Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers by Li Lai, Yohannes T. Ghebremariam

“…The concentration of ADMA in plasma and tissue is enzymatically regulated by dimethylarginine dimethylaminohydrolase (DDAH), a widely expressed enzyme in the cardiovascular system. In preclinical studies, overexpression of DDAH has been shown to reduce ADMA levels, improve vascular compliance, and increase insulin sensitivity. …”
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Hemodynamics in chronic pain: A pathway to multi-modal health risks. by Dmitry M Davydov, Carmen M Galvez-Sánchez, Gustavo A Reyes Del Paso

“…Pain-o-metry provides biomarkers indicating connections between pain-related conditions and the health of various physiological systems, including the cardiovascular system. In this study, a non-linear data-driven analytical technique was employed to analyze second-by-second hemodynamic responses to recurrent clino-orthostatic challenges in 43 female fibromyalgia patients and 38 healthy women. …”
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Deciphering Oxidative Stress in Cardiovascular Disease Progression: A Blueprint for Mechanistic Understanding and Therapeutic Innovation by Zhaoshan Zhang, Jiawei Guo

“…A major contribution of this study is the systematic review of the differential effects of oxidative stress across different stages of CVDs, in addition to the proposal of innovative, multi-level intervention strategies, which open new avenues for precision treatment of the cardiovascular system.…”
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Life-Threatening Cardiac Manifestations of Pheochromocytoma by Luiz R. Leite, Paula G. Macedo, Simone N. Santos, Luiz Quaglia, Cezar E. Mesas, Angelo De Paola

“…However, a wide range of signs and symptoms may be present. In the cardiovascular system, the most common signs are labile hypertension and sinus tachycardia. …”
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Epicardial Coronary Arteries in Khat Chewers Presenting with Myocardial Infarction by Ahmed Al-Motarreb, Adel Shabana, Ayman El-Menyar

“…Khat chewing is a common habit in Yemen despite increased evidence of its negative impact on the cardiovascular system. Aims. We aimed to study the epicardial coronary arteries in khat chewers presenting with myocardial infarction (AMI). …”
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A Multidisciplinary Approach to Anesthetic Management of a Parturient with Severe Aortic Stenosis by Kalpana Tyagaraj, David A. Gutman, Lynn Belliveau, Adnan Sadiq, Alok Bhutada, Dennis E. Feierman

“…The effects of normal gestation on the cardiovascular system are particularly significant in a parturient with cardiac valvular pathology. …”
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Biosynthetic Pathways and the Role of the Mas Receptor in the Effects of Angiotensin-(1–7) in Smooth Muscles by Marcio Augusto Fressatto de Godoy, Larissa Pernomian, Ana Maria de Oliveira, Satish Rattan

“…Ang-(1–7) is produced via degradation of Ang II by the human angiotensin converting enzyme, also known as ACE2. In the cardiovascular system, Ang-(1–7) has been shown to produce effects that are opposite to those of Ang II. …”
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Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids by Scott J. Thomson, Ara Askari, David Bishop-Bailey

“…This paper will highlight the growing evidence that EETs also mediate a number of anti-inflammatory effects in the cardiovascular system. In particular, numerous studies have demonstrated that potentiation of EET activity using different methods can inhibit inflammatory gene expression and signalling pathways in endothelial cells and monocytes and in models of cardiovascular diseases. …”
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Differential Effects of Leptin and Adiponectin in Endothelial Angiogenesis by Raghu Adya, Bee K. Tan, Harpal S. Randeva

“…Leptin has been documented to influence a multitude of organ systems, that is, central nervous system (appetite regulation, satiety factor) and cardiovascular system (endothelial dysfunction leading to atherosclerosis). …”
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Regulation and Roles of Urocortins in the Vascular System by Kazunori Kageyama, Ken Teui, Naoki Tamasawa, Toshihiro Suda

“…Ucns would have potent effects on the cardiovascular system via the CRF receptor type 2 (CRF2 receptor). …”
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Mechanosensitive molecular interactions in atherogenic regions of the arteries: development of atherosclerosis by E. L. Mishchenko, A. M. Mishchenko, V. A. Ivanisenko

