Cryoimmobilized anther analysis reveals new ultrastructural insights into Rhynchospora (Cyperaceae) asymmetrical microsporogenesis by Danilo M. Rocha, Ulla Neumann, Fernanda M. Nogueira, Georgios Tsipas, André L. L. Vanzela, André Marques

“…IntroductionThe Cyperaceae family is distinguished by holocentric chromosomes and a distinctive microsporogenesis process, which includes inverted meiosis, asymmetric tetrad formation, selective cell death, and the formation of pseudomonad pollen. …”
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Neurotoxic Effect of Myricitrin in Copper-Induced Oxidative Stress Is Mediated by Increased Intracellular Ca²⁺ Levels and ROS/p53/p38 Axis by Ignacija Vlašić, Antonio Krstačić-Galić, Anđela Horvat, Nada Oršolić, Anja Sadžak, Lucija Mandić, Suzana Šegota, Maja Jazvinšćak Jembrek

“…The toxic effects of myricitrin were alleviated by the p38 inhibitor SB203580, the intracellular calcium chelator BAPTA-AM, and the NMDA receptor blocker MK-801, highlighting the significant role of the ROS/p53/p38 axis in cell death and the critical involvement of calcium ions in apoptosis induction. …”
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Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer by Eeshrita Jog, Ashwin Kumar Jainarayanan, Alessandro La Ferlita, Arnab Chakraborty, Afiya Dalwai, Showket Yahya, Anusha Shivashankar, Bhagya Shree Choudhary, Aakash Chandramouli, Mufaddal Kazi, Darshan Jain, Nileema Khapare, Akshaya B, Bushra K. Khan, Poonam Gera, Prachi Patil, Rahul Thorat, Nandini Verma, Lalit Sehgal, Avanish Saklani, Siddhesh S. Kamat, Sorab N. Dalal, Nazia Chaudhary

“…Blocking the conversion of free fatty acids into LDs by treatment with statins or inhibiting lipin1 expression disrupts lipid homeostasis, leading to lipotoxicity and ferroptotic cell death in both DTPs and patient-derived organoids (PDOs) in vitro. …”
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S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism by Min Yang, Weiwei Cui, Xiaoting Lv, Gaozhong Xiong, Caiyu Sun, Haocheng Xuan, Wei Ma, Xiuling Cui, Yeping Cheng, Lihui Han, Bo Chu

“…Abstract Ferroptosis is a newly identified programmed cell death induced by iron-driven lipid peroxidation and implicated as a potential approach for tumor treatment. …”
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Importance of OsRac1 in Signalling of Pigm-1 Mediated Resistance to Rice Blast Disease by Dewei Yang, Niqing He, Fenghuang Huang, Jialin Chen, Minxiang Yu, Yidan Jin, Shaojun Lin, Shengping Li

“…This study shows that the nucleotide-binding site (NBS) domain of Pigm-1 facilitates its binding to and activation of OsRac1 while the coiled-coil (CC) domain enables its binding to and activation of RAI1, ultimately inducing cell death. At the same time, after knocking out <i>OsRac1</i> in the background of Shuangkang 77009 containing <i>Pigm-1</i>, two knockout lines showed susceptibility to rice blast. …”
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Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics by David Chamoso-Sanchez, Martina Panini, Clarissa Caroli, Matilde Marani, Lorenzo Corsi, Francisco J Rupérez, Antonia Garcia, Federica Pellati

“…The results highlight some important lipid alterations related to CBD treatment, plausibly connected with different metabolic mechanisms involved in the process of cell death by apoptosis in cancer cell lines.…”
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PARP‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing MDA‐MB‐231 Breast Cancer Cells by Magalie Hervieu, Arnaud J. Legrand, Emilie Floquet, Thierry Idziorek, Corentin Spriet, Didier Monté, Vincent Villeret, Marc Aumercier, Souhaila Choul‐li

