TG : HDL-C Ratio Is a Good Marker to Identify Children Affected by Obesity with Increased Cardiometabolic Risk and Insulin Resistance by Ahmad Kamil Nur Zati Iwani, Muhammad Yazid Jalaludin, Ruziana Mona Wan Mohd Zin, Md Zain Fuziah, Janet Yeow Hua Hong, Yahya Abqariyah, Abdul Halim Mokhtar, Wan Nazaimoon Wan Mohamud

“…Metabolic syndrome (MetS) is an important predictor of cardiovascular diseases in adulthood. This study aims to examine the clinical utility of triglyceride to high-density lipoprotein ratio (TG : HDL-C) in identifying cardiometabolic risk and insulin resistance (IR) among children with obesity, in comparison with MetS as defined by the International Diabetes Federation (IDF). …”
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Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis by Yijian Deng, Liying Zeng, Yigui Lai, Shuai Ji, Baizhao Peng, Hanqi Lu, Ming Wang, Hiu Yee Kwan, Qi Wang, Xiaoshan Zhao

“…Background: Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. Branched-chain amino acids (BCAAs) are derived from dietary intake and mainly involved in energy metabolism. …”
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Hyperglycemia Is a Potential Prognostic Factor for Exacerbation in Severe Psoriasis with Diabetes or Prediabetes by Yongpisarn T, Thadanipon K, Suchonwanit P, Rattanakaemakorn P

“…Research suggests that psoriasis-induced inflammation can trigger insulin resistance and high blood sugar (hyperglycemia), which in turn triggers abnormal functioning of the blood vessel’s inner lining, ultimately leading to atherosclerosis and cardiovascular disease. Interestingly, insulin resistance may also worsen psoriatic skin lesions. …”
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Primary Terminal Haemochromatosis in a 50 Year-Old Patient by M. I. Gonik, M. S. Zharkova, O. Yu. Kiseleva, E. V. Berezina, Sh. A. Ondos, Yu. V. Lerner, E. A. Kogan, V. T. Ivashkin

“…Acute and chronic adrenal failure. Despite a cardiovascular and renal failure compensation therapy and albumin transfusion, the patient died. …”
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Validation of insurance claims data on aetiology, surgical type and prosthesis for isolated valve surgery: a retrospective observational surgery by Shao-Wei Chen, Victor Chien-Chia Wu, Pao-Hsien Chu, An-Hsun Chou, Chun-Yu Chen, Feng-Cheng Chang, Yi‐Hsin Chan, Chia-Pin Lin, Yu-Ting Cheng, Bo-Cheng Hou, Jo-Ting Huang

“…Objectives Administrative database research is pivotal for developing guidelines in cardiovascular surgery and valvular heart disease. However, validation studies specific to Asia are lacking. …”
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Impact of Novel Guidelines on Multifactorial Control and Its Association with Mortality in Adult Patients with Hypertension and Newly Diagnosed Type 2 Diabetes: A 4-Year Prospectiv... by Ngoc-Thanh-Van Nguyen, Hoa Ngoc Chau, Nam Hoai Le, Hai Hoang Nguyen, Hoai-An Nguyen

“…Hypertensive patients with newly diagnosed diabetes are associated with heightened risks for cardiovascular events. Yet endorsement of state-of-the-art guidelines with more stringent goals poses significant challenges in obtaining multifactorial control. …”
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Polygenic height prediction for the Han Chinese in Taiwan by Chih-Hao Chang, Che-Yu Chou, Timothy G. Raben, Shih-Ann Chen, Yuh-Jyh Jong, Jeng-Yih Wu, Shun-Fa Yang, Hsiang-Cheng Chen, Yen-Lin Chen, Ming Chen, Gwo-Chin Ma, Chih-Yang Huang, Tso-Fu Wang, Sing-Lian Lee, Chen-Fang Hung, See-Tong Pang, Erik Widen, Yao-Ming Chang, Erh-Chan Yeh, Chun-Yu Wei, Chien-Hsiun Chen, Stephen D. H. Hsu, Pui-Yan Kwok

