Contextual adaptation of digital wellbeing interventions for young people: insights from a project in Saudi Arabia by Dahlia Aljuboori, Laura K. Clary, Saud Abdulaziz Alomairah, Saud Abdulaziz Alomairah, Michelle Colder Carras, Nazmus Saquib, Juliann Saquib, Fahad Albeyahi, Antonius J. Van Rooij, Anouk Tuijnman, Vincent G. Van der Rijst, Michelle R. Kaufman, Michelle R. Kaufman, Johannes Thrul, Johannes Thrul, Johannes Thrul

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An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure by Seth Kwadjo Angmorterh, Andrew England, Sonia Aboagye, Eric Kwasi Ofori, Peter Hogg

“…The incidence of pressure ulcers (PUs) presents a substantial threat to patients, especially geriatric patients, those with restricted mobility, and patients suffering from chronic diseases such as cancer. PUs creates a huge financial burden on healthcare authorities and patients, costing billions to treat and manage. …”
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LncRNA GAS5 inhibits glioma progression through miR-135b-5p/APC axis by ZHANG Jidong, WANG Yutao, JI Jianwen

“…Western blotting and qRT-PCR indicated that GAS5 was down-regulated in the glioma cell lines and tissues than human normal astrocytes and para-cancer tissues (P<0.01). The results of CCK-8, Transwell and wound healing assays revealed that overexpression of GAS5 significantly inhibited the viability, invasion and migration abilities in T98 cells when compared with the cells of the vector group (P<0.01). …”
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Effectiveness of nurse-led care in patients with rheumatoid arthritis: a systematic review and meta-analysis by Dan Liu, Li Liu, Lin Yang, Ting Wen, Peng Xiang, Guifang Pi

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Role and sensitivity of Positron Emission Tomography with [18F]Fluorodeoxyglucose in diagnosis and follow-up of patients affected by chronic pulmonary aspergillosis (CPA) by Gianfranco Schiraldi, Cristina Elena Popescu, Michele Chiericozzi, Salvatore Lo Cicero, Flavio Allegri, Franco Mosca, Claudio Rossetti

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On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (<i>Actaea racemosa</i> L.) by Martin J. Spiering, James F. Parsons, Edward Eisenstein

“…., Ranunculaceae) is a multicomponent botanical therapeutic used as a popular remedy for menopause and dysmenorrhea and explored as a treatment in breast and prostate cancer. However, its use and safety are controversial. …”
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Providing medically tailored groceries and food resource coaching through the charitable food system to patients of a safety-net clinic in Dallas, Texas: a randomised controlled tr... by Michael Bowen, Sandi L Pruitt, Jaclyn Albin, Tammy Leonard, Willis Wong, Milette Siler, Carolyn Haskins, Jessica Turcios, Carla Pezzia, Alisha Ford, Bianca Schinzer, Kelseanna Hollis-Hansen

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Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: R... by John Porter, Donald K. Bowden, Marina Economou, Jacques Troncy, Arnold Ganser, Dany Habr, Nicolas Martin, Adam Gater, Diana Rofail, Linda Abetz-Webb, Helen Lau, Maria Domenica Cappellini

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Identifying specific subgroups of older patients at risk of repeated hospital readmissions and death after discharge in a prospective multicentre cohort in France by Jean-Baptiste Beuscart, Fabien Visade, Genia Babykina, Jesus Carretero-Bravo, Guillaume Deschasse, Vincent Vandewalle

“…A multivariate logistic regression analysis identified only four characteristics weakly associated with the risk of being in subgroup 2 (at least one hospital admission in the 6 months preceding the index hospital admission, cancer, polymedication and weight changes (gain or loss) during the index hospital admission). …”
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Thyroid Dysfunction After Intensity-Modulated Radiotherapy and PD&#x2043;1 Inhibitor Treatment for Locally Advanced Nasopharyngeal Carcinoma by Shang K, He Q, Xu X, Luo X, Zhao C, Liu L, Li Z, Li Y, Jin F

