Glycosylated lysosomal membrane protein promotes tissue repair after spinal cord injury by reducing iron deposition and ferroptosis in microglia by Fangru Ouyang, Meige Zheng, Jianjian Li, Jinxin Huang, Jianan Ye, Jingwen Wang, Yuanzhe Zhao, Fangli Shan, Ziyu Li, Shuishen Yu, Fei Yao, Dasheng Tian, Li Cheng, Juehua Jing

“…Abstract Excessive iron deposition can lead to ferroptosis, a form of iron-dependent cell death detrimental to neuronal survival. Microglia have been identified as having a high capacity for iron deposition, yet it remains unclear whether microglia undergo ferroptosis while phagocytosing excessive amounts of iron after spinal cord injury (SCI). …”
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Cardiorenal Syndrome Type 5: In Vitro Cytotoxicity Effects on Renal Tubular Cells and Inflammatory Profile by Alessandra Brocca, Grazia Maria Virzì, Chiara Pasqualin, Silvia Pastori, Stefano Marcante, Massimo de Cal, Claudio Ronco

“…Plasma from patients and controls was incubated with renal tubular cells (RTCs) and cell death was evaluated. Plasma cytokines were detected. …”
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Oncogenic RIT1 mutations confer ferroptosis vulnerability in lung adenocarcinoma by Ruilan Ma, Dian Yang, Peng Wang, Ziyi Zhang, Xuehong Zhang, Jialiang Song, Han Liu, Shuyan Liu, Yingqiu Zhang, Lijuan Zou

“…Importantly, RIT1 mutants markedly sensitized cells to ferroptosis induction, and RIT1 knockdown suppressed ferroptotic cell death. Lung adenocarcinoma NCI-H2110 cells containing endogenous RIT1 M90I mutation were susceptible to ferroptosis induction both in vitro and in vivo within xenograft models. …”
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Inhibition of cancer cells using target-specific 2A3 antibody-conjugated gold nanoclusters by Jui-Chi Kuo, Tsung-Rong Kuo, Fajar Rinawati, Erna Susilowati, Sucipto, Dyah Ika Krisnawati

“…The cell viability was measured by resazurin dye reduction assay. The cell death was analyzed by fluorescence imaging. …”
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Hypericin mediated photodynamic therapy induces ferroptosis via inhibiting the AKT/mTORC1/GPX4 axis in cholangiocarcinoma by Wei An, Kai Zhang, Guangbing Li, Shunzhen Zheng, Yukun Cao, Jun Liu

“…Ferroptosis is a novel regulated cell death(RCD), which is controlled by glutathione peroxidase4(GPX4) with the characteristics of iron dependent and excessive intracellular accumulation of lipid peroxides. …”
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Investigating the Expression of c-Myc and BIRC5 in TRAIL and PBOX-15 treated Metastatic Prostate Cancer Cells by Corinne Kai Leng Chew, Hannah O'Toole, Daniela M Zisterer, Seema M. Nathwani, Jade K. Pollock

“…Previous studies demonstrated that PBOX-15 is capable in sensitising cancer cells to TRAIL-mediated cell death by upregulation of death receptors and downregulation of related oncogenes. …”
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Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy by Julia Uffenorde, Mehran Hariri, Eleftherios Papalanis, Annika Staffas, Josefine Berg, Bo Stenerlöw, Hanna Berglund, Christer Malmberg, Diana Spiegelberg, Diana Spiegelberg

“…Further, migration capacity and effects on protein expression were studied after exposure to Onalespib and radiation using Proximity Extension Assay analysis.ResultsHSP90 inhibition with Onalespib synergistically enhanced the radiosensitivity of glioblastoma cells grown in 2D and 3D models, resulting in increased cell death, reduced migration capacity and activation of the apoptotic signaling pathway. …”
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Mechanisms of Cytotoxicity of Chemical Agents to Giant Cell Tumors: An In Vitro Study by Achmad Fauzi Kamal, Akbar Rizki Beni Asdi, Ahmad Jabir Rahyussalim, Rio Wikanjaya, Resda Akhra Syahrani, Tri Kurniawati, Septelia Inawati Wanandi

“…Flow cytometry using Annexin V showed cell death due to necrosis, with the highest concentration amounting to 0.3%. …”
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Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics by Seyede Sara Pakdaman Kolour, Saeide Nematollahi, Masoud Dehbozorgi, Farnaz Fattahi, Fatemeh Movahed, Neda Esfandiari, Mohammad Saeed Kahrizi, Nima Ghavamikia, Bahareh Salmanian Hajiagha

“…Dysregulated miRNAs upregulate the synthesis of enzymes that degrade cartilage, downregulate the expression of components in the cartilage matrix, promote the production of proinflammatory cytokines, induce programmed cell death in chondrocytes, inhibit the process of autophagy in chondrocytes, and participate in pathways related to pain. …”
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Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus) by Jiale Shi, Congji Yang, Yuanyuan Qin, Qingqing Liu, Shengqi Hua, Defeng Wu, Wei Dong

