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Microbial signatures in head and neck squamous cell carcinoma: an in silico study
Published 2025-02-01“…Conclusion The oral-gut microbial dysbiosis, as reflected by the differential abundance of bacterial species in oral and GI carcinomas, suggests the implication of tumor microbiome and their genomic interactions with the host in carcinogenesis.…”
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263
Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection
Published 2017-01-01“…H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. …”
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264
Morphopathology of the Prussian carp (Carassius auratus gibelio Bloch, 1782) liver under the effect of allyl acetate
Published 2024-12-01“…Under conditions of prolonged exposure to chemical stress, carcinogenesis was activated in the fish liver. This was evidenced by a characteristic picture of a failure of the moment of transition of the sequence and periodicity of morphogenetic processes, which manifested itself in the form of atypical cellular polymorphism. …”
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265
Natural products based on Correa's cascade for the treatment of gastric cancer trilogy: Current status and future perspective
Published 2025-02-01“…This review is the first to investigate and summarize the multi-step effects and regulatory mechanisms of NPs on the Correa's cascade in gastric carcinogenesis. In phase I, NPs modulate Helicobacter pylori urease activity, motility, adhesion, virulence factors, and drug resistance, thereby inhibiting H. pylori-induced gastric mucosal inflammation and oxidative stress, and facilitating ulcer healing. …”
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266
Temporally and Spatially Controlled Age-Related Prostate Cancer Model in Mice
Published 2025-01-01“…This novel approach provides a powerful age-related murine model for PCa, emphasizing the effect of aging on prostate carcinogenesis.…”
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267
An untargeted metabolomic analysis of acute AFB1 treatment in liver, breast, and lung cells.
Published 2025-01-01“…A better understanding of how AFB1 disrupts metabolism would provide insight into how this mycotoxin leads to carcinogenesis, growth impairment, and/or immunomodulation, and may reveal potential targets for pharmacological or nutritional interventions to protect against these effects. …”
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268
The role of HSPA14 in breast cancer: implications for tumorigenesis, immune response modulation, and personalized therapies
Published 2025-12-01“…Background Heat shock proteins have been implicated in the process of carcinogenesis. HSPA14, a member of the heat shock protein family, remains poorly understood in terms of its significance and pathomechanisms in breast cancer.Methods We analyzed the expression levels of HSPA14 and its prognostic significance in breast cancer using TCGA data. …”
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Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma
Published 2022-01-01“…FXYD2, a gene coding for the γ subunit of Na+/K+-ATPase, was demonstrated to involve in carcinogenesis recently. However, the specific role of FXYD2 in clear cell renal cell carcinoma (ccRCC) remains unknown. …”
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272
Association of ERCC2/XPD polymorphisms and the risk of head and neck carcinoma: a systematic review, meta-analysis, trial sequential analysis, network analysis, and functional effe...
Published 2025-02-01“…Abstract Objectives and aims The combination of genetic and environmental factors may contribute to the carcinogenesis of HNC. Despite the reported associations between xeroderma pigmentosum group D (XPD) polymorphisms and HNC, the results have been inconsistent, with different studies reporting varying results. …”
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273
Role of Bone Marrow-Derived Stem Cells in Polyps Development in Mice with ApcMin/+ Mutation
Published 2015-01-01“…We explored the hypothesis that an altered microenvironment (intestinal adenomatous polyp) could modify the differentiation program of bone marrow-derived stem cells (BMSCs), involving them in colon carcinogenesis. Sublethally irradiated 8-week-old female ApcMin/+ mice were transplanted with bone marrow (BM) cells obtained from either male age-matched ApcMin/+ (Apc-Tx-Apc) or wild type (WT) (WT-Tx-Apc) mice. …”
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274
Multi-omics analysis reveals the sensitivity of immunotherapy for unresectable non-small cell lung cancer
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275
DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma
Published 2025-01-01“…Abstract Background Altered metabolism has become an important characteristic of cancer, and acyl-CoA dehydrogenase short-chain (ACADS), a regulator of lipid synthesis, is involved in carcinogenesis-associated metabolic pathways. DNA methylation is an important mechanism for silencing ACADS in various malignancies. …”
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A Micro-RNA Connection in BRafV600E-Mediated Premature Senescence of Human Melanocytes
Published 2012-01-01“…However, the mechanism by which the oncogenic BRaf induces the senescent barrier remains poorly defined. microRNAs have regulatory functions toward the expression of genes that are important in carcinogenesis. Here we show that expression of several microRNAs is altered when the oncogenic version of BRaf is introduced in cultured primary melanocytes and these cells undergo premature cellular senescence. …”
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Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype
Published 2021-01-01“…Different mutation sites in APC are associated with the severity of FAP, risks of carcinogenesis, and extraintestinal manifestations. We used next-generation sequencing (NGS) and capture techniques to screen suspected mutation points in the proband in this pedigree. …”
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Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells
Published 2013-01-01“…Evidence sustains a role for the acute-phase protein serum amyloid A (SAA) in carcinogenesis and metastasis, and the protein has been suggested as a marker for tumor progression. …”
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Transcriptome Analysis of the Effect of Acute Ammonia Stress on <i>Pseudobagrus ussuriensis</i> Liver Tissue
Published 2025-01-01“…These results suggest that ammonia stress induces liver damage in <i>P. ussuriensis</i>, causing genetic mutations and cellular carcinogenesis, thereby accelerating cell apoptosis.…”
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GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma
Published 2022-01-01“…Although glutathione peroxidase 8 (GPX8) is intimately associated with carcinogenesis, its function in primary gliomas has not yet been thoroughly understood. …”
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