Tumor Necrosis Factor Alpha Mediates GABAA Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo by Ellen D. Stück, Randolph N. Christensen, J. Russell Huie, C. Amy Tovar, Brandon A. Miller, Yvette S. Nout, Jacqueline C. Bresnahan, Michael S. Beattie, Adam R. Ferguson

“…The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. …”
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Immunotherapy-associated autoimmune hemolytic anemia by Uqba Khan, Tarik Hadid, Farman Ali, Muhammad Siddique Khurram, Awais Zaka

“…Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) pathway are the prototypic checkpoint targets for immunotherapy. …”
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Identification of cuproptosis and ferroptosis-related subtypes and development of a prognostic signature in colon cancer. by Yinghao He, Fuqiang Liu, Qingshu Li, Zheng Jiang

“…In recent years, ferroptosis and cuproptosis, as two novel forms of cell death, have attracted widespread attention for their potential roles in the development and treatment of colon cancer. …”
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Antioxidant activity of Micractinium sp. (Chlorophyta) extracts against H2O2 induced oxidative stress in human breast adenocarcinoma cells by Onur Bulut, Işkın Engin Köse, Çağla Sönmez, Hüseyin Avni Öktem

“…Moreover, extracts from Micractinium sp. exhibited remarkable cytoprotective activity by effectively inhibiting hydrogen peroxide-induced oxidative stress and cell death in human breast adenocarcinoma (MCF-7) cells. …”
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Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells by Ihraiz Worood G., Ahram Mamoun, Bardaweel Sanaa K.

“…Cell migration was assessed using the wound-healing assay. The mechanism of cell death was assessed using annexin V-FITC/propidium iodide staining flow cytometry method. …”
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Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents by Mirna Jabbour, Mohammad Ammar Al-Khayat, Mahmoud Al-Ktaifani

“…Furthermore, we have studied the effect of compounds on proliferation, cell cycle, and cell death in two human cancer cell lines (Caco-2 and HCT-116). …”
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Comparative efficacy of programmed death ligand 1 inhibition and chemotherapy in advanced gastric or gastroesophageal junction cancer with combined positive score – a meta-analysis... by Zakari Shaibu, Fumeng Yang, Liu Ting, Lily Dzidula, Amina Elmi Yusuf, Zhi-hong Chen, Wei Zhu

“…Immune checkpoint inhibitors, particularly targeting programmed cell death ligand-1 (PD-L1), have emerged as promising agents to enhance patient outcomes. …”
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Interruption of mitochondrial symbiosis is associated with the development of osteoporosis by Haoling Zhang, Haoling Zhang, Haoling Zhang, Rui Zhao, Xuemei Wang, Yaqian Qi, Doblin Sandai, Wei Wang, Zhijing Song, Zhijing Song, Qiudong Liang

“…Nevertheless, the controlled release of mitochondrial components into the cytoplasm can initiate cell death, activate innate immunity, and provoke inflammation. …”
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Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase by Lies De Groef, Manuel Salinas-Navarro, Griet Van Imschoot, Claude Libert, Roosmarijn E. Vandenbroucke, Lieve Moons

“…Moreover, MMP-2 null mice display attenuated retinal ganglion cell death upon excitotoxic insult to the retina, which is accompanied by normal glial reactivity, yet reduced TNF levels. …”
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Anti-angiogenic effects of cationic zinc (II) phthalocyanine derivatives through photodynamic therapy by Seyma Isik, Mukaddes Ozcesmeci, Ayfer Kalkan Burat, Esin Hamuryudan, Ozge Can, Muge Serhatli

“…ZnPc-PDT led to significant cell death via apoptosis. ZnPc1 exhibited enhanced ROS generation, particularly at elevated concentrations. …”
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Acidic Microenvironment Enhances Cisplatin Resistance in Bladder Cancer via Bcl-2 and XIAP by Kaede Hiruma, Vladimir Bilim, Akira Kazama, Yuko Shirono, Masaki Murata, Yoshihiko Tomita

“…A Western blot analysis revealed that the activations of Bcl-2 and XIAP expression appear to inhibit both apoptotic and autophagic cell death. Taken together, these results suggest that alleviating the acidity of the tumor microenvironment in clinical settings might enhance BC sensitivity to CDDP.…”
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Electroacupuncture-Regulated miR-34a-3p/PDCD6 Axis Promotes Post-Spinal Cord Injury Recovery in Both In Vitro and In Vivo Settings by Lili Ma, Lizhong Ma, Yu Yang, Ting Chen, Limin Wang, Qilong Deng

