The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells by Junguo Cao, Qingchun Mu, Haiyan Huang

“…Its dysregulation is associated with insulin resistance, diabetes, and carcinogenesis and may potentially be a powerful biomarker and candidate target for relevant diseases. …”
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Efficacy and safety of surufatinib plus toripalimab in treatment-naive, PD-L1-positive, advanced or metastatic non-small-cell lung cancer and previously treated small-cell lung can... by Ying Cheng, Panpan Zhang, Ming Lu, Zhendong Chen, Lijie Song, Si Shi, Feng Ye, Xing Zhang, Baorui Liu, Dongmei Ji, Yanqiao Zhang, Weiguo Su, Michael Shi, Songhua Fan, Panfeng Tan, Chen Zhong

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MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment by Di Cao, Shi-Juan Mai, Hui-yun Wang, Ge Ren, Yue-Ning Wang, Chao-Yue Sun, Haojiang Li, Yu-Feng Zhou, Mei-Yin Zhang, Shuo-Cheng Wang

“…Background The biological significance of MAF1, a tumor suppressor, in carcinogenesis and immune response of hepatocellular carcinoma (HCC) remains unreported. …”
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Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma by Yunping Lu, Yajun Shen, Lingyu Li, Min Zhang, Min Wang, Lihua Ge, Jing Yang, Xiaofei Tang

“…By employing a 4NQO-induced oral carcinogenesis mouse model, we confirmed that FOXO4 expression was reduced in 4NQO-induced squamous cell carcinoma (SCC) tongue tissues compared with those in normal tissues. …”
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Chemokines in Cancer Development and Progression and Their Potential as Targeting Molecules for Cancer Treatment by Naofumi Mukaida, So-ichiro Sasaki, Tomohisa Baba

“…Here, we will discuss the roles of chemokines in carcinogenesis and the possibility of chemokine targeting therapy for the treatment of cancer.…”
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SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease by James J. Mason, Bart O. Williams

“…HBM patients live to a normal age and do not appear to have increased susceptibility to carcinogenesis or other disease. Thus, devising methods to mimic the molecular consequences of this mutation to treat bone diseases associated with low bone mass is a promising avenue to pursue. …”
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Microbiome in development of esophageal diseases by Yu. V. Yevsyutina, V. T. Ivashkin

“…Toll-like receptors, cytokines, nuclear factor κB, cyclooxygenase-2 can be potential mediators of inflammation and carcinogenesis which expression can be modified by microbiome spectrum. …”
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A Role for PPARβ/δ in Tumor Stroma and Tumorigenesis by Rolf Müller, Martin Kömhoff, Jeffrey M. Peters, Sabine Müller-Brüsselbach

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Saliva: Physiology and Diagnostic Potential in Health and Disease by Sebastien J. C. Farnaud, Ourania Kosti, Stephen J. Getting, Derek Renshaw

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The Mammary Gland Carcinogens: The Role of Metal Compounds and Organic Solvents by Stephen Juma Mulware

“…Despite the fact that women who inherited mutations in the BRCA1 and BRCA2 genes have a high risk of developing breast cancer, studies have also shown that significant exposure to certain metal compounds and organic solvents also increases the risks of mammary gland carcinogenesis. While physiological properties govern the uptake, intracellular distribution, and binding of metal compounds, their interaction with proteins seems to be the most relevant process for metal carcinogenicity than biding to DNA. …”
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The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas by Elias A. El Habr, Christos Adamopoulos, Georgia Levidou, Aggeliki A. Saetta, Penelope Korkolopoulou, Christina Piperi

“…Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. …”
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Helicobacter pylori and the microbiome in gastric cancer development and treatment: A year in review by P. Vieira, M. Barbedo-Tavares, C. Figueiredo

“…However, there is increasing evidence that, in addition to H. pylori, the non-H. pylori microbiome also plays a role in gastric carcinogenesis. Furthermore, the microbiome may influence the gastric tumor microenvironment and modulate response to treatment, in particular, treatment with immune checkpoint inhibitors. …”
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Black Pepper’s Anti-Aging and Chemoprevention Properties: A Review by Endah

“…Additionally, cell cycle regulation, antiangiogenic and anti-metastatic action, apoptosis induction, and the suppression of carcinogenesis are some of the mechanisms utilized in cancer prevention activities. …”
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Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation by Vladimir Jurišić, Jasmina Obradovic, Sonja Pavlović, Nataša Djordjevic

“…The accumulation of knowledge regarding SNPs lately suggests their significant and important role in the onset of carcinogenesis, the prediction of the onset of metastases, the response to therapy with TKI inhibitors, and the onset of toxic effects of the applied therapy. …”
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Lung Cancer Associated with Neurofibromatosis Type I by Anastasia Oikonomou, Dimitrios Mikroulis, Paraskevi Mintzopoulou, Lawal Lukman, Panos Prassopoulos

“…There is some evidence that a genetic linkage between neurofibromatosis and carcinogenesis in the lung may exist. We present a 42-year-old female, lifetime nonsmoker with a known history of neurofibromatosis type I, free of respiratory symptoms, who underwent a low-dose HRCT of the lungs to investigate any occult interstitial lung changes. …”
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Renal Cancer Stem Cells: Characterization and Targeted Therapies by Anna Julie Peired, Alessandro Sisti, Paola Romagnani

“…In conclusion, CSCs are an important player in carcinogenesis and represent a valid target for therapy in RCC patients.…”
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Simultaneous Coexistence of Thyrotropin-Prolactin-Secreting Adenoma and Papillary Thyroid Carcinoma by Somaya Safi, Yousra Benabdelfedil, Sara Derrou, Faycal El Guendouz

“…The unusual association of thyroid adenocarcinoma and TSHoma enriches the hypothesis of a potential link between thyrotropic hypersecretion and thyroid carcinogenesis. Our case also illustrates the difficulty of monitoring thyroid carcinoma in nonremission of a TSHoma.…”
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Association between Probiotics and Modulation of Gut Microbial Community Composition in Colorectal Cancer Animal Models: A Systematic Review (2010–2021) by Shabnam Zeighamy Alamdary, Shahnaz Halimi, Akram Rezaei, Roghayeh Afifirad

“…The goal of this systematic review was to gather the preclinical studies that examined the impact of probiotics on the alteration of gut microbiota profiles (bacterial communities) and their link to colorectal carcinogenesis as well as the potential processes involved. …”
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Antipsychotic-induced hyperprolactinemia: Toxicologic mechanism and the increased breast cancer risk by Steven B. Bird

“…As many breast cancers are responsive to prolactin concentrations, the persistent increase in prolactin of the antipsychotics has implications for public health and carcinogenesis. The objective of this study was to review the extant literature on hyperprolactinemia due to antipsychotics, and to determine the risk imposed by those drugs on human breast cancer. …”
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A review of the pathogenesis of mitochondria in breast cancer and progress of targeting mitochondria for breast cancer treatment by Aoling Huang, Haochen Xue, Ting Xie, Lingyan Xiang, Zhengzhuo Chen, Aolong Ma, Honglin Yan, Jingping Yuan

“…Altered mitochondrial function plays a critical role in various diseases, and recent studies have elucidated its pathophysiological mechanisms in breast carcinogenesis. This review explores the role of mitochondrial dysfunction in breast cancer pathogenesis and assesses potential mitochondria-targeted therapies.…”
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