Anesthetic-Induced Oxidative Stress and Potential Protection by Cheng Wang, Xuan Zhang, Fang Liu, Merle G. Paule, William Slikker, Jr.

“…Stimulation of immature neurons by NMDA antagonists or GABA agonists is thought to increase overall nervous system excitability and may contribute to abnormal neuronal cell death during development. Although the precise mechanisms by which NMDA antagonists or GABA agonists cause neuronal cell death are still not completely understood, up-regulation of the NMDA receptor subunit NR1 may be an initiative factor in neuronal cell death. …”
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Targeting ferroptosis: opportunities and challenges of mesenchymal stem cell therapy for type 1 diabetes mellitus by Le Dai, Qing Wang

“…Abstract Type 1 diabetes mellitus (T1DM) is characterized by progressive β-cell death, leading to β-cell loss and insufficient insulin secretion. …”
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Panoptosis – new frontier in research in head neck cancer by Shrikant B. Mali

“…PANoptosis, a non-apoptotic cell death mechanism, has been identified as a potential solution. …”
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Inhibition of Growth and Induction of Apoptosis in Fibrosarcoma Cell Lines by Echinophora platyloba DC: In Vitro Analysis by Fatemeh Zare Shahneh, Samira Valiyari, Abbas Azadmehr, Reza Hajiaghaee, Saeid Yaripour, Ali Bandehagh, Behzad Baradaran

“…The cell death was identified as apoptosis using terminal deoxynucleotidyl transferase- (TdT-) mediated dUTP nick end labeling (TUNEL) assay. …”
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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…Results Our targeted variants and cells with intrinsic BRCA1/2 mutations responded to low dose combination therapeutic treatment by G2M stalling, compounded DNA damage, severely attenuated colony formation, and importantly, increased cell death. In contrast, the parental MDA-MB-231 cells and other HRR proficient cell lines produced smaller cell populations with short term treatment, but with much less cumulative DNA damage, and minimal cell death. …”
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Mitochondria of transformed cell as a target of antitumor influence by E. M. Frantsiyants, I. V. Neskubina, E. A. Sheiko

“…Mitochondria play a crucial role in cellular energy metabolism and the regulation of programmed cell death. mitochondria activate numerous signaling pathways associated with cell death. …”
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Basic fibroblast growth factor helps protect facial nerve cells in a freeze-induced paralysis model. by Shinji Iwata, Hiroyuki Yamada, Masato Teraoka, Takemichi Tanaka, Takuya Kimura, Tomonori Joko, Yasuhiko Tabata, Hiroyuki Wakisaka, Naohito Hato

“…The freezing-induced facial paralysis model showed a facial neuronal cell death rate of 29.0%; however, bFGF administration reduced neuronal cell death to 15.8%. …”
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Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer Diseases by Paweł Rusin, Karolina Jabłońska

“…This mechanism of programmed cell death is designed to protect the body against uncontrolled proliferation of cells with impaired functions. …”
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Ferroptosis plays a role in osteoarthritis by Ruba Altahla, Jamal Alshorman, Xu Tao

“…In recent years, ferroptosis has been identified as a novel type of regulated cell death. As a cell death process, it differs from other processes like necrosis and apoptosis in the expression of morphology, biochemistry, and genetics. …”
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An annotated high-content fluorescence microscopy dataset with EGFP-Galectin-3-stained cells and manually labelled outlineszenodo by Salma Kazemi Rashed, Malou Arvidsson, Rafsan Ahmed, Sonja Aits

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The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts by Ajith Vengellur, Elizabeth Grier, John J. LaPres

“…Cadmium treatment did not affect HIF1-mediated transcription but led to caspase activation and apoptotic cell death in wild-type and HIF1α −/− cells. Cadmium-induced cell death, however, was significantly higher in HIF1α −/− cells as compared to their wild-type counterparts. …”
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Mechanisms of Rhodopsin-Related Inherited Retinal Degeneration and Pharmacological Treatment Strategies by Maria Azam, Beata Jastrzebska

