ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation by Ruiping Cao, Dian Fang, Jiahui Wang, Ying Yu, Hongwei Ye, Pinfang Kang, Zhenghong Li, Hongju Wang, Qin Gao

Get full text

Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, Spain by Beatriz Fernández-Vallejo, Francisco Jiménez Monteagudo, Lourdes Romero, Maria Isabel López Aznárez, María del Carmen Romero Cobas, Laura Pérez-Martínez

“…Background: Childhood obesity is a major public health concern, being linked to an increased risk of metabolic disorders and cardiovascular disease. Even in childhood, obesity is associated with systemic low-grade inflammation, which is a critical factor in the development of atherosclerosis and a predictor of cardiovascular morbidity and mortality. …”
Get full text

Home Healthcare Medication Safety risks among older adults with chronic diseases: a qualitative study by Tahereh Najafi Ghezeljeh, Zahra Amrollah Majdabadi Kohne, Mansoureh Ashghali Farahani, Forough Rafii, Sahar Keyvanloo Shahrestanaki

Get full text

Empowering access: unveiling an overall composite spatial accessibility index to healthcare services in Southeastern Iran by Ahmad Raeesi, Soheil Hashtarkhani, Mahmood Tara, Narjes Sargolzaei, Behzad Kiani

Get full text

PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury by Hui Liu PhD, MD, Hongjun Jin PhD, Xuyi Yue PhD, Junbin Han PhD, Pamela Baum SRS, Dana R. Abendschein PhD, Zhude Tu PhD

Get full text

Acute and prolonged toxicity assessment of Cannabis sativa extract in rodents and lagomorphs by Alana C. Costa, Arquimedes Gasparotto, Jr., Alana A.K. Garcia, Cícero A.C. Pereira, Emerson L.B. Lourenço, Helena P.G. Joaquim

“…Additionally, administering the extract acutely to rabbits had minimal impact on the central nervous, cardiovascular, and respiratory systems, with only a temporary reduction in motor activity at the highest dose. …”
Get full text

Clinical characteristics and outcomes in Asian patients with heart failure with mildly reduced ejection fraction by Julian Cheong Kiat Tay, Shaw Yang Chia, Siew Hui Michelle Koh, David Kheng Leng Sim, Ping Chai, Seet Yoong Loh, Fazlur Rehman Jaufeerally, Sheldon Shao Guang Lee, Patrick Zhan Yun Lim, Jonathan Yap

“…This was similarly seen with cardiovascular mortality and HF hospitalisations, with the exception of similar HF hospitalisations between HFmrEF and HFpEF patients. …”
Get full text

Prognostic Value of Atherosclerotic Extent in Diabetic Patients with Nonobstructive Coronary Artery Disease by Yipu Ding, Zinuan Liu, Guanhua Dou, Xia Yang, Xi Wang, Dongkai Shan, Bai He, Jing Jing, Yundai Chen, Junjie Yang

“…During a median follow-up of 31.77 months, 50 major adverse cardiovascular events (MACEs) (6.15%) were experienced, including 2 cardiovascular deaths, 14 nonfatal myocardial infarctions, 27 unstable anginas requiring hospitalization, and 7 strokes. …”
Get full text

Possibility of Using NO Modulators for Pharmacocorrection of Endothelial Dysfunction After Prenatal Hypoxia by Igor Belenichev, Olena Popazova, Oleh Yadlovskyi, Nina Bukhtiyarova, Victor Ryzhenko, Sergii Pavlov, Valentyn Oksenych, Oleksandr Kamyshnyi

“…Prenatal hypoxia (PH) is a key factor in the development of long-term cardiovascular disorders, which are caused by various mechanisms of endothelial dysfunction (ED), including those associated with NO deficiency. …”
Get full text

Machine Learning-Based predictive model for adolescent metabolic syndrome: Utilizing data from NHANES 2007–2016 by Yu-zhen Zhang, Hai-ying Wu, Run-wei Ma, Bo Feng, Rui Yang, Xiao-gang Chen, Min-xiao Li, Li-ming Cheng

“…Abstract Metabolic syndrome (Mets) in adolescents is a growing public health issue linked to obesity, hypertension, and insulin resistance, increasing risks of cardiovascular disease and mental health problems. Early detection and intervention are crucial but often hindered by complex diagnostic requirements. …”
Get full text

