Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer by Wei Li, Qingyong Ma, Erxi Wu

“…The antitumor effects of PDT include three main mechanisms: direct tumor cell death (necrosis, apoptosis, and autophagy), vascular destruction, and immune system activation. …”
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Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3 by Viktoria Korn, Kristyna Pluhackova

“…Abstract Gasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To unveil the process of their pore formation, we examine the energy landscapes upon insertion of the gasdermin D and A3 monomers into a lipid bilayer by extensive atomistic molecular dynamics simulations. …”
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Temozolomide-Induced Myelodysplasia by Ethan A. Natelson, David Pyatt

“…TMZ is an orally active imidazotetrazine which methylates guanine residues in DNA, ultimately causing single and double-strand DNA breaks leading to apoptotic cell death. TMZ does not chemically cross-link DNA and is considered a nonclassical alkylating agent, similar in structure and activity to dacarbazine. …”
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Emerging roles of checkpoint molecules on B cells by Hiromitsu Asashima, Satoshi Akao, Isao Matsumoto

“…During the last decades, immunotherapies targeting these molecules (such as programmed cell death 1 (PD-1), and lymphocyte activation gene 3 (LAG-3)) have provided clinical benefits in many cancers. …”
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An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival by Alexis B. Cook, Daniel R. Ziazadeh, Jianfeng Lu, Trachette L. Jackson

“…Apoptosis resistance is a hallmark of human cancer, and tumor cells often become resistant due to defects in the programmed cell death machinery.Targeting key apoptosis regulators to overcome apoptotic resistance and promote rapid death of tumor cells is an exciting new strategy for cancer treatment, either alone or in combination with traditionally used anti-cancer drugs that target cell division. …”
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Heat Shock Protein 70 Neutralizes Apoptosis-Inducing Factor by Guido Kroemer

“…Programmed cell death (apoptosis) is the physiological process responsible for the demise of superfluous, aged, damaged, mutated, and ectopic cells. …”
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The Function of T Follicular Helper Cells in the Autoimmune Liver Diseases by Lin Li, Panyang Xu, Qi Zhou, Jiancheng Xu

“…TFH cells participate in the immune response associated with AILDs by expressing surface receptors such as programmed cell death protein-1, C-X-C motif chemokine receptor 5, and inducible T cell costimulators, as well as cytokines such as interleukin-21. …”
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Targeting the initiator to activate both ferroptosis and cuproptosis for breast cancer treatment: progress and possibility for clinical application by Murshid Imam, Jiale Ji, Zhijie Zhang, Shunchao Yan

“…The accumulation of iron and copper ions triggers distinct cell death pathways, known as ferroptosis and cuproptosis, respectively. …”
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Protocol to detect neutral lipids with BODIPY staining in myeloid-derived suppressor cells in mouse mammary tumors by Ukjin Kim, Rumela Chakrabarti

“…Furthermore, we introduce alternative protocols with MDSC sorting to overcome risk of cell death by BODIPY.For complete details on the use and execution of this protocol, please refer to Kim et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases by Fivos Borbolis, Christina Ploumi, Konstantinos Palikaras

“…While controlled mitochondrial calcium uptake supports ATP synthesis and metabolic regulation, excessive accumulation can trigger oxidative stress, mitochondrial membrane permeabilization, and cell death. Emerging findings underscore the intricate interplay between calcium homeostasis and mitophagy, a selective type of autophagy for mitochondria elimination. …”
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Research progress of endoplasmic reticulum stress in peritoneal dialysis by Li Yan-ling, Zou Xun-liang

“…This article summarized the research progress of ER stress in peritoneal dialysis at home and abroad in recent years， mainly from the aspects of cell death， inflammatory signal transduction and epithelial-mesenchymal transition induced by ER stress through three classic signaling pathways， aiming to provide new ideas and directions for the prevention and treatment of peritoneal dialysis-related peritonitis and peritoneal fibrosis.…”
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Modeling the interaction of cytotoxic T lymphocytes and influenzavirus infected epithelial cells by Abdessamad Tridane, Yang Kuang

