Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…Abstract Osteoarthritis (OA) is a joint disease characterized by articular cartilage degradation. Persistent low-grade inflammation defines OA pathogenesis, with crucial involvement of pro-inflammatory M1-like macrophages. …”
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The role of VNTR aggrecan gene polymorphism in the development of osteoarthritis in women by D. A. Shapovalova, A. V. Tyurin, S. S. Litvinov, E. K. Khusnutdinova, R. I. Khusainova

“…Aggrecan is one of the major structural components of cartilage and it provides the ability to resist compressive loads throughout life. …”
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Effects of gestational and lactational exposure to ethanol on body and bone growth of rat offspring by Natalia Viana Tamiasso, Fabiana Rocha Araújo, Natália de Melo Ocarino, Amanda Maria Sena Reis, Athelson Stefanon Bittencourt, Rogéria Serakides

“…The length and width of the femur and tibia and the thickness of the epiphysis were measured in the neonates, and the thickness of the articular cartilage, epiphyseal plate, and its zones were measured at 17 days of age. …”
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The effect of a barley-based food product in alleviating knee osteoarthritis discomfort symptoms in Egyptian female patients by Suzanne Fouad, Rasha Monir, Fatma A. Ibrahim, Ahmed M.S. Hussein, Heba F. Shafei, Aliaa El Gendy

“…Background/aim Osteoarthritis is a common joint condition that causes cartilage to erode. There are numerous conventional treatments available, including nonsteroidal anti-inflammatory medicines and pharmaceuticals containing glucosamine; however, taking them can result in serious side effects. …”
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Paradigms of intraoperative neuromonitoring in paediatric thyroid surgery by Yuchuan Li, Chunhai Zhang, Yi Zhang, Gianlorenzo Dionigi, Gianlorenzo Dionigi, Yishen Zhao, Hui Sun, Hui Sun, Yingying Wang

“…The use of innovative devices such as laryngeal masks with surface electrodes and thyroid cartilage receiving electrodes could replace monitoring tubes as a new form of IONM. …”
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Tissue-specific roles of de novo DNA methyltransferases by Dániel Márton Tóth, Flóra Szeri, Mária Ashaber, Muhyiddeen Muazu, Lóránt Székvölgyi, Tamás Arányi

“…Our findings indicate that DNMT3A primarily regulates hematopoietic differentiation, while DNMT3B is crucial for cartilage homeostasis and ossification. We emphasize the context-dependent roles of DNMT3A and DNMT3B and demonstrate that they also complement DNMT1 maintenance methyltransferase activity. …”
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Tracheal Resection for Critical Airway Obstruction in Morquio A Syndrome by Claire Frauenfelder, Elizabeth Maughan, Johnny Kenth, Reema Nandi, Simon Jones, Robert Walker, Bill Walsh, Nagarajan Muthialu, Iain Bruce, Richard Hewitt, Colin Butler

“…The relative pathophysiological contributions of an inherent cartilage processing defect versus a mismatch in longitudinal growth between the trachea and the thoracic cage are currently a subject of debate. …”
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Does the Harvesting Site Influence the Osteogenic Potential of Mesenchymal Stem Cells? by Van Thi Nguyen, Irene Tessaro, Antonio Marmotti, Camilla Sirtori, Giuseppe M. Peretti, Laura Mangiavini

“…In chondrogenic and adipogenic conditions, bone marrow cells possessed a predominant differential capacity compared with the others, illustrated by high collagen type II expression together with a cartilage-like lacuna structure and the presence of fat-specific markers, respectively. …”
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Fourier Transform Infrared Spectroscopic Imaging of Fracture Healing in the Normal Mouse by Hans Gollwitzer, Xu Yang, Lyudmila Spevak, Lyudmila Lukashova, Allina Nocon, Kara Fields, Nancy Pleshko, Hayden William Courtland, Mathias P. Bostrom, Adele L. Boskey

“…Following microcomputerized tomography, bone samples were cut in consecutive sections for FTIRI and histology, allowing for spatial correlation of both imaging methods in different callus areas (early calcified cartilage, woven bone, areas of intramembranous and endochondral bone formation). …”
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Effects of gestational and lactational exposure to ethanol on body and bone growth of rat offspring by Natalia Viana Tamiasso, Fabiana Rocha Araújo, Natália de Melo Ocarino, Amanda Maria Sena Reis, Athelson Stefanon Bittencourt, Rogéria Serakides

“…The length and width of the femur and tibia and the thickness of the epiphysis were measured in the neonates, and the thickness of the articular cartilage, epiphyseal plate, and its zones were measured at 17 days of age. …”
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The Effects of Low-Level Laser Therapy, 670 nm, on Epiphyseal Growth in Rats by Adriana Regina de Andrade, Anamaria Meireles, Elisangela Lourdes Artifon, Rose Meire Costa Brancalhão, José Roberto Leonel Ferreira, Gladson Ricardo Flor Bertolini

“…It was concluded that the treatment with LLLT within the parameters used caused changes neither in areas of the epiphyseal cartilage nor in the final length of limbs.…”
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Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimenta... by Ren J, Liu Z, Qi X, Meng X, Guo L, Yu Y, Dong T, Li Q

