Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics by Seyede Sara Pakdaman Kolour, Saeide Nematollahi, Masoud Dehbozorgi, Farnaz Fattahi, Fatemeh Movahed, Neda Esfandiari, Mohammad Saeed Kahrizi, Nima Ghavamikia, Bahareh Salmanian Hajiagha

“…Further, attractive candidates for cell-free therapy for OA are MSC-derived extracecellulr vesicles (EVs) that convey bioactive molecules of the original cells, such as microRNAs. …”
Get full text

Increased Chemokine Production is a Hallmark of Rhesus Macaque Natural Killer Cells Mediating Robust Anti-HIV Envelope-Specific Antibody-Dependent Cell-Mediated Cytotoxicity by Junsuke Nohara, Tyler Evangelous, Madison Berry, Whitney Beck, Sarah Mudrak, Shalini Jha, R. Keith Reeves, Kevin J. Wiehe, Justin Pollara, Georgia Tomaras, Todd Bradley, Guido Ferrari

“… Background: Antibody-dependent cell-mediated cytotoxic (ADCC) response mediated by natural killer (NK) cells correlates with decreased infection risk in studies involving simian immunodeficiency virus (SIV)/simian-human immunodeficiency virus (SHIV), and human immunodeficiency virus (HIV) vaccine candidates. Currently, the heterogeneities of the functional subset of rhesus macaque natural killer (RMNK) cells are under-characterized.  …”
Get full text

Research advances of metal fluoride for energy conversion and storage by Runlin Zhang, Zijin Xu, Zeyu Hao, Zeshuo Meng, Xiufeng Hao, Hongwei Tian

“…This makes them promising candidates for future electrochemical applications in various fields. …”
Get full text

Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics by Peter S. Kim, Joseph J. Crivelli, Il-Kyu Choi, Chae-Ok Yun, Joanna R. Wares

“…Some of the most promising therapeutic candidates are now being engineered to produce immunostimulatory factors, such as cytokines and co-stimulatory molecules, which, in addition to viral oncolysis, initiate a cytotoxic immune attack against the tumor. …”
Get full text

Localized COUP‐TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts by Mengmeng Xing, Fei Wang, Ruowen Chu, He Wang, Yuyao Sun, Meng Qian, Huan Jiang, Adam C. Midgley, Guohao Dai, Qiang Zhao

“…Abstract Decellularized allografts have emerged as promising candidates for vascular bypass grafting, owing to their inherent bioactivity and minimal immunogenicity. …”
Get full text

MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers by Yixin Yang, Christopher Alderman, Ayoub Sehlaoui, Yuan Xiao, Wei Wang

“…This review also analyzes the ongoing challenge of identifying appropriate therapy candidates for complex and dynamic tumor microenvironment, ensuring efficient and targeted delivery to specific cancer tissues, and developing strategy for avoiding off-target effect.…”
Get full text

Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications by Wang Meng, Wang Chao, Zhao Kaiwei, Ma Sijia, Sang Jiajia, Xu Shijie

“…These compounds have demonstrated significant anti-inflammatory, antioxidant, and neurogenic effects, making them promising candidates for the prevention and treatment of neurological conditions, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and depression. …”
Get full text

Potential Piperolactam A Isolated From Piper betle as Natural Inhibitors of Brucella Species Aminoacyl‐tRNA Synthetase for Livestock Infections: In Silico Approach by Diding Latipudin, Sefren Geiner Tumilaar, Yoga Ramdani, Dudi Dudi, Dikdik Kurnia

“…The urgency of discovering new drug candidates to combat Brucella’s infection necessitates the exploration of novel alternative agents with unique protein targets. …”
Get full text

Position Paper by Canadian Dental Sleep Medicine Professionals Regarding the Role of Different Health Care Professionals in Managing Obstructive Sleep Apnea and Snoring with Oral A... by Luc Gauthier, Fernanda Almeida, Patrick Arcache, Catherine Ashton-McGregor, David Côté, Helen Driver, Kathleen Ferguson, Gilles Lavigne, Philippe Martin, Jean-François Masse, Florence Morisson, Jeffrey Pancer, Charles Samuels, Maurice Schachter, Frédéric Sériès, Glendon Sullivan

“…OAs offer an effective, first-line treatment option for patients with mild to moderate OSA who prefer an OA to continuous positive airway pressure (CPAP) therapy, or for severe OSA patients who cannot tolerate CPAP, are inappropriate candidates for CPAP or who have failed CPAP treatment attempts. …”
Get full text

FingerDTA: A Fingerprint-Embedding Framework for Drug-Target Binding Affinity Prediction by Xuekai Zhu, Juan Liu, Jian Zhang, Zhihui Yang, Feng Yang, Xiaolei Zhang

