An emerging trend in Novel Psychoactive Substances (NPSs): designer THC by Cristian Caprari, Elena Ferri, Maria Angela Vandelli, Cinzia Citti, Giuseppe Cannazza

“…Moreover, to circumvent legal issues, many manufacturers resort to semi-synthetic processes starting from legal products extracted from hemp, such as cannabidiol (CBD). Despite the aim to encompass all known THC-like molecules, new species emerge on the drug users’ pipeline each month. …”
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Nanosilicon application changes the morphological attributes and essential oil compositions of hemp (Cannabis sativa L.) under water deficit stress by Ayyub Rezghiyan, Hassan Esmaeili, Mohsen Farzaneh

“…However, the highest content of cannabidiol in the essential oil was achieved in the severe water stress (40% FC) and treatment of 0.5 mM nanosilicon. …”
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Medical cannabis in the management of musculoskeletal pain: a systematic review of clinical trials by Przemysław Płatek, Laura Piejko

“…In this paper, we focus on two of the most extensively studied cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Recent scientific findings suggest that cannabinoids may be therapeutically beneficial for conditions such as neurodegenerative disorders, seizures, nausea and vomiting, insomnia, neuropathic pain, excessive muscle tension, fibromyalgia, osteoarthritis (OA), rheumatoid arthritis (RA), and chronic wounds. …”
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Medical Cannabis for Gilles de la Tourette Syndrome: An Open-Label Prospective Study by Saar Anis, Corinne Zalomek, Amos D. Korczyn, Alina Rosenberg, Nir Giladi, Tanya Gurevich

“…Δ9-Tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) content within MC product and monthly dose were titrated during the study. …”
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Extraction, GC-MS analysis, cytotoxic, anti-inflammatory and anticancer potential of Cannabis sativa female flower; in vitro, in vivo and in silico by Waqas Safir, Arif Malik, Arif Malik, Haleema Saadia, Ayesha Zahid, Jinyao Li

“…From the GC-MS analysis, the following bioactive compounds were found: cannabidiol (CBD), tetrahydrocannabinol (THC), and humulene. …”
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Seguridad de los cannabinoides empleados como terapéutica en Odontología: Una revisión de la literatura by Matias Mederos, Alejandro Francia

“…Métodos: Se realizó una búsqueda en las bases de datos Pubmed, Science Direct, Scielo y Google Académico hasta marzo 2024 utilizando la siguiente combinación de términos MeSH: ( (cannabis OR cannabidiol) AND (dentistry) AND (pain OR burning mouth syndrome OR recurrent aphthous ulcers OR trigeminal neuralgia)). …”
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Longitudinal Relationship between the Introduction of Medicinal Cannabis and Polypharmacy: An Australian Real-World Evidence Study by Maja Kalaba, Graham M. L. Eglit, Matthew T. Feldner, Patrizia D. Washer, Tracie Ernenwein, Alistair W. Vickery, Mark A. Ware

“…The most common daily oral dose was 10 mg for delta-9-tetrahydrocannabinol (THC) and 15 mg for cannabidiol (CBD). With the introduction of MC, patients’ total number of medications consumed decreased over the course of one year; significant reductions in NSAIDs, benzodiazepines, and antidepressants were observed (p < .001). …”
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Plant-Derived Compounds in Hemp Seeds (<i>Cannabis sativa</i> L.): Extraction, Identification and Bioactivity—A Review by Virginia Tanase Apetroaei, Daniela Ionela Istrati, Camelia Vizireanu

“…Since THC (tetrahydrocannabinol) and CBD (cannabidiol) are found only in traces, hemp seeds can be used in food applications because the psychoactive effects associated with cannabis are avoided. …”
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Disruption of biological membranes by hydrophobic molecules: a way to inhibit bacterial growth by Alejandra Gabriela Valdez-Lara, Ángela M. Jaramillo-Granada, Daniel Ortega-Zambrano, Eristeo García-Marquez, Jorge Alberto García-Fajardo, H. Mercado-Uribe, J. C. Ruiz-Suárez

“…We propose the utilization of hydrophobic molecules, namely, propofol (PFL) and cannabidiol (CBD), dissolved in nanodroplets of oil, to effectively strike the membrane of two well-known pathogens: Escherichia coli and Staphylococcus aureus. …”
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Cannabis in cosmetics: regulatory and scientific insights into hemp seed extracts for skincare by Abhilash Aditya, Too Jae Min, Sornkanok Vimolmangkang, Namsoo P. Kim

“…It addresses the ambiguity in Korean regulations on cannabinoids, such as cannabidiol (CBD) and tetrahydrocannabinol (THC), and their impact on legal compliance and industry stability. …”
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Population genomics of a natural Cannabis sativa L. collection from Iran identifies novel genetic loci for flowering time, morphology, sex and chemotyping by Mahboubeh Mostafaei Dehnavi, Annabelle Damerum, Sadegh Taheri, Ali Ebadi, Shadab Panahi, George Hodgin, Brian Brandley, Seyed Alireza Salami, Gail Taylor

