Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain by Michaela Berankova, Jiri Holoubek, Vaclav Hönig, Zuzana Matusova, Martin Palus, Jiri Salat, Imtissal Krayem, Jarmila Vojtiskova, Pavel Svoboda, Veronika Pranclova, Lukas Valihrach, Peter Demant, Marie Lipoldova, Daniel Ruzek

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Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments by Ding B, Li M, Zhang J, Zhang X, Gao H, Gao J, Shen C, Zhou Y, Li F, Liu A

“…Baoyue Ding,1,2,* Mingjuan Li,2,* Jie Zhang,2,* Xiaojuan Zhang,2 Huan Gao,2 Jianqing Gao,3 Chunyan Shen,4 Yan Zhou,4 Fanzhu Li,5 Ailin Liu1 1Department of Pharmaceutical Analysis, Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, The School of Pharmacy, Fujian Medical University, Fuzhou, 350122, People’s Republic of China; 2Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, Jiaxing University College of Medicine, Jiaxing, Zhejiang, People’s Republic of China; 3Institute of Pharmaceutics, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058 People’s Republic of China; 4Jiaxing Institute for Food, Drug and Product Quality Control, Jiaxing, Zhejiang, People’s Republic of China; 5Zhejiang Chinese Medical University, School of Pharmaceutical Science, Hangzhou, 310053, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fanzhu Li; Ailin Liu, Email lifanzhu@zcmu.edu.cn; ailinliu@mail.fjmu.edu.cnPurpose: The incidence of malignant melanoma (MM) has risen over the past three decades, and despite advancements in treatment, there is still a need to improve treatment modalities. …”
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Noninvasive oxygenation and ventilation strategies for viral acute respiratory failure: a comprehensive systematic review and meta-analysis by Fredy Leonardo Carreño-Hernández, Sergio Prieto, Daniela Abondando, Jairo Alejandro Gaitán, Yenny Rocío Cárdenas -Bolívar, Adriana Beltrán, Jorge Iván Alvarado-Sánchez, Joseph L. Nates

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Effect of General Anesthesia Combined with Transversus Abdominis Plane Block on Postoperative Sleep Disorders in Elderly Patients Undergoing Gastrointestinal Tumor Surgery: A Prosp... by Pu J, Guo C, Xiao Y, Cao Y, Liu Z, Jin Y, Hu Y

“…Jie Pu,1 Chendong Guo,1 Yue Xiao,2 Yanan Cao,1 Zhenhua Liu,3 Yuzhong Jin,3 Yimin Hu4 1Department of Anesthesiology, The Second People’s Hospital of Changzhou, Nanjing Medical University, Changzhou, 213003, People’s Republic of China; 2Department of Anesthesiology, Sichuan Cancer Hospital, Chengdu, 100062, People’s Republic of China; 3Changzhou Wujin Hospital of Traditional Chinese Medicine, Changzhou, 213161, People’s Republic of China; 4Department of Anesthesiology, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, People’s Republic of ChinaCorrespondence: Yimin Hu, Department of Anesthesiology, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, People’s Republic of China, Tel +86 18951767577, Email guyueym@njmu.edu.cnPurpose: The aim of this study was to investigate the effect of general anesthesia combined with transversus abdominis plane block on postoperative sleep disorders in elderly patients undergoing gastrointestinal tumor surgery.Methods: For elderly patients with gastrointestinal malignant tumors, we recruited 94 patients, aged 65– 80, who were scheduled for radical laparoscopic surgery. …”
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Workplace Health Promotion as a good solution to the negative impact of the financial crisis on healthcare systems by Francesco Chirico

“…Primary care, especially preventive medicine, has been one of the sectors most affected by the deterioration of healthcare standards, which is in turn the most effective strategies against some of the deadliest conditions affecting developed countries, such as cancer and cardiovascular diseases. An often-neglected solution to the lack of government funds for healthcare and preventive medicine is Workplace Health Promotion (WHP). …”
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The Croton genera (Euphorbiaceae) and its richness in chemical constituents with potential range of applications by Carlos Andrés Coy-Barrera, Laura Galvis, Maria Juliana Rueda, Sergio Alejandro Torres-Cortés

