Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity. by Haleema Sadia Malik, James B Bliska

“…Here, we review the origins of ETI and focus on 5 mechanisms, in which the key steps of a pathway can include activation of a caspase by a RIPoptosome or inflammasome, formation of pores in the plasma membrane, release of cytokines and ending in cell death by pyroptosis. Survey of the 5 mechanisms, which have been shown to be host protective in mouse models of bacterial infection, reveal how distinct regulators of RIPoptosome or inflammasome pathways can act as guards or integrated decoys to trigger ETI. …”
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Multi-assay assessment of cytotoxicity reveals multiple mechanisms of action in 3D microtissues by Ahbid Zein-Sabatto, Katerina St. Angelo, Samantha J. Madnick, Diane Hoffman-Kim, Jeffrey R. Morgan, Jonghwan Lee

“…Abstract Cell viability assays are an integral component of toxicology and high-throughput drug screening studies; however, many assays rely on a single biomarker of cell death which provides an incomplete assessment of cell viability. …”
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The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment by Yi-Cheng Chang, Siow-Wey Hee, Meng-Lun Hsieh, Yung-Ming Jeng, Lee-Ming Chuang

“…Specifically, excessive nutrients trigger endoplasmic reticulum stress and increase the production of mitochondrial reactive oxygen species, leading to activation of stress signaling pathway, inflammatory response, lipogenesis, and pancreatic beta-cell death. Autophagy is required for clearance of hepatic lipid clearance, alleviation of pancreatic beta-cell stress, and white adipocyte differentiation. …”
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CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma by Lingling Xing, Zhenyu Jiang, Ruize Xu, Tong Dang, Jinbao Wu, Jianyuan Chai, Xianmei Meng

“…Unlike TRAIL, which primarily triggers cell death, APRIL and BAFF promote cell growth via NFκB signaling. …”
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Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells by K. Gouthamchandra, H.V. Sudeep, B.J. Venkatesh, K. Shyam Prasad

“…From our results we found CGA7 treatment induces cell death in a dose and time dependent manner in different cancer cell lines. …”
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Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy by Izabela Zdolińska-Malinowska, Dariusz Boruczkowski, Dominika Hołowaty, Paweł Krajewski, Emilian Snarski

“…In several animal models of HIE, CB decreased oxidative stress, cell death markers, CD4+ T cell infiltration, and microglial activation; restored normal brain metabolic activity; promoted neurogenesis; improved myelination; and increased the proportion of mature oligodendrocytes, neuron numbers in the motor cortex and somatosensory cortex, and brain weight. …”
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Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation by Annette Plesner, C. Bruce Verchere

“…Once the islets are engrafted, both prompt revascularization and protection from beta-cell death and graft rejection are key to secure long-term survival and function. …”
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Peripheral membrane protein endophilin B1 probes, perturbs and permeabilizes lipid bilayers by Arni Thorlacius, Maksim Rulev, Oscar Sundberg, Anna Sundborger-Lunna

“…We also show that endophilin B1 efficiently permeabilizes negatively charged liposomes that contain mitochondria-specific lipid cardiolipin and propose a new model for Bax-mediated cell death.…”
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Condensin-mediated restriction of retrotransposable elements facilitates brain development in Drosophila melanogaster by Bert I. Crawford, Mary Jo Talley, Joshua Russman, James Riddle, Sabrina Torres, Troy Williams, Michelle S. Longworth

“…Here, we show that condensin subunit knockdown in NSPCs of the Drosophila larval central brain increases RTE expression and mobility which causes cell death, and significantly decreases adult head sizes and brain volumes. …”
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Antimicrobial activity and mechanisms of action of Origanum vulgare L. essential oil: effects on membrane-associated properties by Armenuhi Moghrovyan, Naira Sahakyan