“…The data obtained enabled an association analysis, linking genotypes with key phenotypes such as inflorescence characteristics, flowering time, plant morphology, tetrahydrocannabinol (THC) and cannabidiol (CBD) content, and sex. We detected approximately 23,266 significant high-quality Single Nucleotide Polymorphisms (SNPs), establishing associations between markers and traits. …”
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Electronic Vaping-Induced Methicillin-Sensitive Staphylococcus Aureus Pneumonia and Empyema by Sachin M. Patil, Phillip Paul Beck, Tarang Pankaj Patel, Richard Dale Swaney, Dima Dandachi, Armin Krvavac

“…We report a 38-year-old female who developed acute MSSA pneumonia, which was complicated by left empyema due to ECVE from JUUL device with third-party compatible cannabidiol pods. The patient completed treatment successfully with a chest tube placement followed by fibrinolysis and intravenous antibiotics.…”
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Explorando o Potencial Terapêutico do Canabidiol em Crianças com Paralisia Cerebral: Uma Revisão Integrativa by Camila Harmuch, Anny Caroline Ribeiro Devechi, Cecily Barbosa, Ana Luisa Serrano Lima, Jéssica dos Santos Pini, André Estevam Jaques, Marcelle Paiano

“…Foram utilizados os descritores “Cannabidiol”, “Cerebral Palsy” e “Child”. Foram incluídos um total de nove artigos que corresponderam aos critérios de inclusão e exclusão. …”
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Optimization and Evaluation of <i>Cannabis</i>-Based Magistral Formulations: A Path to Personalized Therapy by Bożena Grimling, Magdalena Fast, Magdalena Okoniewska, Artur Owczarek, Bożena Karolewicz

“…The concentrations of ∆-9-THC, cannabidiol (CBD), and cannabinol (CBN) were determined using an HPLC method. …”
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Solid-state fermentation of hemp waste: enhancing the performance of Hermetia illucens larvae and altering the composition of hemp secondary metabolites by Wael Yakti, Nadja Förster, Marcus Müller, Sebastian Beck, Simon Schulz, Inga Mewis, Christian Ulrichs

“…SSF using Trichoderma reesei increased the cannabidiol and ∆9-tetrahydrocannabinol mass fractions in the substrate, and consequently in the produced BSFL biomass, while decreasing the amounts of acidic cannabinoids. …”
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Role of Cannabis in the Management of Chronic Non-Cancer Pain: A Narrative Review by Lou’i Al-Husinat, Shrouq Obeidat, Saif Azzam, Yara Al-Gwairy, Fatima Obeidat, Sarah Al Sharie, Deema Haddad, Fadi Haddad, Martina Rekatsina, Matteo Luigi Giuseppe Leoni, Giustino Varrassi

“…Cannabis, containing the key compounds Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), has garnered interest for its potential in pain management, though it remains controversial due to its psychoactive effects and illegal status in many countries. …”
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Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review by José Luis Estela-Zape, Mayra Liliana Pizarro-Loaiza, Gabriel Arteaga, Santiago Castaño, Leonardo Fierro

“…Isoquinoline alkaloids from Corydalis yanhusuo, hangeshashinto, osthol, and cannabidiol inhibited Na+ currents in cell models, primarily affecting Nav1.7 and Nav1.5. …”
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Influence of different priming treatments on germination potential and seedling establishment of four important hemp (Cannabis sativa L.) cultivars by Saba Latif, Rahmatullah Qureshi, Abdul Rauf, NoshinIlyas, Qaiser Hussain, Syed Sabir Hussain Shah, Sabith Rehman, Arshad Mahmood Khan, Nasrullah Khan, Mostafa A. Abdel-Maksoud, Abdul Malik, Sabiha Fatima, Bushra Hafeez Kiani

“…The crop is primarily grown using feminized seeds or popular varieties to achieve higher cannabidiol (CBD) yields, with seeds costing approximately $5–10 each. …”
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Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies by Sigal Fleisher-Berkovich, Nitzan Sharon, Yvonne Ventura, Valeria Feinshtein, Jonathan Gorelick, Nirit Bernstein, Shimon Ben-Shabat

“…Results Extracts of the CN2 cultivar contained tetrahydrocannabinolic acid (THCA) and tetrahydrocannabinol (THC) without cannabidiol (CBD), and a number of monoterpenes. CN4 contained cannabidiolic acid (CBDA) and tetrahydrocannabidiolic acid (THCA), with significant amounts of THC: CBD in a 1:1 ratio, as well as sesquiterpenes and some monoterpenes; and CN6 contained primarily CBDA and THCA, as well as THC and CBD in a 2:1 ratio, with some sesquiterpenes and no monoterpenes. …”
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Evaluación de la solución nutritiva Steiner aplicada al cultivo de cáñamo medicinal (Cannabis sativa L.) var. Cherry Oregon, bajo invernadero by Michelle Arcos, Yamil Cartagena, Jorge Merino, Patricio Pérez Guerrero, Rafael Parra, Julio Moreno

“…Esta investigación tuvo por objetivo evaluar el efecto de cinco concentraciones de solución nutritiva Steiner en la fenología del cáñamo medicinal, y determinar la dosis óptima de la solución nutritiva para el contenido de cannabinoides (cannabidiol [CBD] y tetrahidrocannabinol [THC]). La investigación fue realizada en el Instituto Nacional de Investigaciones Agropecuarias [INIAP], Estación Experimental Santa Catalina [EESC], en Ecuador, en condiciones de invernadero. …”
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