“…Since detailed and definite mechanisms thattrigger CTL production and cell death are still debatable, we utilize two plausiblemathematical models for the CTLs response to influenza infection (i) logisticgrowth and (ii) threshold growth. …”
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A Mathematical Model of Receptor-Mediated Apoptosis: Dying to Know Why FasL is a Trimer by Ronald Lai, Trachette L. Jackson

“…The scientific importance of understanding programmed cell death isundeniable; however, the complexity of death signal propagation andthe formerly incomplete knowledge of apoptotic pathways has left thistopic virtually untouched by mathematical modeling. …”
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Pseudomonas syringae lytic transglycosylase HrpH interacts with host ubiquitin ligase ATL2 to modulate plant immunity by Jun-Zhou Li, Yi-Lin Gu, Wei Zhang, Shen Cong, Ruo-Na Wang, Yi-Nan Ma, Ya Jin, Hai-Lei Wei

“…HrpH and its SLT domain induce host cell death and suppress pattern-triggered immunity (PTI). …”
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Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles by Kowichi Jimbow, Yasue Ishii-Osai, Shosuke Ito, Yasuaki Tamura, Akira Ito, Akihiro Yoneta, Takafumi Kamiya, Toshiharu Yamashita, Hiroyuki Honda, Kazumasa Wakamatsu, Katsutoshi Murase, Satoshi Nohara, Eiichi Nakayama, Takeo Hasegawa, Itsuo Yamamoto, Takeshi Kobayashi

“…NPrCAP was exploited from melanogenesis substrates, which are expected to be selectively incorporated into melanoma cells and produce highly reactive free radicals through reacting with tyrosinase, resulting in chemotherapeutic and immunotherapeutic effects by oxidative stress and apoptotic cell death. Magnetite nanoparticles were conjugated with NPrCAP to introduce thermotherapeutic and immunotherapeutic effects through nonapoptotic cell death and generation of heat shock protein (HSP) upon exposure to alternating magnetic field (AMF). …”
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Construction of a novel cuproptosis-related gene signature and integrative analyses in cholangiocarcinoma by Liye Wang, Pan Li, Shuai Gong, Lina Pang, Mingyu Li, Chi Zhang, Shengli Zhang, Xiaoke Zhang, Guozhong Jiang, Wei He

“…Background: Cuproptosis is a unique form of cell death that is dependent on copper, which is fundamentally different from other recognized forms of cell death. …”
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Identifying disulfidptosis-related biomarkers in epilepsy based on integrated bioinformatics and experimental analyses by Sijun Li, Lanfeng Sun, Hongmi Huang, Xing Wei, Yuling Lu, Kai Qian, Yuan Wu

“…One of the underlying mechanisms of epilepsy (EP), a brain disease characterized by recurrent seizures, is considered to be cell death. Disulfidptosis, a proposed novel cell death mechanism, is thought to play a part in the pathogenesis of epilepsy, but the exact role is unclear. …”
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Tennis Rehabilitation Training-Assisted Paclitaxel Nanoparticles in Treatment of Lung Tumor by Di Hu, YiMin Yang

“…Its mechanism of action is to prevent tumor rupture by stabilizing tumor proteins, while preventing cell division, leading to cell death, thereby inhibiting the spread of lung tumors. …”
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Circulating Tumor Cells Measurements in Hepatocellular Carcinoma by Franck Chiappini

“…CTC are an interesting source of biological information in order to understand dissemination, drug resistance, and treatment-induced cell death. Our aim is to review and analyze the different new methods existing to detect, enumerate, and characterize the CTC in the peripheral circulation of patients with HCC.…”
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The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective by Xuchen Xu, Jianing Zhang, Xin Yang, Yuanyuan Zhang, Zhimin Chen

“…In this short review, we summarize studies of relationships between PM and pediatric asthma and recent advances on the fundamental mechanisms of PM-related asthma, with emphases on cell death regulation and immune system responses. We further discuss the inadequacy of current studies and give a perspective on the prevention strategies for pediatric asthma.…”
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