Biomarkers in metastatic castration-resistant prostate cancer for efficiency of immune checkpoint inhibitors by Zixi Wu, Junbiao Zhang, Le Li, Zhihua Wang, Chunguang Yang

“…However, while immune checkpoint inhibitor monotherapy or combination therapy targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and/or programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) axis has been regarded as the standard therapy in many solid tumours, mCRPC as ‘cold’ tumours are considered to be relatively resistant to ICB treatment. …”
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Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia by Yanhua Qin, Weiming Hu, Yang Yang, Zhiying Hu, Weiyun Li, Marong Fang

“…Aberrant production of nitric oxide following inducible nitric oxide synthase (iNOS) expression has been implicated in cell death and contributes to ischemic brain injury. …”
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Allium Cepa (Onion) Extract Enhances and Protects Testicular Function and Architecture against Paraquat Induced Oxidative Damage. by Uzozie Chikere, Ofoego, Ejike, Daniel Eze

“…Paraquat administration caused significantly (P<0.05) reduced sperm count, motility, alteration in sperm morphology and induced cell death. Oral gavage of paraquat also caused significant (P<0.05) decrease in serum testosterone and SOD levels with concomitantly elevated MDA levels. …”
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Genetic characteristics involving the PD-1/PD-L1/L2 and CD73/A2aR axes and the immunosuppressive microenvironment in DLBCL by Tingting Zhang, Zhenzhen Zhang, Xiubao Ren, Jin He, Zhengzi Qian, Bin Meng, Lei Jiao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Wenchen Gong, Huilai Zhang, Xianhuo Wang

“…Background Targeting the PD-1/PD-L1/L2 (programmed cell death protein 1/programmed cell death ligand 1/ligand 2) pathway combined with other immunosuppressive signalings, such as CD73/A2aR (A2a adenosine receptor) adenosine signaling, has emerged as a promising strategy for cancer treatment. …”
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The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…Potassium phosphite inhibits cell death by enhancing the activity of antioxidant enzymes, such as CAT, PPO, and SOD, thereby impeding the progression of the fungus. …”
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Lidocaine could promote the cuproptosis through up-regulating the long noncoding RNA DNMBP-AS1 in Hep-2 cells by Wei Liu, Yi Yu, Yi He, Meihong Lv

“…Cuproptosis is a copper triggered mitochondrial cell death mode. In this study, we explored the biological effects of lidocaine on cuproptosis in Hep-2 cells and studied the relevant mechanisms. …”
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Identification of PANoptosis associated lncRNAs associated with clinical prognosis and immune infiltration microenvironment in colon adenocarcinoma by Yangyang Wang, Shihui Zhao, Songtao Du, Tianyi Xia, Liqiang Song, Mingyu Xia, Bomiao Zhang

“…PANoptosis is defined as a form of inflammatory cell death regulated by PANoptosome, with common features of pyroptosis, apoptosis and necroptosis. …”
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Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives by Hubo Yang, Xuefeng Zhang, Zongming Jia, He Wang, Jixiang Wu, Xuedong Wei, Yuhua Huang, Wenying Yan, Yuxin Lin

“…Ferroptosis is a new form of regulatory cell death caused by iron-dependent lipid peroxidation, which has a dual role in PCa evolution and treatment due to the multi-omics cascade of interactions among pathways and environmental stimuli. …”
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Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition by Aimin Yang, Xia Xiao, Mingfeng Zhao, Amanda C. LaRue, Bradley A. Schulte, Gavin Y. Wang

“…Here we report that dual inhibition of mTORC1/2 by AZD or its analogue (KU-63794) depletes mouse BM Lin−Sca-1+c-Kit+ cells in cultures via the induction of apoptotic cell death. Subsequent colony-forming unit (CFU) assays revealed that inhibition of mTORC1/2 suppresses the clonogenic function of hematopoietic progenitor cells (HPCs) in a dose-dependent manner. …”
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Examining alternative approaches to antibiotic utilisation: A critical evaluation of phage therapy and antimicrobial peptides combination as potential alternatives by Chibuzo Vincent Alisigwe, Chibuzor Stanley Ikpa, Uchenna Joseph Otuonye

“…Bacteriophages kill bacteria by injecting their genomes (DNA or RNA), leading to bacterial cell lysis, while AMPs can either disrupt bacterial cell membranes or interfere with their intracellular targets after penetrating the cell, causing cell death. Our review highlights that both AMPs and bacteriophages have been successfully employed in vitro, in clinical trials, and in patient treatments to eliminate bacterial isolates. …”
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Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments by Jia-Haur Chen, John Vincent Lim, Yih-Chih Hsu

