Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update by Douglas B Johnson, Kylie Fletcher

“…These chronic irAEs have been noted to affect many different organ systems, including endocrine, rheumatologic, gastrointestinal, dermatologic, neurologic, and cardiovascular systems. In this review, we discuss current knowledge surrounding the frequency, time course, and risk factors associated with chronic irAEs affecting various organ systems, treatment approaches, and future directions.…”
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Metabolic Syndrome, Chronic Kidney, and Cardiovascular Diseases: Role of Adipokines by Manfredi Tesauro, Maria Paola Canale, Giuseppe Rodia, Nicola Di Daniele, Davide Lauro, Angelo Scuteri, Carmine Cardillo

“…A better understanding of these interactions will help in designing more effective treatments aimed to protect both renal and cardiovascular systems.…”
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Neurofibromatosis Type 1 Complicated by Atypical Coarctation of the Thoracic Aorta by Masato Kimura, Shuhei Kakizaki, Kengo Kawano, Shinichi Sato, Shigeo Kure

“…NF1 vasculopathy is a serious but underrecognized complication involving the cerebrovascular and cardiovascular systems. The incidence of hypertension in patients with NF1 is around 1% and is associated mainly with renal artery stenosis in children. …”
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Neurocirculatory asthenia and mitral valve prolapse syndrome from a psychopathological perspective by Łukasz Grabowski

“…NA is a disease which manifests mostly in respiratory and cardiovascular systems, while MVPS is characterized by the disturbed displacement of an abnormally thickened and superfluous mitral valve to the left atrium over the systole. …”
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Space and Time Resolved Detection of Platelet Activation and von Willebrand Factor Conformational Changes in Deep Suspensions by Jacopo Biasetti, Kaushik Sampath, Angel Cortez, Alaleh Azhir, Assaf A. Gilad, Thomas S. Kickler, Tobias Obser, Zaverio M. Ruggeri, Joseph Katz

“…Tracking cells and proteins’ phenotypic changes in deep suspensions is critical for the direct imaging of blood-related phenomena in in vitro replica of cardiovascular systems and blood-handling devices. This paper introduces fluorescence imaging techniques for space and time resolved detection of platelet activation, von Willebrand factor (VWF) conformational changes, and VWF-platelet interaction in deep suspensions. …”
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Loeys-Dietz syndrome by Bogumiła Wójcik-Niklewska, Erita Filipek

“…A 6-year-old boy with Loeys-Dietz syndrome, confirmed by molecular genetic testing, presented with high myopia, subluxated lenses, dysmorphic features, and disorders of the osteoarticular and cardiovascular systems. The boy underwent a complete ophthalmic examination, ocular ultrasound (US), ultrasound biomicroscopy (UBM), electrophysiological assessment (flash VEP), and magnetic resonance imaging (MRI) of the orbits. …”
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Liquefied Petroleum Gas Poisoning in a Child: A Case Report from a Low-Middle Income Country by Abid Jamali, Latif Shamasuddin, Aimen Yunus, Nadeem Ullah Khan

“…Propane primarily affects the respiratory, nervous, and cardiovascular systems.Conclusion: This case highlights the importance of admitting children exposed to LPG to higher care units for close monitoring, as initial cardiac enzyme levels and ECG may appear normal but can rapidly worsen. …”
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Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system by Ying Zhao, Yuke Zhong, Liuqing Wu, Jiao Yan, Weitao Lu

“…Signals showing significant sex differences were mainly concentrated on agents of the immune, nervous, musculo-skeletal, and cardiovascular systems. We offered a series of FRIDs and suggested their sex differences in falls through the FAERS. …”
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DNA copy number variations and craniofacial abnormalities in 1,457 children with neurodevelopmental disorders by Dandan Wu, Ran Chen, Jerry Zhang, Wu Yan, Mengyin Chen, Dongqing Xia, Xiaonan Li, Yanyan Dai, Yinhua Chen, Rong Li

“…Simultaneously, a specific sign-scoring scale was created to evaluate characteristics related to the developments of eyes, nose, ears, eyebrows, head, mouth, face, trunk, limbs, and reproductive, urinary, and cardiovascular systems. Results A total of 536 children (36.78%, 536/1,457) were found to have genetic variations, with 379 (70.71%, 379/536) exhibiting pathogenic monogenic mutations. …”
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