Medicinal Use of Cannabis: History and Current Status by Harold Kalant

“…OBJECTIVE: To provide an overview of the history and pharmacology of cannabis in relation to current scientific knowledge concerning actual and potential therapeutic uses of cannabis preparations and pure cannabinoids.…”
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Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models by Willias Masocha

“…There is a scarcity of drugs to either prevent or properly manage chemotherapy-induced neuropathic pain (CINP). Cannabis or cannabinoids have been reported to improve pain measures in patients with neuropathic pain. …”
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Computer-Aided Classification of New Psychoactive Substances by Alina Bărbulescu, Lucica Barbeș, Cristian-Ştefan Dumitriu

“…The appearance on the free market of synthetic cannabinoids raised the researchers’ interest in establishing their molecular similarity by QSAR analysis. …”
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Regulation of noradrenaline synthesis, uptake, and degradation in the left ventricle by fatty acid amide hydrolase (FAAH) inhibitor URB597 in the chronic unpredictable stress model... by Ferizović Harisa, Spasojević Nataša, Janković Milica, Stefanović Bojana, Dronjak Slađana

“…One promising therapeutic strategy for treating different diseases is inhibiting the enzyme fatty acid amide hydrolase (FAAH), which increases the availability of endogenous cannabinoids. We examined the effect of chronic FAAH inhibition with URB597 treatment on the noradrenaline (NA) content, synthesis, transport, and degradation in the left ventricle of female and male rats exposed to chronic unpredictable stress (CUS). …”
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An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp by Tennille K. Marx, Robin Reddeman, Amy E. Clewell, John R. Endres, Erzsébet Béres, Adél Vértesi, Róbert Glávits, Gábor Hirka, Ilona Pasics Szakonyiné

“…A battery of toxicological studies was conducted on a supercritical CO2 extract of the aerial parts of the Cannabis sativa plant, containing approximately 25% cannabinoids. No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames), in an in vitro mammalian chromosomal aberration test, or in an in vivo mouse micronucleus study. …”
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Recent trends in studying of alcohol-induced liver disease by I. I. Komkova, M. S. Zharkova, M. V. Mayevskaya

“…Application of acidic sphingomyelinase, influence on Kupffer's cells phenotype, cannabinoids receptors as new targets for treatment of alcoholic liver disease is possible. …”
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Caffeine-Induced Suppression of GABAergic Inhibition and Calcium-Independent Metaplasticity by Masako Isokawa

“…Time course of suppression and the subsequent recovery of IPSCs resembled DSI (depolarization-induced suppression of inhibition), mediated by endogenous cannabinoids that require a [Ca2+]i rise. However, unlike DSI, caffeine-induced suppression of IPSCs (CSI) persisted in the absence of a [Ca2+]i rise. …”
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Pharmacological Management of Chronic Neuropathic Pain – Consensus Statement and Guidelines from the Canadian Pain Society by DE Moulin, AJ Clark, I Gilron, MA Ware, CPN Watson, BJ Sessle, T Coderre, PK Morley-Forster, J Stinson, A Boulanger, P Peng, GA Finley, P Taenzer, P Squire, D Dion, A Cholkan, A Gilani, A Gordon, J Henry, R Jovey, M Lynch, A Mailis-Gagnon, A Panju, GB Rollman, A Velly

“…Recommended fourth-line treatments include cannabinoids, methadone and anticonvulsants with lesser evidence of efficacy, such as lamotrigine, topiramate and valproic acid. …”
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Exploring the Therapeutic Potential of Cannabidiol in U87MG Cells: Effects on Autophagy and NRF2 Pathway by Laura Giannotti, Benedetta Di Chiara Stanca, Francesco Spedicato, Daniele Vergara, Eleonora Stanca, Fabrizio Damiano, Luisa Siculella

“…Cannabinoids include both endogenous endocannabinoids and exogenous phytocannabinoids, such as cannabidiol (CBD), and have potential as therapeutic agents in cancer treatment due to their selective anticancer activities. …”
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Underlying Anticancer Mechanisms and Synergistic Combinations of Phytochemicals with Cancer Chemotherapeutics: Potential Benefits and Risks by Muhammad Ayaz, Asif Nawaz, Sajjad Ahmad, Osama F. Mosa, Alashary Adam Eisa Hamdoon, Modawy Alnour Khalifa, Abdul Sadiq, Farhat Ullah, Abdul Wadood, Atul Kabra, H. C. Ananda Murthy

“…Several lead phytochemicals including curcumin, resveratrol, quercetin, and cannabinoids synergistically act with cancer chemotherapeutics reducing cell proliferation and inducing apoptosis and cell cycle arrest. …”
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