Antiepileptic activity and potential mechanism of full-spectrum hemp extract by Zengliang Jin, Zhuo Huang

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Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta‐9‐Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes by Lixuan Qian, Tao Zhang, Jean Dinh, Mary F. Paine, Zhu Zhou

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Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cell Lines by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

Subjects: “…CB1 cannabinoids…”
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Uncovering the Metabolic Footprint of New Psychoactive Substances by Metabolomics: A Systematic Review by Ana Sofia Almeida, Paula Guedes de Pinho, Fernando Remião, Carla Fernandes

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Cryptogenic stroke in young patients and cannabis use: case presentation and literature review by A. Atkočiūnas, A. Jasionis, G. Lengvenis, R. Badaras, K. Ryliškienė

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Medical cannabis in the management of musculoskeletal pain: a systematic review of clinical trials by Przemysław Płatek, Laura Piejko

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Extraction, GC-MS analysis, cytotoxic, anti-inflammatory and anticancer potential of Cannabis sativa female flower; in vitro, in vivo and in silico by Waqas Safir, Arif Malik, Arif Malik, Haleema Saadia, Ayesha Zahid, Jinyao Li

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Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity by Aditya R. Kumar, Lyndsey S. Benson, Erica M. Wymore, Jocelyn E. Phipers, Jennifer C. Dempsey, Lucinda A. Cort, Jashvant D. Unadkat

“…To determine causality, preclinical studies mimicking human fetal cannabinoid exposure must be conducted. Here we show cannabinoid concentrations across gestation in maternal plasma and paired fetal tissues in trimester 1 and 2 and maternal plasma and fetal umbilical venous plasma in trimester 3. …”
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Alternative Argets Within the Endocannabinoid System for Future Treatment of Gastrointestinal Diseases by Rudolf Schicho, Martin Storr

“…Of major therapeutic interest are nonpsychoactive cannabinoids or compounds that do not directly target cannabinoid receptors but still possess cannabinoid-like properties. …”
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Synthetic Cannabis-Induced Mania by Mehmet Fatih Ustundag, Esra Ozhan Ibis, Atakan Yucel, Halil Ozcan

“…Synthetic cannabinoids (SC), cannabinoid 1 and cannabinoid 2 receptors agonists, are the psychoactive substances. …”
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Recurrent Nausea and Vomiting in a Pregnant Woman with Chronic Marijuana Use by Hyunyoung G. Kim, Jeremiah Moon, Heather Dixon, Paul Tullar

“…Background. Cannabinoid hyperemesis syndrome is a condition characterized by chronic cannabis use and cyclic episodes of nausea, vomiting, and abdominal pain, relieved by compulsive bathing. …”
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Synthetic Cannabis Overdose and Withdrawal in a Young Adult: A Case Report, Commentary on Regulation, and Review of the Literature by John Samaan, Gerardo F. Ferrer, Boye Akinyemi, Patricia Junquera, Juan Oms, Rhaisa Dumenigo

“…This case, as many others nationwide, exemplifies the impact of synthetic cannabinoid use and abuse in adolescents. Side effects and adverse health consequences of synthetic cannabinoid use warrant stricter regulations and policies in order to decrease psychiatric hospital admissions and associated healthcare costs.…”
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Murine model for chronic rhinosinusitis: an interventional study by Amr F. Hamour, John JW. Lee, Ewa Wasilewski, Eric Monteiro, John M. Lee, Allan Vescan, Lakshmi P. Kotra

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Characterization of the Cannabis sativa glandular trichome epigenome by Lee J. Conneely, Bhavna Hurgobin, Sophia Ng, Muluneh Tamiru-Oli, Mathew G. Lewsey

“…The glandular trichomes of Cannabis sativa are an emerging model system that produce large quantities of cannabinoid and terpenoid specialised metabolites with known medicinal and commercial value. …”
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Role of the Endocannabinoid System in the Central Regulation of Nonmammalian Vertebrate Reproduction by Erika Cottone, Valentina Pomatto, Patrizia Bovolin

“…The morphofunctional distribution of brain cannabinoid receptors will be discussed in relation to other crucial signalling molecules involved in the control of reproductive functions, such as GnRH, dopamine, aromatase, and pituitary gonadotropins.…”
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Addiction and Pain Medicine by Douglas Gourlay

“…Another factor that needs to be considered when assessing the practicality of prescribing medicinal cannabinoids is the difficulty in differentiating illicit from prescribed cannabinoids in urine drug testing. …”
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CBD for pets: navigating quality assurance, safety standards, and marketing strategies by Hannah Rideout, Alasdair J. C. Cook, Anthony D. Whetton

“…Abstract As the human cannabinoid (CBD) market grows, there is an inevitable transfer of the same or similar products into the veterinary sector. …”
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Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification by Jantana Keereetaweep, Kent D. Chapman

“…They are biologically active lipid molecules that activate G-protein-coupled cannabinoid receptors found in various organisms. After AEA and 2-AG were discovered in the 1990s, they have been extensively documented to have a broad range of physiological functions. …”
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A Unique Case of Cardiac Arrest following K2 Abuse by Saif Ibrahim, Farah Al-Saffar, Thomas Wannenburg

“…We describe a case of out-of-hospital cardiac arrest temporally related to abuse of the synthetic cannabinoid street drug known as K2. To our knowledge, there are no previously documented cases of sudden cardiac death associated with synthetic cannabinoids although they have been linked to myocardial infarction in teenagers despite normal coronary angiography (Mir et al. (2011)).…”
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Overview of Novel Antipsychotic Drugs: State of the Art, New Mechanisms, and Clinical Aspects of Promising Compounds by Letizia Biso, Marco Carli, Marco Scarselli, Biancamaria Longoni

“…In particular, we analyzed the main classes of investigational antipsychotics, such as monoamine, glutamate, acetylcholine, cannabinoid receptor modulators, enzyme inhibitors, ion channel modulators, and mixed receptor modulators. …”
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