Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme by Peter Nash, Yoshiya Tanaka, Kevin L Winthrop, Eun Bong Lee, Xavier Mariette, Jeffrey R Curtis, Kenneth Kwok, Connie Chen, Pinaki Biswas, Lisy Wang, Christina Charles-Schoeman, Ann Madsen, Stanley B Cohen, Andrea Shapiro, Jürgen Wollenhaupt

“…IRs (95% CI) for gastrointestinal perforations, deep vein thrombosis, pulmonary embolism, venous thromboembolism, arterial thromboembolism and major adverse cardiovascular events were 0.1 (0.1 to 0.2), 0.2 (0.1 to 0.2), 0.1 (0.1 to 0.2), 0.3 (0.2 to 0.3), 0.4 (0.3 to 0.5) and 0.4 (0.3 to 0.5), respectively. …”
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Gestational diabetes mellitus and offspring’s carotid intima–media thickness at birth: MySweetHeart Cohort study by Umberto Simeoni, Antje Horsch, Arnaud Chiolero, Yvan Vial, Nicole Sekarski, Jardena J Puder, Pascal Bovet, Stefano Di Bernardo, Yvan Mivelaz, Adina Mihaela Epure, Sandrine Estoppey Younes, Bobby Stuijfzand, Leah Gilbert, Stefano Lanzi, Justine Gross, Stefano Di Bernardo, Dan Quansah, Jean-Benoît Rossel, Amar Arhab, Sandrine Estoppey Younes, Seyda Mayerat

“…A longer-term follow-up that includes additional vascular measures, such as endothelial function or arterial stiffness, may shed further light on the cardiovascular health trajectories in children born to mothers with GDM.Trial registration number NCT02872974; Pre-results.…”
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Outcome differences in acute vs. acute on chronic heart failure and cardiogenic shock by Tara L. Jones, Michael C. Tan, Vidang Nguyen, Kathleen E. Kearney, Charles C. Maynard, Emily Anderson, Claudius Mahr, James M. McCabe

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Impact of Population-Based Screening for Diabetes and Prediabetes Among 67-Year-Olds Using Point-of-Care HbA1c on Healthcare Ultilisation, Results from the VISP Cohort by Andersen JW, Høgh A, Lindholt JS, Søgaard R, Støvring H, Yderstræde KB, Sandbæk A, Dahl M

“…Jesper Winkler Andersen,1,2 Annette Høgh,1,3 Jes Sanddal Lindholt,1,3– 6 Rikke Søgaard,5 Henrik Støvring,3,7 Knud Bonnet Yderstræde,5,8 Annelli Sandbæk,9– 11 Marie Dahl1,3– 5 1Vascular Research Unit, Department of Vascular Surgery, Viborg Regional Hospital, Viborg, Denmark; 2Department of Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; 3Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 4Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark; 5Department of Clinical Research, University of Southern Denmark, Odense, Denmark; 6Elite Centre of Individualized Treatment of Arterial Diseases (CIMA), Odense University Hospital, Odense, Denmark; 7Department of Biomedicine, Aarhus University, Aarhus, Denmark; 8Diabetes Center, Steno, Odense, Denmark; 9Department of Public Health, Aarhus University, Aarhus, Denmark; 10Research unit of General Medical Practice, Aarhus University, Aarhus, Denmark; 11Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, DenmarkCorrespondence: Jesper Winkler Andersen, Vascular Research Unit, Department of Surgery, Viborg Regional Hospital, Toldbodgade 12, Viborg, 8800, Denmark, Tel +45 28118736, Email jesper.andersen@midt.rm.dkPurpose: The present study aims to evaluate the changes in healthcare utilization following population-based screening for diabetes mellitus (DM) using point-of-care HbA1c measurement in the Viborg Screening Program (VISP) cohort, which invites all 67-year-olds in Viborg, Denmark, for cardiovascular disease (CVD) and DM screening.Patients and Methods: We conducted a cohort study using data from VISP and Danish national health registers. …”
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CHEMICAL COMPOSITION OF CHICKPEA by S. Sots, I. Kustov, I. Butsenko, I. Solonytska

“…At the same time, kabuli chickpea has a higher content of monounsaturated fatty acids, making it beneficial for cardiovascular health. Fats in both chickpea varieties are present in small amounts (2-6%), but their composition is diverse, primarily consisting of unsaturated fatty acids that help reduce "bad" cholesterol levels. …”
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Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Background: Arterial hypertension and left ventricular hypertrophy and remodeling are independent cardiovascular risk factors in patients with Cushing’s syndrome. …”
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Efficacy of a Mobile Health–Based Behavioral Treatment for Lifestyle Modification in Type 2 Diabetes Self-Management: Greenhabit Randomized Controlled Trial by Ana Maria Ruiz-Leon, Rosa Casas, Sara Castro-Barquero, Sofia Alfaro-González, Petia Radeva, Emilio Sacanella, Francesc Casanovas-Garriga, Ainhoa Pérez-Gesalí, Ramon Estruch

