Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation by Chisato Yamada, Kimiko Kuroki, Naoyoshi Maeda, Hiroshi Watanabe, Ami Takahashi, Katsumi Maenaka

“…These results suggest that PEGylated soluble HLA-G2 homodimers could be candidates for immunosuppressive biologics that specifically target LILRB2-positive myelomonocytic antigen-presenting cells.…”
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Immediate results of the еndovascular aneurysm repair in abdominal aortic aneurysm patients with an unfavorable proximal neck by S.M. Furkalo, V.A. Kondratyuk, O.A. Vlasenko, I.V. Khasyanova, A.V. Khohlov, P.A. Gindich, I.A. Mazanovich, O.O. Pustyntsev

“…However, due to the anatomical characteristics of the aorta about 40 % of patients cannot be candidates for еndovascular aneurysm repair (EVAR). …”
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Antimicrobial properties of selected microalgae exopolysaccharide-enriched extracts: influence of antimicrobial assays and targeted microorganisms by Marion Pointcheval, Marion Pointcheval, Marion Pointcheval, Anthony Massé, David Floc’hlay, Franck Chanonat, Jacques Estival, Marie-José Durand

“…To our knowledge, this study is the first to explore the algicidal properties of EPS-enriched extracts derived from microalgae, identifying promising candidates for future investigations into their potential applications.…”
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The association between sarcopenia and clinical outcomes among Chinese patients with triple-negative breast cancer: a retrospective study by Huayan Gu, Teng Zhu, JiaLing Ding, Zhi Yang, Yiqiao Lu, Guilong Guo

“…These patients with high risk might be candidates for individual programmed exercise and diet interventions to optimize survival outcomes.…”
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Novel (±)-trans-β-lactam ureas: Synthesis, in silico and in vitro biological profiling by Jurin Mladenka, Stepanić Višnja, Bojanić Krunoslav, Vadlja Denis, Kontrec Darko, Dražić Tonko, Roje Marin

“…Considering low toxicity risk, molecules 4a and 4f can be selected as the most promising candidates for further structure modifications.…”
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Isolation, Characterization, and Safety Evaluation of Human Skin-Derived Precursors from an Adherent Monolayer Culture System by Ru Dai, Wei Hua, Wei Chen, Lidan Xiong, Li Li, Yiming Li

“…Skin-derived precursors (SKPs) are promising candidates for regenerative medicine. Several studies have transcultured human SKPs (termed tSKPs) from fibroblasts (FBs) expanded in monolayer culture. …”
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Evaluation of Siemens Healthineers’ StrokeSegApp for automated diffusion and perfusion lesion segmentation in patients with ischemic stroke by Lynnet-Samuel J. Teichmann, Ahmed A. Khalil, Kersten Villringer, Jochen B. Fiebach, Stefan Huwer, Eli Gibson, Ivana Galinovic

“…Out of 56 subjects meeting DEFUSE 2/3 criteria in the cohort, it correctly identified mechanical thrombectomy candidates with a sensitivity of 82.1% (95% CI: 63.1–93.9%) and a specificity of 96.4% (95% CI: 81.7–99.9%).ConclusionThe Siemens Healthineers’ StrokeSegApp provides accurate automated segmentation of ischemic stroke lesions, comparable to human experts as well as similar commercial software, and shows potential as a reliable tool in clinical decision-making for stroke treatment.…”
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Chitosan Nanoparticles for Enhanced Immune Response and Delivery of Multi-Epitope <i>Helicobacter pylori</i> Vaccines in a BALB/c Mouse Model by Rita Amaral, Tomás Concha, Jorge Vítor, António J. Almeida, Cecília Calado, Lídia M. Gonçalves

“…<b>Conclusions</b>: These findings indicate that both pDNA and recombinant protein vaccines encapsulated into chitosan nanoparticles are promising candidates for eradicating <i>H. pylori</i> and mitigating associated gastric diseases in humans.…”
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Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy by Qin Qin, Wenxing Wu, Ling Che, Xing Zhou, Diedie Wu, Xiaohui Li, Yumin Yang, Jie Lou

