Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB’WHU Chronically Infected Chinese Rhesus Macaque by Gao-Hong Zhang, Run-Dong Wu, Hong-Yi Zheng, Xiao-Liang Zhang, Ming-Xu Zhang, Ren-Rong Tian, Guang-Ming Liu, Wei Pang, Yong-Tang Zheng

“…The downregulated effector memory cells are associated with a lower frequency of monofunctional and polyfunctional cells, and an upregulated programmed cell death-1 (PD-1) expression on CD4+ and CD8+ T cells was observed in monkeys after LPS stimulation. …”
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The transcriptional response of cortical neurons to concussion reveals divergent fates after injury by Mor R. Alkaslasi, Eliza Y. H. Lloyd, Austin S. Gable, Hanna Silberberg, Hector E. Yarur, Valerie S. Tsai, Mira Sohn, Gennady Margolin, Hugo A. Tejeda, Claire E. Le Pichon

“…We find that a population in layer V undergoes cell death acutely after injury, while another in layer II/III survives long term and remains electrically active. …”
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Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis by Rongjiong Zheng, Songsong Xie, Qiong Zhang, Ling Cao, Shaniya Niyazi, Xiaobo Lu, Lihua Sun, Yan Zhou, Yuexin Zhang, Kai Wang

“…The frequencies of Th1, Th2, Th17, Treg, and PD-1 (programmed cell death protein 1) in peripheral blood were examined by flow cytometry, and the expressions of T lymphocyte cytokines in serum were detected by cytometric bead array. …”
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Preclinical evaluation and preliminary clinical study of 68Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression by Lingzhou Zhao, Jiali Gong, Sisi Liao, Wenhua Huang, Jinhua Zhao, Yan Xing

“…Abstract Background Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-small-cell lung cancer (NSCLC). …”
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Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK‐inhibitor‐induced tolerant persister cells in ALK‐fusion‐positive lung cancer... by Koh Furugaki, Takaaki Fujimura, Narumi Sakaguchi, Yasutaka Watanabe, Ken Uchibori, Eisaku Miyauchi, Hidetoshi Hayashi, Ryohei Katayama, Shigeki Yoshiura

“…GPX4 was found to be upregulated in DTP cells and to promote cell survival by suppressing reactive oxygen species (ROS) accumulation; GPX4 inhibitors blocked this upregulation and facilitated ROS‐mediated cell death. Activated bypass signals involving epidermal growth factor receptor (EGFR)/receptor tyrosine‐protein kinase erbB‐3 (HER3) were also identified in DTP cells, and co‐treatment with EGFR‐TKI plus ALK‐TKI enhanced ROS levels. …”
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Negative heterosis for meiotic recombination rate in spermatocytes of the domestic chicken Gallus gallus by L. P. Malinovskaya, K. V. Tishakova, T. I. Bikchurina, A. Yu. Slobodchikova, N. Yu. Torgunakov, A. A. Torgasheva, Y. A. Tsepilov, N. A. Volkova, P. M. Borodin

“…However, it involves a massive generation of double-strand DNA breaks, erroneous repair of which may lead to germ cell death or various mutations and chromosome rearrangements. …”
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The steady-state level of plasma membrane ceramide is regulated by neutral sphingomyelinase 2 by Anne G. Ostermeyer-Fay, Abhay Kanodia, Ranjana Pathak, Maria Jose Hernandez-Corbacho, Aarnoud C. van der Spoel, Yusuf A. Hannun, Daniel Canals

“…One of these pools of ceramide resides in the plasma membrane, and several works have suggested that an increase in plasma membrane ceramide (PMCer) in response to stimulation leads to cell death and modulates cell adhesion and migration. …”
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Comprehensive Analysis of the Mechanism of Anoikis in Hepatocellular Carcinoma by Dongqian Li, Qian Bao, Shiqi Ren, Haoxiang Ding, Chengfeng Guo, Kai Gao, Jian Wan, Yao Wang, MingYan Zhu, Yicheng Xiong

“…Anoikis, a type of programmed cell death, serves as a barrier against the dissemination of cancer cells to distant organs, thereby constraining the progression of cancer. …”
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Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential by Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

“…Notably, 4, 5, 21 and 25 exhibited remarkable efficacy in reducing intracellular lipid accumulation without inducing cellular stress or cell death. Molecular analysis revealed significant alterations in the expression of key transcription factors involved in adipogenesis and lipid metabolism, including PPARγ, C/EBPα, ADD-1, Pref-1, IRS-1, GLUT-4, adiponectin, FAS, aP2, ATGL, and HSL. …”
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Phenylbutyric Acid Modulates Apoptosis and ER Stress‐Related Gene Expression in Glycogen Storage Disease Type Ib In Vitro Model by Marina Parezanovic, Nina Stevanovic, Marina Andjelkovic, Milena Ugrin, Sonja Pavlovic, Maja Stojiljkovic, Anita Skakic

