Design, synthesis, structural characterization, in vitro anticancer activity, and in silico studies of some new hydroxylated and fluorinated-substituted hydrazone derivatives by Reşit Çakmak, Eyüp Başaran, Ömer Erdoğan, Suraj N. Mali, Semiha Köprü, Haya Yasin, Shailesh S. Gurav, Giray Topal

“…In this study, novel hydroxylated and fluorinated-substituted hydrazone derivatives bearing an aromatic nitro moiety (2a-d and 3a-d) were designed as potential anticancer drug candidates, synthesized for the first time, and evaluated for their anticancer activity against chondrosarcoma (SW1353), a common primary malignant cartilage-forming tumor, neuroblastoma (SH-SY5Y), a type of brain cancer, and healthy (L929) cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method for 24 h. …”
Get full text

In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives by Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete

“…The antitumor and immunomodulatory activities of molecules derived from 1,2,4-oxadiazole, as demonstrated in the literature, highlight the potential of this class as a source of promising candidates for therapeutic applications. Thus, the present study aims to evaluate the antitumor and immunomodulatory effects of the synthetic derivative 1,2,4-oxadiazole, N-cyclohexyl-3-(3-methylphenyl)-1,2,4-oxadiazole-5-amine (1,2,4-oxadiazole derivative 2), in melanoma cells and murine Bone Marrow-Derived Macrophages (BMDMs). …”
Get full text

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…In proof-of-concept applications on vascular diseases, we demonstrate that Pathopticon helps guide in vitro experiments by identifying pathways that are potentially regulated by the predicted therapeutic candidates. Conclusions Our network-based analytical framework integrating pharmacogenomics and cheminformatics (available at https://github.com/r-duh/Pathopticon ) provides a feasible blueprint for a cell type-specific drug discovery and repositioning platform with broad implications for the efficiency and success of drug development.…”
Get full text

Kinomic profiling to predict sunitinib response of patients with metastasized clear cell Renal Cell Carcinoma by Jeannette C. Oosterwijk-Wakka, Liesbeth Houkes, Loes F.M. van der Zanden, Lambertus A.L.M. Kiemeney, Kerstin Junker, Anne Y Warren, Tim Eisen, Ulrich Jaehde, Marius T Radu, Rob Ruijtenbeek, Egbert Oosterwijk

“…Additionally, it is possible that mRCC patients with an immune kinase signature are better checkpoint inhibitor candidates, but this needs to be studied.…”
Get full text

Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

“…Methods RESTORE is a multicenter, open-label randomized controlled trial. Candidates were assessed for CLBP associated with multifidus dysfunction, with no indication for or history of lumbar spine surgery. …”
Get full text

High-throughput methylation sequencing reveals novel biomarkers for the early detection of renal cell carcinoma by Wenhao Guo, Weiwu Chen, Jie Zhang, Mingzhe Li, Hongyuan Huang, Qian Wang, Xiaoyi Fei, Jian Huang, Tongning Zheng, Haobo Fan, Yunfei Wang, Hongcang Gu, Guoqing Ding, Yicheng Chen

“…Conclusions Our findings highlight the critical role of hypermethylation in RCC etiology and progression, and present these identified biomarkers as promising candidates for diagnostic and prognostic applications.…”
Get full text

No major impact of new grape varieties on Bordeaux wine typicity: expert assessments in blind and non-blind tastings by Marc Plantevin, Sophie Tempère, Cécile Thibon, Lucile Dijkstra, Julien Lecourt, Agnès Destrac-Irvine, Cornelis van Leeuwen

“…Recently, a study investigating the typicity of 26 red varieties isolated five potential candidates (Fer Servadou, Duras, Manseng noir, Vinhão and Arinarnoa) sharing similar sensorial spaces compared to classical Bordeaux varieties. …”
Get full text

Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer by Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia, Huanxin Lin