“…<b>Conclusions:</b> PLL-HDCA NPs represent a safe, efficient, and multifunctional nano-drug suitable for topical applications to control bleeding, combat infection, and facilitate wound healing, making them promising candidates for use in battlefield and hospital settings.…”
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Malnutrition risk, weight loss, and subsequent survival in patients listed for heart transplantation by Tae Kyung Yoo, MD, MS, Satoshi Miyashita, MD, Ariella Stein, MSCIS-HI, Michael Wu, BS, MPH, Lauren Parsly Read-Button, MPH, RD, LDN, Masashi Kawabori, MD, Greg S. Couper, MD, Edward Saltzman, MD, Amanda R. Vest, MBBS, MPH

“…We investigated which malnutrition risk scores – geriatric nutrition risk index (GNRI), prognostic nutritional index (PNI), or controlling nutritional status (CONUT) – have the strongest mortality association for HT candidates, and whether they are prognostic at the time of HT listing or HT operation. …”
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Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…RNAseq experiments allowed the identification of 170 differentially expressed genes, including known Wnt/β-catenin target genes such as Notum, Axin2, and Lef1, as well as novel potential candidates Fam84a, Stk32a, and Itga9. Main biological processes enriched with differentially expressed genes included neural precursor (GO:0061364, p-adjusted = 2.5 × 10−7), forebrain development (GO:0030900, p-adjusted = 7.3 × 10−7), and stem cell differentiation (GO:0048863 p-adjusted = 7.3 × 10−7). …”
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A nucleoside-modified mRNA vaccine prevents enterovirus A71 infection in mouse model by Fengyu Chi, Fengyu Chi, Xu Zhang, Xu Zhang, Dong Zhang, Dong Zhang, Airu Zhu, Zhen Zhuang, Zhaoyong Zhang, Zhenjie Zhang, Chuansong Quan, Kaixiao Nie, Juan Li, Chunhong Yin, Jie Tong, Yuming Li, Yuming Li, Yuming Li

“…Although inactivated vaccines have been approved, there is growing interest in developing new candidates using advanced platforms. mRNA vaccines, widely used for enveloped viruses, are less studied for non-enveloped viruses like EV-A71. …”
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Multiomics unravels the complexity of male obesity: a prospective observational study by Georgios E. Papadakis, Lucie Favre, Yassine Zouaghi, Nathalie Vionnet, Nicolas J. Niederländer, Michela Adamo, James S. Acierno, Dassine Berdous, Alexia Boizot, Jenny Meylan, Julijana Ivanisevic, Emmanuelle Paccou, Hector Gallart-Ayala, Tim Reyns, Elise Van Caeneghem, Bruno Lapauw, Jérôme Pasquier, Yasser Aleman, Styliani Mantziari, Olivier Salamin, Raul Nicoli, Tiia Kuuranne, Tom Fiers, Patric Hagmann, Federico Santoni, Andrea Messina, Nelly Pitteloud

“…Methods Thirty-two morbidly men with obesity who were candidates for Roux-en-Y gastric bypass (RYGB) surgery were prospectively followed. …”
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Effectiveness of a bacteriophage YZU_PF006 in controlling dairy spoilage caused by Pseudomonas fluorescens by Lei Yuan, Lili Ma, Yang Liu, Xinhai Yuan, Shuo Wang, Wenyuan Zhou, Zhenbo Xu, Zhenquan Yang

“…Results demonstrated that phage YZU_PF006 can be used alone or in combination with other control strategies to serve as one of the good antimicrobial candidates to control P. fluorescens contamination in dairy processing environments, and to promote the safety and sensory quality of raw milk and milk products.…”
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JWST, ALMA, and Keck Spectroscopic Constraints on the UV Luminosity Functions at z ∼ 7–14: Clumpiness and Compactness of the Brightest Galaxies in the Early Universe by Yuichi Harikane, Akio K. Inoue, Richard S. Ellis, Masami Ouchi, Yurina Nakazato, Naoki Yoshida, Yoshiaki Ono, Fengwu Sun, Riku A. Sato, Giovanni Ferrami, Seiji Fujimoto, Nobunari Kashikawa, Derek J. McLeod, Pablo G. Pérez-González, Marcin Sawicki, Yuma Sugahara, Yi Xu, Satoshi Yamanaka, Adam C. Carnall, Fergus Cullen, James S. Dunlop, Eiichi Egami, Norman Grogin, Yuki Isobe, Anton M. Koekemoer, Nicolas Laporte, Chien-Hsiu Lee, Dan Magee, Hiroshi Matsuo, Yoshiki Matsuoka, Ken Mawatari, Kimihiko Nakajima, Minami Nakane, Yoichi Tamura, Hiroya Umeda, Hiroto Yanagisawa