“…Ethnobotanical studies reflect numerous uses in different communities, addressing issues such as intestinal disorders, general pain, cancer, hypertension, diabetes, hemorrhoids, sexual impotence, respiratory diseases, COVID -19, ulcers, and intestinal parasites. …”
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Promotional tone in reviews of menopausal hormone therapy after the Women's Health Initiative: an analysis of published articles. by Adriane Fugh-Berman, Christina Pike McDonald, Alicia M Bell, Emily Catherine Bethards, Anthony R Scialli

“…Scientific accuracy was assessed based on whether or not the findings of the WHI were accurately reported using two criteria: (1) Acknowledgment or lack of denial of the risk of breast cancer diagnosis associated with hormone therapy, and (2) acknowledgment that hormone therapy did not benefit cardiovascular disease endpoints. …”
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Types of electronic nicotine delivery systems (ENDS) used by people of different age and smoking status groups: results from a US nationally representative survey by Lucy Popova, Robert T Fairman, David L Ashley, Zachary B Massey, Bai Cham, Ruiyan Luo, Mohammed Alqahtani, Scott Weaver

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Factors associated with decreased anal sphincter tone and the accuracy of forced anal examinations to detect individuals having receptive anal intercourse: an observational study by John A Schneider, Alan G Nyitray, Derek Smith, Michael W Ross, Elizabeth Y Chiao, Timothy J Ridolfi, Bridgett Brzezinski, B R Simon Rosser, Aniruddha Hazra, Jenna Nitkowski, Sandrine Sanos, Ever Mkonyi, Lucy Mgopa

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Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study by Kerry Woolfall, Mark J Peters, Padmanabhan Ramnarayan, Elizabeth Deja, Jennifer Preston, Paul R Mouncey, Julie C Menzies, Doug William Gould, Tracy Karen Mitchell, Shelley Marsh, Jennifer Ainsworth, Hannah Sedgwick, Carly Tibbins

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Complementary Embryonic and Adult Cell Populations Enhance Myocardial Repair in Rat Myocardial Injury Model by Sergio Li Calzi, Todd Cook, Domenico G. Della Rocca, Juan Zhang, Vinayak Shenoy, Yuanqing Yan, Andrew Espejo, Anandharajan Rathinasabapathy, Max H. Jacobsen, Tatiana Salazar, George E. Sandusky, Lynn C. Shaw, Keith March, Mohan K. Raizada, Carl J. Pepine, Michael J. Katovich, Maria B. Grant

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Life cycle assessment of paper products based on recycled and virgin fiber by J. Simamora, E.I. Wiloso, M. Yani

“…The results of the impact assessment of global warming potential fossil, acidification, particulates, fossil abiotic depletion, and human toxicity-cancer for duplex board were 1,848.26 kilogram carbon dioxide equivalent, 8.12 kilogram-sulfur-dioxide-equivalent, 2.12 kilogram particulate matter 2.5-equivalent, 14,668.06 megajoule, and 0.0000017 comparative toxic unit, while for folding boxboard 2,651.25 kilogram carbon- dioxide-equivalent, 13.95 kilogram sulfur-dioxide-equivalent, 3.27 kilogram particulate matter 2.5-equivalent, 22,395.81 mega-joule, and 0.0000021 comparative toxic unit, respectively. …”
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Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme by Peter Nash, Yoshiya Tanaka, Kevin L Winthrop, Eun Bong Lee, Xavier Mariette, Jeffrey R Curtis, Kenneth Kwok, Connie Chen, Pinaki Biswas, Lisy Wang, Christina Charles-Schoeman, Ann Madsen, Stanley B Cohen, Andrea Shapiro, Jürgen Wollenhaupt

“…IRs (95% CI) for malignancies (excluding non-melanoma skin cancer [NMSC]), NMSC and lymphomas were 0.8 (0.7 to 0.9), 0.6 (0.5 to 0.7) and 0.1 (0.0 to 0.1), respectively. …”
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Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atro... by Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, Weihao You, Yujie Duan, Yawen An, Shiwei He, Weimin Ye

