Identifying key genes in cancer networks using persistent homology by Rodrigo Henrique Ramos, Yago Augusto Bardelotte, Cynthia de Oliveira Lage Ferreira, Adenilso Simao

“…We integrate mutation data from six cancer types and three biological functions: DNA Repair, Chromatin Organization, and Programmed Cell Death. We systematically evaluated the impact of gene removal on topological voids ( $$\beta _2$$ structures) within the Cancer Consensus Networks. …”
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GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth by Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Michael G Rosenblum, Brian Aguirre, Cheng-Hsiang Lu, Anubhav Chandla, Nidhi Kejriwal, Lucia Liu, Ann M Chan, SuYin Kok, Sergio Duarte, David Casero, Madhuri Wadehra

“…Background Granzyme B (GrB) is a key effector molecule, delivered by cytotoxic T lymphocytes and natural killer cells during immune surveillance to induce cell death. Fusion proteins and immunoconjugates represent an innovative therapeutic approach to specifically deliver a deadly payload to target cells. …”
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Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function by Carola Stockburger, Davide Miano, Thea Pallas, Kristina Friedland, Walter E. Müller

“…The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired neuroplasticity, and finally cell death as one major pathomechanism underlying the continuum from brain aging over mild cognitive impairment to initial and advanced late onset Alzheimer’s disease. …”
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Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis by Raffaella Chiaramonte, Giulia Sauro, Domenica Giannandrea, Patrizia Limonta, Lavinia Casati

“…Cancer cells maintain moderate levels of ROS to promote tumorigenesis, metastasis, and drug resistance; indeed, once the cytotoxicity threshold is exceeded, ROS trigger oxidative damage, ultimately leading to cell death. Based on this, mitochondrial metabolic functions and ROS generation are considered attractive targets of synthetic and natural anticancer compounds. …”
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The “Trojan Horse” Approach to Tumor Immunotherapy: Targeting the Tumor Microenvironment by Delia Nelson, Scott Fisher, Bruce Robinson

“…Numerous studies have demonstrated that intratumoural therapy has the capacity to minimizing local suppression, inducing sufficient “dangerous” tumor cell death to cross-prime strong immune responses, and rending tumor blood vessels amenable to immune cell traffic to induce effector cell changes in secondary lymphoid organs. …”
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The Effect and Related Mechanism of Action of Astragalus Compatible with Curcumin against Colon Cancer Metastasis in Mice by Jiafei Wu, Decai Tang

“…Traditional treatment focuses on eliminating tumor cells by triggering cell death or activating the immune system, which often results in side effects or chemoresistance recurrence. …”
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Advances in Illuminating Prostate Cancer with Emerging Phototherapies by Ali Usman

“…PDT employs photosensitizers to produce reactive oxygen species, thereby stimulating anti-tumor immune responses, disrupting the tumor microvasculature and/or inducing aopotitic or necrotic cell death. In contrast, PTT leverages photothermal agents to generate localized hyperthermia, achieving effective thermal ablation of tumor cells. …”
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Up-Regulation of Endothelin Receptors Induced by Cigarette Smoke — Involvement of MAPK in Vascular and Airway Hyper-Reactivity by Yaping Zhang, Lars Edvinsson, Cang-Bao Xu

“…The structural alteration by adverse remodeling involves changes in cell growth, cell death, cell migration, and production or degradation of the extracellular matrix. …”
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Pan-Cancer Analysis of the Cuproptosis-Related Gene DLD by Jiahui Lin, Guowei Wang, Sha Cheng, Yanan Hu, Huan Li, Wanjiang Feng, Xiaoming Liu, Canxia Xu

“…Cuproptosis is a recently discovered novel mode of cell death. The exact function of the cuproptosis-related gene dihydrolipoamide dehydrogenase (DLD) and its role in pan-cancer is unknown. …”
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Secretion of One Adipokine Nampt/Visfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells by Yi-Ching Lin, Hui-Chung Wu, Chen-Chung Liao, Yi-Chih Chou, Shwu-Fen Pan, Chi-Ming Chiu

“…We found that the transition of Nampt/visfatin from intracellular into extracellular form was induced by H2O2 treatment in 293T cells and confirmed that this phenomenon was not due to cell death but through the secretion of Nampt/visfatin. …”
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Immunotherapeutic Potential of Lactobacillus Species as Immune Checkpoint Inhibitors in Cancer Immunotherapy by Renukadevi J, Sam Helinto J, Prena D

