Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts by Bo Hang

“…DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex mixtures of carcinogens such as polycyclic aromatic hydrocarbons and N-nitrosamines. …”
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Peroxisome Proliferator-Activated Receptors in Lung Cancer by Venkateshwar G. Keshamouni, ShouWei Han, Jesse Roman

“…PPARs are expressed by many tumors including lung carcinoma cells, and their function has been linked to the process of carcinogenesis in lung. Consequently, intense research is being conducted in this area with the hope of discovering new PPAR-related therapeutic targets for the treatment of lung cancer. …”
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Identification of neoantigens derived from alternative splicing and RNA modification by Jiyeon Park, Yeun-Jun Chung

“…Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. …”
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Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines by R. Sitarz, R. J. Leguit, W. W. J. de Leng, F. H. M. Morsink, W. P. Polkowski, R. Maciejewski, G. J. A. Offerhaus, A. N. Milne

“…Background: COX-2 and E-cadherin, involved in invasion and metastasis, are molecules critical for gastric carcinogenesis. A relationship between them is documented in non-small cell lung and prostate cancer. …”
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Thrombospondin-1: Multiple Paths to Inflammation by Zenaida Lopez-Dee, Kenneth Pidcock, Linda S. Gutierrez

“…If the underlying event inducing inflammation is not addressed and homeostasis is not restored, this process can become chronic and lead to angiogenesis and carcinogenesis. Thrombospondin-1 (TSP-1) is a matricellular protein involved in angiogenesis, cancer, and inflammation. …”
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The high-density lipoprotein binding protein HDLBP is an unusual RNA-binding protein with multiple roles in cancer and disease by Jonathan Feicht, Ralf-Peter Jansen

“…HDLBP is involved in various processes, including translation, chromosome segregation, cholesterol transport and carcinogenesis. Especially, its association with the latter two has attracted specific interest in the HDLBP’s molecular role. …”
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Emerging Stem Cell Therapies: Treatment, Safety, and Biology by Joel Sng, Thomas Lufkin

“…The discovery of induced pluripotent stem cells has led to an improved understanding of the underlying epigenetic keys of pluripotency and carcinogenesis. More in-depth studies of these epigenetic differences and the physiological changes that they effect will lead to the design of safer and more targeted therapies.…”
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Multitarget CDK inhibitors roscovitine and UCN‑01 induce apoptosis in colorectal cancer cells by inhibiting cell cycle progression and transcription by Sonal Mohan Manohar, Kalpana Sanjay Joshi

“…Cell cycle aberrations due to deregulation of cyclin dependent kinases (CDKs) and cyclins are common events during colorectal carcinogenesis. Herein, we investigate the anticancer potential of two multitarget CDK inhibitors viz. roscovitine (specific inhibitor of CDK1, 2, 7, and 9) and UCN-01 (pan CDK inhibitor) against three CRC cell lines. …”
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COX-2 Inhibitors and Gastric Cancer by Zhen Wang, Jun-qiang Chen, Jin-lu Liu

“…The evidence that cyclooxygenase-2 (COX-2) is upregulated and plays an important role in carcinogenesis of gastric cancer has triggered the topic of COX-2 inhibitors as chemopreventive agents for gastric cancer. …”
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Peroxisome proliferator–activated receptor delta and liver diseases by Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl

“…PPAR-delta not only regulates physiologic processes of lipid, glucose, and bile acid metabolism but also attenuates pathologic responses to alcohol metabolism, inflammation, fibrosis, and carcinogenesis, and is considered an important therapeutic target in liver diseases. …”
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Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review by Michela Migliaro, Daniela Massuh, María Fernanda Infante, Ana María Brahm, María Trinidad San Martín, Duniel Ortuño

“…In conclusion, there is an association between oropharyngeal carcinogenesis and HPV and also between the former and EBV. …”
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Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies by Nidhi Agrawal, S.K. Lanjhiyana, Meenakshi Jaiswal, Mohammad Akbar Siddiqui, Sakshi Gupta

“…The present article provides an overview of the molecular subtypes, epidemiology, carcinogenesis, risk factors, diagnostic approaches, and recent advancements in therapeutic options for the treatment of CRC.…”
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Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword by Howard Li, Mary C. M. Weiser-Evans, Raphael Nemenoff

“…Here, we review the available data that implicate PPARγ in lung carcinogenesis and highlight the challenges of targeting PPARγ in lung cancer treatments.…”
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PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma by Osamu Kimura, Yasuteru Kondo, Tooru Shimosegawa

“…Peroxisome proliferator-activated receptor (PPAR) is known to have an important role in fatty liver, and the mechanism of carcinogenesis has been clarified. PPAR controls ligand-dependent transcription, and three subtypes (α, δ, and γ) in humans are known. …”
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Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an Update by Hiroyuki Aihara, Hisao Tajiri, Takeshi Suzuki

“…Autofluorescence endoscopy (AFE) can detect slight alterations in their distribution and concentration during the colorectal carcinogenesis process and, thus facilitate noninvasive screening colonoscopies without the need for fluorescent substances or staining reagents to be administered. …”
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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

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Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma by Yunping Lu, Yajun Shen, Lingyu Li, Min Zhang, Min Wang, Lihua Ge, Jing Yang, Xiaofei Tang

“…By employing a 4NQO-induced oral carcinogenesis mouse model, we confirmed that FOXO4 expression was reduced in 4NQO-induced squamous cell carcinoma (SCC) tongue tissues compared with those in normal tissues. …”
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Chemokines in Cancer Development and Progression and Their Potential as Targeting Molecules for Cancer Treatment by Naofumi Mukaida, So-ichiro Sasaki, Tomohisa Baba

“…Here, we will discuss the roles of chemokines in carcinogenesis and the possibility of chemokine targeting therapy for the treatment of cancer.…”
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SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease by James J. Mason, Bart O. Williams

“…HBM patients live to a normal age and do not appear to have increased susceptibility to carcinogenesis or other disease. Thus, devising methods to mimic the molecular consequences of this mutation to treat bone diseases associated with low bone mass is a promising avenue to pursue. …”
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Microbiome in development of esophageal diseases by Yu. V. Yevsyutina, V. T. Ivashkin

“…Toll-like receptors, cytokines, nuclear factor κB, cyclooxygenase-2 can be potential mediators of inflammation and carcinogenesis which expression can be modified by microbiome spectrum. …”
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