“…In the in vitro study, CDDP and LPC nanoparticles enhanced higher amounts of cell death as the concentration increased. The treatment effects of PDT+LPC NPs using pancreatic MIAPaCa-2 and PANC-1 tumor models revealed that PDT+LPC significantly inhibited tumor growth. …”
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Roles of Copper Transport Systems Members in Breast Cancer by Yichang Chen, Chen Li, Mengxin Li, Bing Han

“…These members influence the onset, progression, and cell death of breast cancer by modulating biological pathways such as intracellular copper ion levels and ROS. …”
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RNA N4‐acetylcytidine modification and its role in health and diseases by Qiang Wang, Yixiao Yuan, Qiang Zhou, YingDong Jia, Jing Liu, GuangJun Xiao, Chunhong Li, Xiulin Jiang

“…Furthermore, this review delves into the central roles and molecular mechanisms of ac4C modification in regulating malignant proliferation, cell cycle arrest, EMT, drug resistance, cell death, cancer metabolism, and tumor immunotherapy. …”
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IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome by Min Guo, Rui Yan, Hongmei Yao, Liqin Duan, Meng Sun, Zheng Xue, Yongping Jia

“…IFN regulatory factor 1 (IRF-1) is a pleiotropic transcription factor involved in various immune processes and cell death. We propose that IRF-1 may be implicated in macrophage pyroptosis in the pathogenesis of AS and ACS. …”
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High Throughput Approaches to Unravel the Mechanism of Action of a New Vanadium-Based Compound against Trypanosoma cruzi by M. Florencia Mosquillo, Pablo Smircich, Analía Lima, Sergio A. Gehrke, Gonzalo Scalese, Ignacio Machado, Dinorah Gambino, Beatriz Garat, Leticia Pérez-Díaz

“…We found a good IC50 value, (3.76 ± 0.08) μM, on CL Brener epimastigotes. The analysis of cell death mechanism allowed us to rule out the implication of a mechanism based on early apoptosis or necrosis. …”
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Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis by Claire M. Payne, Cheray Crowley-Skillicorn, Hana Holubec, Katerina Dvorak, Carol Bernstein, Mary Pat Moyer, Harinder Garewal, Harris Bernstein

“…Rapamycin pre-treatment of the apoptosis-resistant colon cancer cell line, HCT-116RC (developed in our laboratory), resulted in a significant decrease in DOC-induced cell death. Bafilomycin A1 and hydroxychloroquine (inhibitors of the autophagic process) increased the DOC-induced percentage of apoptotic cells in HCT-116RC cells. …”
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A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer by Xin Zhang, Xingda Zhang, Guozheng Li, Yi Hao, Lei Liu, Lei Zhang, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu

“…Necroptosis is a type of programmed cell death (PCD) and exhibits regulatory effects on tumor progression, but few studies have focused on the relationships between necroptosis-associated lncRNAs and BRCA. …”
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Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies by Blessing A. Obafemi, Isaac A. Adedara, Cássia Pereira Delgado, Olabisi T. Obafemi, Michael Aschner, Joao B.T. Rocha

“…Studies have also shown that neurotoxicity due to FB1 involves dysregulation of several biochemical events in the brain, such as induction of oxidative stress and inflammation, mitochondrial dysfunction and associated programmed cell death, inhibition of acetylcholinesterase and alteration of neurotransmitter levels, decreased activity of Na+K+ ATPase, as well as disruption of blood-brain barrier. …”
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Evaluation of extracts from Phyllostachys makinoi for their antibacterial and accelerated wound healing potential by Te-Hua Liu, Ju-Yun Wu, Meng-Chun Cheng, Bang-Yuan Chen, Tsung-Yu Tsai

“…The extracts disrupted the cell membranes, causing electrolyte, protein, and nucleic acid leakage, leading to cell death. Additionally, P. makinoi extracts reduced lipopolysaccharide-induced nitric oxide, tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 levels in RAW264.7 cells, and promoted wound healing by enhancing CCD-1112Sk cell proliferation. …”
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Dramatic response of advanced pulmonary sarcomatoid carcinoma to tislelizumab combined with anlotinib: a case report by Ranran Li, Xiliang Di, Yuan Li, Hao Li, Chonghua Liu

“…Radiotherapy was performed for the brain and skull metastases, followed by treatment with tislelizumab combined with anlotinib, a programmed cell death protein 1 (PD-1) inhibitor with anti angiogenic drug, respectfully. …”
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