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361
Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models
Published 2025-01-01“…GI elicits a more controlled immune response and extended cell death. At the peak of cell death, AI glands harbored more immunosuppressive myeloid-derived suppressor cells (MDSCs) and CD206 + M2-like macrophages, known to promote oncogenic events, compared to GI glands. …”
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362
A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line
Published 2025-01-01“…Results: The data indicated that curcumin-induced cell death is independent of apoptosis in this type of thyroid cancer cell line. …”
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363
A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy
Published 2022-01-01“…Immune checkpoint blockade therapy targeting the programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L 1) receptors have shown efficacy in early phase I clinical trials, with ongoing phase III clinical trials. …”
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364
Role of ferroptosis in atrial fibrillation: a review
Published 2025-02-01“…Ferroptosis, a recently discovered form of regulated cell death characterized by lipid peroxidation and disrupted cellular redox balance leading to cell death due to iron overload, has attracted significant attention. …”
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365
Aqueous Extract of Leaves and Flowers of Acmella caulirhiza Reduces the Proliferation of Cancer Cells by Underexpressing Some Genes and Activating Caspase-3
Published 2024-01-01“…The increasing prevalence of cancers and the multiple side effects of cancer treatments have led researchers to constantly search for plants containing bioactive compounds with cell death properties. This work aimed at evaluating the antiproliferative effect of an Acmella caulirhiza extract. …”
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366
Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia
Published 2025-01-01“…VPA treatment upregulated the expression of Bax and Bak, further supporting apoptosis induction. The cell death induced by the venetoclax–VPA combination was predominantly apoptotic, as confirmed by the near-complete blockade of cell death by a pan-caspase inhibitor. …”
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367
NETosis Secondary to the Use of Levamisole-Adulterated Cocaine: A Likely Underlying Mechanism of Vasculopathy
Published 2024-01-01“…Cocaine, levamisole, and a cocaine-levamisole mixture induced neutrophil cell death. DNA/MPO extrusion and cell morphology patterns were consistent with NETosis. …”
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368
Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects
Published 2021-01-01“…We focused on the role of primed MSCs (human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) exposed to an AD cell line via a coculture system) in reducing the levels of Aβ and inhibiting cell death. We demonstrated that mouse groups treated with naïve MSCs and primed MSCs showed significant reductions in cell death, ubiquitin conjugate levels, and Aβ levels, but the effects were greater in primed MSCs. …”
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369
Effect of eicosapentaenoic acid on innate immune responses in Atlantic salmon cells infected with infectious salmon anemia virus
Published 2025-01-01“…Cell death via ferroptosis may therefore be a mechanism for controlled cell death and thus reduction of virus replication when there are enough polyunsaturated fatty acids (PUFAs) in the membrane.…”
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370
Hair Cell Protection from Ototoxic Drugs
Published 2021-01-01“…HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. …”
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371
Detection of Myocardial Ischemia-Reperfusion Injury Using a Fluorescent Near-Infrared Zinc(II)-Dipicolylamine Probe and Tc Glucarate
Published 2012-05-01“…In this study, we investigated the cell death targeting properties of probe 1 in myocardial ischemia-reperfusion injury. …”
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372
Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival
Published 2015-01-01“…Pyroptosis is the most recently identified type of regulated cell death with inflammatory response and has characteristics distinct from those of apoptosis or necrosis. …”
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373
Torsion-Induced Traumatic Optic Neuropathy (TITON): A physiologically relevant animal model of traumatic optic neuropathy.
Published 2025-01-01“…TON is characterized by axon damage in the optic nerve followed by retinal ganglion cell death in the days and weeks following injury. At present, no therapeutic or surgical approach has been found to offer any benefit beyond observation alone. …”
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374
Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation
Published 2024-09-01“…Ferroptosis is a novel form of cell death driven by iron-dependent lipid peroxidation and it is implicated in various diseases, such as liver disease, acute kidney injury, cardiovascular disease, neurodegenerative disease and cancer. …”
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375
Renal Tubular Cells from Hibernating Squirrels are Protected against Cisplatin Induced Apoptosis
Published 2020-01-01“…To determine whether XIAP and Akt1 are necessary for RTEC protection against cisplatin induced apoptotic cell death, gene expression of Akt1 or XIAP was silenced in squirrel RTECs. …”
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376
In Vitro Effect of Aqueous Extract and Fraction IV Portion of Ximenia americana Stem Bark on Trypanosoma congolense DNA
Published 2014-01-01“…Subsequent isolation of the parasite DNA and agarose gel electrophoresis did not reveal that cell death was as a result of DNA fragmentation. This suggests that cell death was by another mechanism of action.…”
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377
Interleukin-1 Modulation of Human Placental Trophoblast Proliferation
Published 2006-01-01“…Analyzing the mode of action, IL-1<mml:math alttext="$eta$"> <mml:mi>β</mml:mi> </mml:math> was found to induce cell cycle arrest in the G0/G1 phase and triggered apoptotic cell death. These findings demonstrated that IL-1 regulates human trophoblast growth by induction of cell cycle delay and cell death.…”
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378
Chorein deficiency promotes ferroptosis
Published 2025-01-01“…Ferroptosis is a type of programmed cell death owed to an intracellular accumulation of iron resulting in the generation reactive oxygen species, which in turn can cause peroxidation of plasma membrane lipids and ultimately result in cell death. …”
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379
Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis
Published 2025-03-01“…Pyroptosis is the programmed cell death of inflammation and an effective way to eliminate tumors. …”
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380
Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury
Published 2025-02-01“…RNA-seq analysis showed upregulation of cell death, inflammatory, and profibrotic pathways in DDC-injured DKO liver as compared to DDC-injured WT liver. …”
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