“…Our results proved the concept that 4‐PBA could alleviate markers of ER stress detected in the GSD Ib in vitro model system and prevent cell death. Conclusion This cost‐effective in vitro model screens the therapeutic potential of SMs affecting ER stress and apoptosis in G6PT‐deficient kidney cells, offering a first‐line screening assay for promising compounds. 4‐PBA's potential repurposing for GSD Ib patients opens new research directions.…”
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Neuroprotective and Antiapoptotic Activity of Lineage-Negative Bone Marrow Cells after Intravitreal Injection in a Mouse Model of Acute Retinal Injury by Anna Machalińska, Dorota Rogińska, Ewa Pius-Sadowska, Miłosz P. Kawa, Edyta Paczkowska, Michał Rudnicki, Renata Lejkowska, Bartłomiej Baumert, Barbara Wiszniewska, Bogusław Machaliński

“…The first relates to downregulated genes associated with regulation of neuron cell death and apoptosis, response to oxidative stress/hypoxia and external stimuli, and negative regulation of cell proliferation. …”
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Cupric Doping Hollow Prussian Blue Nanoplatform for Enhanced Cholesterol Depletion: a Promising Strategy for Breast Cancer Therapy and Metastasis Inhibition by Shuangqian Yan, Panpan Xue, Ying Sun, Tingjie Bai, Sijie Shao, Xuemei Zeng

“…Transcriptomic analysis validates Cu‐HPB/C's impact on cholesterol homeostasis and reveals cell death mechanisms including oxidative stress, ferroptosis, cuproptosis, and apoptosis. …”
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The Generation and Characterization of Recombinant Protein and Antibodies of Clostridium perfringens Beta2 Toxin by Jin Zeng, Fuyang Song, Yi Yang, Chenjie Ma, Guangcun Deng, Yong Li, Yujiong Wang, Xiaoming Liu

“…The rCPB2 could induce apoptotic cell death rather than necrotic death in part through a pathway involved in caspase-3 signaling. …”
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Biological evaluation of novel 5-((1H-indol-3-yl) methyl)-2-(4-chlorobenzyl)-6-phenyl-imidazo[2,1-b][13,4]thiadiazole derivatives as novel BCL-2 specific inhibitors by Shivangi Sharma, Sadashivamurthy Shamanth, Humaira Siddiqua, Laijau Goyary, Kunigal S. Sagar, Susmita Kumari, Divya Sathees, Gudapureddy Radha, Bibha Choudhary, Sathees C. Raghavan, Kempegowda Mantelingu

“…Treatment of cancer cell lines with the Disarib derivatives, DSR 43 and 4-OCH3 led to the activation of the apoptotic pathway without generating any ROS or disrupting the mitochondrial membrane potential within the cells, leading to cell death. Western blot analysis in tandem with Annexin V/PI staining confirmed the activation of apoptosis. …”
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The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism by Xue Wang, Chunyou Ning, Xingyi Cheng, Zhengzhong Wu, Dongbo Wu, Xuemei Ding, Cunxiang Ju, Zhihang Zhou, Lingfeng Wan, Wei Zhao, Peiliang Shi

“…After crossing the two strains together, we induced conditional cell death by doxycycline to construct a mouse model of liver fibrosis. …”
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Zinc regulates microglial polarization and inflammation through IKBα after spinal cord injury and promotes neuronal repair and motor function recovery in mice by Daoyong Li, Daoyong Li, Mingyu Bai, Mingyu Bai, Zhanpeng Guo, Yang Cui, Yang Cui, Xifan Mei, Xifan Mei, He Tian, He Tian, Zhaoliang Shen

“…These results were confirmed in the SCI mouse model, where zinc ions also reduced inflammation and cell death.DiscussionOur findings highlight a novel mechanism by which zinc ions regulate inflammation in SCI by upregulating IKBα and inhibiting NF-κB activation. …”
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HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice by Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao

“…Conclusion Collectively, our data show that myocardial I/RI is associated with HACE1 downregulation and Drp1 activation, causing cardiomyocytes to undergo cell death. Therefore, HACE1 could be a promising therapeutic target for the treatment of myocardial I/RI.…”
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…Its anti-tumor efficacy was enhanced when combined with programmed cell death protein 1 (PD-1) or cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) checkpoint inhibitors. …”
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Phytochemical Analysis and Anti-Inflammatory Activity of the Extracts of the African Medicinal Plant Ximenia caffra by Jing Zhen, Yue Guo, Tom Villani, Steve Carr, Thomas Brendler, Davis R. Mumbengegwi, Ah-Ng Tony Kong, James E. Simon, Qingli Wu

“…It was further demonstrated that the underlying therapeutic mechanism involves the suppression of NF-κB, a shared pathway between cell death and inflammation.…”
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Transcriptional activity of repair, apoptosis and cell cycle genes (TP53, MDM2, ATM, BAX, BCL-2, CDKN1A, OGG1, XPC, PADI4, MAPK8, NF-KB1, STAT3, GATA3) in chronically exposed perso... by V. S. Nikiforov, E. A. Blinova, A. I. Kotikova, A. V. Akleyev

“…These data are consistent with current views on the activation of programmed cell death.…”
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