Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

“…Hence, a contribution to the increased cell death observed in WWP1‐depleted cells also possibly arises from the attenuation of glucose up‐take and glycolytic flux resulting from TXNIP accumulation. …”
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Novel combination strategy of high intensity focused ultrasound (HIFU) and checkpoint blockade boosted by bioinspired and oxygen-supplied nanoprobe for multimodal imaging-guided ca... by Ying Zhou, Chen Cheng, Qi Wang, Min Zheng, Pan Li, Yang Zhou, Yuting Cao, Li Wan, Xun Guo, Xiaohong Lin, Rui Tang, Hongye He, Nianhong Wu, Qiaoqi Chen, Yaqin Hu, Xialin Xiong, Faqi Li

“…Here, we describe a synergistic regimen combining HIFU facilitation with immunomodulation based on a novel oxygen-carrying biomimetic perfluorocarbon nanoparticle (M@P-SOP) to stimulate immunogenic cell death in tumor cells while alleviating immune suppression tumor microenvironment.Methods M@P-SOP was prepared by double emulsion and film extrusion method. …”
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In Vitro Cytotoxic Study and Detection of Apoptosis on Breast Cancer Cell lines MDA-MB 231 after Exposed to Azadirachta Indica A. Juss (neem) Extract by Dessy Arisanty

“…Thus, the results from this study strongly suggest that the ethanol extract of A.indica may contain bioactive compound(s) that caused breast carcinoma, MDA-MNB 231 cell death by apoptosis. It’s needed to do advance research to know more deeply the mechanism this plant on breast cancer cell line MDA-MB.…”
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Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity by Karine Andreau, Melanie Leroux, Aida Bouharrour

“…Environmental air pollutants are a heterogeneous mixture of particles suspended into a liquid and gaseous phase which trigger the disruption of redox homeostasis—known under the term of cellular oxidative stress—in relation with the establishment of inflammation and cell death via necrosis, apoptosis, or autophagy. Activation or repression of the apoptotic process as an adaptative response to xenobiotics might lead to either acute or chronic toxicity. …”
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Establishment of a Rapid and Convenient Fluoroimmunoassay Platform Using Antibodies Against PDL1 and HER2 by Ji Eun Choi, Hanool Yun, Hee-Jin Jeong

“…In this study, we developed a simple and rapid fluorescence-linked immunosorbent assay (FLISA) using fluorescent dye-conjugated antibody fragments against programmed cell death ligand 1 (PDL1) and human epithelial growth factor receptor 2 (HER2). …”
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Epigenetics and Shared Molecular Processes in the Regeneration of Complex Structures by Labib Rouhana, Junichi Tasaki

“…For example, structural damage is recognized and wound healing initiated upon injury, which is followed by programmed cell death in the vicinity of damaged tissue and a burst in proliferation of progenitor cells. …”
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Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease by Enrico Desideri, L. Miguel Martins

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Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far? by Aleksandra Pyzik, Ewelina Grywalska, Beata Matyjaszek-Matuszek, Jacek Roliński

“…The process of programmed cell death also plays an equally important role in the pathogenesis and the development of hypothyroidism.…”
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Mitochondrial Dysfunction in Parkinson's Disease by P. C. Keane, M. Kurzawa, P. G. Blain, C. M. Morris

“…This paper aims to illustrate the considerable body of evidence linking mitochondrial dysfunction with neuronal cell death in the substantia nigra pars compacta (SNpc) of PD patients and to highlight the important need for further research in this area.…”
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Guiding the Differentiation Direction of Pancreatic Islet-Derived Stem Cells by Glycated Collagen by Gokhan Duruksu, Aysegul Aciksari

“…The results showed that the modifications did not induce apoptosis or cause cell death. However, the culture of cells on modified collagens improved the proliferation. …”
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The molecular mechanisms of cuproptosis and its relevance to atherosclerosis by Jiankang Wang, Zhian Chen, Hang Shang, Jiajuan Guo

