Aqueous Extract of Leaves and Flowers of Acmella caulirhiza Reduces the Proliferation of Cancer Cells by Underexpressing Some Genes and Activating Caspase-3 by Huiny Miriane Tienoue Fotso, Mary-Ann Mbong Angie, Françoise Raïssa Ntentie, Inelle Makamwe, Ferdinand Lanvin Edoun Ebouel, Emmerencia Kenjing Ndansack, Enyong Julius Oben

“…The increasing prevalence of cancers and the multiple side effects of cancer treatments have led researchers to constantly search for plants containing bioactive compounds with cell death properties. This work aimed at evaluating the antiproliferative effect of an Acmella caulirhiza extract. …”
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Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia by Renshi Kawakatsu, Kenjiro Tadagaki, Kenta Yamasaki, Yasumichi Kuwahara, Tatsushi Yoshida

“…VPA treatment upregulated the expression of Bax and Bak, further supporting apoptosis induction. The cell death induced by the venetoclax–VPA combination was predominantly apoptotic, as confirmed by the near-complete blockade of cell death by a pan-caspase inhibitor. …”
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NETosis Secondary to the Use of Levamisole-Adulterated Cocaine: A Likely Underlying Mechanism of Vasculopathy by Manuela Osorio, Isabel Velásquez, Ruben Vargas, Adriana Vanegas-García, Mauricio Rojas, Gloria Vásquez, Carlos Muñoz-Vahos

“…Cocaine, levamisole, and a cocaine-levamisole mixture induced neutrophil cell death. DNA/MPO extrusion and cell morphology patterns were consistent with NETosis. …”
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Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects by Sang Eon Park, Hyeong Seop Kim, Soo Jin Kwon, Min-Jeong Kim, Suk-joo Choi, Soo-young Oh, Gyu Ha Ryu, Hong Bae Jeon, Duk L. Na, Jong Wook Chang

“…We focused on the role of primed MSCs (human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) exposed to an AD cell line via a coculture system) in reducing the levels of Aβ and inhibiting cell death. We demonstrated that mouse groups treated with naïve MSCs and primed MSCs showed significant reductions in cell death, ubiquitin conjugate levels, and Aβ levels, but the effects were greater in primed MSCs. …”
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Hair Cell Protection from Ototoxic Drugs by Peng Wu, Xianmin Wu, Chunhong Zhang, Xiaoyun Chen, Yideng Huang, He Li

“…HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. …”
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Looking for Pyroptosis-Modulating miRNAs as a Therapeutic Target for Improving Myocardium Survival by Seahyoung Lee, Eunhyun Choi, Min-Ji Cha, Ki-Chul Hwang

“…Pyroptosis is the most recently identified type of regulated cell death with inflammatory response and has characteristics distinct from those of apoptosis or necrosis. …”
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Torsion-Induced Traumatic Optic Neuropathy (TITON): A physiologically relevant animal model of traumatic optic neuropathy. by Annie K Ryan, Brooke I Asemota, Tyler Heisler-Taylor, Claire Mello, Luis Rodriguez, William E Sponsel, Julie Racine, Tonia S Rex, Randolph D Glickman, Matthew A Reilly

“…TON is characterized by axon damage in the optic nerve followed by retinal ganglion cell death in the days and weeks following injury. At present, no therapeutic or surgical approach has been found to offer any benefit beyond observation alone. …”
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Renal Tubular Cells from Hibernating Squirrels are Protected against Cisplatin Induced Apoptosis by Swati Jain, Alkesh Jani

“…To determine whether XIAP and Akt1 are necessary for RTEC protection against cisplatin induced apoptotic cell death, gene expression of Akt1 or XIAP was silenced in squirrel RTECs. …”
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In Vitro Effect of Aqueous Extract and Fraction IV Portion of Ximenia americana Stem Bark on Trypanosoma congolense DNA by Victor Ambrose Maikai, Beatty Viv Maikai, Patricia Ishyaku Kobo

“…Subsequent isolation of the parasite DNA and agarose gel electrophoresis did not reveal that cell death was as a result of DNA fragmentation. This suggests that cell death was by another mechanism of action.…”
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Interleukin-1 Modulation of Human Placental Trophoblast Proliferation

