Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…Background Metformin (Met) is the first-line treatment for type 2 diabetes mellitus and plays an effective role in treating various diseases, such as cardiovascular disease, neurodegenerative disease, cancer, and aging. …”
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Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia by Chaoqun Wang, Jiantao Chen, Zicong Feng, Bohao Jian, Suiqing Huang, Kangni Feng, Haoliang Liu, Zhuoming Zhou, Ziyin Ye, Jing Lu, Mengya Liang, Zhongkai Wu

“…These highlight its potential as a therapeutic target for mitigating vein graft failure associated with cardiovascular procedures. Spatial transcriptomics profiles and morphological observations demonstrated that a newly generated cell population outside the grafted vein with hybrid phenotype between SMCs and fibroblasts contributes to neointimal formation.…”
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Sex Differences in the Prognostic Value of Circulating Biomarkers in Patients Presenting With Acute Chest Pain by Gard Mikael Sæle Myrmel, MD, Nasir Saeed, Ole Thomas Steiro, MD, Hilde Lunde Tjora, MD, PhD, Jørund Langørgen, MD, PhD, Rune Oskar Bjørneklett, MD, PhD, Øyvind Skadberg, MD, Vernon Vijay Singha Bonarjee, MD, PhD, Øistein Rønneberg Mjelva, MD, Eva Ringdal Pedersen, MD, PhD, Kjell Vikenes, MD, PhD, Torbjørn Omland, MD, PhD, Kristin Moberg Aakre, MD, PhD

“…Background: Biomarkers are used for long-term risk prediction of cardiovascular (CV) events in patients presenting with suspected acute coronary syndromes. …”
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Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor by Ke Sun, Yong-Li Wang, Chen-Chen Hou, Da Shang, Lin-Juan Du, Lan Bai, Xing-Yu Zhang, Chuan-Ming Hao, Sheng-Zhong Duan

“…Introduction: Nuclear receptor corepressor 1(NCOR1) is reported to play crucial roles in cardiovascular diseases, but its function in the kidney has remained obscure. …”
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Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract by Yassin Belahnech, Gerard Martí-Aguasca, Laura Dos-Subirà, Pedro Betrian-Blasco, Bruno García del Blanco, Maria Calvo-Barceló, Eduard Ródenas-Alesina, Antonia Pijuan-Domènech, Ferran Gran, Queralt Ferrer, Gemma Giralt-García, Berta Miranda, Blanca Gordon, Víctor González-Fernández, José A. Barrabés, Ferran Roses-Noguer, Ignacio Ferreira-González

“…The primary endpoint was a composite of endocarditis, reinterventions, and cardiovascular death and secondary outcomes included prosthetic valve dysfunction (PVD), tricuspid regurgitation (TR), right ventricular ejection fraction (RVEF), and indexed ventricular volumes. …”
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Reduction of intestinal RIPK1 ameliorates HFD-induced metabolic disorders in female mice by Ye Yuan, Xiaomin Hu, Chunguang Guo, Yihua Xu, Shihan Li, Wei Wen, Xinli Hu, Fanxin Zeng, Weiyi Cui, Wenli Chen, Xueting Sun, Ning Hou, Jue Wang, Rui-Ping Xiao, Xiuqin Zhang

“…Summary: In modern society, excessive nutrient intake from food is a major factor contributing to the development of a series of metabolic disorders and cardiovascular diseases. Further investigation of the mechanisms underlying nutrient absorption in the intestine will help to better understand and develop preventive or therapeutic strategies. …”
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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…Physical function was assessed using standing broad jump and handgrip for strength, and the shuttle-run test for cardiovascular fitness. Growth was assessed by anthropometry. …”
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Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides by Hidenori Shimizu, Junki Miyamoto, Keiko Hisa, Ryuji Ohue-Kitano, Hiromi Takada, Mayu Yamano, Akari Nishida, Daiki Sasahara, Yuki Masujima, Keita Watanabe, Shota Nishikawa, Sakura Takahashi, Takako Ikeda, Yuya Nakajima, Naofumi Yoshida, Chiaki Matsuzaki, Takuya Kageyama, Ibuki Hayashi, Akari Matsuki, Ryo Akashi, Seiichi Kitahama, Masako Ueyama, Takumi Murakami, Shinsuke Inuki, Junichiro Irie, Noriko Satoh-Asahara, Hirokazu Toju, Hiroshi Mori, Shinji Nakaoka, Tomoya Yamashita, Atsushi Toyoda, Kenji Yamamoto, Hiroaki Ohno, Takane Katayama, Hiroshi Itoh, Ikuo Kimura