“…Our findings may serve as a foundation for elucidating the mechanism underlying the molecular metabolism of programmed cell death and should be useful for marker-assisted selection breeding in watermelon.…”
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Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway by Attalla Farag El-kott, Ali A. Shati, Mohammed Ali Al-kahtani, Sultan Alqahtani

“…However, while AG treatment had no effect on control cell viability, it significantly increased cell viability and proliferation and inhibited cell death in Cis-treated cells. In both control and Cis-treated cells, AG treatment significantly increased PI3K/Akt/mTOR signaling and enhanced the nuclear accumulation of NF-κB. …”
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Lipid peroxidation and sarcopenia: molecular mechanisms and potential therapeutic approaches by Yifan Lu, Yifan Lu, Tiao Li, Yang Shu, Yang Shu, Chengyin Lu, Chengyin Lu, Zhiqiang Luo, Zhiqiang Luo, Jingrui Wang, Jingrui Wang, Hui Xiong, Wangyang Li, Wangyang Li

“…This review summarizes the mechanisms by which lipid peroxidation contributes to sarcopenia, with a focus on its regulatory effects on cell membrane damage, mitochondrial dysfunction, and cell death. In addition, we discuss the protective role of antioxidant factors such as GPX4 (glutathione peroxidase 4) and antioxidant peptides like SS peptides in mitigating lipid peroxidation and delaying the progression of sarcopenia. …”
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Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy by Xiaopeng Li, Yang Zhong, Pengyuan Qi, Daoming Zhu, Chenglong Sun, Nan Wei, Yang Zhang, Zhanggui Wang

“…This nanodrug combines dual GSH depletion, starvation therapy, and RT to promote immunogenic cell death and stimulate the systemic immune response. …”
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Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis by Xue Zhang, Ruli Ge, Hongliang Chen, Maxwell Ahiafor, Bin Liu, Jinbo Chen, Xueli Fan

“…TFH cells express the nuclear transcriptional repressor B cell lymphoma 6 (Bcl-6), the chemokine (C-X-C motif) receptor 5 (CXCR5), the CD28 family members programmed cell death protein-1 (PD-1) and inducible costimulator (ICOS) and are also responsible for the secretion of interleukin-21 (IL-21) and IL-4. …”
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Prioritization of biological processes based on the reconstruction and analysis of associative gene networks describing the response of plants to adverse environmental factors by P. S. Demenkov, E. A. Oshchepkova, T. V. Ivanisenko, V. A. Ivanisenko

“…The prioritization results indicate that fundamental processes, such as gene expression, post-translational modifications, protein degradation, programmed cell death, photosynthesis, signal transmission and stress response play important roles in the common molecular genetic mechanisms for plant response to various adverse factors. …”
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Pharmacological Characterization of the Mechanisms Involved in Delayed Calcium Deregulation in SH-SY5Y Cells Challenged with Methadone by Sergio Perez-Alvarez, Maria E. Solesio, Maria D. Cuenca-Lopez, Raquel M. Melero-Fernández de Mera, Carlos Villalobos, Hanna Kmita, Maria F. Galindo, Joaquin Jordán

“…Previously, we have shown that SH-SY5Y cells exposed to high concentrations of methadone died due to a necrotic-like cell death mechanism related to delayed calcium deregulation (DCD). …”
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Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB... by Yuan Xu, Naiyuan Shao, Feng Zhi, Ronghua Chen, Yilin Yang, Jiahui Li, Ying Xia, Ya Peng

“…Methods We compared the delta-opioid receptor (DOR)- and mu-opioid receptor (MOR)-mediated effects on AD-associated cognitive deficits, pathologies, neuroinflammations, cell death using transgenic APP/PS1 mouse model and BV2 cell line at behavioral, molecular, and cellular levels. …”
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Genomics Analysis of Metabolic Pathways of Human Stem Cell-Derived Microglia-Like Cells and the Integrated Cortical Spheroids by Julie Bejoy, Xuegang Yuan, Liqing Song, Thien Hua, Richard Jeske, Sébastien Sart, Qing-Xiang Amy Sang, Yan Li

“…In addition, the metabolic pathways and the signaling pathways involved in cell proliferation, cell death, PIK3/AKT/mTOR signaling, eukaryotic initiation factor 2 pathway, and Wnt and Notch pathways were analyzed. …”
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Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma by O. V. Saik, N. A. Konovalova, P. S. Demenkov, N. V. Ivanisenko, T. V. Ivanisenko, D. E. Ivanoshchuk, O. S. Konovalova, O. A. Podkolodnaya, I. N. Lavrik, N. A. Kolchanov, V. A. Ivanisenko

“…It was shown that genes associated with POAG are statistically significantly more often represented among the genes involved in the interactions between CRMS and neuronal apoptosis than it was expected by random reasons, which can be an explanation for the effect of POAG leading to the retinal ganglion cell death.…”
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Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment by Yanyan Zhang, Zhichao Yang, Yuchen Liu, Jinjin Pei, Ruojie Li, Yanhui Yang

“…By enhancing lipid peroxidation, the induction of ferroptosis—a form of regulated cell death—could impair the survival of PC cells and hinder disease progression.…”
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