“…In a previous study, we revealed that poly(ADP‐ribose) polymerase‐1 (PARP‐1) inhibition by PJ‐34 results in Ets‐1 level increase in cells, which is related with cell death of Ets‐1‐expressing cancer cells. Aims The mechanism of the antitumor effect of PARP‐1 inhibition was investigated in the Ets‐1‐expressing MDA‐MB‐231 breast cancer cells. …”
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Protection of the Peritoneal Membrane by Peritoneal Dialysis Effluent-Derived Mesenchymal Stromal Cells in a Rat Model of Chronic Peritoneal Dialysis by Lan Zhou, Ming Zong, Qiunong Guan, Gerald da Roza, Hao Wang, Hualin Qi, Caigan Du

“…In vitro incubation with pMSC-conditioned medium prevented cell death in cultured human peritoneal mesothelial cells (HPMCs) and downregulated proinflammatory (i.e., CXCL6, NOS2, IL1RN, CCL5, and NR3C1) while upregulated anti-inflammatory (i.e., CCR1, CCR4, IL9, and IL-10) gene expression in activated THP1 cells. …”
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Integrative analysis of anoikis-related prognostic signature to evaluate the immune landscape and predict therapeutic response in stomach adenocarcinoma by Ziyi Zhou, Lanlan Yang, Yuan Fang, Rongzhong Xu, Xi Wang, Yuli Wang, Zhihong Fang

“…Anoikis, a process of programmed cell death that occurs when cells detach from the extracellular matrix, is closely associated with tumor invasion and metastasis. …”
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Evaluation of autophagic and apoptotic markers during infection with animal virus causing hemorrhagic fever in rabbits by Dominika Bębnowska, Dominika Bębnowska, Sylwia Rzeszotek, Agnieszka Kolasa, Karolina Wiśniewska, Karolina Wiśniewska, Magdalena Żabińska, Aneta Szulc, Zuzanna Cyske, Zuzanna Cyske, Karolina Pierzynowska, Karolina Pierzynowska, Aleksandra Wilk, Paulina Niedźwiedzka-Rystwej, Paulina Niedźwiedzka-Rystwej, Paulina Niedźwiedzka-Rystwej

“…This is particularly important because infection with different strains is associated with a different host immune response profile.MethodsIn this work, we analyzed the expression of selected genes and proteins involved in autophagic flux in the liver, spleen, kidney and peripheral blood, but also apoptotic cell death in the liver and peripheral blood of rabbits infected with the GI.2 strain.ResultsAs a result, we showed that autophagy is strongly activated in the liver, spleen and kidney of infected rabbits, and confirmed the activation of apoptosis in the liver.DiscussionThis study highlights the role of apoptosis and autophagy in the immune response in rabbits infected with Lagovirus europaeus/GI.2.…”
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Research Progress on the Role of Inflammasomes in Kidney Disease by Kun Chi, Xiaodong Geng, Chao Liu, GuangYan Cai, Quan Hong

“…Inflammasomes are multimeric complexes composed of cytoplasmic sensors, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC or PYCARD), and procaspase-1 and play roles in regulating caspase-dependent inflammation and cell death. Inflammasomes are assembled by sensing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) and initiate inflammatory responses by activating caspase-1. …”
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Aqueous humor metabolomic profiling identifies a distinct signature in pseudoexfoliation syndrome by Arturs Zemitis, Arturs Zemitis, Juris Vanags, Juris Vanags, Theresa Schiemer, Theresa Schiemer, Kristaps Klavins, Kristaps Klavins, Guna Laganovska, Guna Laganovska

“…These results suggest a potential link to ferroptosis.ConclusionFerroptosis is a form of programmed cell death characterized by iron-dependent LPO. The inhibition of the antiporter system Xc− leads to increased oxidative stress, suggesting that the changes seen in PEXS could be linked to ferroptosis. …”
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Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix by Liju Zong, Qianqian Zhang, Yuncan Zhou, Yujia Kong, Shuangni Yu, Jie Chen, Youzhong Zhang, Yang Xiang

