Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae by Isabel Ramón Roth, Pavel Kats, Timm Fiebig, Françoise Routier, Roman Fedorov, Larissa Dirr, Jana I. Führing

“…UGPs have, therefore, gained attention as anti-bacterial drug target candidates, prompting us to study their structure-function relationships to provide a basis for the rational development of specific inhibitors. …”
Get full text

Prevalence and Predictors of Nonadherence to Diet and Physical Activity Recommendations among Type 2 Diabetes Patients in Southwest Ethiopia: A Cross-Sectional Study by Getandale Zeleke Negera, Dariowani Charles Epiphanio

“…Variables with p value ≤0.25 in bivariate logistic regression were considered as candidates for multivariable regression. Multivariate logistic regression was performed to identify independent predictors. …”
Get full text

Effect of Isoniazid Preventive Therapy on the Incidence of Tuberculosis among Seropositive Children Attending HIV/AIDS Care in Two General Hospitals, Northwest Ethiopia, 2021 by Fassikaw Kebede, Birhanu Kebede, Tsehay Kebede, Melaku Agmasu

“…Categorical variables at bivariable Cox regression were assessed for candidates transferred at P value <0.25 for multivariable Cox regression to claiming predictors associated with TB incidence rate at 95% CI at P<0.005. …”
Get full text

Exploring RNA cargo in extracellular vesicles for pleural mesothelioma detection by Agnieszka Kraft, Michaela B. Kirschner, Vanessa Orlowski, Manuel Ronner, Caroline Bodmer, Valentina Boeva, Isabelle Opitz, Mayura Meerang

“…While extracellular vesicles (EVs) have emerged as promising candidates for blood-based biomarkers, their role in PM has not been studied yet. …”
Get full text

Klasifikasi Presiden Republik Indonesia Menggunakan SVM Kernel Polynomial Dengan Fitur Ektraksi Gabor by Kristianingrum Kristianingrum, Aviv Yuniar Rahman, Istiadi Istiadi

“…Presidential elections or what are often called elections (general elections) are useful for selecting presidential and vice presidential candidates in a country. considering the change of president after 5 years in 2 periods, today's youth tend to follow the millennial era. …”
Get full text

Evolution of gender representation among Canadian OTL-HNS residents: a 27-year analysis by Sarah Chorfi, Joseph S. Schwartz, Neil Verma, Meredith Young, Lawrence Joseph, Lily H. P. Nguyen

“…There was parity in success rates of female and male candidates ranking OTL-HNS as their first choice specialty for most years. …”
Get full text

Brodalumab: Six-Year US Pharmacovigilance Report by Mark G. Lebwohl, John Y. Koo, April W. Armstrong, Bruce E. Strober, Soo Han Yoon, Nicole N. Rawnsley, Earl L. Goehring, Gina D. Mangin, Abby A. Jacobson

“…Abstract Introduction Brodalumab is a human interleukin-17 receptor A antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy and have failed to respond or have lost response to other systemic therapies. …”
Get full text

The Impact of Coronavirus Disease 2019 Pandemic on Female Patients Seeking or Undergoing Fertility Treatment in a Single In Vitro Fertilisation Clinic in Greece: An International,... by Konstantina Pappa, Emmanouil M. Xydias, Apostolos C. Ziogas, Kanelina Bimba, Elias Tsakos, Efstratios Kolibianakis

“…Results: From 409 initial candidates, 106 women, with a mean age of 41.2 years, completed the questionnaire (26% response rate). …”
Get full text

The quality of judicial decisions in cases of bullying in professional educational institutions by O. G. Yushkevych

“…The researchers also distinguish between objective (legal training, legal experience, qualification requirements for judicial candidates, opportunities for practicing judges to improve their skills, mechanisms for monitoring the work of judges, unrestricted public access to judicial decisions, the role of legal science in analysing judicial decisions) and subjective (the judge’s personality, salary, social guarantees, working conditions and ability to organise their work) factors that affect the quality of a judicial decision. …”
Get full text

Differentiated approach at the choice of chronic hepatitis C antiviral therapy mode (real clinical practice experience) by I. Yu. Pirogova, N. B. Kovaleva, E. P. Patlusov, E. S. Radchenko