“…ConclusionsThe 12-week intervention with the Greenhabit behavioral treatment mHealth app showed beneficial effects on T2D outcomes and reduced the burden of cardiovascular risk factors. Although larger studies are warranted, these results suggest that mHealth apps can be a promising tool for improving T2D self-management. …”
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Myocardial Infarction-Associated Shock: A Comprehensive Analysis of Phenotypes, SCAI Classification, and Outcome Assessment by Stanislav Dil, Maria Kercheva, Oleg Panteleev, Sergey Demianov, Aleksandr Kanev, Nina Belich, Boris Kornienko, Vyacheslav Ryabov

“…This study aimed to analyze the clinical, historical, instrumental, and laboratory characteristics of the primary phenotypes of MI-CS, stratified according to the Society for Cardiovascular Angiography and Interventions (SCAI) shock severity scale. …”
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Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-Ana... by Maurizio Zizzo, Andrea Morini, Magda Zanelli, Chiara Grasselli, Francesca Sanguedolce, Sze Ling Wong, Munyaradzi G. Nyandoro, Andrea Palicelli, Giuseppe Broggi, Nektarios I. Koufopoulos, Lucia Mangone, Angelo Cormio, Rosario Caltabiano, Antonino Neri, Massimiliano Fabozzi

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Blood coagulation system in patients with chronic kidney disease: a prospective observational study by Xi Yang, Yang Wang, Ri-bao Wei, Ting-yu Su, Meng-jie Huang, Ping Li, Xiang-mei Chen, Ping Di, Qing-ping Li

“…During the 1-year of follow-up, one cardiovascular event occurred in patients with CKD 5 stage, whereas no thromboembolic event occurred in the CKD 3 and 4 and control groups.Conclusions Patients with CKD are characterised by endothelial dysfunction and increased coagulation, especially FVIII activity. …”
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International Society of Sports Nutrition Position Stand: Long-Chain Omega-3 Polyunsaturated Fatty Acids by Ralf Jäger, Jeffery L. Heileson, Sidney Abou Sawan, Broderick L. Dickerson, Megan Leonard, Richard B. Kreider, Chad M. Kerksick, Stephen M. Cornish, Darren G. Candow, Dean M. Cordingley, Scott C. Forbes, Grant M. Tinsley, Tindaro Bongiovanni, Roberto Cannataro, Bill I. Campbell, Shawn M. Arent, Jeffrey R. Stout, Douglas S. Kalman, Jose Antonio

“…The following conclusions represent the official position of the ISSN: Athletes may be at a higher risk for ω-3 PUFA insufficiency.Diets rich in ω-3 PUFA, including supplements, are effective strategies for increasing ω-3 PUFA levels.ω-3 PUFA supplementation, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been shown to enhance endurance capacity and cardiovascular function during aerobic-type exercise.ω-3 PUFA supplementation may not confer a muscle hypertrophic benefit in young adults.ω-3 PUFA supplementation in combination with resistance training may improve strength in a dose- and duration-dependent manner.ω-3 PUFA supplementation may decrease subjective measures of muscle soreness following intense exercise.ω-3 PUFA supplementation can positively affect various immune cell responses in athletic populations.Prophylactic ω-3 PUFA supplementation may offer neuroprotective benefits in athletes exposed to repeated head impacts.ω-3 PUFA supplementation is associated with improved sleep quality.ω-3 PUFA are classified as prebiotics; however, studies on the gut microbiome and gut health in athletes are currently lacking.…”
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gp91phox, a Novel Biomarker Evaluating Oxidative Stress, Is Elevated in Subclinical Hypothyroidism by Xiaochun Ma, Furong Wang, Xiaowen Zhen, Lifang Zhao, Li Fang, Zhenfang Dong, Wenbin Chen, Xiaoming Zhou

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Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza

“…Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor gamma (PPARγ) ligand, has been reported to act as insulin sensitizer and exert cardiovascular actions. In this work, we hypothesized that RGZ exerts a PPARγ–dependent regulation of blood pressure through modulation of angiotensin-converting enzyme (ACE)-type 2 (ACE2)/angiotensin-(1-7)/angiotensin II type-2 receptor (AT2R) axis in an experimental model of high blood pressure. …”
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Mechanisms of L-citrulline on phosphodiesterase 5 in erectile dysfunction intervention by Abdulhakeem Olarewaju Sulyman, Olawale Moshood Aliyu, Emmanuel Oladipo Ajani, Yusuf Folohunsho Abdulkareem, Isaac Ade Afe, Fathia Oluwakemi Abdulyakeen, Halimat Yusuf Lukman, Saheed Sabiu, Karishma Singh, Kuben Naidoo

