Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence by Valentina Gonzalez-Jaramillo, Eliana Portilla-Fernandez, Marija Glisic, Trudy Voortman, Mohsen Ghanbari, Wichor Bramer, Rajiv Chowdhury, Tamar Nijsten, Abbas Dehghan, Oscar H. Franco, Jana Nano

“…There was no overlap in the methylated sites investigated in candidate gene studies and EWAS, except for TMEM49, which was found to be hypomethylated with higher inflammatory markers in both types of studies. …”
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Designing an intervention to improve cognitive evaluations in primary care by Kyra S. O’Brien, Kristin Harkins, MaryAnne Peifer, Melanie Kleid, Cameron Coykendall, Judy Shea, Jason Karlawish, Robert E. Burke

“…Implementation mapping resulted in a list of 15 candidate strategies. Using the modified Delphi process, these were narrowed to six. …”
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A nociceptor-specific RNAi screen in Drosophila larvae identifies RNA-binding proteins that regulate thermal nociception by Amber Dyson, Gita Gajjar, Katherine C. Hoffman, Dakota Lewis, Sara Palega, Erik Rangel Silva, James Auwn, Andrew Bellemer

“…In this study, we conducted a nociceptor-specific RNAi screen of 112 candidate RNA-binding protein genes to identify those that are required for normal sensitivity to noxious thermal stimuli. …”
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Genomic Characterization and Functional Validation of Six <i>cis</i>-Regulatory Sequences in Medicinal Plant <i>Andrographis paniculata</i> by Xingbin Lv, Hua Yang, Yufang Hu, Qi Liang, Shuyun Tian, Lang Yang, Mingkun Huang, Ling Zhang, Yanqin Xu

“…In this study, we provided a comprehensive analysis of the published genomic data of <i>Andrographis paniculata</i> and identified six candidate <i>ApACRs</i>. Based on the transient assays, two candidate CRSs (<i>ApACR1</i> and <i>ApACR2</i>) demonstrated high transcriptional activities comparable to those of the <i>35S</i> promoter in several plant species, in contrast to others with lower activities, suggesting their further potential applications in plant biotechnology and genetic engineering.…”
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The Carcinoma–Stromal Ratio of Colon Carcinoma Is an Independent Factor for Survival Compared to Lymph Node Status and Tumor Stage by Wilma E. Mesker, Jan M. C. Junggeburt, Karoly Szuhai, Pieter de Heer, Hans Morreau, Hans J. Tanke, Rob A. E. M. Tollenaar

“…We have evaluated, for the primary tumor, if the carcinoma-percentage (CP), as a derivative from the carcinoma-stromal ratio, can be applied as a candidate marker to identify patients for adjuvant therapy. …”
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Safety of transtympanic application of probiotics in a chinchilla animal model by Carol Nhan, Aren Bezdjian, Shyamali Saha, Satya Prakash, Lily H. P. Nguyen, Sam J. Daniel

“…Lactobacillus plantarum is a probiotic that has been shown to decrease S. aureus and P. aeruginosa growth in wounds, making it a good candidate for the treatment of chronic suppurative otitis media. …”
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Mining Potential Drug Targets and Constructing Diagnostic Models for Heart Failure Based on miRNA-mRNA Networks by Xiangming Fang, Rensheng Song, Jiaxing Wei, Qin Liao, Zhenhong Zeng

“…In conclusion, we identified TAP1, a key candidate gene in the diagnosis and treatment of HF, and determined that compound DB04847 is highly likely to be a potential inhibitor of TAP1. …”
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Immunogenicity and Protective Efficacy of a Novel Recombinant BCG Strain Overexpressing Antigens Ag85A and Ag85B by Chun Wang, Ruiling Fu, Zhenhua Chen, Kun Tan, Lingxia Chen, Xindong Teng, Jia Lu, Chunwei Shi, Xionglin Fan

“…Recombinant Bacillus Calmette-Guérin (rBCG) strain is the promising vaccine candidate for tuberculosis (TB) prevention, which aims at providing more enduring and enhanced protection than the parental BCG vaccine. …”
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T cell receptors specific for an imatinib-induced mutation in BCR-ABL for adoptive T cell therapy by Meng-Tung Hsu, Gerald Willimsky, Gerald Willimsky, Gerald Willimsky, Leo Hansmann, Leo Hansmann, Leo Hansmann, Leo Hansmann, Thomas Blankenstein

