Unveiling immune resistance mechanisms in nasopharyngeal carcinoma and emerging targets for antitumor immune response: tertiary lymphoid structures by Huilin Wang, Yuting Zhan, Jiadi Luo, Weiyuan Wang, Songqing Fan

“…The presence of intense lymphocytic infiltration and elevated expression of programmed cell death ligand 1(PD-L1) in NPC highlights its potential for immunotherapy, yet current treatment outcomes remain suboptimal. …”
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Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation by Annette Plesner, C. Bruce Verchere

“…Once the islets are engrafted, both prompt revascularization and protection from beta-cell death and graft rejection are key to secure long-term survival and function. …”
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Evaluation of Glucose Uptake in Normal and Cancer Cell Lines by Positron Emission Tomography by Francesca Maddalena, Giacomo Lettini, Rosj Gallicchio, Lorenza Sisinni, Vittorio Simeon, Anna Nardelli, Angela Assunta Venetucci, Giovanni Storto, Matteo Landriscina

“…Notably, [ 18 F]FDG incorporation resulted in low apoptotic rates, with fibroblasts being slightly more sensitive to radiotracer-induced cell death. The quantitative analysis of [ 18 F]FDG uptake in living cells by PET represents a valuable and reproducible method to study tumor cell metabolism in vitro, being representative of the differences in the molecular profile of normal and tumor cell lines.…”
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Peripheral membrane protein endophilin B1 probes, perturbs and permeabilizes lipid bilayers by Arni Thorlacius, Maksim Rulev, Oscar Sundberg, Anna Sundborger-Lunna

“…We also show that endophilin B1 efficiently permeabilizes negatively charged liposomes that contain mitochondria-specific lipid cardiolipin and propose a new model for Bax-mediated cell death.…”
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Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster by Bert I. Crawford, Mary Jo Talley, Joshua Russman, James Riddle, Sabrina Torres, Troy Williams, Michelle S. Longworth

“…Here, we show that condensin subunit knockdown in NSPCs of the Drosophila larval central brain increases RTE expression and mobility which causes cell death, and significantly decreases adult head sizes and brain volumes. …”
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Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties by Armenuhi Moghrovyan, Naira Sahakyan

“…The components of this EO disrupt membrane integrity, ion transport, membrane surface charge, biofilm formation, and other biophysical parameters, eventually leading to cell death. Research highlights its potential in combatting antibiotic resistance, either alone or in synergy with traditional antibiotics. …”
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S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor α Stability and Function by Ying Xiong, Yefim Manevich, Kenneth D. Tew, Danyelle M. Townsend

“…Thus, redox regulation of PDI causes its S-glutathionylation, thereby mediating cell death through activation of the UPR and abrogation of ERα stability and signaling.…”
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Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…These impairments may result from mechanisms including insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, and functional and structural damage to reward networks. …”
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Microalgae: A Treasure Trove of Anticancer Nutraceuticals and Promising Therapeutic Mechanisms by Sajjad Masoumi, Maryam Zokaei, Ardavan Ahmadvand, Nogol Ghalamkarpour, Naghmeh Asadimanesh, Armin Azarimatin, Khashayar Fattah, Zahra Payandeh, Masoumeh Rostami, Afsaneh Farjami, Rajan Kumar Pandey, Mohsen Nabi-Afjadi

“…Carotenoids, including astaxanthin, have shown the ability to hinder the development of tumors and trigger programmed cell death (apoptosis) in several types of cancer cells. …”
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Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity by Peng Wang, Xin Li, Xuran Li, Weiwei Yang, Shun Yu

“…Compared with NS plasma, PD plasma added to primary neuron cultures caused more cell death in the presence of extracellular α-syn. This was supported by the observations that phosphorylated α-syn oligomers entered neurons, rapidly increased accumulated thioflavin S-positive inclusions, and induced a series of metabolic changes that included activation of polo-like kinase 2, inhibition of glucocerebrosidase and protein phosphatase 2A, and reduction of ceramide levels, all of which have been shown to promote α-syn phosphorylation and aggregation. …”
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Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy by Rangarirai Makuku, Neda Khalili, Sepideh Razi, Mahsa Keshavarz-Fathi, Nima Rezaei

