Identification of a novel immunogenic cell death-related classifier to predict prognosis and optimize precision treatment in hepatocellular carcinoma by Dongjing Zhang, Bingyun Lu, Qianqian Ma, Wen Xu, Qi Zhang, Zhiqi Xiao, Yuanheng Li, Ren Chen, An-jiang Wang

Subjects: “…Immunogenic cell death…”
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Editorial: Mechanism explorations of enhancing immunotherapeutic sensitivity via mediating immune infiltration and programmed cell death in solid tumor microenvironment by Fang Zheng, Fang Zheng, Fang Zheng, Zhiliang Li, Ruoyu Weng, Baochi Ou, Tao Zhang, Ren Zhao, Ren Zhao, Ren Zhao, Haoran Feng, Haoran Feng, Haoran Feng

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DNA Replication Arrest and P53-Dependent and P53-Independent Cell Death Pathways in Xeroderma Pigmentosum Variant Cells by James E. Cleaver, Eileen Crowley, Mohammed Kashani-Sabet, Charles L. Limoli

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4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions by Sujin Park, Yoon A Kim, Jaewang Lee, Hyunsoo Seo, Sang-Jip Nam, Dong-Gyu Jo, Dong-Hoon Hyun

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FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma by Jian Chen, Cheng Zhu, Yan He, Liping Huang, Weizhuo Wang, Shuaishuai Huang

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Programmed cell death-related gene IL20RA facilitates tumor progression and remodels tumor microenvironment in thyroid cancer by Yuqi Wang, Yunlong Zhang, Min Liu, Yu Liu, Yu Zeng, Wei Zhang, Shuping Wu, Linfei Hu, Xianhui Ruan, Xiangqian Zheng, Ming Gao, Jingzhu Zhao

Subjects: “…Programmed cell death…”
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Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism by Felix Pfister, Lucas R. Carnell, Lisa Löffler, Philipp Boosz, Niels Schaft, Jan Dörrie, René Stein, Malte Lenz, Erdmann Spiecker, Christian M. Huber, Sami Haddadin, Carola Berking, Christoph Alexiou, Christina Janko

“…Importantly, SPIONs suppressed cytokine release in the loaded CAR‐T cells, shifting the cell death phenotype in the tumor cells from pyroptosis to apoptosis. …”
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Combination of Anti-programmed Cell Death Protein 1 and Antiangiogenesis Displaying a Response Disparity between Pulmonary and Nonpulmonary Metastases by Bing-Syuan Chung, Peng-Chan Lin, Shang-Hung Chen, Yu-Min Yeh

“…Targeting the vascular endothelial growth factor-mediated immune suppression is a strategy to overcome the resistance of anti-programmed cell death protein 1/programmed death-ligand 1 (anti-PD-1/PD-L1) therapy. …”
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MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies by Bu-Fu Tang, Wang-Ting Xu, Shi-Ji Fang, Jin-Yu Zhu, Rong-Fang Qiu, Lin Shen, Yang Yang, Qiao-You Weng, Ya-Jie Wang, Jia-Yi Ding, Xiao-Jie Zhang, Wei-Qian Chen, Li-Yun Zheng, Jing-Jing Song, Biao Chen, Zhong-Wei Zhao, Min-Jiang Chen, Jian-Song Ji

“…Results It was found that RFA treatment upregulated MELK expression, and MELK inhibition promoted RFA efficacy by immunogenic cell death and the antitumor response, including anti-tumoral macrophage polarization and increased CD8+ T cell cytotoxicity in HCC. …”
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Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models by Andrea Mancini, Alessandro Colapietro, Loredana Cristiano, Alessandra Rossetti, Vincenzo Mattei, Giovanni Luca Gravina, Giovanni Luca Gravina, Héctor Perez-Montoyo, Marc Yeste-Velasco, Jose Alfon, Carles Domenech, Claudio Festuccia