“…Ultimately, the docking experiment demonstrates that FingerDTA can find novel drug candidates for targets. All codes are available at http://lanproxy.biodwhu.cn:9099/mszjaas/FingerDTA.git.…”
Get full text

Semantic search helper: A tool based on the use of embeddings in multi-item questionnaires as a harmonization opportunity for merging large datasets – A feasibility study by Karl Gottfried, Karina Janson, Nathalie E. Holz, Olaf Reis, Johannes Kornhuber, Anna Eichler, Tobias Banaschewski, Frauke Nees, IMAC-Mind Consortium

“…Expert ratings of semantic similarity candidates showed high agreement with model-generated pairs, confirming the validity of our approach. …”
Get full text

Evolutionary Algorithms and Quantum Computing: Recent Advances, Opportunities, and Challenges by Junaid Ur Rehman, Muhammad Shohibul Ulum, Abdurrahman Wachid Shaffar, Amirul Adlil Hakim, Mujirin, Zaid Abdullah, Hayder Al-Hraishawi, Symeon Chatzinotas, Hyundong Shin

“…Nature-inspired metaheuristics have emerged as promising candidates for fulfilling this optimization role. In this paper, we discuss both of these potential directions at the intersection of evolutionary computing and quantum computing while surveying some of the most promising advancements in these directions. …”
Get full text

Propensity score matching analysis of valve-sparing versus aortic root replacement in type A aortic dissection patients by Ling Chen, Yichao Pan, Huaijian Zhang, Yi Chen, Chunsheng Wang, Zhihuang Qiu, Heng Lu, Liangwan Chen

“…These findings support the wider utilization of valve-sparing root replacement (VSRR) in appropriately selected patients, highlighting its potential advantages for suitable candidates.…”
Get full text

Unconventional quantum oscillations and evidence of nonparabolic electronic states in quasi-two-dimensional electron system at complex oxide interfaces by Km Rubi, Denis R. Candido, Manish Dumen, Shengwei Zeng, Emily L.Q.N. Ammerlaan, Femke Bangma, Mun K. Chan, Michel Goiran, Ariando Ariando, Suvankar Chakraverty, Walter Escoffier, Uli Zeitler, Neil Harrison

“…The simultaneous occurrence of electric-field controlled superconductivity and spin-orbit interaction makes two-dimensional electron systems (2DES) constructed from perovskite transition metal oxides promising candidates for the next generation of spintronics and quantum computing. …”
Get full text

The Electoral History of the Post-Soviet Crimea: from UkSSR to Russia by A. A. Tokarev

“…For each vote, except for the regional elections, the average results of the main candidates are presented in the Crimea and in Ukraine. …”
Get full text

Liver Transplantation: Evolving Patient Selection Criteria by Andy S Yu, Aijaz Ahmed, Emmet B Keeffe

“…The mounting disparity between the number of liver transplant candidates and the limited supply of donor organs has led to reassessment of the selection and listing criteria for liver transplantation, as well as revision of organ allocation and distribution policies for cadaver livers. …”
Get full text

Investigation of Selected Companies' Websites for Online Recruitment and Sustainability Indicators by Gamze Ay, Hasan Tutar

“…Online platforms should be established to access and communicate employee and potential employee candidates to Human Resources. The era we live in is called the information age and the most important concept defining this era is change and the increase in the speed of change. …”
Get full text

Controlled human malaria infection: overview and potential application in the evaluation of transmission-blocking interventions in malaria-endemic areas by Enock J. Kessy, Ally I. Olotu

“…The establishment of such a model in malaria-endemic countries will facilitate the selection of potential transmission-blocking intervention (TBI) candidates and accelerate their development. Here is an overview of CHMI, key challenges and ethical considerations in adopting CHMI for the evaluation of malaria transmission-blocking interventions in malaria-endemic countries.…”
Get full text

Acute Stroke Management and Outcome: An Experience from One Private Tertiary Care Center in Eastern India by Debabrata Chakraborty, Devarati Biswas, Sakshi Puri, Abdul Malik, Shagufta Eqbal, Insha Aleena, Ritwika Ghosh, Sadanand Dey, Priyanjita Sen, Sucharita Paul

“…In a significant number of cases, patients arrived late (only 45 out of 366 were candidates for acute stroke intervention), and attendants were not immediately ready with their consent for 15 of these 45 patients. …”
Get full text

Retrograde recanalization of chronic coronary occlusion by S.М. Furkalo

“…Successful recanalization of CТO is associated with better survival compared to patients where the procedure of recanalization was not successful. Thus, potential candidates for retrograde recanalization of CТO are рatients after failed attempt of recanalization with clear indications and motivated to implement PCI; with refractory angina and CТO of native coronary arteries after CABG; single-vessel coronary artery disease (right coronary artery, RCA or left anterior disease, LAD) with preserved left ventricular function and preserved kidney; patients with multivessel disease and related comorbidity making coronary artery bypass surgery impossible. …”
Get full text