“…Jinhong Ren, Ze Liu, Xiaoming Qi, Xiangda Meng, Linglin Guo, Yating Yu, Tao Dong, Qingshan Li Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, People’s Republic of ChinaCorrespondence: Qingshan Li, Email sxlqs0501@sxtcm.edu.cnBackground: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease in which macrophages produce cytokines that enhance inflammation and contribute to the destruction of cartilage and bone. Additive Sishen decoction (ASSD) is a widely used traditional Chinese medicine for the treatment of RA; however, its active ingredients and the mechanism of its therapeutic effects remain unclear.Methods: To predict the ingredients and key targets of ASSD, we constructed “drug-ingredient-target-disease” and protein–protein interaction networks. …”
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Systemic Proteomic Analysis Reveals Distinct Exosomal Protein Profiles in Rheumatoid Arthritis by Qiu Qin, Ronghua Song, Peng Du, Chaoqun Gao, Qiuming Yao, Jin-an Zhang

“…Bioinformatics analysis revealed that transthyretin (TTR), angiotensinogen (AGT), lipopolysaccharide-binding protein (LBP), monocyte differentiation antigen CD14 (CD14), cartilage oligomeric matrix protein (COMP), serum amyloid P (SAP/APCS), and tenascin (TNC) can interact with each other. …”
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Evaluation of the quality characteristics of fermented sausages and sausage-like products sold in kars by Çiğdem Sezer, Aksem Aksoy, Özgür Çelebi, Turgay Deprem, Metin Öğün, Nebahat Bilge Oral, Leyla Vatansever, Abamüslüm Güven

“…Thirteen (32.5%) of the sausage samples that were examined contained epithelial tissue, 27.5% (11 samples) contained glandular epithelial tissue, which was mostly seromucous in nature, and five (12.5%) contained cartilage and bone tissue with smooth muscle tissue.…”
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Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression by Yuanyuan Chen, Zongying Zhang, Yuan Yao, Xiaorong Zhou, Yong Ling, Liming Mao, Zhifeng Gu

“…Rheumatoid arthritis (RA) is an autoimmune disorder that leads to severe cartilage deterioration and synovial impairment in the joints. …”
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Chondrosarcoma Arising from the Posterior Iliac Crest Extending into the Spinal Canal by Kota Wada, Akio Sakamoto, Rei Kato, Takashi Noguchi, Takayoshi Shimizu, Bungo Otsuki, Koichi Murata, Shunsuke Fujibayashi, Shuichi Matsuda

“…Chondrosarcoma is a malignant tumor characterized by the production of a cartilage matrix. Extension into the spinal canal from the extracannular space is seen mainly for neurogenic tumors, but it is rare in nonneurogenic tumors. …”
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Retroperitoneal Teratoma in an Adult: A Potential Pitfall in the Differential Diagnosis of Adrenal Myelolipoma by Madoka Kataoka, Hiroshi Fukushima, Yasukazu Nakanishi, Minato Yokoyama, Nobuaki Funata, Toru Motoi, Ken-ichi Tobisu, Fumitaka Koga

“…Histopathological examination revealed that the cystic tumor is composed of keratinized epidermis, mature fat, nerve, cartilage, bone, and sebaceous glands compressing the normal adrenal gland, leading to the diagnosis of retroperitoneal mature cystic teratoma. …”
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Case report: identification of novel variant in SLC26A2 gene and preimplantation genetic testing for monogenic disorders in preventing diastrophic dysplasia by Ziravard N. Tonyan, Yulia A. Nasykhova, Maria M. Danilova, Elena S. Shabanova, Olesya N. Bespalova, Igor Y. Kogan, Andrey S. Glotov

“…Abstract Background Diastrophic dysplasia is a rare autosomal recessive disorder characterized by abnormalities in bone and cartilage development, caused by pathogenic variants in the SLC26A2 gene. …”
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Subacute Urinary Retention due to a Subpubic Cartilaginous Cyst Treated with Surgical Resection and Internal Fixation: A Case Report and Review of the Literature by Yu Taniguchi, Hiroshi Kamada, Hisashi Sugaya, Tomofumi Nishino, Hajime Mishima, Naoyuki Ochiai, Masashi Yamazaki

“…On pathological assessment, the mass was diagnosed as a subpubic cartilaginous cyst arising from the cartilage of the pubic symphysis. No tumor recurrence was identified over a 4-year follow-up. …”
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Frontal Sinus “Hump”: An Anatomical Risk Factor for Anterior Skull Base Injury in the Endoscopic Modified Lothrop Approach (Outside-In Frontal Drill-Out) by Teppei Takeda, Kazuhiro Omura, Haw Torng, Teru Ebihara, Satoshi Aoki, Kosuke Tochigi, Hiromi Kojima, Nobuyoshi Otori

“…We reconstructed the skull base in multiple layers using fascia and cartilage. Postoperative cerebrospinal fluid leakage or intracranial haemorrhage was not observed. …”
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