“…The progression of this disease involves complex cellular responses to restore cellular homeostasis, including the unfolded protein response (UPR) signaling, autophagy, and various cell death pathways. These mechanisms, however, often fail to prevent photoreceptor cell degradation and instead contribute to cell death under certain conditions. …”
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Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance by Peng Zhao, Shuangshuang Yin, Yuling Qiu, Changgang Sun, Haiyang Yu

“…Therefore, ferroptosis and pyroptosis have crosstalk via autophagy, potentially leading to a switch in cell death types under certain conditions. As two forms of inflammatory programmed cell death, ferroptosis and pyroptosis have different effects on inflammation, and the cGAS-STING signaling pathway is also involved. …”
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Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy by Tom Verfaillie, Maria Salazar, Guillermo Velasco, Patrizia Agostinis

“…However, when persistent, ER stress can switch the cytoprotective functions of UPR and autophagy into cell death promoting mechanisms. Recently, a variety of anticancer therapies have been linked to the induction of ER stress in cancer cells, suggesting that strategies devised to stimulate its prodeath function or block its prosurvival function, could be envisaged to improve their tumoricidial action. …”
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Increased Death of Peripheral Blood Mononuclear Cells after TLR4 Inhibition in Sepsis Is Not via TNF/TNF Receptor-Mediated Apoptotic Pathway by Chien-Ming Chu, Li-Chung Chiu, Chung-Chieh Yu, Li-Pang Chuang, Kuo-Chin Kao, Li-Fu Li, Huang-Pin Wu

“…The cell death of CD4 lymphocytes was unchanged. Conclusion. …”
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3-Epi-betulinic acid 3-O-β-D-glucopyranoside (eBAG) induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma by Mengjie Liu, Xuqiang Liu, Kaiyue He, Yongping Jian, Yujia Li, Jinrong Guo, Jingyu Yang, Zhixiang Xu, Wenyi Kang

“…EBAG induced non-apoptotic cell death in hepatocellular carcinoma cells. The eBAG-induced cell death was inhibited by knock-down of autophagy related gene (ATG) 5 and ATG7, by administration of 3-methyladenine, a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase (PI3K), and by chloroquine, a classic autophagy f lux inhibitor. …”
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Dasatinib enhances curcumin-induced cytotoxicity, apoptosis and protective autophagy in human schwannoma cells HEI-193: The role of Akt/mTOR/p70S6K signalling pathway by Pang Pengfei, Zhang Shirong

“…Cellular toxicity, cell proliferation, and cell death were determined by LDH, MTT, and trypan blue dye assays, respectively. …”
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Downregulated Copper Homeostasis-Related Gene FOXO1 as a Novel Indicator for the Prognosis and Immune Response of Breast Cancer by Rong Zeng, Bi Peng, Emin Peng

“…Moreover, FOXO1 expression was positively associated with multiple immune checkpoints, such as sialic acid-binding immunoglobulin-like lectin 15 (SIGLEC15), indoleamine 2,3-dioxygenase 1 (IDO1), programmed cell death 1 ligand 1 (PD-L1/CD274), hepatitis A virus cellular receptor 2 (HAVCR2), programmed cell death 1 (PDCD1), cytotoxic T lymphocyte antigen 4 (CTLA4), and programmed cell death 1 ligand 2 (PDCD1LG2). …”
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Evasion of Apoptosis as a Cellular Stress Response in Cancer by Simone Fulda

“…Apoptosis resistance may contribute to carcinogenesis, tumor progression, and also treatment resistance, since most current anticancer therapies including chemotherapy as well as radio- and immunotherapies primarily act by activating cell death pathways including apoptosis in cancer cells. …”
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Roles of Retinoids and Retinoic Acid Receptors in the Regulation of Hematopoietic Stem Cell Self-Renewal and Differentiation by Louise E. Purton

“…While many key factors involved in regulating HSC/progenitor cell differentiation and cell death are known, the critical regulators of HSC self-renewal are largely unknown. …”
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