“…Kai Shang,1,2,&ast; Qianyong He,1– 3,&ast; Xinyu Xu,2 Xunyan Luo,2 Chaofen Zhao,1,3 Lina Liu,1– 3 Zhuoling Li,1– 3 Yuanyuan Li,1– 3 Feng Jin1,3 1Department of Oncology, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 2School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 3Department of Oncology, the Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Feng Jin, Department of Oncology, the Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, People’s Republic of China, Tel +851-86512802, Email tjzlk2023@163.comPurpose: Analyze the incidence and risk factors of thyroid dysfunction in patients with advanced nasopharyngeal carcinoma (LA-NPC) after intensity-modulated radiotherapy (IMRT) and PD⁃1 inhibitor treatment and their relationship with treatment efficacy and prognosis.Methods: Eighty-five LA-NPC patients treated with IMRT and PD-1 inhibitors were retrospectively collected from March 1, 2019, to May 30, 2022. …”
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MicroRNA-3145 as a potential therapeutic target for hepatitis B virus: inhibition of viral replication via downregulation of HBS and HBX by Amrizal Muchtar, Amrizal Muchtar, Daichi Onomura, Daichi Onomura, Dan Ding, Dan Ding, Hironori Nishitsuji, Kunitada Shimotohno, Shunpei Okada, Keiji Ueda, Koichi Watashi, Takaji Wakita, Kei Iida, Kei Iida, Hironori Yoshiyama, Hisashi Iizasa

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Postoperative mortality in New Zealand following general anaesthetic: demographic patterns and temporal trends by James Stanley, Sarah Jackson, Jason K Gurney, Melissa McLeod, Doug Campbell, Luke Boyle, Elizabeth Dennett, Jonathan Koea, Dick Ongley, Diana Sarfati

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Machine learning models reveal microbial signatures in healthy human tissues, challenging the sterility of human organs by Anargyros Skoulakis, Anargyros Skoulakis, Giorgos Skoufos, Giorgos Skoufos, Armen Ovsepian, Armen Ovsepian, Artemis G. Hatzigeorgiou, Artemis G. Hatzigeorgiou

“…Exploring the microbiome of internal tissues holds promise for elucidating the pathophysiology underlying both health and a spectrum of diseases, including sepsis, inflammation, and cancer.…”
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Determination of Total Levels of Secondary Metabolites and Oral Acute Toxicity Testing of Purple Leaf Ethanol Extract (PLEE) in Wistar Rats by Niluh Puspita Dewi, Miranti Miranti, Magfirah Magfirah, Athia Kurnia Kasim, I Made Dipayana

“…These leaves are traditionally used to treat rheumatism, menstruation, hemorrhoids, urinary tract infections, scabies, swelling, wounds, dermatitis, ear diseases, laxatives, and cancer. The aim of this study was to determine the total levels of secondary metabolites from purple leaf extract ethanol (PLEE) and evaluate the effect of administering PLEE on acute toxicity (LD50) in Wistar rats. …”
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The association of public health interventions regarding both infant sleep position and pertussis immunization with sudden infant death syndrome rates: an ecological study by Jacqueline Müller-Nordhorn, Amir Hakimhashemi, Stefan N. Willich, Sylvia Binting, Thomas Keil

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Self-reported knowledge and difficulties towards palliative care among healthcare professionals in rural China: a cross-sectional study by Junwei Niu, Min Feng, Changhui Song, Hui Xie

“…Data were collected on participants’ demographic characteristics, information on recently deceased cancer patients they had cared for, and PC-related information. …”
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Fortifying plant fortresses: siderophores in defense against Cercospora leaf spot disease in Vigna radiata L. by Anushree Kamath, Abhishek Sharma, Arpit Shukla, Arpit Shukla, Arpit Shukla, Paritosh Parmar, Dhara Patel

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Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation by Laura Kampe, Laura Kampe, Christian Melcher, Christian Melcher, Katrin Westphal, Katrin Westphal, Korbinian Brand, Niko Föger, Niko Föger, Kyeong-Hee Lee, Kyeong-Hee Lee

“…This process could also manifest as clinical complication of therapy-induced lymphopenia in the context of transplantation and cancer in human patients.…”
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Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

“…The M6P-conjugated antibody against a protein of interest (POI) efficiently internalized targeted soluble proteins, such as human tumor necrosis factor (TNF), in both cancer cell lines and human immune cells, through the endo-lysosomal pathway as demonstrated by confocal microscopy and flow cytometry. …”
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Phytochemical and Biological Investigations of Crude Extracts of <i>Astragalus pisidicus</i> by Esra Aydemir, Elif Odabaş Köse, Serap Özkaya Gül, Alaaddin Korkut, A. Cansu Kilit, Mehmet Engin Celep, Mustafa Yavuz, R. Süleyman Göktürk, Cengiz Sarikurkcu

“…<b>Conclusions</b>: <i>A. pisidicus</i> elicited apoptotic cell death in cancer cells selectively by the activation of caspases and subsequent DNA fragmentation and may serve as a novel source of an apoptosis-inducing anticancer drug.…”
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