The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study by Jundong Yang, Wenjun Xue, Zhicheng Wei, Caiqiong Hou, Huaming Zhu, Huajun Xu, Xiaolin Wu, Yunhai Feng, Xinyi Li

“…Obstructive sleep apnoea (OSA) is associated with an increased risk of cardiovascular disease, with alterations in coagulability suspected as the mediating factor. …”
Get full text

Economic and Clinical Impact of Stroke and Warfarin Use for Patients with Non-valvular Atrial Fibrillation by Li Wang, Elyse Fritschel, Onur Baser

“…Risk-adjusted overall and cardiovascular-related hospital readmission rates in 30 days, length of stay (LOS), clinical outcomes, and health care costs were assessed using propensity score matching. …”
Get full text

Surgical techniques and prognostic nomogram for patients with supravalvular aortic stenosis by Yuekun Sun, Lizhi Lv, Xinyue Lang, Aihua Zhi, Simeng Zhang, Cheng Wang, Qiang Wang

Get full text

Residual Dyslipidemia Leads to Unfavorable Outcomes in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention by Bin Que, Chunmei Wang, Hui Ai, Xinyong Zhang, Mei Wang, Shaoping Nie

“…For the follow-up study, major adverse cardiovascular cerebrovascular events (MACCE; including total death, cardiovascular death, myocardial infarction, and revascularization) were documented. …”
Get full text

CYP2C19 Genotype‐Guided Antiplatelet Therapy and Clinical Outcomes in Patients Undergoing a Neurointerventional Procedure by Kayla R. Tunehag, Ashton F. Pearce, Layna P. Fox, George A. Stouffer, Sten Solander, Craig R. Lee

“…In patients with cardiovascular disease undergoing a percutaneous coronary intervention, CYP2C19 no‐function allele carriers treated with clopidogrel experience a higher risk of major adverse cardiovascular outcomes, and multiple large prospective outcomes studies have shown an improvement in clinical outcomes when antiplatelet therapy selection was guided by CYP2C19 genotype. …”
Get full text

Polymorphisms of Vitamin D Signaling Pathway Genes and Calcium-Sensing Receptor Gene in respect to Survival of Hemodialysis Patients: A Prospective Observational Study by Alicja E. Grzegorzewska, Monika K. Świderska, Adrianna Mostowska, Wojciech Warchoł, Paweł P. Jagodziński

“…In conclusion, GC rs2298849 and VDR rs2228570 SNPs are associated with survival on HD. VDR-related cardiovascular mortality may occur due to connections of rs2228570 with dyslipidemia.…”
Get full text

Infarct‐like myocarditis with coronary vasculitis and aneurysm formation caused by Epstein–Barr virus infection by Cristina Chimenti, Romina Verardo, Claudia Grande, Marco Francone, Andrea Frustaci

Get full text

Vitamin D Supplementation and Hemoglobin Levels in Hypertensive Patients: A Randomized Controlled Trial by Jana B. Ernst, Andreas Tomaschitz, Martin R. Grübler, Martin Gaksch, Katharina Kienreich, Nicolas Verheyen, Winfried März, Stefan Pilz, Armin Zittermann

Get full text

Effect of breathing exercises with biofeedback on blood pressure in pre-hypertensive women: a randomised controlled trial by Afaf M. Botla, Reham S. Ebrahim, Soheir M. Elkosery, Ahmed M. Darwesh, Dina M.A. Mohamed

“…Introduction Pre-hypertensive women are significantly more likely to develop hypertension or serious cardiovascular disease (CV). Autonomic nervous system abnormalities, such as sympathetic overactivity and parasympathetic withdrawal, are most likely the earliest functional changes in hypertension. …”
Get full text

Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial by Nour Elkhair Ali, Lamis AbdelGadir Kaddam, Suad Yousif Alkarib, Babikir Gabir Kaballo, Sami Ahmed Khalid, Abdalazim Higawee, Alaa AbdElhabib, Alaa AlaaAldeen, Aled O. Phillips, Amal Mahmoud Saeed

“…Oxidative stress (OS) is a risk factor of atherosclerosis and cardiovascular complications, which are major causes of mortality among ESRD patients. …”
Get full text