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Incidence of type 2 diabetes and metabolic syndrome by Occupation – 10-Year follow-up of the Gutenberg Health Study by Juliane Bauer, Janice Hegewald, Karin Rossnagel, Sylvia Jankowiak, Michaela Prigge, Julian Chalabi, Matthias Nübling, Alice Freiberg, Merle Riechmann-Wolf, Pavel Dietz, Philipp S. Wild, Thomas Koeck, Manfred E. Beutel, Norbert Pfeiffer, Karl J. Lackner, Thomas Münzel, Konstantin Strauch, Philipp Lurz, Oliver Tüscher, Julia Weinmann-Menke, Stavros Konstantinides, Andreas Seidler

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Impact of a phone call with a medical student/general practitioner team on morbidity of chronic patients during the first French COVID-19 lockdown (COVIQuest): a cluster randomised... by Bruno Giraudeau, Estelle Boivin, Vincent Camus, Agnes Caille, Olivier Saint-Lary, Jean-Pierre Lebeau, Stéphanie Sidorkiewicz, Denis Pouchain, Maeva Jego, Sophie Sun, Denis Angoulvant, Wissam El-Hage, Sébastien Bruel, Clarisse Dibao-Dina, Julie Léger, Isabelle Ettori-Ajasse, Juliette Chambe, Karim Abou-Mrad-Fricquegnon, Baptiste Motte, Benoit Chiron, Cam-Anh Khau, Tiphanie Bouchez, Maria Ghali, Leslie Guillon-Grammatico, Emeline Laurent, Rémy Boussageon

“…Objectives The first COVID-19 lockdown led to a significantly reduced access to healthcare, which may have increased decompensations in frail patients with chronic diseases, especially older patients living with a chronic cardiovascular disease (CVD) or a mental health disorder (MHD). …”
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Dynamic Profile of CD4+ T-Cell-Associated Cytokines/Chemokines following Murine Myocardial Infarction/Reperfusion by Dongsheng Yuan, Jinjun Tie, Zhican Xu, Guanya Liu, Xinyu Ge, Zhulin Wang, Xumin Zhang, Shiyu Gong, Gang Liu, Qingshu Meng, Fang Lin, Zhongmin Liu, Huimin Fan, Xiaohui Zhou

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Recent advances in the role of high-salt diet in anti- and pro-cancer progression by Shiwei Tang, Juan Xu, Ping Wan, Ping Wan, Ping Wan, Shumen Jin, Ying Zhang, Ying Zhang, Linting Xun, Linting Xun, Jinli Wang, Jinli Wang, Mei Luo, Mei Luo, Wenjie Chen, Wenjie Chen, Zan Zuo, Zan Zuo, Zan Zuo, Hui Tang, Hui Tang, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi, Jialong Qi

“…Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney disease, cancer, and osteoporosis. …”
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Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021) by Le HHL, Thuc LC, Ta TB, Tran TV, Hung DV, Kien HT, Le MN, Luong VH, Nguyen VTH, Pham HQ, Le HV, Viet NH, Hoang LH, Nguyen TT, Latsavong M, Le TD, Trong Tuan D, An NV

“…Hai Ha Long Le,1,2 Luong Cong Thuc,3 Thang Ba Ta,4 Tien Viet Tran,5 Dinh Viet Hung,6 Hoang Trung Kien,7 Minh Nhat Le,8,9 Vu Huy Luong,10,11 Vinh Thi Ha Nguyen,11,12 Hoa Quynh Pham,13 Hung Van Le,11,13 Nguyen Hoang Viet,14 Le Huy Hoang,15 Tram Thuy Nguyen,15 Mixay Latsavong,16 Tuan Dinh Le,17 Dao Trong Tuan,18 Nguyen Van An19 1Department of Clinical Microbiology and Parasitology, Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam; 2Department of Biochemistry, Hematology and Immunology, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 3Cardiovascular Center, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 4Respiratory Center, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 5Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 6Department of Psychiatry, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 7Department of Immunology, Vietnam Military Medical University, Hanoi, Vietnam; 8Tay Nguyen Institute of Science Research, Vietnam Academy of Science and Technology, VAST, Hanoi, Vietnam; 9Antimicrobial Resistance Research Center, National Institute of Infectious Disease, Tokyo, Japan; 10Department of Laser and Skincare, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 11Department of Dermatology and Venereology, Hanoi Medical University, Hanoi, Vietnam; 12Department of General Planning, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 13Department of Microbiology, Mycology and Parasitology, National Hospital of Dermatology and Venereology, Hanoi, Vietnam; 14Molecular Pathology Department, Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam; 15Department of Bacteriology, National of Hygiene and Epidemiology, Hanoi, Vietnam; 16Department of Nephrology-Hemodialysis, Military Central Hospital 103, Vientiane, Laos; 17Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 18ENT Department, Central Military Hospital 108, Hanoi, Vietnam; 19Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, VietnamCorrespondence: Nguyen Van An, Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, 100000, Vietnam, Tel + 84 982 860 055, Email ank59hvqy@gmail.comPurpose: In a Vietnamese teaching hospital, this study examined the prevalence and patterns of antimicrobial resistance (AMR) of common bacteria isolated from hospitalized patients with urinary tract infections (UTIs) between 2014 and 2021.Methods: From 4060 urine samples collected, common pathogens were isolated using quantitative culture on brilliance UTI Clarity agar and blood agar. …”
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Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry by Shani A D Mathara Diddhenipothage, Katharina J Beck, Gayana Amiyangoda, Jillian Bryce, Luminita Cima, Katya De Groote, Yana Deyanova, Evgenia Globa, Gloria Herrmann, Anders Juul, Anna Sophie L Kjaer, Anette Tønnes Pedersen, Sukran Poyrazoglu, Ursina Probst-Scheidegger, Theo C J Sas, Simona Fica, Sumudu Nimali Seneviratne, Justyna Karolina Witczak, Elizabeth Orchard, Jeremy W Tomlinson, S Faisal Ahmed, Helen E Turner