“…Erectile dysfunction (ED) is a prevalent condition linked to diabetes and cardiovascular diseases, with conventional treatments often associated with adverse effects. …”
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Assessing the feasibility of measuring residents’ quality of life in English care homes and the construct validity and internal consistency of measures completed by staff proxy: a... by Claire Goodman, Julienne Meyer, Karen Spilsbury, Barbara Hanratty, Rachael Carroll, Adam L Gordon, Gizdem Akdur, Anne Killett, Jennifer Burton, Ann-Marie Towers, Stacey Rand, Nick Smith, Sinead Palmer, Stephen Allan, Lucy Anne Webster

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Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans by Chih Jen Yang, Lyndsey E. Shorey-Kendrick, Cristina Puy, Ashley E. Benson, Phillip A. Wilmarth, Ashok P. Reddy, Keith D. Zientek, Kilsun Kim, Adam Crosland, Chaevien S. Clendinen, Lisa M. Bramer, Olivia L. Hagen, Helen H. Vu, Joseph E. Aslan, Owen J.T. McCarty, Joseph J. Shatzel, Brian P. Scottoline, Jamie O. Lo

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Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial by Michael Walsh, Salim Yusuf, Chirag Parikh, Jessica Vincent, P J Devereaux, Francois Lamontagne, Matthew T V Chan, Richard Whitlock, Meaghan Cuerden, Amit X Garg, Andre Lamy, Daniel I Sessler, Kevin Teoh, Ainslie Hildebrand, Yunxia Zuo, Pallav Shah, Seyed Hesameddin Abbasi, Mackenzie Quantz, Jean-Pierre Yared, Nicolas Noiseux, Georgios Tagarakis, Antoine Rochon, Janice Pogue, Abbas Salehiomran

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Validity, Accuracy, and Safety Assessment of an Aerobic Interval Training Using an App-Based Prehabilitation Program (PROTEGO MAXIMA Trial) Before Major Surgery: Prospective, Inter... by Sara Fatima Faqar Uz Zaman, Svenja Sliwinski, Lisa Mohr-Wetzel, Julia Dreilich, Natalie Filmann, Charlotte Detemble, Dora Zmuc, Felix Chun, Wojciech Derwich, Waldemar Schreiner, Wolf Bechstein, Johannes Fleckenstein, Andreas A Schnitzbauer

“…Regression analysis revealed a significant impact of the BMI (odds ratio 0.90, 95% CI 0.82-0.98, P=.02) and Timed Up and Go Test score (odds ratio 0.12, 95% CI 0.03-0.55, P=.006) on the accuracy of heart rate measurement; 29 (39%) patients experienced adverse events: pain (5/12, 42%), ECG electrode–related skin irritations (2/42, 17%), dizziness (2/42, 17%), shortness of breath (2/42, 17%), and fatigue (1/42, 8%). No cardiovascular or serious adverse events were reported, and no serious device deficiency was detected. …”
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What all physicians should know about women’s health: a Delphi study by Susanna Price, Eva Gerdts, Julien Mazières, Alexandra Kautzky-Willer, Fedde Scheele, Chiara Benedetto, Kerry Wilbur, Gertraud Stadler, Marieke Wermer, Jeanine Roeters van Lennep, Merel H de Heer-Koster, Vesna Bjegović-Mikanović, Indre Banaitytė-Baleišienė, Mary Perdiou, Alyson McGregor, Connie Newman, Simona Stankevičiūtė, Iris E Sommer, Florence Thibaut, Karine van 't Land

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Feasibility and usefulness of Gini coefficients of primary care visits as a measure of service inequality: preliminary findings from a cross-sectional study using region-wide elect... by Xin Yang, Jing Chai, Jing Cheng, DeBin Wang, XingRong Shen, Rong Liu, ManMan Lu, Jia Xu, Ningjing Yang, Guocheng Li

“…The observed GPVs for system-specific diseases, as estimated using the 27-month electronic medical records, ranged from 0.341 for skin-immune disease to 0.514 for cardiovascular disease. While the observed GPVs for all causes witnessed: great inter-region variations, with the highest GPV being 4.38 times the lowest; a general decreasing trend over the 9-quarter period, being reduced by 18.48% on average; and atypical J-shaped trajectories along age groups for both sexes. …”
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