Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies by Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke

“…Furthermore, state of the art research increasingly implicates neuronal dysfunction and possibly even irreversible neuronal cell death. Cell-type specific investigation in animal models highlights the need for critical revision of the contribution of astrocytes and microglia to well-established and novel cellular and molecular alterations in hepatic encephalopathy. …”
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Exploring prognosis and therapeutic strategies for HBV-HCC patients based on disulfidptosis-related genes by Chuankuo Zhang, Xing Zhang, Shengjie Dai, Wenjun Yang

“…Disulfidptosis is a newly discovered form of regulated cell death. This study aims to develop a novel HBV-HCC prognostic signature related to disulfidptosis and explore potential therapeutic approaches through risk stratification based on disulfidptosis.MethodsTranscriptomic data from HBV-HCC patients were analyzed to identify BHDRGs. …”
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CRISPR/Cas9-Based Protocol for Precise Genome Editing in Induced Pluripotent Stem Cells by Avinash Singh, Swathy Babu, Marcus Phan, Shauna Yuan

“…P53 activation as a result of traditional CRISPR editing can lead to apoptosis, potentially worsening cell health or even resulting in cell death. Mitigating this apoptotic response can enhance cell survival post-CRISPR editing, which will ultimately increase editing efficiency. …”
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Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors by Shashank Shekhar, Charles Tracy, Peter V. Lidsky, Raul Andino, Katherine J. Wert, Helmut Krämer

“…Cytosolic restraint of the ATF4 and XRP1 transcription factors dampens expression of their downstream targets including genes of cell death pathways activated during chronic cellular stress and thus constitutes a chronic stress protective response (CSPR). …”
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VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration by Shirel Argueti-Ostrovsky, Shir Barel, Joy Kahn, Adrian Israelson

“…The pivotal functions of VDAC1 in controlling mitochondrial membrane permeability, regulating calcium balance, and facilitating programmed cell death pathways, position it as a key determinant in the delicate balance between neuronal viability and degeneration. …”
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Role of cytokines in myocardial ischemia and reperfusion by H. S. Sharma, D. K. Das

“…At the cellular level it has been shown that hypoxia causes a series of well documented changes in cardiomyocytes that includes loss of contractility, changes in lipid metabolism and subsequent irreversible cell membrane damage leading to cell death. For instance, hypoxic cardiomyocytes produce interleukin-6 (IL-6) which could contribute to the myocardial dysfunction observed in ischemia reperfusion injury. …”
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Phagocytosis by macrophages decreases the radiance of bioluminescent Staphylococcus aureus by Elles C. Boonstra, Liliana Agresti, Henny C. van der Mei, Paul C. Jutte, Jelmer Sjollema

“…S. aureus was released extracellularly as a result of macrophage cell death. Following this release, the bacteria increased their bioluminescence again. …”
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Activation of osteoblast ferroptosis by risperidone accelerates bone loss in mice models of schizophrenia by Hongyan Fan, Zaihong Yang, Lan Pang, Peifan Li, Changrong Duan, Guangyuan Xia, Lei Zheng

“…Abstract Background Ferroptosis is an iron-dependent regulatory cell death, which plays an essential role in bone loss. …”
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Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy by Axel H. Schönthal

“…Other studies seek to pharmacologically aggravate chronic ER stress in cancer cells in order to enhance apoptosis and achieve tumor cell death. In the following, these principles will be presented and discussed.…”
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Cuproptosis genes in predicting the occurrence of allergic rhinitis and pharmacological treatment. by Ting Yi

“…Cuproptosis is a novel form of programmed cell death, and its role in allergic rhinitis has not yet been explored. …”
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Cytotoxic Effect of the Genus Sinularia Extracts on Human SCC25 and HaCaT Cells by Guey-Horng Wang, Tzung-Han Chou, Rong-Jyh Lin, Jyh-Horng Sheu, Shih-Hao Wang, Chia-Hua Liang