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Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil by Pâmela Guimarães Reis, Christiane Maria Ayo, Luiz Carlos de Mattos, Cinara de Cássia Brandão de Mattos, Karina Mayumi Sakita, Amarilis Giaretta de Moraes, Larissa Pires Muller, Julimary Suematsu Aquino, Luciana Conci Macedo, Priscila Saamara Mazini, Ana Maria Sell, Divina Seila de Oliveira Marques, Reinaldo Bulgarelli Bestetti, Jeane Eliete Laguila Visentainer

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Extreme Temperature Events in Kazakhstan and Their Impacts on Public Health and Energy Demand by Parya Broomandi, Alfrendo Satyanaga, Mehdi Bagheri, Mostafa Hadei, David Galán‐Madruga, Ali Mozhdehi Fard, Adib Roshani, Aram Fathian, Amir Nourian, Michael Leuchner, Klaus Reicherter, Mehdi Hamidi, Prashant Kumar, Jong Ryeol Kim

“…The impact of heatwaves on various health conditions, notably consistent and statistically significant rises in all‐cause and cardiovascular mortalities, is observed. Shifts in energy demand are also unveiled with a noticeable spike in cooling‐degree days and a reduction in heating‐degree days. …”
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Machine learning-based plasma metabolomics for improved cirrhosis risk stratification by Jingru Song, Ziwei Gao, Liqun Lai, Jie Zhang, Binbin Liu, Yi Sang, Siqi Chen, Jiachen Qi, Yujun Zhang, Huang Kai, Wei Ye

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Emulation of ARISTOTLE and ROCKET AF trials in real-world atrial fibrillation patients results in similar efficacy and safety as original landmark trials: insights from the GARFIEL... by Ralf E Harskamp, Karen Pieper, A John Camm, Ajay K Kakkar, Jelle C L Himmelreich, Saverio Virdone, Jean-Pierre Bassand, Frank Misselwitz, Freek W A Verheugt, Frank Cools, Harry Gibbs, Antônio C Pereira-Barretto

“…Real-world AF patients selected according to trial criteria had lower cardiovascular burden than the original trial participants, especially compared with ROCKET AF. …”
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A Multicenter Observational Prospective Cohort Study of Association of the Prehospital National Early Warning Score 2 and Hospital Triage with Early Mortality by Francisco Martín-Rodríguez, Raúl López-Izquierdo, Carlos del Pozo Vegas, Juan F. Delgado-Benito, Carmen del Pozo Pérez, Virginia Carbajosa Rodríguez, Agustín Mayo Iscar, José Luis Martín-Conty, Carlos Escudero Cuadrillero, Miguel A. Castro-Villamor

“…Early mortality within the first 48 hours after the index event affected 55 patients (5.2%), of which 23 cases (41.8%) had causes of cardiovascular origin. In the stratification by triage levels, the AUC of the NEWS2 obtained for short-term mortality varied between 0.77 (95% CI: 0.65-0.89) for level I and 0.94 (95% CI: 0.79-1) for level III. …”
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Current applications and challenges in large language models for patient care: a systematic review by Felix Busch, Lena Hoffmann, Christopher Rueger, Elon HC van Dijk, Rawen Kader, Esteban Ortiz-Prado, Marcus R. Makowski, Luca Saba, Martin Hadamitzky, Jakob Nikolas Kather, Daniel Truhn, Renato Cuocolo, Lisa C. Adams, Keno K. Bressem

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Prevalence, management, and outcomes of haemorrhagic events in left ventricular assist device recipients by Laetitia Pourtau, Maxime Beneyto, Jean Porterie, Jerome Roncalli, Montse Massot, Caroline Biendel, Pauline Fournier, Romain Itier, Michel Galinier, Olivier Lairez, Clement Delmas