“…Results of the present study demonstrate that screening for treatment candidates allows to achieve high efficacy and favorable safety profile of double treatment mode (cPEG-IFNα2b and ribavirin).…”
Get full text

Revealing Sarcophyton extract's alleviating potential against gentamicin-induced renal and testicular toxicity in rat model by Nada S. Badr, Aml Talaat, Salwa A. El-Saidy, Aml Zaki Ahmed Ghoneim

“…Sarcophyton species possess significant antioxidant and anti-inflammatory properties, making them potential candidates for addressing oxidative stress and inflammation-related gentamicin toxicity. …”
Get full text

Dinamika dan Profil Undecided Voters Menjelang Pemilu 2024 di Indonesia by Vincentius Gitiyarko Priyatno

“…Leading up to the 2024 elections, the public is starting to show their political preferences for both presidential candidates and political parties. However, there is still a portion of the population that hasn't disclosed their choices. …”
Get full text

DYSFUNCTION OF MODERN RUSSIAN INSTITUTES OF STATE AWARDS IN THE SPHERE OF EDUCATION AND SCIENCE by Aleksey V. Ruchkin

“…Both officially established rules and other requirements to candidates on reception of the state honourable distinctions, observed with the Soviet period are considered. …”
Get full text

Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer&rsquo;s Disease by Cai Y, Huang G, Ren M, Chai Y, Fu Y, Yan T, Zhu L

“…Notably, gefitinib and plumbagin may be therapeutic candidates for intervening in KI-associated AD by targeting EGFR and RELA. …”
Get full text

Acceptability and Preliminary Effects of Intensive Brief Trauma-Focused PTSD Treatment for Refugees by Petter Tinghög, Lina Vågbratt, Julia Jennstål, Maria Bragesjö, Niklas Möller

“…Identifying less suitable candidates and conducting larger, controlled studies with longer follow-up periods are needed to establish ITT's efficacy in this population.…”
Get full text

Targeted Polymer–Peptide Conjugates for E-Selectin Blockade in Renal Injury by Nenad Milošević, Marie Rütter, Yvonne Ventura, Valeria Feinshtein, Ayelet David

“…Directly interfering with these interactions is a viable strategy to limit the extent of excessive inflammation; however, several small-molecule drug candidates failed during clinical translation. We hypothesized that a synthetic polymer presenting multiple copies of the high-affinity E-selecting binding peptide (P-Esbp) could block E-selectin-mediated functions and decrease leukocytes infiltration, thus reducing the extent of inflammatory kidney injury. …”
Get full text

Integrating Metabolomics and Genomics to Uncover the Impact of Fermented Total Mixed Ration on Heifer Growth Performance Through Host-Dependent Metabolic Pathways by Zhenzhen Hu, Minyu Zuo, Shixuan Ding, Yifan Zhong, Mingyuan Xue, Huichao Zheng

“…In conclusion, feeding HSF and ZF FTMR enhances glutathione metabolism and antioxidant capacity in heifers, positioning key metabolites as candidates for ADG markers. This integrative omics approach underscores the potential for enhancing livestock productivity and promoting sustainable agricultural practices.…”
Get full text

The Impact of Thyme and Rosemary on Prevention of Osteoporosis in Rats by Amr S. Elbahnasawy, E. R. Valeeva, Eman M. El-Sayed, I. I. Rakhimov

“…Our study demonstrates that thyme and rosemary effectively mitigated calcium deficiency-induced bone loss and maybe considered as promising candidates for preventing bone resorption and osteoporosis.…”
Get full text

Comparison of miRNA expressions among benign, premalignant and malignant lesions of the larynx: could they be transformation biomarkers? by Fatma Ruya Tuncturk, Ibrahim Akalin, Lokman Uzun, Tulay Zenginkinet

“…Finding a biomarker to overcome these concerns are ongoing challenges and recently microRNAs (miRNAs) are attributed as possible candidates since they can regulate gene expressions in the human genome. …”
Get full text

Roadmap for Designing Donor-<inline-formula><math display="inline"><semantics><mrow><mi mathvariant="bold-sans-serif">π</mi></mrow></semantics></math></inline-formula>-Acceptor Flu... by Guliz Ersoy, Maged Henary

“…These features make them good candidates for various applications such as bioimaging, photovoltaic devices and nonlinear optical materials. …”
Get full text