The Role of PDGFs and PDGFRs in Colorectal Cancer by Roberta M. Manzat Saplacan, Loredana Balacescu, Claudia Gherman, Romeo I. Chira, Anca Craiu, Petru A. Mircea, Cosmin Lisencu, Ovidiu Balacescu

“…Angiogenesis was reported as one important mechanism activated in colorectal carcinogenesis. Tumor microenvironment associated angiogenesis involves a large spectrum of signaling molecules and deciphering their role in colorectal carcinogenesis still represents a major challenge. …”
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Prognostic Value of Melanoma Inhibitory Activity Protein in Localized Cutaneous Malignant Melanoma by Angela Sandru, Eugenia Panaitescu, Silviu Voinea, Madalina Bolovan, Adina Stanciu, Sabin Cinca, Alexandru Blidaru

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Impact of ABO gene polymorphism and von Willebrand factor on genetic susceptibility to acute lymphoblastic leukemia in Egyptian pediatric patients by Elsayed I. Salim, Ahmed N. Shaaban, Amal K. Seleem, Zeinab I. Attia

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TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State by Simone Cardaci, Maria Rosa Ciriolo

“…Moreover, we debate on the ability of these mutations to affect cellular redox state and to promote carcinogenesis by impacting on redox biology.…”
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The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes? by Ruggero Ridolfi

“…In the past 20 years, epigenetic studies have described how the changes induced by the cell microenvironment on the non-coding parts of the genome can heavily influence gene function, contributing to the carcinogenesis process. Connecting links amongst the external environment, cellular microenvironment and functional epigenetic and genetic mutations promote carcinogenesis. …”
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Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice by Donatas Stakisaitis, Raminta Mozuraite, Nomeda Juodziukyniene, Janina Didziapetriene, Saule Uleckiene, Paulius Matusevicius, Angelija Valanciute

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Genetic Alterations in Presumptive Precursor Lesions of Breast Carcinomas by Michaela Aubele, Martin Werner, Heinz Höfler

“…The hypothetical multistep model of breast carcinogenesis suggests a transition from normal epithelium to invasive carcinoma via intraductal hyperplasia (without and with atypia) and in situcarcinoma. …”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

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Prognostic Value of N1/N2 Neutrophils Heterogeneity and Tertiary Lymphoid Structure in Hepatocellular Carcinoma Patients by Yanfei Lang, Weiwei Fu, Wei Xu, Chao Ma, Xiuyun Tian, Chunyi Hao, Shigang Ding

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Cytopathological characteristics for provoked lesions of squamous epithelia of digestive system in animal models by V. G. Shestakova, L. I. Nigmatullina, I. B. Atadzhanov, S. A. Donskov, Yu. V. Kozlovskaya, I. S. Dolgopolov, M. Yu. Rykov

“…This model of provocation of carcinogenesis will be used in the next study of neoplastic processes of the female reproductive system.…”
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Ultraviolet Radiation and the Slug Transcription Factor Induce Proinflammatory and Immunomodulatory Mediator Expression in Melanocytes by Stephanie H. Shirley, Elizabeth A. Grimm, Donna F. Kusewitt

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O istotnych kontrowersjach wokół oceny zagrożeń środowiska i jego naprawy by Konrad Gałuszko

“…Subsequently to the above were discussed: the criticism of some misconceptions and the evolution of scientists. opinions about derivations of the greenhouse effect, toxicity and carcinogenesis criteria, evidence supporting the threshold dose versus the linear hypothesis at the evaluation of harmful environmental effects, examples of ecological utopia assuming a possibility of “life in the world without toxins”, the consequences of acts of law created with the idea, untrustworthy examples of alleged hazards, Poland’s law delay with the assimilation of the new toxicological and carcinogenesis evidence, DDT application dilemma concerned with the latter, the acceptance of the threshold dose also for radioactivity, the latest news about ravages of the Chernobyl catastrophe, the author’s belief in better cooperation of humanists, ecophilosophers, scientists and mass media people to create sensible social attitudes of the public in the face of the ecological and civilization crisis.…”
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Morphological and functional analysis of colorectal cancer cell lines in 2D and 3D culture models by Seiichi Shinji, Yutaro Ogawa, Takeshi Yamada, Akihisa Matsuda, Kay Uehara, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Toshimitsu Miyasaka, Shintaro Kanaka, Koki Hayashi, Yuuki Shichi, Masakazu Fujiwara, Kimimasa Takahashi, Tomio Arai, Toshiyuki Ishiwata, Hiroshi Yoshida

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7,12-Dimethylbenz(a)anthracene as a Model for Ovarian Cancer Induction in Rats by Ana Carolina Ciseski Gonçalves, Katia Candido Carvalho, José Antônio Orellana Turri, Ricardo dos Santos Simões, Jesus Paula Carvalho, Luiz Fernando Ferraz da Silva, José Maria Soares Júnior, Edmund Chada Baracat

“…Animal models using 7,12-dimethylbenz(a)anthracene (DMBA) have been developed to investigate the mechanisms of ovarian carcinogenesis. The present study is a systematic review of efforts to establish DMBA as a model for ovarian cancer induction in rat models. …”
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Multifocal Aggressive Squamous Cell Carcinomas Induced by Prolonged Voriconazole Therapy: A Case Report by C. Morice, A. Acher, N. Soufir, M. Michel, F. Comoz, D. Leroy, L. Verneuil

“…Exploration of gene mutations involved in skin carcinogenesis showed two variants of the MICR gene. The occurrence of multiple, recurrent, aggressive squamous cell carcinomas is rare with voriconazole, but its imputability is strongly suggested. …”
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The Role of the TGF-β Coreceptor Endoglin in Cancer by Eduardo Pérez-Gómez, Gaelle del Castillo, Juan Francisco Santibáñez, Jose Miguel Lêpez-Novoa, Carmelo Bernabéu, Miguel Quintanilla

“…In addition, recent studies on human and experimental models of carcinogenesis point to an important tumor cell–autonomous role of endoglin by regulating proliferation, migration, invasion, and metastasis. …”
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Helicobacter pylori and gastric cancer: mechanisms and new perspectives by Yantao Duan, Yonghu Xu, Yi Dou, Dazhi Xu

“…This review summarizes the latest research advances to elucidate the molecular mechanisms underlying the H. pylori infection in gastric carcinogenesis. Our investigation of the molecular mechanisms reveals a complex network involving STAT3, NF-κB, Hippo, and Wnt/β-catenin pathways, which are dysregulated in gastric cancer caused by H. pylori. …”
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The Correlation between Chronic Periodontitis and Oral Cancer by Maximilian Krüger, Torsten Hansen, Adrian Kasaj, Maximilian Moergel

“…Infections are increasingly considered as potential trigger for carcinogenesis apart from risk factors like alcohol and tobacco. …”
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Induction of Cell Activation Processes by Low Frequency Electromagnetic Fields by Myrtill Simkó

“…In some of these reports, the effects were related to other mechanisms of carcinogenesis. Modification in cell proliferation was observed after EMF exposure and a few reports on cytotoxic effects have also been published. …”
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Serrated Polyps and Their Alternative Pathway to the Colorectal Cancer: A Systematic Review by Łukasz Szylberg, Marlena Janiczek, Aneta Popiel, Andrzej Marszałek

“…For a long time, only one pathway of colorectal carcinogenesis was known. In recent years, a new “alternative” pathway through serrated adenoma was described. …”
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