“…The purpose of this study was to investigate the expression levels of the immune checkpoint proteins, programmed cell death-ligand 1 (PD-L1), B7-H3, B7-H4, and V-domain Ig suppressor of T cell activation (VISTA), as well as the significance thereof, in clear cell carcinoma (CCC) of the cervix (a rare histological subtype of cervical cancer). …”
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NCOA4 linked to endothelial cell ferritinophagy and ferroptosis:a key regulator aggravate aortic endothelial inflammation and atherosclerosis by Li Zhu, Zijian Liu, Jiahui Liu, Zhenglong Li, Youli Bao, Xin Sun, Wenchen Zhao, An Zhou, Hongfei Wu

“…Ferroptosis is a novel mode of cell death induced by decreased antioxidant capacity of the organism and accumulation of reactive oxygen species. …”
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PD-1 suppresses human CD38+ circulating Tfr cells and regulates humoral immunity by Heng Zhang, Hui Zheng, Lin Guo, Ying Tong, Xiaolu Ma, Yanchun Wang, Renquan Lu, Cuncun Chen, Suhong Xie

“…Background Anti-programmed cell death protein 1 (anti-PD-1) antibodies have achieved revolutionary success in cancer therapy. …”
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Cellular Responses in Human Dental Pulp Stem Cells Treated with Three Endodontic Materials by Alejandro Victoria-Escandell, José Santiago Ibañez-Cabellos, Sergio Bañuls-Sánchez de Cutanda, Ester Berenguer-Pascual, Jesús Beltrán-García, Eva García-López, Federico V. Pallardó, José Luis García-Giménez, Antonio Pallarés-Sabater, Ignacio Zarzosa-López, Manuel Monterde

“…Cell viability and cell death rate were assessed by flow cytometry. Oxidative stress was measured by OxyBlot. …”
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Single-cell transcriptomics of bronchoalveolar lavage during PRRSV infection with different virulence by Byeonghwi Lim, Seung-Chai Kim, Hwan-Ju Kim, Jae-Hwan Kim, Young-Jun Seo, Chiwoong Lim, Yejee Park, Sunirmal Sheet, Dahye Kim, Do-Hwan Lim, Kyeongsoon Park, Kyung-Tai Lee, Won-Il Kim, Jun-Mo Kim

“…Viral tracking reveals less than 5% of macrophages are directly infected, and further analysis indicates bystander cell death, likely regulated by exosomal microRNAs as a significant factor. …”
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Blocking the CD39/CD73 pathway synergizes with anti-CD20 bispecific antibody in nodal B-cell lymphoma by Carsten Müller-Tidow, Peter Dreger, Joseph Kauer, Wolfgang Huber, Clara Kolbe, Berit Brinkmann, Sascha Dietrich, Tobias Roider

“…We discovered that blockade of the CD39/CD73 pathway was particularly effective in patients with a high proportion of Programmed cell death protein 1 (PD-1)+ T-cell immunoglobulin and mucin-domain containing-3 (TIM3)+ exhausted T cells. …”
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The effect of beet leaf (Beta vulgaris) extract on learning and memory after cerebral ischemic reperfusion in rats by Kobra Mirahmadi, Najmeh Asgharzadeh, Zahra Lorigooini, Marzieh Mardani, Zahra Rabiei, Diana Shahrani, Mohamad Shahrani, Mehrdad Shahrani Korrani

“…Background and aims: Cerebral ischemia causes tissue oxidative damage and leads to cell death. Antioxidants can reduce the adverse effects of ischemia in the brain. …”
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Disulfidptosis-related gene SLC3A2: a novel prognostic biomarker in nasopharyngeal carcinoma and head and neck squamous cell carcinoma by Xinyi Zhang, Yiqi Lin, Liang Shi, Aixia Zhai, Chao Wu, Qian-Ying Zhu

“…Recently, disulfidoptosis, a novel form of cell death, has been proposed. Several studies in recent years have extensively investigated the function of the disulfidoptosis-related SLC7A11 gene in cancer, but the role of its partner protein, SLC3A2, remains unknown unclear in NPC.MethodsGEO database analysis confirmed SLC3A2's prognostic impact on nasopharyngeal carcinoma. …”
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