A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis by Rolf Müller, Martin Kömhoff, Jeffrey M. Peters, Sabine Müller-Brüsselbach

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Saliva: Physiology and Diagnostic Potential in Health and Disease by Sebastien J. C. Farnaud, Ourania Kosti, Stephen J. Getting, Derek Renshaw

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The Mammary Gland Carcinogens: The Role of Metal Compounds and Organic Solvents by Stephen Juma Mulware

“…Despite the fact that women who inherited mutations in the BRCA1 and BRCA2 genes have a high risk of developing breast cancer, studies have also shown that significant exposure to certain metal compounds and organic solvents also increases the risks of mammary gland carcinogenesis. While physiological properties govern the uptake, intracellular distribution, and binding of metal compounds, their interaction with proteins seems to be the most relevant process for metal carcinogenicity than biding to DNA. …”
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The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas by Elias A. El Habr, Christos Adamopoulos, Georgia Levidou, Aggeliki A. Saetta, Penelope Korkolopoulou, Christina Piperi

“…Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. …”
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Black Pepper’s Anti-Aging and Chemoprevention Properties: A Review by Endah

“…Additionally, cell cycle regulation, antiangiogenic and anti-metastatic action, apoptosis induction, and the suppression of carcinogenesis are some of the mechanisms utilized in cancer prevention activities. …”
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Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation by Vladimir Jurišić, Jasmina Obradovic, Sonja Pavlović, Nataša Djordjevic

“…The accumulation of knowledge regarding SNPs lately suggests their significant and important role in the onset of carcinogenesis, the prediction of the onset of metastases, the response to therapy with TKI inhibitors, and the onset of toxic effects of the applied therapy. …”
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Lung Cancer Associated with Neurofibromatosis Type I by Anastasia Oikonomou, Dimitrios Mikroulis, Paraskevi Mintzopoulou, Lawal Lukman, Panos Prassopoulos

“…There is some evidence that a genetic linkage between neurofibromatosis and carcinogenesis in the lung may exist. We present a 42-year-old female, lifetime nonsmoker with a known history of neurofibromatosis type I, free of respiratory symptoms, who underwent a low-dose HRCT of the lungs to investigate any occult interstitial lung changes. …”
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Renal Cancer Stem Cells: Characterization and Targeted Therapies by Anna Julie Peired, Alessandro Sisti, Paola Romagnani

“…In conclusion, CSCs are an important player in carcinogenesis and represent a valid target for therapy in RCC patients.…”
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Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma by Somaya Safi, Yousra Benabdelfedil, Sara Derrou, Faycal El Guendouz

“…The unusual association of thyroid adenocarcinoma and TSHoma enriches the hypothesis of a potential link between thyrotropic hypersecretion and thyroid carcinogenesis. Our case also illustrates the difficulty of monitoring thyroid carcinoma in nonremission of a TSHoma.…”
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Association between Probiotics and Modulation of Gut Microbial Community Composition in Colorectal Cancer Animal Models: A Systematic Review (2010–2021) by Shabnam Zeighamy Alamdary, Shahnaz Halimi, Akram Rezaei, Roghayeh Afifirad

“…The goal of this systematic review was to gather the preclinical studies that examined the impact of probiotics on the alteration of gut microbiota profiles (bacterial communities) and their link to colorectal carcinogenesis as well as the potential processes involved. …”
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Antipsychotic-induced hyperprolactinemia: Toxicologic mechanism and the increased breast cancer risk by Steven B. Bird

“…As many breast cancers are responsive to prolactin concentrations, the persistent increase in prolactin of the antipsychotics has implications for public health and carcinogenesis. The objective of this study was to review the extant literature on hyperprolactinemia due to antipsychotics, and to determine the risk imposed by those drugs on human breast cancer. …”
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A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment by Aoling Huang, Haochen Xue, Ting Xie, Lingyan Xiang, Zhengzhuo Chen, Aolong Ma, Honglin Yan, Jingping Yuan

“…Altered mitochondrial function plays a critical role in various diseases, and recent studies have elucidated its pathophysiological mechanisms in breast carcinogenesis. This review explores the role of mitochondrial dysfunction in breast cancer pathogenesis and assesses potential mitochondria-targeted therapies.…”
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Prognostic Parameters for the Primary Care of Melanoma Patients: What Is Really Risky in Melanoma? by Daniela Göppner, Martin Leverkus

“…This review summarizes the current understanding of carcinogenesis and gives a detailed overview of known morphologic and potentially future genetic prognostic parameters in malignant melanoma.…”
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ESTRÉS OXIDATIVO EN PECES INDUCIDO POR CONTAMINANTES AMBIENTALES by DM Ochoa, JF González

“…el estrés oxidativo inducido por diversas clases de contaminantes como mecanismo de toxicidad ha sido un foco de interés en el campo de la toxicología acuática y ambiental durante la última década. numerosas evidencias indican que muchos de estos agentes con-taminantes al llegar a cuerpos de agua pueden desencadenar el proceso de estrés oxidativo en organismos que allí habitan, y son responsables de efectos en células y tejidos asociados a mutagénesis y carcinogénesis. el estrés oxidativo se genera cuando existe una sobrecar-ga en la formación de radicales libres o agentes prooxidantes, la cual no es debidamente compensada por los mecanismos de defensa antioxidante que posee el organismo. …”
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Oxidative Stress and DNA Methylation in Prostate Cancer by Krishna Vanaja Donkena, Charles Y. F. Young, Donald J. Tindall

“…Oxygen radicals are associated with different steps of carcinogenesis, including structural DNA damage, epigenetic changes, and protein and lipid alterations. …”
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A Rare Extraskeletal Osteosarcoma Appearing After 55 Years on a Large Stage 3 Burn Scar by O. Vanhooteghem, I. Theate

“…Deep stage 3 burned areas may facilitate deeper carcinogenesis. Deep tissues are probably less subject to severe insult than is the epithelial layer during physical insult, suggesting that soft tissues transform to a lesser extent during the late stages of tumoral development as in an immunocompromised district with altered local immune defense with both cellular and humoral defense affected. …”
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Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers by Zhihao Lu, Mingfei Geng, Yongtao Han, Jianzhong Cao, Jun Wang, Tianshu Liu, Xianglin Yuan, Xue Meng, Yanqiao Zhang, Rong Zhao, Lixin Wan, Enxiao Li, Wenran Wang, Zhijie Li, Danfeng Shi, Jing Qian, Si Shi, Fengshi Dong, Lin Shen

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Relationship between programmed cell death and targeted therapy for thyroid cancer in patients with a poor prognosis: an update by Yuejia Zhao, Simeng Zhao, Zhe Fan, Yongfu Zhao, Guangzhi Wang

“…Therefore, a comprehensive understanding of the underlying carcinogenesis mechanisms of thyroid cancer is required. …”
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Combination Therapy of PPAR𝛾 Ligands and Inhibitors of Arachidonic Acid in Lung Cancer by Jordi Tauler, James L. Mulshine

“…Numerous studies have shown that chronic inflammation may lead to progression of carcinogenesis. As a result of inflammatory stimulation, arachidonic acid (AA) metabolism produces proliferation mediators through complex and dynamic interactions of the products of the LOX/COX enzymes. …”
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Lone Hepatocellular Carcinoma: An Isolated Chest Wall Malignancy by Joseph Allencherril, Sebastian Bruera, Ronan Allencherril, Richard J. Hamill

“…HCC should be considered in cases of isolated tumors with unclear primaries as ectopic carcinogenesis and occult primary malignancy are possibilities.…”
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