“…Immune checkpoint blockade through targeting programmed cell death protein-1 (PD-1) has demonstrated promising antitumor effects in cancer immunotherapy of many different solid and hematologic malignancies. …”
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The Acetone Extract of Sclerocarya birrea (Anacardiaceae) Possesses Antiproliferative and Apoptotic Potential against Human Breast Cancer Cell Lines (MCF-7) by Nicoline Fri Tanih, Roland Ndip Ndip

“…The extract also exerted apoptotic programmed cell death in MCF-7 cells with significant effect on the DNA. …”
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Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells by Ramazan Üzen, Hamiyet Altuntaş, Mustafa Çakır, Pınar Altın Çelik, Muazzez Derya Andeden

“…Although recent results support the mechanism that honey induces cell death, the full mechanisms are still unknown. This study investigates the potential use of Pervari honey (PH) as an in vitro therapeutic agent in breast cancer. …”
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Severe Inflammation Caused by Coinfection of PCV2 and Glaesserella parasuis Is Associated with Pyroptosis via Noncanonical Inflammasome Pathway by Jiahui An, Chao Zhang, Jinshuang Cai, Yufeng Li

“…Coinfection with PCV2 and G. parasuis can enhance RAW264.7 cell phagocytosis and elimination to G. parasuis. Cell death rate of cells increased in coinfection was measured with Flow cytometry. …”
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Bacteria as Precision Tools for Cancer Therapy by Carmen Michán, José Prados, Juan‐Luis Ramos

“…ABSTRACT The discovery at the end of the 20th century of genes that induce cell death revolutionised the biocontaintment of genetically manipulated bacteria for environmental or agricultural applications. …”
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Mitochondrial transplantation: a promising strategy for the treatment of retinal degenerative diseases by Jing Chi, Bin Fan, Yulin Li, Qing Jiao, Guang-Yu Li

“…These abnormalities lead to an inadequate energy supply, the exacerbation of oxidative damage, and the activation of cell death pathways, ultimately resulting in neuronal injury and dysfunction in the retina. …”
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Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo by Liliana M. R. Silva, Tamara Muñoz-Caro, Rafael A. Burgos, Maria A. Hidalgo, Anja Taubert, Carlos Hermosilla

“…ETs are released in response to intact protozoan parasites or to parasite-specific antigens in a controlled cell death process. Released ETs consist of nuclear DNA as backbone adorned with histones, antimicrobial peptides, and phagocyte-specific granular enzymes thereby producing a sticky extracellular matrix capable of entrapping and killing pathogens. …”
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Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells by Da Jung Kim, Yong Sik Kim

“…Trimethyltin (TMT) is known as a potent neurotoxicant that causes neuronal cell death and neuroinflammation, particularly in the hippocampus. …”
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Advanced Role of Neutrophils in Common Respiratory Diseases by Jinping Liu, Zhiqiang Pang, Guoqiang Wang, Xuewa Guan, Keyong Fang, Ziyan Wang, Fang Wang

“…With the development of scientific research, the involvement of neutrophils in respiratory diseases is being brought to light with emerging data on neutrophil subsets, trafficking, and cell death mechanism (e.g., NETosis, apoptosis) in diseases. …”
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Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease by Ishaq A. Viringipurampeer, Abu E. Bashar, Cheryl Y. Gregory-Evans, Orson L. Moritz, Kevin Gregory-Evans

“…Diverse genetic abnormalities and environmental causes have been implicated in triggering multiple pathological mechanisms such as oxidative stress, lipofuscin deposits, neovascularisation, and programmed cell death. In recent years, inflammation has also been highlighted although whether inflammatory mediators play a central role in pathogenesis or a more minor secondary role has yet to be established. …”
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