GnRH Agonist versus hCG Trigger in Ovulation Induction with Intrauterine Insemination: A Randomized Controlled Trial by Minh Tam Le, Dac Nguyen Nguyen, Jessica Zolton, Vu Quoc Huy Nguyen, Quang Vinh Truong, Ngoc Thanh Cao, Alan Decherney, Micah J. Hill

“…A clinical pregnancy was defined as the presence of gestational sac with fetal cardiac activity. There was no difference in ovulation rates in either group receiving GnRHa or hCG trigger for ovulation. …”
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Application of Handheld Tele-ECG for Health Care Delivery in Rural India by Meenu Singh, Amit Agarwal, Vineet Sinha, Rohit Manoj Kumar, Nishant Jaiswal, Ishita Jindal, Pankaj Pant, Munish Kumar

“…The objective of our study was clinical validation of handheld tele-ECG as a screening tool for evaluation of cardiac diseases in the rural population. ECG was obtained in 450 individuals (mean age 31.49 ± 20.058) residing in the periphery of Chandigarh, India, from April 2011 to March 2013, using the handheld tele-ECG machine. …”
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Nanobody-thioesterase chimeras to specifically target protein palmitoylation by Chien-Wen Kuo, Caglar Gök, Hannah Fulton, Eleanor Dickson-Murray, Samuel Adu, Emily K. Gallen, Sheon Mary, Alan D. Robertson, Fiona Jordan, Emma Dunning, William Mullen, Godfrey L. Smith, William Fuller

“…Using a thioesterase fused to a nanobody directed against the Ca(v)1.2 beta subunit we reduce palmitoylation of the Ca(v)1.2 alpha subunit, modifying the channel’s voltage dependence and arrhythmia susceptibility in stem cell derived cardiac myocytes. We conclude that nanobody enzyme chimeras represent an approach to specifically manipulate PTMs, with applications in both the laboratory and the clinic.…”
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Deaths during Sexual Activity by Agnė Okulevičiūtė, Sigitas Chmieliauskas, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“…The perforation led to complications, including purulent diffuse peritonitis, intoxication, and acute cardiac and respiratory failure, resulting in death within 3-6 hours after insertion. …”
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Association of non-selective β blockers with the development of renal dysfunction in liver cirrhosis: a systematic review and meta-analysis by Xiangbo Xu, Fangbo Gao, Ting Wang, Zuyao Yang, Qingchun Zhao, Xingshun Qi

“…Background & Aims Non-selective β blockers (NSBBs) may negatively influence renal function through decreasing heart rate and cardiac output. This study aimed to systematically investigate their association.Methods PubMed, EMBASE, and Cochrane library databases were searched to identify all relevant studies evaluating the association of NSBBs with renal dysfunction in cirrhotic patients. …”
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Myocardial Perfusion Scintigraphy in Ischemic Heart Disease by Sonia María Sánchez Valcarcel, Katia Ravelo Llanes, Iván Rodríguez Cortina, Geovedy Martínez García, Cesia Rivera Garmendia

“…The fall in the post-stress left ventricular ejection fraction behaved as a predictive variable of future cardiac events.…”
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Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial by Matthias Behrends, Marc Alan Buren, Alekos Theologis, Ariadne Zuraek, Aaron J Clark, Jacqueline M Leung

“…Introduction Postoperative delirium is a frequent adverse event following elective non-cardiac surgery. The occurrence of delirium increases the risk of functional impairment, placement to facilities other than home after discharge, cognitive impairment at discharge, as well as in-hospital and possibly long-term mortality. …”
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Clinical and Prognostic Significance of Idiopathic Left Bundle-Branch Block in Young Adults by Pietro Delise, Luigi Rivetti, Giuseppe Poletti, Monica Centa, Giuseppe Allocca, Nadir Sitta, Arianna Cati, Giovanni Turiano, Emanuela Lanari, Paolo Zeppilli, Luigi Sciarra

“…Thirty patients underwent cardiac magnetic resonance; in 60% it was normal, while in 40% it revealed late enhancement, which in 33% was localized in the basal septum, suggesting fibrosis of the left bundle branch. …”
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Mesothelioma in Two Nondomestic Felids: North American Cougar (Felis concolor) and Cheetah (Acinonyx jubatus) by Amanda Whiton, Juergen Schumacher, Erika E. Evans, Janelle M. Novak, Amanda Crews, Edward Ramsay, Robert Donnell

“…During attempts to remove the fluid, cardiac tamponade developed and the cat died. At necropsy, nodular masses decorated the pericardium at the level of the base of the heart. …”
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Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction by Elizabeth J. Wright, Nigel W. Hodson, Michael J. Sherratt, Moustapha Kassem, Andrew L. Lewis, Christine Wallrapp, Nadim Malik, Cathy M. Holt

