Determination of genetic diversity in persimmon accessions using morphological and inter simple sequence repeat markers by Yazgan Tunç, Canan Aydınlıoğlu, Kadir Uğurtan Yılmaz, Ali Khadivi, Daya Shankar Mishra, El Hassan Sakar, Tomáš Vyhnánek

“…Notably, accessions ‘P78’, ‘P7’, ‘P48’, ‘P29’, ‘P44’, ‘P25’, ‘P5’, ‘P98’, ‘P80’, ‘P50’, ‘P37’, ‘P77’, ‘P57’, ‘P56’, ‘P41’, ‘P73’, ‘P39’, ‘P65’, ‘P72’, and ‘P61’ were identified as promising candidates for further study. Conclusions: This study demonstrates significant genetic diversity in persimmon accessions from Hatay. …”
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Immortalized Mesenchymal Stem Cells: A Safe Cell Source for Cellular or Cell Membrane-Based Treatment of Glioma by Yuxuan Zhang, Jie Liu, Yunzhao Mo, Zetao Chen, Taoliang Chen, Yan Li, Yaofeng Zheng, Shaokang Deng, Xiangdong Xu, Huajian Chen, Haoqi He, Jiansheng Chen, Tao Jin, Xinlin Sun, Yiquan Ke, Jihui Wang

“…In this study, we focused on the safety of immortalized mesenchymal stem cells (im-MSCs) and, for the first time, studied the feasibility of im-MSCs as candidates for the treatment of glioma. The im-MSCs were constructed by lentiviral transfection of genes. …”
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A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor... by Lejing Qu, Meizhi Jiao, Zilong Zhang, Yuanyuan Ou, Xue Zhao, Yajun Zhang, Xinfeng Zhao

“…Conclusion We reasoned that aloe-emodin and emodin had the potential to become dual-target candidates against hypertrophic scar through the regulation of AT1R and AT2R signaling pathways. …”
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The cinnamyl alcohol dehydrogenase gene family is involved in the response to Fusarium oxysporum in resistant and susceptible flax genotypes by R. O. Novakovskiy, L. V. Povkhova, G. S. Krasnov, T. A. Rozhmina, A. A. Zhuchenko, L. P. Kudryavtseva, E. N. Pushkova, P. Kezimana, A. V. Kudryavtseva, A. A. Dmitriev, N. V. Melnikova

“…Our study indicates the strong involvement of CAD genes in flax response to F. oxysporum but brings no evidence of their role as resistance gene candidates. These findings contribute to the understanding of the mechanisms underlying the response of flax to F. oxysporum infection and the role of CAD genes in stress resistance.…”
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LoSI: Large Scale Location Inference Through FM Signal Integration and Estimation by Tathagata Mukherjee, Piyush Kumar, Debdeep Pati, Erik Blasch, Eduardo Pasiliao, Liqin Xu

“…The system first runs a DCD feature detector on the observed spectrum and then solves a subset query formulation to find Inference Candidates (IC). Finally, it uses a simple Euclidean nearest neighbor search on the ICs to localize the observation. …”
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In silico design of an epitope-based vaccine ensemble for fasliolopsiasis by Ruchishree Konhar, Ruchishree Konhar, Kanhu Charan Das, Kanhu Charan Das, Aiboklang Nongrum, Rohan Raj Samal, Shailesh Kumar Sarangi, Devendra Kumar Biswal, Devendra Kumar Biswal

“…In the present study, we developed an in silico workflow to select antigens for composing a chimeric vaccine, which could be a significant technique for developing a fasciolopsiasis vaccine that prevents the parasite from causing serious harm.Results and discussionThis chimeric vaccine can now be tested experimentally and compared to other vaccine candidates to determine its potential influence on human health. …”
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Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer’s disease pathologic process via GPR4... by Zifan Wang, Cai Wang, Boyu Yuan, Li Liu, Haoming Zhang, Mingqiang Zhu, Hongxia Chai, Jie Peng, Yanhua Huang, Shuo Zhou, Juxiong Liu, Liyong Wu, Wei Wang

“…Conclusions Taken together, our results demonstrate that A. muciniphila and its metabolite propionate protect against AD-like pathological events in AD mouse models by targeting mitochondrial homeostasis, making them promising therapeutic candidates for the prevention and treatment of AD. Video Abstract…”
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Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail by Lorena V. Cortés-Medina, Herminia Pasantes-Morales, Alejandro Aguilera-Castrejon, Arturo Picones, Cesar O. Lara-Figueroa, Enoch Luis, Juan Jose Montesinos, Victor A. Cortés-Morales, M. P. De la Rosa Ruiz, Erika Hernández-Estévez, Laura C. Bonifaz, Marco Antonio Alvarez-Perez, Gerardo Ramos-Mandujano

“…Human mesenchymal stem cells (MSCs) are good candidates for brain cell replacement strategies and have already been used as adjuvant treatments in neurological disorders. …”
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Truncated NS1 Influenza A Virus Induces a Robust Antigen-Specific Tissue-Resident T-Cell Response and Promotes Inducible Bronchus-Associated Lymphoid Tissue Formation in Mice by Anna-Polina Shurygina, Marina Shuklina, Olga Ozhereleva, Ekaterina Romanovskaya-Romanko, Sofia Kovaleva, Andrej Egorov, Dmitry Lioznov, Marina Stukova

