Association between Genetic Instability and Helicobacter pylori Infection in Gastric Epithelial Dysplasia by Jin Su Kim, Woo Chul Chung, Kang-Moon Lee, Chang Nyol Paik, Kyeong Soo Lee, Hye Ji Kim, Young Wook Kim, Ji Han Jung, Seung June Noh, Yun Kyung Lee

“…Coexistence of H. pylori infection and MSI might be a driving force of gastric carcinogenesis.…”
Get full text

High Prevalence of Human Papillomavirus in Colorectal Cancer in Hispanics: A Case-Control Study by Raul D. Bernabe-Dones, Maria Gonzalez-Pons, Alejandro Villar-Prados, Mercedes Lacourt-Ventura, Heriberto Rodríguez-Arroyo, Sharon Fonseca-Williams, Francisco E. Velazquez, Yaritza Diaz-Algorri, Sofia M. Lopez-Diaz, Nayra Rodríguez, Yasuhiro Yamamura, Marcia Cruz-Correa

“…Despite evidence of HPV integration into the host genome, further mechanistic analysis examining HPV oncoprotein expression and the putative role of these oncoproteins in colorectal carcinogenesis is warranted.…”
Get full text

Chimeric RNA in Cancer and Stem Cell Differentiation by Justin Elfman, Hui Li

“…In this review, we outline proven mechanisms through which intergenically spliced chimeric RNAs are involved in carcinogenesis. We highlight their similarity to canonical chimeric RNAs resulting from gene fusions as well as their unique qualities. …”
Get full text

Basal Cell Carcinoma in Type 2 Segmental Darier's Disease by Lynne Robertson, Maxwell B. Sauder

“…In addition, nonmelanoma skin cancer (NMSC) arising from DD is rarely reported; however, there may be an association between DD and risk of carcinogenesis.…”
Get full text

Mathematical Analysis Of A Modular Network Coordinating The Cell Cycle And Apoptosis by Gheorghe Craciun, Baltazar Aguda, Avner Friedman

“…The cell-division cycle and apoptosis are key cellular processes deregulated during carcinogenesis. Recent work of Aguda and Algar suggests a modular organization of regulatory molecular pathways linking the cellular processes of division and apoptosis. …”
Get full text

Spatial Positioning of RET and H4 Following Radiation Exposure Leads to Tumor Development by Yuri E. Nikiforov

“…Although it has been known for a long time that radiation exposure to the cell results in extensive DNA damage, including double strand DNA breaks, the exact mechanisms of radiation-induced carcinogenesis remain unknown. Recently, a large increase in incidence of thyroid cancer was observed in children exposed to radiation after the Chernobyl nuclear accident [1]. …”
Get full text

Expression of ERα, ERβ and Co-Regulator PELP1/MNAR in Colorectal Cancer: Prognostic Significance and Clinicopathologic Correlations by Petros D. Grivas, Vassiliki Tzelepi, Georgia Sotiropoulou-Bonikou, Zinovia Kefalopoulou, Athanasios G. Papavassiliou, Haralabos Kalofonos

“…Background: Estrogen receptor β (ERβ) is abundantly expressed in colorectal tissue, but its role in colorectal carcinogenesis remains elusive. ER novel co-regulator, proline-, glutamic acid- and leucine-rich protein 1 (PELP1/MNAR) has been characterized, but its expression in colorectal carcinomas has not been investigated.…”
Get full text

What is true and what is new in esophageal microbiome in 2024? by M. Jauvain, E. Bessède

“…The esophageal microbiota refers to the dynamic community of microorganisms that inhabit the esophagus, influenced by several factors, including diet, age, and diseases, and it is proposed to play a role in several esophageal disorders, including eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), esophageal carcinomas and carcinogenesis, and achalasia. This review will outline data from studies published in the past year, mainly focusing on esophageal cancer and motility disorders, characterizing the esophageal microbiome in both health and disease states.…”
Get full text

Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets by Jean-Ehrland Ricci

“…Recent studies indicate that cancer metabolism not only sustains carcinogenesis and survival via altered signaling but also modulates immune cell function. …”
Get full text

A bird's eye view to the homeostatic, Alzheimer and Glioblastoma attractors by Joan Nieves, Gabriel Gil, Augusto Gonzalez

“…Dimensional reduction analysis of available data for white matter of the brain allows to locate the normal (homeostatic), Glioblastoma and Alzheimer's disease attractors in gene expression space and to identify paths related to transitions like carcinogenesis or Alzheimer's disease onset. A predefined path for aging is also apparent, which is consistent with the hypothesis of programmatic aging. …”
Get full text