“…We examined the effects of MSCs, either native, or engineered to secrete a GLP-1 fusion protein (MSCs ± GLP-1), on human cardiomyocyte apoptosis in vitro. The effect on cardiac remodeling when encapsulated in alginate beads (CellBeads-MSC and CellBeads-MSC + GLP-1) was also evaluated in a pig MI model, whereby pigs were treated with Empty Beads, CellBeads-MSC, or CellBeads-MSC + GLP-1 and sacrificed at one or four weeks following MI. …”
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Comparisons between chest trunk mobilization with sustained maximum inspiration and flow incentive spirometry on chest expansion, respiratory muscle strength, and functional exerci... by Khanistha Wattanananont, Sasipa Buranapuntalug, Sira Laohathai

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Role of Terlipressin in Cirrhotic Patients with Ascites and without Hepatorenal Syndrome: A Systematic Review of Current Evidence by Zhaohui Bai, Yang An, Xiaozhong Guo, Rolf Teschke, Nahum Méndez-Sánchez, Hongyu Li, Xingshun Qi

“…In 3 studies (1 randomized controlled trial and 2 single-arm studies without controls) involving 32 patients who received terlipressin for nonrefractory ascites, terlipressin improved hemodynamics by decreasing the heart rate and cardiac output and increasing the mean arterial pressure and systemic vascular resistance. …”
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Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtili... by Berick Moturi Sieberi, George Isanda Omwenga, Rachael Kitondo Wambua, Judith Chemutai Samoei, Mathew Piero Ngugi

“…Phytochemical screening of the DCM-MeOH extract revealed the presence of alkaloids, flavonoids, phenolics, terpenoids, cardiac glycosides, saponins, steroids, and tannins. …”
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Impact of Body Mass Index on Short-Term Outcomes in Patients Undergoing Percutaneous Coronary Intervention in Newfoundland and Labrador, Canada by Anne B. Gregory, Kendra K. Lester, Deborah M. Gregory, Laurie K. Twells, William K. Midodzi, Neil J. Pearce

“…Patients with obesity were younger and had a higher incidence of diabetes, hypertension, and family history of cardiac disease. Obese patients experienced less vascular complications (normal, overweight, and obese: 8.2%, 7.2%, and 5.3%, p=0.001). …”
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Interventional real-time molecular MRI for targeting early myocardial injury in a pig model by Timo Heidt, Simon Reiss, Julien Thielmann, Christian Weber, Alexander Maier, Thomas Lottner, Heidi R. Cristina-Schmitz, Timon Bühler, Diana Chiang, Claus Jülicher, Carolin Wadle, Ingo Hilgendorf, Dennis Wolf, Gavin Tumlinson, Luis Hortells, Dirk Westermann, Michael Bock, Constantin von zur Mühlen

“…Here, we assessed ischemic cardiac lesions non-invasively directly after ischemia/reperfusion (I/R) in a porcine model by advanced MRI techniques and molecular imaging, targeting the cell adhesion molecule P-selectin functionalized with microparticles of iron oxide (MPIO). …”
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Can the Onset of Type 2 Diabetes Be Delayed by a Group-Based Lifestyle Intervention in Women with Prediabetes following Gestational Diabetes Mellitus (GDM)? Findings from a Randomi... by Angela O’Dea, Marie Tierney, Brian E. McGuire, John Newell, Liam G. Glynn, Irene Gibson, Eoin Noctor, Andrii Danyliv, Susan B. Connolly, Fidelma P. Dunne

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Kounis Syndrome as First Manifestation of Allergic Sensitization by D. Forlani, G. Scarano, A. D’Alleva, M. Di Marco, L. Paloscia, A. Gatta, L. Della Valle, A. Farinelli, A. Lumaca, C. Petrarca, R. Paganelli, L. Di Giampaolo, M. Di Gioacchino

“…Conversely, measurement of cardiac biomarkers during anaphylaxis, even without obvious signs of myocardial ischemia, might identify patients at risk of myocardial injury.…”
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Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell-Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after Circulatory Death Hearts by Zifeng Zeng, Liwei Xu, Yu Xu, Yongsheng Ruan, Deshen Liu, Jiale Li, Chuanjie Niu, Shaoyi Zheng, Pengyu Zhou, Zezhou Xiao

“…Vehicle or CM (300 μl) was added to the perfusate at the beginning of the perfusion process. The cardiac function of DCD hearts in the DCD-Control and DCD-CM groups was measured every 30 minutes. …”
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Similarities and Differences between Coronavirus Disease 2019-related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease in Indian Patients by Utkarsh Singh, Suhas Prabhu, Deepak Phalgune

“…The primary objectives were to compare the gastrointestinal manifestations between the two groups, whereas the secondary objectives were to compare the mucocutaneous and cardiac manifestations. Results: The mean duration of fever was significantly longer in children with KD compared to those with MIS-C. …”
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Preclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency by Maximiliano Presa, Rachel M. Bailey, Somdatta Ray, Lauren Bailey, Saurabh Tata, Tara Murphy, Pierre-Alexandre Piec, Harold Combs, Steven J. Gray, Cathleen Lutz

“…The treated mice show wide distribution of the SUMF1 gene, no signs of toxicity or neuropathy, improved vision and cardiac function, and no behavioral deficits. One-year post treatment, tissues show increased sulfatase activity, indicating functional SUMF1. …”
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