“…Hence, drug resistance and mitochondrial energy metabolism-related differentially expressed genes (DMRDEGs) may emerge as candidates for novel cancer biomarkers. This study endeavors to assess the viability of DMRDEGs as biomarkers or therapeutic targets for breast cancer. …”
Get full text

Toward accurate prediction of carbon dioxide (CO2) compressibility factor using tree-based intelligent schemes (XGBoost and LightGBM) and equations of state by Behnam Amiri-Ramsheh, Aydin Larestani, Saeid Atashrouz, Elnaz Nasirzadeh, Meriem Essakhraoui, Ali Abedi, Mehdi Ostadhassan, Ahmad Mohaddespour, Abdolhossein Hemmati-Sarapardeh

“…Among various gas mixtures that are proposed as candidates to be injected into mature oil reservoirs, CO2 gas attains miscibility with the resident hydrocarbon fluid at a reasonable pressure and increases the oil recovery factor. …”
Get full text

Effectiveness and safety of PD-1/L1 inhibitors as first-line therapy for patients with advanced or metastatic urothelial carcinoma who are ineligible for platinum-based chemotherap... by Weiming Liang, Weiming Liang, Zhijing Wang, Zhilong Huang, Yanping Huang, Chunyan Li, Yiwen Liang, Miaoyan Huang, Duo Zhang, Chenchen Li

“…However, there was no significant difference in PFS and OS between the two groups.ConclusionThe findings indicated that PD-1/L1 inhibitors could be used as a safe and viable first-line treatment option for patients with advanced or metastatic urothelial carcinoma who were not suitable candidates for platinum-based chemotherapy. Specifically, the combination of Enfortumab vedotin (EV) and pembrolizumab (Pembro) showed more effectiveness in treating patients compared to trials using the current standard treatment, suggesting that it could be a promising alternative treatment option.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024510152.…”
Get full text

Identification of sex linked molecular markers in Indonesian giant freshwater prawn Macrobrachium rosenbergii by Novi Megawati, Alimuddin, Ratu Siti Aliah

“…The MrMKn primers have the opportunity to be used in the selection of the female ZZ (neo-female) prawns from Solo without progeny test, so that the determination of female ZZ candidates can be identified more quickly. However, the primer still needs to be redesigned to distinguish neo-female prawns from Sukabumi and Aceh.   …”
Get full text

Implementasi Simple Additive Weight pada Sistem Pendukung Keputusan Penerima Bantuan Stimulan Perumahan Swadaya Berbasis Web di Dinas Perumahan dan Kawasan Pemukiman Kota Magelang by Eko Joko Pamungkas, Uky Yudatama, Emilya Ully Artha

“…In determining Recipients of Bantuan Stimulan Perumahan Swadaya Dinas Perumahan dan Kawasan Permukiman is still ineffective in determining recipients of Bantuan Stimulan Perumahan Swadaya such as the number of prospective recipients of Bantuan Stimulan Perumahan Swadaya while the funds for Bantuan Stimulan Perumahan Swadaya that have come down from the center are only a few of the many potential recipients of Bantuan Stimulan Perumahan Swadaya. then it is necessary to rank each of the criteria of the existing beneficiary candidates. In addition, the survey data is still written using paper manually so it is prone to loss or damage and the process of selecting aid recipients has not been published. …”
Get full text

Aplikasi untuk Mencari Kelayakan Siswa Penerima Bantuan Pendidikan dengan Metode Simple Additive Weighting (Studi Kasus : SMK NU Ma'arif Kudus) by Syaifuddin Syaifuddin, Solikhin Solikhin, Eko Riyanto

“…To overcome this problem and get candidates who are entitled to receive and achieve the desired standards, it is necessary to apply the eligibility selection of students receiving educational assistance using the Simple Additive Weighting (SAW) method as decision support. …”
Get full text