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Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure by Sophie Shen, Tessa Werner, Samuel W. Lukowski, Stacey Andersen, Yuliangzi Sun, Woo Jun Shim, Dalia Mizikovsky, Sakurako Kobayashi, Jennifer Outhwaite, Han Sheng Chiu, Xiaoli Chen, Gavin Chapman, Ella M. M. A. Martin, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Men Chee Tan, Enakshi Sinniah, Qiongyi Zhao, Sumedha Negi, Meredith A. Redd, Joseph E. Powell, Sally L. Dunwoodie, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant

“…Interrogation of temporal and signalling-specific gene expression in this atlas, evaluated against cell type-specific gene expression in human complex trait data highlights the WNT-inhibitor gene TMEM88 as a regulator of mesendodermal lineages influencing cardiovascular and anthropometric traits. Genetic TMEM88 loss of function models show impaired differentiation of endodermal and mesodermal derivatives in vitro and dysregulated arterial blood pressure in vivo. …”
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Home-Based Intervention Tool for Cardiac Telerehabilitation: Protocol for a Controlled Trial by Francesca Mastorci, Maria Francesca Lodovica Lazzeri, Lamia Ait-Ali, Paolo Marcheschi, Paola Quadrelli, Massimiliano Mariani, Rafik Margaryan, Wanda Pennè, Marco Savino, Giuseppe Prencipe, Alina Sirbu, Paolo Ferragina, Corrado Priami, Alessandro Tommasi, Cesare Zavattari, Pierluigi Festa, Stefano Dalmiani, Alessandro Pingitore

“… BackgroundAmong cardiovascular diseases, adult patients with congenital heart disease represent a population that has been continuously increasing, which is mainly due to improvement of the pathophysiological framing, including the development of surgical and reanimation techniques. …”
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Cardio-renal effect of dapagliflozin and dapagliflozin- saxagliptin combination on CD34 + ve hematopoietic stem cells (HSCs) and podocyte specific markers in type 2 diabetes (T2DM)... by Seshagiri Rao Nandula, Arad Jain, Sabyasachi Sen

“…Therefore, contrary to our initial hypothesis we do not believe the more expensive Dapa + Saxa combination offers any specific cardiovascular benefit compared to Dapagliflozin alone. …”
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Bronchiectasis Exacerbation Increases the Risk of Adverse Renal Outcomes—Results From a Large Territory‐Wide Cohort Study by Wang Chun Kwok, Chung Ki Tsui, Leung Sze Him Isaac, Chun Ka Emmanuel Wong, Terence Chi Chun Tam, James Chung Man Ho, Desmond Yat Hin Yap

“…ABSTRACT Introduction Bronchiectasis exacerbation (BE) is associated with unfavorable sequelae in other organs such as the cardiovascular system; data regarding its impact on adverse term renal outcomes, however, is lacking. …”
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The Effect of Combining mHealth and Health Professional–Led Intervention for Improving Health-Related Outcomes in Chronic Diseases: Systematic Review and Meta-Analysis by Masashi Kanai, Takahiro Miki, Toshiya Sakoda, Yuta Hagiwara

“… BackgroundChronic diseases such as diabetes and cardiovascular disease are global health challenges, affecting millions of people worldwide. …”
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Exploring the genotypic potential of perilla (Perilla frutescens L.) for climate-resilient agriculture in the North Eastern Himalayas by Meraj Alam Ansari, Meraj Alam Ansari, Amit Kumar, T. P. Ahammed Shabeer, Alok Kumar, Subhra Saikat Roy, Subhra Saikat Roy, Majhrool Hak Ansari, Raghavendra Singh, Raghavendra Singh, Moirangthem Sangeeta, Jayanta Layek, Narendra Prakash, Vinay K. Mishra

“…Large-scale cultivation of perilla improves food security and offers numerous health benefits, including cardiovascular support and disease prevention, thereby enhancing human wellbeing. …”
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