“…A terrible disease of the cardiovascular system, atherosclerosis, develops in the areas of bends and branches of arteries, where the direction and modulus of the blood flow velocity vector change, and consequently so does the mechanical effect on endothelial cells in contact with the blood flow. …”
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Human stem cell models for Marfan syndrome: a brief overview of the rising star in disease modelling by Jeffrey Aalders, Laura Muiño Mosquera, Laura Muiño Mosquera, Jolanda van Hengel

“…This promising avenue has also been applied to model Marfan syndrome, a disease affecting multiple organ systems, including the skeletal and cardiovascular system. Marfan syndrome is caused by pathogenic variants in FBN1, the gene encoding for the extracellular matrix protein fibrillin-1 which ensembles into microfibrils. …”
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Validation of the unique OUES scale (ΔV02, VE slope) in functional reserve assessment of cardiorespiratory system for Iranian children by Akbar Sazvar, Farzad Nazem

“…In studies of screening and clinical diagnosis of cardiovascular system performance, the supplying of OUES index during the ergometry tests in the lower than lactate threshold conditions is usable for Iranian healthy boys. …”
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Assessing Exercise Limitation Using Cardiopulmonary Exercise Testing by Michael K. Stickland, Scott J. Butcher, Darcy D. Marciniuk, Mohit Bhutani

“…In healthy subjects, of the variables involved in oxygen delivery, it is the limitations of the cardiovascular system that are most responsible for limiting exercise, as ventilation and gas exchange are sufficient to maintain arterial O2 content up to peak exercise. …”
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The Role of Angiotensin Antagonism in Coronary Plaque Regression: Insights from the Glagovian Model by Abdul H. Alkatiri, Doni Firman, Amir A. Alkatiri, Paskalis I. Suryajaya, Albert Sudharsono

“…The benefit of antagonizing the effect of the renin angiotensin aldosterone system (RAAS), notably by the use of angiotensin-converting enzyme inhibitor (ACEi) and angiotensin II type 1 receptor blocker (ARB) for coronary artery disease (CAD), has been demonstrated in multiple studies, which may be attributed to their ability to inhibit the deleterious effect of RAAS to the cardiovascular system. It is well known that angiotensin II (Ang II) plays a vital role in atheromatous plaque formation and progression through multiple pathways, including inflammatory and arterial remodeling aspects. …”
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The interdependent hemodynamic influence between abdominal aortic aneurysm and renal artery stenosis by Jiaqi Lim, Hung Dong Truong, Tae Yoon Song, Wilkin Jing Han Giam, Evelyn Linyi Koh, Justin Kok Soon Tan

“…The confluence of AAA and RAS represents a complex interplay within the cardiovascular system, one that is often overlooked in clinical practice and research. …”
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Features of the electrolyte distribution in various tissues in miniature pigs by A. V. Fatianova, V. A. Lavrinenko, O. V.  Trapezov, N. S. Yudin

“…Striking similarities between human and miniature pig anatomy and physiology of the cardiovascular system, skin and digestive organs have made miniature pigs a successful animal model for addressing problems of xenotransplantation. …”
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Cardiovascular Reactivity: its Association with Physical Activity, and Some Hemodynamic and Anthropometric Variables by Milagros Lisset León Regal, Rosmari Álvarez Hernández, Mikhail Benet Rodríguez, Cynthia Olivia Morales Pérez, Rachel Yanes Seijo, José Omar de Armas García

“…<strong>Background:</strong> several studies show the influence of physical activity as a protective factor of the cardiovascular system. New evidence forcorroborating this are needed to ensure the prevention of cardiovascular disease. …”
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Technique for Measuring the Internal Diameter and Area of Visible Vessels of the Eye by V. A. Firago, A. I. Kubarko

“…Examples of the construction of histograms of the distribution of the internal diameter and cross-sectional area of these blood vessels are presented.The proposed technique and hardware solutions have the prospect of being used in creating equipment for complex non-invasive diagnostics of the microvasculature and monitoring the effectiveness of treating various diseases of the cardiovascular system, since the conditions of the eye blood vessels correlate with the state of the blood vessels in other organs.…”
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