“…Introduction: Cardiovascular disease is the most common cause of death in Turner syndrome (TS) for which arterial hypertension has a direct influence and is a key modifiable risk factor. …”
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Risankizumab Versus Secukinumab: A Real-World Efficacy and Cost per Responder Comparison in Patients With Psoriasis in Italy by Federico Pirro, Giacomo Caldarola, Nicoletta Bernardini, Maria Grazia Celeste, Annunziata Dattola, Eleonora De Luca, Marco Galluzzo, Domenico Giordano, Chiara Izzi, Giulia Maretti, Lorenzo Marcelli, Roberto Ravasio, Antonio Giovanni Richetta, Nevena Skroza, Marina Talamonti, Arianna Zangrilli, Luca Bianchi, Giovanni Pellacani, Severino Persechino, Concetta Potenza, Ketty Peris, Clara De Simone

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Evaluating the World Health Organization’s Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala by Irmgardt Alicia Wellmann, Luis Fernando Ayala, Taryn M. Valley, Vilma Irazola, Mark D. Huffman, Michele Heisler, Peter Rohloff, Rocío Donis, Eduardo Palacios, Manuel Ramírez-Zea, David Flood

“…Background: The World Health Organization HEARTS Technical Package is a widely implemented global initiative to improve the primary care management of cardiovascular disease risk factors. The study’s objective is to report outcomes from a pilot implementation trial of integrated hypertension and diabetes management based on the HEARTS model in Guatemala. …”
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Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary... by Hadar Klein, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Alon Kaplan, Yoash Chassidim, Yftach Gepner, Matthias Blüher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Ilan Shelef, Lu Qi, Jun Li, Frank B. Hu, Meir J. Stampfer, Iris Shai

“…Abstract Background Visceral adipose tissue (VAT) is well established as a pathogenic fat depot, whereas superficial subcutaneous adipose tissue (SAT) is associated with either an improved or neutral cardiovascular state. However, it is unclear to what extent VAT area (VATcm2) and its proportion of total abdominal adipose tissue (VAT%) are distinguished in predicting cardiometabolic status and clinical outcomes during weight loss. …”
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Analysis of Genetic Variation in CD40 and CD40L: Relationship with mRNA Relative Expression and Soluble Proteins in Acute Coronary Syndrome by D. E. Martínez-Fernández, J. R. Padilla-Gutiérrez, F. Casillas-Muñoz, Emmanuel Valdés-Alvarado, Brenda Parra-Reyna, Maricela Aceves-Ramírez, J. F. Muñoz-Valle, U. Zalapa Flores, J. C. Chávez Herrera, Y. Valle

“…Due to the important roles of the CD40-CD40L system in the pathogenesis of ACS, longitudinal studies are required to determine if soluble levels of CD40 and CD40L could be clinically useful markers of a recurrent cardiovascular event after an ACS.…”
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Association between major depressive disorder or depressive symptoms and the risk of vascular complications among patients with type 2 diabetes, and the mediating role of metabolic... by Guochen Li, Yongfu Yu, Chunqing Lin, Shichen Zheng, Hong Tu, Wanghong Xu

“…Cox proportional hazards models were performed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of MDD and depressive symptoms with the risks of incident heart failure (HF); total and individual atherosclerotic cardiovascular disease (ASCVD) including coronary artery disease (CAD), ischemic stroke (IS), and peripheral artery disease (PAD); total and individual microvascular complications of diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic neuropathy (DN). …”
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Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the... by Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo

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