“…This review explores the immunotherapeutic potential of Lactobacillus species via adjuvant therapy with immune checkpoint inhibitors (ICIs), such as programmed cell death protein-1, programmed death ligand-1, and cytotoxic T-lymphocyte antigen-4 inhibitors, which have revolutionized cancer treatment by enhancing T-cell-mediated antitumor immunity. …”
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Serum Cytokine Profile in a Patient Diagnosed with Dysferlinopathy by Svetlana F. Khaiboullina, Ekaterina V. Martynova, Sergey N. Bardakov, Mikhail O. Mavlikeev, Ivan A. Yakovlev, Arthur A. Isaev, Roman V. Deev, Albert A. Rizvanov

“…However, the immune system has been suggested to contribute to muscle cell death and tissue regeneration. Serum levels of 27 cytokines were evaluated in a dysferlinopathy patient. …”
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Mechanism Underlying Tissue Cryotherapy to Combat Obesity/Overweight: Triggering Thermogenesis by Suvaddhana Loap, Richard Lathe

“…The current view is that acute local cooling of AT induces adipocyte cell disruption and inflammation (“cryolipolysis”) that lead to adipocyte cell death, with loss of subcutaneous fat being recorded over a prolonged period of weeks/months. …”
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Gold Nanorod Bioconjugates for Active Tumor Targeting and Photothermal Therapy by Hadiyah N. Green, Dmitry V. Martyshkin, Cynthia M. Rodenburg, Eben L. Rosenthal, Sergey B. Mirov

“…We demonstrate that the binding efficiency of the antibodies conjugated to the PEGylated GNRs is comparable to the binding efficiency of the unmodified antibodies and 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao and Hafner (2005). In addition, cell death by NIRPTT was sufficient to kill nearly 90% of tumor cells, which is comparable to NIRPTT with GNRs alone confirming that NIRPTT using GNRs is not compromised by conjugation of GNRs to antibodies.…”
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Molecular Findings Before Vision Loss in the Streptozotocin-Induced Rat Model of Diabetic Retinopathy by Mădălina Moldovan, Roxana-Denisa Capraș, Raluca Paşcalău, Gabriela Adriana Filip

“…While redox imbalance, activation of microglia, secretion of pro-inflammatory cytokines, and neuronal cell death are also observed, the latter remains an emerging hypothesis requiring further exploration. …”
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A Novel Ferroptosis-Related Gene Signature for Prognosis Prediction in Ewing Sarcoma by Runhan Zhao, Zefang Li, Yanran Huang, Chuang Xiong, Chao Zhang, Hao Liang, Jingtao Xu, Xiaoji Luo

“…Ferroptosis, as a form of programmed cell death independent of apoptosis, has been demonstrated that plays a major role in tumorigenesis and cancer treatment. …”
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Exploring TNFR1: from discovery to targeted therapy development by Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou, Yiming Lu

“…As a critical cell-surface receptor, TNFR1 regulates key signaling pathways, such as nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK), which are associated with pro-inflammatory responses and cell death. The intricate regulatory mechanisms of TNFR1 signaling and its involvement in various diseases, including inflammatory disorders, infectious diseases, cancer, and metabolic syndromes, have attracted increasing scholarly attention. …”
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Inflammation and Inflammasomes: Pros and Cons in Tumorigenesis by Liliana R. Balahura, Aida Selaru, Sorina Dinescu, Marieta Costache

“…The function of this multiprotein complex is not only to reassure inflammation and to promote cell death, through caspase activity, but also has been identified to have significant contributions during tumorigenesis and cancer development. …”
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Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis via Nrf2/GPX4 Pathway by Jinke Huang, Jiaqi Zhang, Zhihong Liu, Jing Ma, Fengyun Wang, Xudong Tang

“…Ferroptosis, a form of programmed cell death, is considered a novel target for the treatment of ulcerative colitis (UC). …”
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Relationship between the ultrasound features of different molecular subtypes of breast cancer and positive PD-1/PD-L1 expression by Ruiqian Yan, Haixia Li, Junxi Gao

“…Objectives To analyze differences in programmed cell death protein 1/ligand 1 (PD-1/PD-L1) expression, as well as the relationships between ultrasound/contrast-enhanced ultrasound characteristics and PD-1/PD-L1 expression, among invasive breast cancer molecular subtypes. …”
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