Evaluation of in-vitro and in-silico antidiabetic potential, glucose metabolism, antioxidant, cytotoxicity and phytochemical content of Ipomoea bolusiana Schinz and Ipomoea crassip... by Garland Kgosi More, Nolitha Nkobole, Charmy Twala, Sechaba Machedi, Tebogo Amos Moswetsa, Ramakwala Christinah Chokwe

“…The results documented in this study will be valuable leads in the development of therapeutic candidates for diabetes and oxidative stress.…”
Get full text

Examining Inclusive Tertiary Education Delivery through the National Open University of Nigeria's Community Study Centres by Musibau O. Oyebode

“… Conventional universities in Nigeria can no longer absorb the growing population of candidates desiring higher education. National Open University of Nigeria (NOUN) came to the rescue in 2003. …”
Get full text

Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inf... by Holger Neb, Verena Roth, Jessica Roos, Jessica Roos, Tom Bauer, Anja Urbschat, Ulrike Heinicke, Carlo Angioni, Dieter Steinhilber, Dieter Steinhilber, Matthias Piesche, Matthias Piesche, Nerea Ferreirós, Robert Gurke, Robert Gurke, Gerd Geisslinger, Gerd Geisslinger, Edith Utech, Kai Zacharowski, Patrick Meybohm, Patrick Meybohm, Patrick Paulus, Elke Schmitt, Elke Schmitt, Thorsten Jürgen Maier, Thorsten Jürgen Maier

“…We therefore hypothesized that fatty-acid-derived lipid mediators might be regulated during inflammatory stages and other clinical events in critically ill patients and might serve as potential biomarker candidates.Methods and study designUsing liquid chromatography-tandem mass spectrometry (LC-MS/MS), we determined the levels of 53 lipid mediators in plasma from nine patients. …”
Get full text

Grain Yield Stability Analysis of Lentil Genotypes by AMMI Indices by Payam Pezeshkpour, Reza Amiri, Iraj Karami, Amir Mirzaei

“…Therefore, they could be candidates for the introduction of new cultivars.…”
Get full text

Combined Age with Mean Decrease Rates of Total Bilirubin and MELD Score as a Novel and Simple Clinical Predictor on 90-Day Transplant-Free Mortality in Adult Patients with Acute Li... by Di Jin, Kai Kang, Bing-zhu Yan, Jian-nan Zhang, Jun-bo Zheng, Zhi-hui Wang, Di Wu, Yu-jia Tang, Xin-tong Wang, Qi-qi Lai, Yang Cao, Hong-liang Wang, Yang Gao

“…Combined age with mean decrease rates of total bilirubin and MELD score as a novel and simple clinical predictor can accurately predict 90-day transplant-free mortality in adult patients with ALF undergoing PE, which is worthy of application and promotion in clinical practice, especially in the identification of potential transplant candidates.…”
Get full text

Architecture et réfection des aqueducs d’Orléans/Cenabum (Loiret) by Julien Courtois, Mathilde Noël, Franck Verneau

“…A thermal facility identified near the monumental centre of Orléans/Cenabum in the 19th century or a peri-urban domus in the eastern districts of the town constitute two potential candidates for the outlet of the aqueducts, but did not show how they fitted into the urban fabric.In the second half of the 19th century, local scholars reported the discovery of the remains of an underground aqueduct (aqueduct A) along the present rue du Faubourg Saint-Vincent. …”
Get full text

Unexpected identification of peak systolic velocity in the radial artery as a risk factor for functional primary patency of radiocephalic fistulas by Rui Cong, Songxiu Li, Shasha Shi

“…Preoperative evaluation of the peak systolic velocity could allow to identify patients with a lower likelihood of long-term radiocephalic fistula patency, facilitating improved selection of candidates for radiocephalic fistula creation. Resumen: Objetivo: Dado que la fístula radiocefálica no es necesariamente adecuada para todos los pacientes con enfermedad renal avanzada, nuestro objetivo consistió en investigar los indicadores sensibles que afectan la supervivencia primaria funcional de las fístulas radiocefálicas. …”
Get full text