“…Background: Influenza viruses with truncated NS1 proteins show promise as viral vectors and candidates for mucosal universal influenza vaccines. …”
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Comparing the Effectiveness of Intra-articular Injection with Autologous Platelet-rich Plasma vs Hyaluronic Acid vs Platelet-derived Growth Factors in Early Osteoarthritis of Knee... by Vidya S Konana, Harish S Yallapura, Sriharsha Bettaswamy, Srinivas P Sivaram, Darshan G Thimmegowda

“…Results: A total of 71 candidates were finally included in the study. Patients' mean age of HA, PRP, and activated PRP was 54.5 ± 6.79, 55.47 ± 6.31, and 55.73 ± 7.33, respectively. …”
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Stability analysis for seed yield of chickpea (<i>Cicer arietinum</i> L.) genotypes by experimental and biological approaches by R. Karimizadeh, P. Pezeshkpour, A. Mirzaee, M. Barzali, P. Sharifi, M. R. Safari Motlagh

“…Therefore, G14 and G5 could be candidates for introduction of new cultivars.…”
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Discovery of phloridzin as a new antagonist for Di(2-ethylhexyl) phthalate-induced male reproductive toxicity based on the adverse outcome pathway network and drug-target gene set... by Huan Gao, Xue Zhang, Ziqi Liu, Xiaoge Yang, Yajie Li, Mengxing Cui, Han Wang, Xiaoyu Chen, Weiying Zhang, Zhihan Liu, Yongjiang Yu, Liping Chen, Daochuan Li, Yongmei Xiao, Wen Chen, Qing Wang

“…Eventually, we developed a novel in silico antagonist screening platform (http://43.136.69.224:3838/wlab/) based on drug-target gene set enrichment analysis (dtGSEA version 2.0). Several potential candidates that mitigate DEHP-mediated cellular apoptosis have been screened out, including quercetin, taurine, methionine, and phloridzin. …”
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Comparative Proteomic Analysis of Visceral Adipose Tissue in Morbidly Obese and Normal Weight Chinese Women by Chen Shang, Wei Sun, Chunlin Wang, Xiangqing Wang, Huijuan Zhu, Linjie Wang, Hongbo Yang, Xue Wang, Fengying Gong, Hui Pan

“…These differential proteins could be potential candidates in addressing the role of VAT in the development of obesity.…”
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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities by Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Kashif Zahoor, Farhat Jabeen, Zinayyera Subhani, Tahira Younis, Muhammad Ali, Iqra Sarfraz, Zeliha Selamoglu

“…It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates.…”
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Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner I... by Lianet Lopez, Hannah Shuster-Hyman, Eden Marco, Hasna Khan, Avishai Gasner, Aleksandra Uzelac, Brandon Wyse, Poonam Mander, Mugundhine Sangaralingam, Joseph Fish, Ariel Gorodensky, Samar Mouazz, Amanda Kauffman, Denis Gallagher, Andrée Gauthier-Fisher, Clifford L. Librach

“…First trimester (FTM) and term human umbilical cord perivascular cells are promising mesenchymal stromal cell candidates to mitigate side effects of oncotherapy, but their safety for cancer patients remains to be determined. …”
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Antifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner by Mohika Damle, Ponsekar Abraham Anandapandian, B. Eswaran, Swapnaneel Pradhan, Silvin Joe C J, Shreyas Dhumke

“…Conclusion: Incorporating chitosan-mediated fenugreek nanocomposite into denture tissue conditioners offers a promising approach to reducing Candidal growth, potentially improving oral health outcomes for denture wearers.…”
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Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomy by Alireza Tabibkhooei, Maziar Azar, Mohsen Nabiuni, Javad Jahandideh, Mohsen Benam, Farid Qoorchi Moheb Seraj, Feizollah Ebrahimnia, Ali Moradi

“…Methods A randomized controlled trial was conducted on 56 consecutive patients who were candidates for unilateral lumbar discectomy on one lumbar surface. …”
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Cochlear implantation in vestibular schwannoma: A game changer? A narrative review by Luis Lassaletta, Miryam Calvino, Isabel Sánchez-Cuadrado, José Manuel Morales-Puebla, Javier Gavilán

“…Audiological outcomes are variable, but worse than those of conventional CI candidates. Small and medium-sized tumors and those with a better preoperative hearing are more likely to benefit from a CI. …”
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Prognostic value of adjuvant chemotherapy for hormone receptor-negative T1a and T1bN0M0 breast cancer patients by Yaxiong Liu, Honghui Li, Jinsong Li, Changlong Wei, Jinsheng Zeng, Qiuhong Tian

“…Our study was to explore prognostic value and identify candidates of adjuvant CT for these patients. The data of hormone receptor-negative T1a and T1bN0M0 breast cancer patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. …”
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The Lipo-DIEP Flap Breast Reconstruction: A Valuable Innovation for Maximizing Abdominal Tissue Volume by Benedetto Longo, MD, PhD, Gennaro D’Orsi, MD, Alessio Farcomeni, PhD, Martina Giacalone, MD, Elettra Gagliano, Lisa Vannucchi, MD, Maximilian Catenacci, MD, Gianluca Vanni, MD, Claudio Oreste Buonomo, MD, Valerio Cervelli, MD

“…We prospectively enrolled patients with BMI less than 25 kg/m2 and candidates for lipo-DIEP flap BR (group A) comparing them with a control group (group B) undergoing traditional DIEP flap BR with the same characteristics of the first group (BMI < 25 kg/m2). …”
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