Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR by Zhongxia Wang, Tao Zhang, Lizhe Sun, Ruifeng Li, Yuanyuan Wei, Xiaojuan Fan, Zuyi Yuan, Junhui Liu, Tao Chen

“…The biologic roles of peroxisome proliferator-activated receptor-γ (PPAR-γ) activators thiazolidinedione (TZD) remain controversial in cardiovascular disease. Herein, we investigated the antiinflammatory effects of pioglitazone (PIO) on circulating peripheral blood mononuclear cells (MNCs) in patients after coronary DES implantation. …”
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Advanced heart failure: guideline‐directed medical therapy, diuretics, inotropes, and palliative care by Daniela Tomasoni, Julie K.K. Vishram‐Nielsen, Matteo Pagnesi, Marianna Adamo, Carlo Mario Lombardi, Finn Gustafsson, Marco Metra

“…However, in the recent Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial, omecamtiv mecarbil was safe and effective in the reduction of the primary outcome of cardiovascular death or HF event compared with placebo (hazard ratio, 0.92; 95% confidence interval, 0.86–0.99; P = 0.03) and its effects were larger in those patients with more severe left ventricular dysfunction. …”
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The Effects of Thyroid Hormone Levels on Patent Ductus Arteriosus Closure in Newborns by Basak KAYA, Hasan AKDUMAN, Dilek DILLI, Semra CETINKAYA, Ahmet OKTEM, Utku Arman ORUN, Mehmet TASAR, Aysegul ZENCIROGLU

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How do staff work in NHS hospital operations management meetings to support resilience in everyday service delivery? A qualitative study by L. Sutton, C. Tarrant, J. Willars, T. Coats, M. Simmonds, D. Mclean, A. Boyle, K. Dreesbeimdiek, S. Richter, A. Oyedijo, D. Roland

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Association between estimated pulse wave velocity and in-hospital mortality of patients with acute kidney injury: a retrospective cohort analysis of the MIMIC-IV database by Xinhai Cui, Yuanlong Hu, Dongxiao Li, Mengkai Lu, Zhiyuan Zhang, Dongfang Kan, Chao Li

“…Background Estimated pulse wave velocity (ePWV) has been found to be an independent predictor of cardiovascular mortality and kidney injury, which can be estimated noninvasively. …”
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The BET inhibitor JQ1 targets fat metabolism and counteracts obesity by Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna

“…Introduction: Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other disorders such as type II diabetes, cardiovascular disorders, physical disability, frailty and sarcopenia. …”
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The Growing Obesity Epidemic: Integrating Lifestyle, Pharmacological, and Surgical Interventions for Effective Management by Jan Siwiec, Olga Śpiołek, Agnieszka Wąsowicz, Marcelina Sztyler-Krąkowska, Mateusz Teofilak, Natalia Smyl, Aleksandra Słowikowska, Julia Szatkowska, Franciszek Kędziora, Dariusz Fabian

“… Introduction: Obesity is a multifactorial disease with a growing global prevalence, significantly increasing the risk of numerous health conditions, including type 2 diabetes and cardiovascular diseases. Its management requires a multifaceted approach that includes lifestyle modifications, pharmacologic interventions and, in severe cases, surgical treatments. …”
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Proceso del cuidado aplicado en adulto mayor con hipertensión arterial by Geraldine Ruby Báez Rentera, Levi Rebeca Morales Miranda, Tamara Angela Ortega Albornoz, Chanell Sthefany Rafaile Bada, Milagros Lizbeth Uturunco Vera, Petronila Elizabeth Alvarado Chavez

“…En el quinto diagnóstico enfermero, aflicción crónica, su puntuación de cambio fue +3 y en el sexto diagnóstico enfermero, riesgo de deterioro de la función cardiovascular, su puntuación de cambio fue +3. …”
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Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis by Xiaohan Liu, Yang Zhang, Youzhao Wang, Yujie Yang, Zhe Qiao, Ping Zhan, Huiying Jin, Qianqian Xu, Wei Tang, Yu Sun, Yan Zhang, Fan Yi, Min Liu

“…Myeloid‐derived growth factor (MYDGF), a novel secreted protein, plays important roles in multiple cardiovascular diseases, but the function of MYDGF in tubular epithelial cells remains unknown. …”
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Sinomenine attenuates uremia vascular calcification by miR-143-5p by Fengyi Yu, Zhong Peng, Ning Gao, Zixu Tang, Zihao Liao, Song Zhao, Shuzhu Zhong, Gloria Umwiza, Hong Huang, Wei Long, Zhangxiu He