“…APSN + CXCL11 + APOE + fibroblasts were found to be associated with gastric cancer (GC) development. Conclusions The main goal of this study was to comprehensively elucidate the cellular changes in CAG lesions. …”
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The infiltration risk prediction models by logistic regression for ground-glass pulmonary nodules: a systematic review and meta-analysis by Mengqian Li, Mengqian Li, Xiaomei Zhang, Yuxin Lai, Yunlong Sun, Tianshu Yang, Xinlei Tan

“…The independent risk factors included in the model can help medical workers to identify the high-risk groups of invasive lung cancer in ground-glass nodules in time and improve the prognosis.…”
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Integrated bioinformatics analysis to explore potential therapeutic targets and drugs for small cell carcinoma of the esophagus by Maofei Zhu, Maofei Zhu, Yueming Chu, Yueming Chu, Qiang Yuan, Qiang Yuan, Junfeng Li, Silin Chen, Lin Li, Lin Li, Lin Li

“…BackgroundSmall cell carcinoma of the esophagus (SCCE) is a rare form of esophageal cancer, which also belongs to the category of neuroendocrine malignant tumors, with a low incidence but high aggressiveness, and a very poor prognosis for patients. …”
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Polygonatum kingianum polysaccharide alleviated intestinal injuries by mediating antioxidant ability and microbiota by Reng Qiu, Chuangye Pan, Yuxi Qin, Qianfei Wei, Yue Yu, Ying Zhang, Xuehan Xie, Jianqin Li, Shouhai Chen, Kun Li, Dalia Fouad, Yi Wu, Qiu Zhong

“…IntroductionPolygonatum kingianum is a well-known medicinal herb with proven bioactivities; however, little is known about the effects of its polysaccharide on intestinal injuries in animals induced by lipopolysaccharide (LPS).MethodsA total of 30 Institute of Cancer Research (ICR) mice were divided into control (CH), induced (MH), and treated (H) groups. …”
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RETRACTED: Mechanism of action of Asparagus officinalis extract against multiple myeloma using bioinformatics tools, in silico and in vitro study by Yanju Li, Xu Yang, Feiqing Wang, Feiqing Wang, Jianing Zhao, Chike Zhang, Dan Wu, Bo Yang, Rui Gao, Peng Zhao, Yun Zan, Min Su, Zhixu He, Yang Liu, Yang Liu, Yang Liu, Jishi Wang, Dongxin Tang

“…Cell experiments showed that asparagus, through the PI3K/AKT/NF-κB pathway, inhibited the proliferation and migration of MM cells, and caused retardation and apoptosis of MM cells in the G0/G1 phase.Discussion: In this study, the anti-cancer activity of asparagus against MM was demonstrated using network pharmacology, and potential pharmacological mechanisms were inferred using in vitro experimental data.…”
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Spatial characteristics and health risks assessments of trace metal pollution from road dusts in the industrialized city of Bangladesh by Masum Howlader, Ashik Md Mamun, Mohammad Mahfuzur Rahman, Md Hasibur Rahman, Sadhon Chandra Swarnokar, Mahfuza Sultana, Md Tanvir Rahman, Tusar Kumar Das

“…The hazard index (HI) showed that Cr, Co, and Pb impose moderate to high non-carcinogenic human health risks. The infant's cancer risk for Cd (1.66−05) and Cr (1.59−04) is very close to the upper limit (10−4 to 10−6). …”
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Establishing a radiomics model using contrast-enhanced ultrasound for preoperative prediction of neoplastic gallbladder polyps exceeding 10 mm by Dong Jiang, Yi Qian, Yijun Gu, Ru Wang, Hua Yu, Zhenmeng Wang, Hui Dong, Dongyu Chen, Yan Chen, Haozheng Jiang, Yiran Li

“…GBP with a diameter exceeding 10 mm are associated with an increased risk of gallbladder cancer, making the key to their management the differentiation between benign and malignant types. …”
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