“…Our JWST/NIRSpec observations have also revealed that very bright galaxy candidates at z ∼ 10–13 identified from ground-based telescope images before JWST are passive galaxies at z ∼ 3–4, emphasizing the necessity of strict screening and spectroscopy in the selection of the brightest galaxies at z > 10. …”
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The JADES Transient Survey: Discovery and Classification of Supernovae in the JADES Deep Field by Christa DeCoursey, Eiichi Egami, Justin D. R. Pierel, Fengwu Sun, Armin Rest, David A. Coulter, Michael Engesser, Matthew R. Siebert, Kevin N. Hainline, Benjamin D. Johnson, Andrew J. Bunker, Phillip A. Cargile, Stephane Charlot, Wenlei Chen, Mirko Curti, Shea DeFour-Remy, Daniel J. Eisenstein, Ori D. Fox, Suvi Gezari, Sebastian Gomez, Jacob Jencson, Bhavin A. Joshi, Sanvi Khairnar, Jianwei Lyu, Roberto Maiolino, Takashi J. Moriya, Robert M. Quimby, George H. Rieke, Marcia J. Rieke, Brant Robertson, Melissa Shahbandeh, Louis-Gregory Strolger, Sandro Tacchella, Qinan Wang, Christina C. Williams, Christopher N. A. Willmer, Chris Willott, Yossef Zenati

“…We also found that two z ∼ 16 galaxy candidates from the first imaging epoch were actually transients that faded in the second epoch, illustrating the possibility that moderate/high-redshift SNe could mimic high-redshift dropout galaxies.…”
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The emerging role of blood-based biomarkers in early detection of colorectal cancer: A systematic review by Faris Shweikeh, Yuhao Zeng, Abdur Rahman Jabir, Erica Whittenberger, Saurav P. Kadatane, Yuting Huang, Mohamad Mouchli, Dani Ran Castillo

“…Protein biomarkers, contrasted with established cancer markers, unveiled notable candidates like Irisin and ANXA2, with AUCs surpassing 0.96. …”
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Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…Their diverse mechanisms of action and minimal side effects position them as candidates for further research and development. Future studies should focus on clinical trials to establish their efficacy and safety in humans, paving the way for new cancer therapies.…”
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Study of the Interplay Among Melt Morphology, Rheology and 3D Printability of Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate) Blends by Marco Costantini, Flavio Cognini, Roberta Angelini, Sara Alfano, Marianna Villano, Andrea Martinelli, David Bolzonella, Marco Rossi, Andrea Barbetta

“…Among the others, poly(hydroxyalkanoates) (PHAs) hold significant potential as candidates for FDM since they meet the sustainability and biodegradability standards mentioned above. …”
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Adherence to the ISHLT Protocol for the Referral of Patients with Idiopathic Pulmonary Fibrosis to the Transplantation Center among of Czech Centers for Interstitial Lung Diseases by Martina Sterclova, Martina Doubkova, Lubica Sykorova, Vladimir Bartos, Monika Zurkova, Vladimira Lostakova, Radka Mokosova, Martina Plackova, Ladislav Lacina, Michaela Cimrova, Radka Bittenglova, Pavlina Lisa, Pavla Musilova, Daniel Dolezal, Jana Psikalova, Petra Ovesna, Martina Koziar Vasakova

“…Among Czech patients with IPF, there may be a larger pool of potential lung transplant candidates than has been reported to the transplant center to date.…”
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