“…Abstract Vascular calcification is considered to be a killer of the cardiovascular system, involved inflammation and immunity. …”
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Significant Calcification of an Entire Aortic Tree with Renal Artery Subocclusion: Acute Kidney Injury, Ischemic Kidney Disease, and the Tissue Viability Question—A Case Report by Marko Baralić, Selena Gajić, Aleksandra Kezić, Ana Bontić, Jelena Pavlović, Voin Brković, Vidna Karadžić Ristanović, Danka Bjelić, Maja Životić, Sanja Radojević-Škodrić, Želimir Antonić, Nenad Ilijevski, Milan Radović

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Assessment of Bendopnea and Its Association With Clinical and Para‐Clinical Findings in Systolic Heart Failure: A Cross‐Sectional Study by Elmira Javanmardi, Tara Reshadmanesh, Sepehr Gohari, Amir Hossein Behnoush, Hassan Ahangar

“…Patients with reduced ejection fraction were followed to assess the 2‐year outcomes for cardiovascular death and rehospitalization. Results A total of 80 patients were included in this study, of whom 54 (67.5%) were male. …”
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The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy by Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li

“…Epilepsy often coexists with cardiovascular disease, cognitive dysfunction, depression, etc., which seriously affects the patient's quality of life. …”
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Post-traumatic Growth in the Link with Resilience, Self-compassion, and the Personal and Clinical Characteristics in Adolescents with Life-threatening Disease: A Cross-sectional Co... by Zahra Ghasemi, Manijeh Nourian, Azam Shirinabadi Farahani, Amir Heidari, Maliheh Nasiri

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Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-κB Pathway by Katyakyini Muniandy, Sivapragasam Gothai, Khaleel M. H. Badran, S. Suresh Kumar, Norhaizan Mohd Esa, Palanisamy Arulselvan

“…However, prolonged inflammation can be detrimental as it is related to many chronic diseases such as delayed wound healing, cardiovascular disease, arthritis, and autoimmune disorders. …”
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Oligonucleotide and Parylene Surface Coating of Polystyrene and ePTFE for Improved Endothelial Cell Attachment and Hemocompatibility by Martina Schleicher, Jan Hansmann, Bentsian Elkin, Petra J. Kluger, Simone Liebscher, Agnes J. T. Huber, Olaf Fritze, Christine Schille, Michaela Müller, Katja Schenke-Layland, Martina Seifert, Heike Walles, Hans-Peter Wendel, Ulrich A. Stock

“…In vivo self-endothelialization by endothelial cell adhesion on cardiovascular implants is highly desirable. DNA-oligonucleotides are an intriguing coating material with nonimmunogenic characteristics and the feasibility of easy and rapid chemical fabrication. …”
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Associations of daily steps and step intensity with peripheral arterial disease in Chinese community-dwelling older women by Chenfei Li, Litao Du, Xiangli Xue, Na Zhao, Qiang He, Si Chen, Xianliang Zhang

“…Increasing the intensity during walking may be a viable strategy to reduce the risk of PAD in self-care and cardiovascular nursing.…”
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Influence of the Coronavirus Disease 2019 Pandemic on Patients with ST-Segment Elevation Myocardial Infarction in Taiwan by Yuan-Heng Su, Kuan-Han Wu, Chih-Min Su, Chi-Yung Cheng, Cheng-I Cheng, Chia-Te Kung, Fu-Cheng Chen

“…In this single-center, retrospective cohort study, we compared the clinical pictures of nontransfer patients who presented to the emergency department directly and received primary percutaneous cardiovascular intervention (PPCI) from February 1 to April 30, 2020 (group 2, N = 28), with patients who received PPCI from February 1 to April 30, 2016–2019 (group 1, N = 130). …”
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Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis by Hamdy A. Makhlouf, Amr K. Hassan, Nereen A. Almosilhy, Ahmed S.A. Osman, Shrouk Ramadan, Moaz Elsayed Abouelmagd

“…Conclusions Statins, already well-established for cardiovascular benefits, emerge as a promising dual-purpose therapy for many neurological disorders. …”
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Association between systemic immune-inflammation index and the risk of all-cause, cancer and non-cancer mortality in the general population: results from national health and nutrit... by Siyu Wu, Zhao Liu, Xing Li, Shan Gao, Peng Xia

“…Summary Background Inflammation plays an important role in the progression of cancer and other diseases, such as diabetes and cardiovascular and cerebrovascular diseases. The systemic immune-inflammation index (SII) was recognized as an objective biomarker reflecting immunoinflammatory status. …”
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