“…The components of this EO disrupt membrane integrity, ion transport, membrane surface charge, biofilm formation, and other biophysical parameters, eventually leading to cell death. Research highlights its potential in combatting antibiotic resistance, either alone or in synergy with traditional antibiotics. …”
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S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor α Stability and Function by Ying Xiong, Yefim Manevich, Kenneth D. Tew, Danyelle M. Townsend

“…Thus, redox regulation of PDI causes its S-glutathionylation, thereby mediating cell death through activation of the UPR and abrogation of ERα stability and signaling.…”
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Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…These impairments may result from mechanisms including insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, and functional and structural damage to reward networks. …”
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Microalgae: A Treasure Trove of Anticancer Nutraceuticals and Promising Therapeutic Mechanisms by Sajjad Masoumi, Maryam Zokaei, Ardavan Ahmadvand, Nogol Ghalamkarpour, Naghmeh Asadimanesh, Armin Azarimatin, Khashayar Fattah, Zahra Payandeh, Masoumeh Rostami, Afsaneh Farjami, Rajan Kumar Pandey, Mohsen Nabi-Afjadi

“…Carotenoids, including astaxanthin, have shown the ability to hinder the development of tumors and trigger programmed cell death (apoptosis) in several types of cancer cells. …”
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Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity by Peng Wang, Xin Li, Xuran Li, Weiwei Yang, Shun Yu

“…Compared with NS plasma, PD plasma added to primary neuron cultures caused more cell death in the presence of extracellular α-syn. This was supported by the observations that phosphorylated α-syn oligomers entered neurons, rapidly increased accumulated thioflavin S-positive inclusions, and induced a series of metabolic changes that included activation of polo-like kinase 2, inhibition of glucocerebrosidase and protein phosphatase 2A, and reduction of ceramide levels, all of which have been shown to promote α-syn phosphorylation and aggregation. …”
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Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy by Rangarirai Makuku, Neda Khalili, Sepideh Razi, Mahsa Keshavarz-Fathi, Nima Rezaei

“…Immune checkpoint blockade through targeting programmed cell death protein-1 (PD-1) has demonstrated promising antitumor effects in cancer immunotherapy of many different solid and hematologic malignancies. …”
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The Acetone Extract of Sclerocarya birrea (Anacardiaceae) Possesses Antiproliferative and Apoptotic Potential against Human Breast Cancer Cell Lines (MCF-7) by Nicoline Fri Tanih, Roland Ndip Ndip

“…The extract also exerted apoptotic programmed cell death in MCF-7 cells with significant effect on the DNA. …”
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Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells by Ramazan Üzen, Hamiyet Altuntaş, Mustafa Çakır, Pınar Altın Çelik, Muazzez Derya Andeden

“…Although recent results support the mechanism that honey induces cell death, the full mechanisms are still unknown. This study investigates the potential use of Pervari honey (PH) as an in vitro therapeutic agent in breast cancer. …”
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Severe Inflammation Caused by Coinfection of PCV2 and Glaesserella parasuis Is Associated with Pyroptosis via Noncanonical Inflammasome Pathway by Jiahui An, Chao Zhang, Jinshuang Cai, Yufeng Li

“…Coinfection with PCV2 and G. parasuis can enhance RAW264.7 cell phagocytosis and elimination to G. parasuis. Cell death rate of cells increased in coinfection was measured with Flow cytometry. …”
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Bacteria as Precision Tools for Cancer Therapy by Carmen Michán, José Prados, Juan‐Luis Ramos

“…ABSTRACT The discovery at the end of the 20th century of genes that induce cell death revolutionised the biocontaintment of genetically manipulated bacteria for environmental or agricultural applications. …”
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Mitochondrial transplantation: a promising strategy for the treatment of retinal degenerative diseases by Jing Chi, Bin Fan, Yulin Li, Qing Jiao, Guang-Yu Li

“…These abnormalities lead to an inadequate energy supply, the exacerbation of oxidative damage, and the activation of cell death pathways, ultimately resulting in neuronal injury and dysfunction in the retina. …”
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