Exploring the Impact of Helicobacter pylori and Potential Gut Microbiome Modulation by Isaac Jingkhai Ong, Ke-Yan Loo, Lydia Ngiik-Shiew Law, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Vengadesh Letchumanan

“…This review aims to discuss the role and effect of H. pylori in gastric carcinogenesis and gut microbiome modulation in eradicating H. pylori infection. …”
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Electrical Impedance Dermography: Background, Current State, and Emerging Clinical Opportunities by Elise K. Brunsgaard, Benjamin Sanchez, Douglas Grossman

“…EID assesses pathological changes to the normal composition and architecture of the skin that influence the flow of electrical current, including changes associated with inflammation, keratinocyte and melanocyte carcinogenesis, and scarring. Assessing the electrical properties of the skin across a range of frequencies and in multiple directions of current flow can provide diagnostic information to aid in the identification of pathologic skin conditions. …”
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Toll-Like Receptor 4 Activation in Cancer Progression and Therapy by Alja Oblak, Roman Jerala

“…Further research of the role and mechanisms of TLR4 activation in cancer may provide novel antitumor vaccine adjuvants as well as TLR4 inhibitors that could prevent inflammation-induced carcinogenesis.…”
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Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts by Bo Hang

“…DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex mixtures of carcinogens such as polycyclic aromatic hydrocarbons and N-nitrosamines. …”
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Peroxisome Proliferator-Activated Receptors in Lung Cancer by Venkateshwar G. Keshamouni, ShouWei Han, Jesse Roman

“…PPARs are expressed by many tumors including lung carcinoma cells, and their function has been linked to the process of carcinogenesis in lung. Consequently, intense research is being conducted in this area with the hope of discovering new PPAR-related therapeutic targets for the treatment of lung cancer. …”
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Identification of neoantigens derived from alternative splicing and RNA modification by Jiyeon Park, Yeun-Jun Chung

“…Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. …”
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Efficacy and safety of dupilumab in a patient with metastatic clear cell renal cell carcinoma by César Ferreira, Egídio Freitas, Tiago Torres

“…In addition to not stimulating carcinogenesis, dupilumab might synergistically inhibit tumor-induced immunosuppression, thereby potentially preventing tumor progression. …”
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Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines by R. Sitarz, R. J. Leguit, W. W. J. de Leng, F. H. M. Morsink, W. P. Polkowski, R. Maciejewski, G. J. A. Offerhaus, A. N. Milne

“…Background: COX-2 and E-cadherin, involved in invasion and metastasis, are molecules critical for gastric carcinogenesis. A relationship between them is documented in non-small cell lung and prostate cancer. …”
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Thrombospondin-1: Multiple Paths to Inflammation by Zenaida Lopez-Dee, Kenneth Pidcock, Linda S. Gutierrez

“…If the underlying event inducing inflammation is not addressed and homeostasis is not restored, this process can become chronic and lead to angiogenesis and carcinogenesis. Thrombospondin-1 (TSP-1) is a matricellular protein involved in angiogenesis, cancer, and inflammation. …”
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The high-density lipoprotein binding protein HDLBP is an unusual RNA-binding protein with multiple roles in cancer and disease by Jonathan Feicht, Ralf-Peter Jansen

“…HDLBP is involved in various processes, including translation, chromosome segregation, cholesterol transport and carcinogenesis. Especially, its association with the latter two has attracted specific interest in the HDLBP’s molecular role. …”
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PLUNC downregulates the expression of PD-L1 by inhibiting the interaction of DDX17/β-catenin in nasopharyngeal carcinoma by Ranran Feng, Yilin Guo, Meilin Chen, Ziying Tian, Yijun Liu, Su Jiang, Jieyu Zhou, Qingluan Liu, Xiayu Li, Wei Xiong, Lei Shi, Songqing Fan, Guiyuan Li, Wenling Zhang

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Emerging Stem Cell Therapies: Treatment, Safety, and Biology by Joel Sng, Thomas Lufkin

“…The discovery of induced pluripotent stem cells has led to an improved understanding of the underlying epigenetic keys of pluripotency and carcinogenesis. More in-depth studies of these epigenetic differences and the physiological changes that they effect will lead to the design of safer and more targeted therapies.…”
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Multitarget CDK inhibitors roscovitine and UCN‑01 induce apoptosis in colorectal cancer cells by inhibiting cell cycle progression and transcription by Sonal Mohan Manohar, Kalpana Sanjay Joshi

“…Cell cycle aberrations due to deregulation of cyclin dependent kinases (CDKs) and cyclins are common events during colorectal carcinogenesis. Herein, we investigate the anticancer potential of two multitarget CDK inhibitors viz. roscovitine (specific inhibitor of CDK1, 2, 7, and 9) and UCN-01 (pan CDK inhibitor) against three CRC cell lines. …”
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COX-2 Inhibitors and Gastric Cancer by Zhen Wang, Jun-qiang Chen, Jin-lu Liu

“…The evidence that cyclooxygenase-2 (COX-2) is upregulated and plays an important role in carcinogenesis of gastric cancer has triggered the topic of COX-2 inhibitors as chemopreventive agents for gastric cancer. …”
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Peroxisome proliferator–activated receptor delta and liver diseases by Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl

“…PPAR-delta not only regulates physiologic processes of lipid, glucose, and bile acid metabolism but also attenuates pathologic responses to alcohol metabolism, inflammation, fibrosis, and carcinogenesis, and is considered an important therapeutic target in liver diseases. …”
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Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review by Michela Migliaro, Daniela Massuh, María Fernanda Infante, Ana María Brahm, María Trinidad San Martín, Duniel Ortuño

“…In conclusion, there is an association between oropharyngeal carcinogenesis and HPV and also between the former and EBV. …”
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Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies by Nidhi Agrawal, S.K. Lanjhiyana, Meenakshi Jaiswal, Mohammad Akbar Siddiqui, Sakshi Gupta

“…The present article provides an overview of the molecular subtypes, epidemiology, carcinogenesis, risk factors, diagnostic approaches, and recent advancements in therapeutic options for the treatment of CRC.…”
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Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword by Howard Li, Mary C. M. Weiser-Evans, Raphael Nemenoff

“…Here, we review the available data that implicate PPARγ in lung carcinogenesis and highlight the challenges of targeting PPARγ in lung cancer treatments.…”
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PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma by Osamu Kimura, Yasuteru Kondo, Tooru Shimosegawa

“…Peroxisome proliferator-activated receptor (PPAR) is known to have an important role in fatty liver, and the mechanism of carcinogenesis has been clarified. PPAR controls ligand-dependent transcription, and three subtypes (α, δ, and γ) in humans are known. …”
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Application of Autofluorescence Endoscopy for Colorectal Cancer Screening: Rationale and an Update by Hiroyuki Aihara, Hisao Tajiri, Takeshi Suzuki

“…Autofluorescence endoscopy (AFE) can detect slight alterations in their distribution and concentration during the colorectal carcinogenesis process and, thus facilitate noninvasive screening colonoscopies without the need for fluorescent substances or staining reagents to be administered. …”
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