raphanus sativus L.) under salinity stress. …”
Get full text
Article -
90
Accumulation of Oxidized Low-Density Lipoprotein in Psoriatic Skin and Changes of Plasma Lipid Levels in Psoriatic Patients
Published 2007-01-01“…Lipid peroxidation mediated by free radicals is believed to be one of the important causes of cell membrane destruction and cell damage. This study shows for the first time the accumulation of oxidized low-density lipoprotein in psoriatic skin lesion. …”
Get full text
Article -
91
Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin
Published 2025-01-01“…The integrity and, consequently, the effective metabolic activity of skin cells is ensured by the cell membrane, the important structural and metabolic elements of which are phospholipids. …”
Get full text
Article -
92
Application of Calcium Chloride-Sodium Alginate to Improve the Texture of Quick-Frozen Heracleum moellendorffii
Published 2021-01-01“…The microstructure found that calcium could adhere to an inherent position on the cell membrane and protected the sample from cell damage and chloroplast spilling from the cell during thawing and quick freezing. …”
Get full text
Article -
93
Evaluation of the Antimicrobial Effect of the Extracts of the Pods of Piliostigma thonningii (Schumach.) Milne-Redh. (Fabaceae)
Published 2021-01-01“…The most potent extract was then used to determine its effect on microbial cell membrane integrity. The results showed that methanol extract had the highest percentage yield of 5%. …”
Get full text
Article -
94
Identification and characterization of antibacterial peptides produced by Lactobacillus plantarum 1407
Published 2024-11-01“…F3 fraction exhibited increased antibacterial activity than F1, F2, and F4 fractions against the indicator organisms. Cell membrane damage and leakage of cytoplasmic content of the bacterial cells treated with the antibacterial F3 fraction peptides were observed. …”
Get full text
Article -
95
Cytotoxicity and Genotoxicity of Biogenic Silver Nanoparticles in A549 and BEAS-2B Cell Lines
Published 2022-01-01“…In this study, AgNPs-GA were endocytosed within lysosomes, which may direct to secondary toxicity effects including oxidative stress, impairment of the cell membrane, DNA fragmentation, and cell death. Conclusions. …”
Get full text
Article -
96
Nanorobots with Hybrid Biomembranes for Simultaneous Degradation of Toxic Microorganism
Published 2022-01-01“…This proposes the development, manufacturing, and testing of a dual–cell membrane–functionalized nanorobot for multifunctional biological threat component elimination, with a focus on the simultaneous targeted and neutralization of the pathogenic bacteria and toxins. …”
Get full text
Article -
97
A New Kinetic Spectrophotometric Method for the Quantitation of Amorolfine
Published 2017-01-01“…Amorolfine (AOF) is a compound with fungicide activity based on the dual inhibition of growth of the fungal cell membrane, the biosynthesis and accumulation of sterols, and the reduction of ergosterol. …”
Get full text
Article -
98
Brassica rapa selenium transporter NPF2.20 (BrNPF2.20) accounts for Se-enrichment in Chinese cabbage
Published 2025-01-01“…We screened for high- and low-Se-enriched Chinese cabbage varieties from 39 different genotypes and identified a key candidate gene for Se enrichment, namely, BrNPF2.20 (BraA07g035670.3.1 C), located on the cell membrane. The expression level of BrNPF2.20 in the high-Se-enriched Chinese cabbage variety P2 was significantly higher than that in the low-Se-enriched variety P6. …”
Get full text
Article -
99
A study on blocking store-operated Ca2+ entry in pulmonary arterial smooth muscle cells with xyloketals from marine fungi
Published 2017-12-01“…The parallel artificial membrane permeability assay (PAMPA) of 1-4 suggested that these xyloketals penetrated easily through the cell membrane. Moreover, the molecular docking study of xyloketal A with activation region of the stromal interaction molecule (STIM) 1 and the calcium release-activated calcium modulator (ORAI) 1 (STIM1-ORAI1) protein complex, the key domain of SOCE, revealed that xyloketal A exhibited a noncovalent interaction with the key residue lysine 363 (LYS363) in the identified cytosolic regions in STIM1-C. …”
Get full text
Article -
100
Improved Therapeutic Effect of Puerarin-Encapsulated PEG-PLGA Nanoparticle on an In Vitro Cerebral Infarction Model
Published 2020-01-01“…The BCEC/TF cell model was obtained after TNF-α treatment, and tissue factor (TF) was widely expressed on the cell membrane of BCEC/TF cells. Furthermore, it was observed that the PEG-PLGA/PUE nanoparticles showed better therapeutic effect on the BCEC/TF cell model than PUE. …”
Get full text
Article