“…Both actions converge to induce autophagy-mediated cell death. ABTL0812 anticancer efficacy was studied in vivo using subcutaneous and orthotopic intra-brain xenograft tumor models. …”
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Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma by Soo Yeon Kim, Miaolu Tang, Stephen Y. Chih, Jessica Sallavanti, Yan Gao, Zhiqiang Qiu, Hong-Gang Wang, Wei Li

“…Cell Death and Disease…”
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The role of PCD in sexual dimorphism of dioecious Spinacia oleracea L. by Asuman Karadeniz Pekgöz, Özal Mutlu, Özlem Aytürk

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Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis... by P. S. Demenkov, E. A. Antropova, A. V. Adamovskaya, E. I. Mishchenko, T. M. Khlebodarova, T. V. Ivanisenko, N. V. Ivanisenko, A. S. Venzel, I. N. Lavrik, V. A. Ivanisenko

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Toxicity Associated with Pembrolizumab Monotherapy in Patients with Gastrointestinal Cancers: A Systematic Review of Clinical Trials by Nikolas Naleid, Amit Mahipal, Sakti Chakrabarti

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Conventional Chemotherapy and Inflammation: What Is the Role of the Inflammasome in the Tumor Microenvironment? by Chiara Colarusso, Michela Terlizzi, Simone Di Caprio, Anna Falanga, Emmanuel D’Andria, Roberta d’Emmanuele di Villa Bianca, Rosalinda Sorrentino

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ATF4-mediated expression of NOXA is critical for necroptosis driven by glucose deprivation by Sasiprapa Sonkaew, Sasiprapa Sonkaew, Ruwaida Rajna, Yeon-Ji Park, Jiong Yan, Zhaoshan Liu, Siriporn Jitkaew, Zheng-Gang Liu, Swati Choksi

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Pembrolizumab and Pemetrexed for Older Patients With Nonsquamous NSCLC and Programmed Cell Death-Ligand 1 Tumor Proportion Scores of Less Than 50% by Yoshihito Kogure, MD, PhD, Hiroya Hashimoto, PhD, Haruko Daga, MD, PhD, Yasushi Fukuda, MD, Akihiro Bessho, MD, PhD, Tadaaki Yamada, MD, PhD, Yukihiro Toi, MD, Tomoki Kimura, MD, PhD, Hiroshige Yoshioka, MD, PhD, Koichi Azuma, MD, PhD, Naoki Furuya, MD, PhD, Yasutaka Fukui, MD, PhD, Akiko M. Saito, MD, PhD, Nobuyuki Yamamoto, MD, PhD, Hideo Saka, MD, Masashi Kondo, MD, PhD

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Corrigendum: Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models by Andrea Mancini, Alessandro Colapietro, Loredana Cristiano, Alessandra Rossetti, Vincenzo Mattei, Giovanni Luca Gravina, Giovanni Luca Gravina, Héctor Perez-Montoyo, Marc Yeste-Velasco, Jose Alfon, Carles Domenech, Claudio Festuccia

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Cinnamaldehyde impacts key cellular signaling pathways for induction of programmed cell death in high-grade and low-grade human glioma cells by Yoo Na Kim, Ketki Patil, S. Balakrishna Pai

“…Moreover, its effect on the extrinsic programmed cell death pathway resulted in the increase of apoptotic cell populations, invoking multicaspase. …”
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Programmed Cell Death, Proliferating Cell Nuclear Antigen and p53 Expression in Mouse Colon Mucosa during Diet-Induced Tumorigenesis by Mauro Risio, Ivana Sarotto, Francesco Paolo Rossini, Harold Newmark, Kan Yang, Martin Lipkin

“…In order to evaluate the roles both of cell proliferation and programmed cell death (PCD) in WD‐induced tumorigenesis, immunohistochemical detection of proliferating nuclear antigen (PCNA), in situ end labeling (TUNEL) of DNA breaks, and p53 protein were carried out in mouse colonic mucosa during prolonged feeding of two WDs. …”
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