“…Flow cytometry shows that extracts sensitized the cells in the G0/G1 and G2/M phases with a concomitant significantly increased sub-G1 fraction, suggesting cell death by apoptosis. Extracts of the genus Sinularia thus apparently cause apoptosis of SCC25 and HaCaT cells, and warrant further research investigating the possible antioral cancer compounds in these soft corals.…”
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Twist-Induced Epithelial-to-Mesenchymal Transition Confers Specific Metabolic and Mitochondrial Alterations by Haleigh N. Parker, Kayla L. Haberman, Tolulope Ojo, Juli Watkins, Adhwaitha Nambiar, Kayla Morales, Bernd Zechmann, Joseph H. Taube

“…EMT confers several advantageous characteristics, including enhanced migration and invasion, resistance to cell death, and altered metabolism. In disease, these adaptations could be leveraged as therapeutic targets. …”
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Combination Effects of Docetaxel and Doxorubicin in Hormone-Refractory Prostate Cancer Cells by Eleftheria Tsakalozou, Allison M. Eckman, Younsoo Bae

“…Equipotent drug combination treatments (7×7) revealed that the DOC/DOX combination leads to high synergy and effective cell death only in a narrow concentration range in DU145. …”
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The histopathological and functional consequences of microplastic exposure by Yujeong Lee, Minkyoung Sung, Soo-Eun Sung, Joo-Hee Choi, Kyung-Ku Kang, Jae Woo Park, Ye-jin Kim, Sijoon Lee

“…Various studies confirm that microplastics stimulate cells, leading to increased reactive oxygen species production, inflammation, and cell death. Consequently, these morphological changes impair related systemic functions. …”
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Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B... by Runhui Zheng, Xiaobo Chen, Chunyan Wang, Pengfei Qin, Huo Tan, Xiaodan Luo

“…We report a case with “double-expressor” DLBCL treated with a combined regimen which consisted of programmed cell death protein 1 (PD-1) inhibitor, DNA methyltransferase inhibitor (DNMTi), and histone deacetylase inhibitor (HDACi). …”
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Necrostatin-1 Reduces Neurovascular Injury after Intracerebral Hemorrhage by Melanie D. King, Wittstatt A. Whitaker-Lea, James M. Campbell, Cargill H. Alleyne, Krishnan M. Dhandapani

“…Necrostatin-1 also limited cell death by 48%, reduced blood-brain barrier opening by 51%, attenuated edema development to sham levels, and improved neurobehavioral outcomes after ICH. …”
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VSTM2L protects prostate cancer cells against ferroptosis via inhibiting VDAC1 oligomerization and maintaining mitochondria homeostasis by Juan Yang, Xiao Lu, Jing-Lan Hao, Lan Li, Yong-Tong Ruan, Xue-Ni An, Qi-Lai Huang, Xiao-Ming Dong, Ping Gao

“…Abstract Ferroptosis is a form of iron-dependent programmed cell death, which is distinct from apoptosis, necrosis, and autophagy. …”
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MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1 by Cairong Zhu, Zhiquan Song, Zhen Chen, Tianqi Lin, Haili Lin, Zhenqiang Xu, Fen Ai, Shijiao Zheng

“…Cell proliferation, colony formation, cell migration, cell invasion, cell death, oxidative stress, lipid peroxidation, and iron metabolism were determined. …”
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SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone. by Stefanos Giannakopoulos, Jin Pak, Jackson Bakse, Monika A Ward, Vivek R Nerurkar, Michelle D Tallquist, Saguna Verma

“…Transcriptomic analysis revealed dysregulation of inflammatory, cell death, and steroidogenic pathways. Furthermore, reduced testosterone levels associated with a transient reduction in sperm count and male fertility. …”
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Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies by Zhichao Liu, Yongkang Gan, Zhen Shen, Siqi Cai, Xizhen Wang, Yong Li, Xiaofeng Li, Huanjie Fu, Jinhong Chen, Ningcen Li

“…Recently, a new type of copper-dependent cell death known as cuproptosis has drawn increasing attention to the impact of copper dyshomeostasis on HF. …”
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