“…Excessive intracellular copper accumulation induces a unique form of cell  death termed “cuproptosis.” The emergence of the concept of cuproptosis has highlighted the potential role of copper in atherosclerosis. …”
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Consensus Clustering and Survival-Related Genes of Cuproptosis in Cutaneous Melanoma by Wentao Qin, Fu Gan, Yiji Jike, Mingyang Jiang, Ang Li

“…As a highly malignant tumor, the morbidity and mortality of cutaneous melanoma (CM) are increasing year by year. A novel type of cell death connected to mitochondrial metabolism is called cuproptosis. …”
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Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease by Sorabh Sharma, Rajeev Taliyan

“…Although the exact underlying mechanisms leading to neural cell death in this disease remains unknown, the genetic causes are often established. …”
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Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis by Junjie Jian, Jun Wei

“…Recent advancements highlight a novel interaction between iron-dependent cell death, known as ferroptosis, and gut microbiota, which may significantly influences the pathophysiology of MS. …”
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Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury by Jingying Zhou, Xue Huo, Benson O. A. Botchway, Luyao Xu, Xiaofang Meng, Songou Zhang, Xuehong Liu

“…The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. …”
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Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities by Jiarui Zhang, Jinan Zhang, Chen Yang

“…Autophagy plays a crucial role in the development of diseases, particularly human cancers, with actions that can either promote survival or induce cell death. However, brain tumors contribute to high levels of both mortality and morbidity globally, with resistance to treatments being acquired due to genetic mutations and dysregulation of molecular mechanisms, among other factors. …”
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Spindle Bursts in Neonatal Rat Cerebral Cortex by Jenq-Wei Yang, Vicente Reyes-Puerta, Werner Kilb, Heiko J. Luhmann

“…Disturbances in spindle burst activity during corticogenesis may contribute to disorders in cortical architecture and in the activity-dependent control of programmed cell death. In this review we discuss (i) the functional properties of spindle bursts, (ii) the mechanisms underlying their generation, (iii) the synchronous patterns and cortical networks associated with spindle bursts, and (iv) the physiological and pathophysiological role of spindle bursts during early cortical development.…”
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Mitochondria as a Therapeutic Target: Focusing on Traumatic Brain Injury by Randhall Bruce Carteri

“…Mitochondria are organelles of eukaryotic cells delimited by two membranes and cristae that consume oxygen to produce adenosine triphosphate (ATP), and are involved in the synthesis of vital metabolites, calcium homeostasis, and cell death mechanisms. Strikingly, normal mitochondria function as an integration center between multiple conditions that determine neural cell homeostasis, whereas lesions that lead to mitochondrial dysfunction can desynchronize cellular functions, thus contributing to the pathophysiology of traumatic brain injury (TBI). …”
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A Hypothesis Concerning a Potential Involvement of Ceramide in Apoptosis and Acantholysis Induced by Pemphigus Autoantibodies by Wendy B. Bollag

“…Our hypothesis is that: (1) the autoantibodies generate pathology through an alteration in ceramide metabolism in targeted keratinocytes, resulting in apoptosis and/or cell death and acantholysis, but only when the cell's ability to metabolize ceramide is exceeded, and (2) apoptosis in response to this altered ceramide metabolism is initiated and/or exacerbated by other agents that increase ceramide levels, such as cytokines, ultraviolet irradiation, and senescence.…”
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Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration by Giuseppina Di Giacomo, Salvatore Rizza, Costanza Montagna, Giuseppe Filomeni

“…In this paper we aim at summarizing the current knowledge of mitochondria-related proteins undergoing S-nitrosylation and how this redox modification might impact on mitochondrial functions, whose impairment has been correlated to tumorigenesis and neuronal cell death. In particular, emphasis will be given to the possible, but still neglected implication of denitrosylation reactions in the modulation of mitochondrial SNOs and how they can affect mitochondrion-related cellular process, such as oxidative phosphorylation, mitochondrial dynamics, and mitophagy.…”
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