“…Electroacupuncture (EA) could enhance neuroregeneration and posttraumatic conditions; however, the underlying regulatory mechanisms remain ambiguous. PDCD6 (programmed cell death 6) is an established proapoptotic regulator which is responsible for motoneuronal death. …”
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Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice by Luciana Lontro Alves, Priscila Gomes Pereira, Bianca Torres Ciambarella, Miguel Porto Campos, Kíssila Rabelo, Ana Lúcia Rosa Nascimento, Raíssa Leal de Carvalho dos Santos Cunha, Cherley Borba Vieira Andrade, Alan Cesar Nunes Moraes, Andressa Bernardi, Fernanda Verdini Guimarães, Jemima Fuentes Ribeiro da Silva, Jorge José de Carvalho

“…Parameters inherent to body mass, glucose tolerance, evaluation of liver enzymes, percentage of hepatic steatosis, oxidative stress, the process of cell death with the apoptotic biomarkers (Bax, Bcl2, and Cytochrome C), and the ultrastructure of hepatocytes were analyzed. …”
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Depletion and Reversal of Hepatocellular Carcinoma Inducing CTL through ER Stress-Dependent PERK-CHOP Signaling Pathway by Mengnan Guo, Wei Wang, Wen Bai, Zekun Bai, Weixi Chen, Yali Su, Jinghua Wu

“…After 4-phenylbutyric acid (4-PBA) or tunicamycin (TM) treatment, programmed cell death protein 1 (PD-1), and mucin domain 3 (TIM-3), PRF1, and GzmB were measured by western blotting and ELISA. …”
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Xylazine as a Drug of Abuse and Its Effects on the Generation of Reactive Species and DNA Damage on Human Umbilical Vein Endothelial Cells by Luz Silva-Torres, Christian Veléz, Lyvia Álvarez, Beatriz Zayas

“…Our previous work demonstrated that XYL and its combination with cocaine (COC) and/or 6-monoacetylmorphine (6-MAM) induce cell death through an apoptotic mechanism. The aim of this study was to determine the effect of xylazine on the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) as well as DNA damage on endothelial cell. …”
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Human Neutrophil Defensins Disrupt Liver Interendothelial Junctions and Aggravate Sepsis by QiXing Chen, Yang Yang, YiHang Pan, LiHua Shen, Yan Zhang, Fei Zheng, Qiang Shu, XiangMing Fang

“…The injection of high dose of HNP-1 did not directly induce liver endothelial cell death but destroyed interendothelial junctions in the liver. …”
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The Role of NF-κB/MIR155HG in Regulating the Stemness and Radioresistance in Breast Cancer Stem Cells by Yunbao Xu, Lu Yang, Guangming Li, Chuangzhou Rao

“…Targeting MIR155HG may enhance the susceptibility of cancer stem cells to radiation-induced cell death, potentially improving therapeutic outcomes. …”
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Design and In Vitro Biological Evaluation of a Novel Organotin(IV) Complex with 1-(4-Carboxyphenyl)-3-ethyl-3-methylpyrrolidine-2,5-dione by Nebojša Đ. Pantelić, Bojana B. Zmejkovski, Željko Žižak, Nebojša R. Banjac, Bojan Đ. Božić, Tatjana P. Stanojković, Goran N. Kaluđerović

“…Furthermore, fluorescence microscopy analysis of HeLa cells reveal that organotin(IV) complex induced apoptosis as a mode of cell death, which is consistent with the increase of cells in the sub-G1 phase.…”
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Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitot... by Ankit A. Gilani, Ranjeet Prasad Dash, Mehul N. Jivrajani, Sandeep Kumar Thakur, Manish Nivsarkar

“…An excess release of glutamate leads to the activation of ionotropic and metabotropic receptors, thus resulting in accumulation of toxic cytoplasmic Ca2+ and cell death. However, it has been observed that gamma-aminobutyric acid-A (GABAA) receptors located in the nerve terminals activate presynaptic Ca2+/calmodulin-dependent signaling to inhibit depolarization-evoked Ca2+ influx and glutamate release from isolated nerve terminals, which suggest a potential implication of GABAA receptor in management of MS. …”
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Carbon Monoxide Poisoning with Neurological, Ocular, and Myocardial Damage: A Case Report by Duc Nguyen, Sinh Nguyen, Anh Lam

“…CO has a high affinity with hemoglobin because it reduces oxygen transport causing tissue hypoxia, lactic acidosis, and cell death.Case report: A 32-year-old female patient entered Poison Control Center of Bach Mai Hospital, Ha Noi, Vietnam, because of decreased consciousness, loss of vision in the right eye. …”
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