“…Analyzing the mode of action, IL-1<mml:math alttext="$eta$"> <mml:mi>&#x03B2;</mml:mi> </mml:math> was found to induce cell cycle arrest in the G0/G1 phase and triggered apoptotic cell death. These findings demonstrated that IL-1 regulates human trophoblast growth by induction of cell cycle delay and cell death.…”
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Single component organic photosensitizer for tumor Photodynamic/Photothermal immunotherapy via apoptosis and pyroptosis by Miao-Yan Xu, Jie Zeng, Xin-Hao Han, Duo-Duo Wei, Bing Fan, Xin‑Hui Qu, Shaorong Huang, Xiao-Jian Han

“…Pyroptosis is the programmed cell death of inflammation and an effective way to eliminate tumors. …”
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Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury by Jessica M. Herrera, Yun Weng, Tyler J. Lieberthal, Marcus Paoletti, Tammy T. Chang

“…RNA-seq analysis showed upregulation of cell death, inflammatory, and profibrotic pathways in DDC-injured DKO liver as compared to DDC-injured WT liver. …”
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Disturbance of Inorganic Phosphate Metabolism in Diabetes Mellitus: Its Relevance to the Pathogenesis of Diabetic Retinopathy by H. Vorum, J. Ditzel

“…Any interruption of optimal ATP production might lead to cell injury and possible cell death, and evidence will be provided herein that such cell death does occur in diabetic retinopathy. …”
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Effects of Cisplatin in Neuroblastoma Rat Cells: Damage to Cellular Organelles by Giada Santin, Luigi Scietti, Paola Veneroni, Sergio Barni, Graziella Bernocchi, Maria Grazia Bottone

“…The results obtained show that the cellular organelles are the target of cisPt, so their damage can induce cell death.…”
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In vitro cytotoxicity (irritant potency) of toothpaste ingredients. by Shaira R Kasi, Sanne Roffel, Mutlu Özcan, Susan Gibbs, Albert J Feilzer

“…The compound concentration resulting in 50% cell death (EC50) and 10% cell death (EC10) was determined by the MTT assay. …”
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Yeast as a Tool to Study Signaling Pathways in Mitochondrial Stress Response and Cytoprotection by Maša Ždralević, Nicoletta Guaragnella, Lucia Antonacci, Ersilia Marra, Sergio Giannattasio

“…The crucial role of mitochondria in cell death is well recognized. Mitochondrial dysfunction has been associated with the death process and the onset of numerous diseases. …”
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Clinical and molecular response to alpha1‐oleate treatment in patients with bladder cancer by Farhan Haq, Samudra Sabari, Jaromir Háček, Antonín Brisuda, Ines Ambite, Michele Cavalera, Parisa Esmaeili, Murphy Lam Yim Wan, Shahram Ahmadi, Marek Babjuk, Catharina Svanborg

“…Uptake of alpha1‐oleate by the tumor triggered rapid shedding of tumor cells into the urine and cell death by an apoptosis‐like mechanism. RNA sequencing of tissue biopsies confirmed the activation of apoptotic cell death and strong inhibition of cancer gene networks, including bladder cancer related genes. …”
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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…This resulted in apoptosis, pyroptosis, and immunogenic cell death in tumor cells by Clo. Furthermore, Clo-induced GSDME-mediated pyroptosis partly assists in activating T cell immunity via CCL5 and CXCL10. …”
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Multiorganelle Localization of Metallated Phthalocyanine Photosensitizer in Colorectal Cancer Cells (DLD-1 and CaCo-2) Enhances Efficacy of Photodynamic Therapy by Palesa Rose Sekhejane, Nicolette Nadene Houreld, Heidi Abrahamse

“…In conclusion, ZnPcSmix showed the ability of inducing apoptotic cell death features in PDT treated cells.…”
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Human cytomegalovirus RNA2.7 inhibits ferroptosis by upregulating ferritin and GSH via promoting ZNF395 degradation. by Mingyi Xu, Shan Ruan, Jingxuan Sun, Jianming Li, Dan Chen, Yanping Ma, Ying Qi, Zhongyang Liu, Qiang Ruan, Yujing Huang

“…The effect of RNA2.7 on other forms of cell death is still unclear. In this work, we found that RNA2.7 deletion significantly decreased the viability of HCMV-infected cells, while treatment with ferroptosis inhibitor Fer-1 rescued the infection-induced cell death, demonstrating an anti-ferroptosis role of RNA2.7. …”
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