Phototherapy in vitiligo by Anuradha Bishnoi, Iltefat Hamzavi

“…The safety profile of phototherapy, including potential risks such as photodamage and carcinogenesis, is critically analyzed. The review underscores the importance of individualized treatment plans and ongoing research to optimize phototherapy protocols, ultimately aiming to improve the quality of life for vitiligo patients.…”
Get full text

Chemokines and Cytokines as Salivary Biomarkers for the Early Diagnosis of Oral Cancer by Gareema Prasad, Michael McCullough

“…Chemokines have been shown to be important in both inflammation and carcinogenesis and are able to be measured in saliva with relatively robust methods including enzyme-linked immunosorbent assays (ELISA). …”
Get full text

Emission Characteristics and Health Risk Assessment of Volatile Organic Compounds in Key Industries: A Case Study in the Central Plains of China by Fengwei Liu, Lei Tong, Qingyue Luo, Yufei Ling, Hongyi Gu, Yangchao Lv, Anwei Shi, Hui Liu, Hang Xiao, Cenyan Huang

“…The furniture manufacturing (4.55 × 10⁻³) and pharmaceutical (1.66 × 10⁻³) industries in organized emissions were at high risk of carcinogenesis, while the pharmaceutical industry in unorganized emissions (3.61 × 10⁻⁴) was at moderate risk of carcinogenesis. …”
Get full text

Hypoxia Induced Lnc191 Upregulation Dictates the Progression of Esophageal Squamous Cell Carcinoma by Activating GRP78/ERK Pathway by Sisi Wei, Xinyi Fan, Xiaoya Li, Wei Zhou, Zhihua Zhang, Suli Dai, Huilai Lv, Yueping Liu, Baoen Shan, Lianmei Zhao, Qimin Zhan, Yongmei Song

“…Abstract Hypoxia is a typical hallmark of solid tumors and plays a crucial role in the progression of esophageal squamous cell carcinogenesis (ESCC). Nevertheless, the precise mechanisms underlying the involvement of hypoxia in tumor development remain unclear. …”
Get full text

A comprehensive analysis of the uterine microbiome in endometrial cancer patients - identification of Anaerococcus as a potential biomarker and carcinogenic cofactor by Olga Kuźmycz, Aleksandra Kowalczyk, Aleksandra Bolanowska, Anna Drozdzowska, Jakub Lach, Jakub Lach, Wiktoria Wierzbińska, Wiktoria Wierzbińska, Tomasz Kluz, Tomasz Kluz, Paweł Stączek

“…The in vitro findings suggest its role in endometrial carcinogenesis, underscoring its potential as a target for future diagnostic and therapeutic applications.…”
Get full text

Unraveling the pathogenesis of Barrett’s esophagus and esophageal adenocarcinoma: the “omics” era by Alberto Barchi, Giuseppe Dell’Anna, Giuseppe Dell’Anna, Luca Massimino, Luca Massimino, Francesco Vito Mandarino, Edoardo Vespa, Edi Viale, Sandro Passaretti, Vito Annese, Vito Annese, Alberto Malesci, Alberto Malesci, Silvio Danese, Silvio Danese, Federica Ungaro

“…Epigenetic alterations (such as hyper or hypo-methylation) play a meaningful role in esophageal carcinogenesis as well as the study of the tumor micro-environment, which has led to the development of novel immunological therapeutic options. …”
Get full text

Disparities in stage at diagnosis of head and neck tumours in Brazil: a comprehensive analysis of hospital-based cancer registriesResearch in context by Flávia Nascimento de Carvalho, Marianna de Camargo Cancela, Luciano Mesentier da Costa, Luís Felipe Leite Martins, Fernando Luiz Dias, Dyego Leandro Bezerra de Souza, Luis Felipe Ribeiro Pinto

Get full text

Antioxidant Functions of the Aryl Hydrocarbon Receptor by Cornelia Dietrich

“…Increasing evidence points to a protective role of the AhR against carcinogenesis and oxidative stress. Herein, I will highlight data demonstrating a causal role of the AhR in the antioxidant response and present novel findings on potential AhR-mediated antioxidative mechanisms.…”
Get full text

Editorial: Current insights in Epigenetics and Epigenomics by Steven Henikoff, Steven Henikoff, Sharon Y. R. Dent, Sharon Y. R. Dent, Raul Mostoslavsky, Raul Mostoslavsky, Ting Wang, Luca Comai

Get full text

A Mathematical Model for DNA Damage and Repair by Philip S. Crooke, Fritz F. Parl

“…In cells, DNA repair has to keep up with DNA damage to maintain the integrity of the genome and prevent mutagenesis and carcinogenesis. While the importance of both DNA damage and repair is clear, the impact of imbalances between both processes has not been studied. …”
Get full text