“…Human CD8+ T cells were engineered to express the specific TCRs for characterization, in which one TCR was identified as a therapeutic candidate due to its superior avidity and lack of detectable off-target reactivity. …”
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Plasma miRNAs in polycystic ovary syndrome drive endometrial cancer progression: insights into molecular pathways and therapeutic targets by Xuedan Lai, Ling Wu, Peihong Lin, Lijiao You, Jianwen Ye

“…Validation was performed using experimental data from Ishikawa cells treated with six candidate drugs. Among the 15 differentially expressed miRNAs, 12 were up-regulated and 3 were down-regulated in PCOS. …”
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Differential attainment at national selection for higher surgical training: a retrospective cohort study by Amanda Lee, Jennifer Cleland, John Hines, Peter Brennan, Ricky Ellis, Yasin Al-Tawarah

“…The objective of this study was to characterise the relationship between candidate sociodemographic factors and performance at National Selection for HST in the UK.Design A retrospective cohort study.Setting National Selection for HST in the UK.Participants All UK graduates in the UKMED database (https://www.ukmed.ac.uk) who underwent selection for HST from 2012 to 2019.Outcomes and measures Performance at HST Selection for each surgical specialty is measured by assessment of the candidate’s academic portfolio and multiple objective structured clinical examination style stations testing knowledge and skills. …”
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Proteomic Identification and Functional Analysis of Babesia microti Reveals Heparin-Binding Proteins by Yu Chun Cai, Bin Xu, Yan Hong Chu, Ying Fang Yu, Jia Hui Sun, Zi Ran Mo, Han Yin Yang, Shu Ning Yan, Mu Xin Chen, Jia Xu Chen

“…Bioinformatics was utilized to analyze the subcellular localization and biological functions of these proteins. Candidate genes encoding proteins with strong heparin affinity will be expressed in a prokaryotic system to produce recombinant proteins. …”
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Yield performance, adaptability and processing qualities of pre-release potato clones under different Rwandan agro-ecologies by Rukundo Placide, Ndacyayisenga Theophile, Elke Vandamme, Nshimiyimana Jean Claude, Mendes Thiago

“…The results of this study highlighted that the clones CIP393371.58 and CIP393077.159 can be recommended as candidate for new varieties for high fresh tuber yields; while the clones CIP398190.615, CIP396018.241, and CIP393280.64 can be recommended as candidate for new potato varieties for crisps and French fries.…”
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La fonction rituelle du dispositif Différents et Compétents : ambiguïtés et dons professionnels by Maude Hatano-Chalvidan

“…This text thus proposes a new reading of what is at stake within the device which can be read as a form of codified co-activity where the visible testing (passage of the candidate in front of a professional jury) also implies invisibly the testing of the accompanying trainer. …”
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Graviatoms with de Sitter Interior by Irina Dymnikova, Michael Fil’chenkov

“…We present a graviatom with de Sitter interior as a new candidate to atomic dark matter generically related to a vacuum dark energy through its de Sitter vacuum interior. …”
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On the implementation of a global optimization method for mixed-variable problems by Nannicini, Giacomo

“…We propose several modifications aimed at generalizing and improving these two algorithms: (i) the use of an extended space to represent categorical variables in unary encoding; (ii) a refinement phase to locally improve a candidate solution; (iii) interpolation models without the unisolvence condition, to both help deal with categorical variables, and initiate the optimization before a uniquely determined model is possible; (iv) a master-worker framework to allow asynchronous objective function evaluations in parallel. …”
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SCIENCE DEVELOPMENT STATISTICAL ANALYSIS IN HIGHER EDUCATION SECTOR by E. A. Dolgikh, L. S. Parshintseva

“…Information about availability of scientific degrees of candidate and doctor of sciences in scientific personnel in the higher education sector has been collected. …”
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New Results on Stability of Delayed Cohen–Grossberg Neural Networks of Neutral Type by Ozlem Faydasicok

“…By setting a new generalized appropriate Lyapunov functional candidate, some novel sufficient conditions are proposed for global asymptotic stability for the considered neural networks of neutral type. …”
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Alternative Definitions of Complexity for Practical Applications of Model Selection Criteria by Murari Andrea, Riccardo Rossi, Teddy Craciunescu

“…The third alternative is focused on assessing the consistency of extrapolation of the candidate models. All the upgrades are easy to implement and typically outperform the traditional versions of model selection criteria and constitute a good set of alternatives to be deployed, depending on the priorities of the investigators and the characteristics of the application.…”
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A Relevant Customer Identification Algorithm Based on the Internet Financial Platform by Guo Yangyudongnanxin

“…The proposed algorithm calculates the customers corresponding to the two selected financial platforms based on the candidate customer set selected from the seed dataset and combined with the restored social relationship. …”
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